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The map label for this gene is pth-1

Identifier: 116328182

GI number: 116328182

Start: 1764324

End: 1764893

Strand: Direct

Name: pth-1

Synonym: LBL_1506

Alternate gene names: 116328182

Gene position: 1764324-1764893 (Clockwise)

Preceding gene: 116328181

Following gene: 116328183

Centisome position: 48.81

GC content: 38.42

Gene sequence:

>570_bases
ATGGCAAACTTAAAACTTTTACTTGTGGGTATTGGAAACCCTGGCCCAAAATATGCCTATAATCGGCATAACATCGGTTT
TGTGATTTTAGATTCTCTTTTAAATTCTTCTTCTGCAAGTTATCAGACGAACTCCAAGTATTCACTGGCAAGAACCGACG
AAGAAGGAGTGACGATCTTTTATTTGAAACCTCTTGAATTCATGAATCTTTCCGGAAAAGCAGTCGCCGAAATTGCAAAG
AAAAACGGGATTTCTCCGGAGAATATATTAGTCATTCACGATGAAATCGATTTTGAATTCGGAAAGTTAAAACTCAAAGA
AGGGGGAGGACATGCTGGACATAACGGCTTGAGAAATATCGTGGAAAAACTCGGAACAAACACATTCTTCCGACTTAGAT
TCGGTGTCGGAAAACCGTCCACAGCGTCGGAAGTTTCGGATTATGTACTCTCTAATTTTTTCCCTGAAGAAAAGGAAAAA
ATTCCGGAATTAGTCCAAGTCTCTTTGCAAAAAATCTACGATTGGGTTCGAGAAAGAAAAAACGAATTTCAAAAACCTTC
CGATATTTAG

Upstream 100 bases:

>100_bases
TGGAAGAAGATCAGACTTTCAAAACAATGGGGGTTCATCCGGATCAAACGATTGCGGCCGTTCACGCAACTGAAAAAATG
CTCAATCAGATCCTGCAACC

Downstream 100 bases:

>100_bases
TAGGACATATTGTATTGTATGGAGAATTCAGTTGGGTGATTATCCTTTCCAATTTCCTAAATTTCCTTCCTCGTTTCTCA
ATGAAACTGCGGAAAAATTC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 189; Mature: 188

Protein sequence:

>189_residues
MANLKLLLVGIGNPGPKYAYNRHNIGFVILDSLLNSSSASYQTNSKYSLARTDEEGVTIFYLKPLEFMNLSGKAVAEIAK
KNGISPENILVIHDEIDFEFGKLKLKEGGGHAGHNGLRNIVEKLGTNTFFRLRFGVGKPSTASEVSDYVLSNFFPEEKEK
IPELVQVSLQKIYDWVRERKNEFQKPSDI

Sequences:

>Translated_189_residues
MANLKLLLVGIGNPGPKYAYNRHNIGFVILDSLLNSSSASYQTNSKYSLARTDEEGVTIFYLKPLEFMNLSGKAVAEIAK
KNGISPENILVIHDEIDFEFGKLKLKEGGGHAGHNGLRNIVEKLGTNTFFRLRFGVGKPSTASEVSDYVLSNFFPEEKEK
IPELVQVSLQKIYDWVRERKNEFQKPSDI
>Mature_188_residues
ANLKLLLVGIGNPGPKYAYNRHNIGFVILDSLLNSSSASYQTNSKYSLARTDEEGVTIFYLKPLEFMNLSGKAVAEIAKK
NGISPENILVIHDEIDFEFGKLKLKEGGGHAGHNGLRNIVEKLGTNTFFRLRFGVGKPSTASEVSDYVLSNFFPEEKEKI
PELVQVSLQKIYDWVRERKNEFQKPSDI

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=187, Percent_Identity=33.6898395721925, Blast_Score=118, Evalue=2e-27,
Organism=Escherichia coli, GI1787455, Length=172, Percent_Identity=41.2790697674419, Blast_Score=99, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321983, Length=169, Percent_Identity=32.5443786982249, Blast_Score=82, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_LEPBJ (Q04TA4)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_800624.1
- ProteinModelPortal:   Q04TA4
- SMR:   Q04TA4
- STRING:   Q04TA4
- GeneID:   4410688
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_1281
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   NESGRQV
- PhylomeDB:   Q04TA4
- ProtClustDB:   PRK05426
- BioCyc:   LBOR355277:LBJ_1281-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21196; Mature: 21065

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLKLLLVGIGNPGPKYAYNRHNIGFVILDSLLNSSSASYQTNSKYSLARTDEEGVTIF
CCCEEEEEEECCCCCCCCCCCCCCCHHEEHHHHHCCCCCCCCCCCCEEEEECCCCCEEEE
YLKPLEFMNLSGKAVAEIAKKNGISPENILVIHDEIDFEFGKLKLKEGGGHAGHNGLRNI
EECCHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCEECEEEEECCCCCCCHHHHHHH
VEKLGTNTFFRLRFGVGKPSTASEVSDYVLSNFFPEEKEKIPELVQVSLQKIYDWVRERK
HHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
NEFQKPSDI
HHCCCCCCC
>Mature Secondary Structure 
ANLKLLLVGIGNPGPKYAYNRHNIGFVILDSLLNSSSASYQTNSKYSLARTDEEGVTIF
CCEEEEEEECCCCCCCCCCCCCCCHHEEHHHHHCCCCCCCCCCCCEEEEECCCCCEEEE
YLKPLEFMNLSGKAVAEIAKKNGISPENILVIHDEIDFEFGKLKLKEGGGHAGHNGLRNI
EECCHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCEECEEEEECCCCCCCHHHHHHH
VEKLGTNTFFRLRFGVGKPSTASEVSDYVLSNFFPEEKEKIPELVQVSLQKIYDWVRERK
HHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
NEFQKPSDI
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA