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The map label for this gene is manB-2 [H]

Identifier: 116328125

GI number: 116328125

Start: 1657038

End: 1658801

Strand: Reverse

Name: manB-2 [H]

Synonym: LBL_1423

Alternate gene names: 116328125

Gene position: 1658801-1657038 (Counterclockwise)

Preceding gene: 116328128

Following gene: 116328124

Centisome position: 45.89

GC content: 41.44

Gene sequence:

>1764_bases
ATGAATCATCCCGAATCCTTTATTCATTCCTGGACACAAGAGCCTTTCCCAAGTACGGTCCGGGAAGAAGCGAATCGAGT
ACTTGAAAAATTTTCCAAGGGAGAATCTGGACCTGACGTGGAAGCTTTTTCGATTCCTCTTGAATTCGGAACCGGCGGAA
TGCGAGGAAAACTCGGAAACGGAATCGGAAGAATGAACGAATTTACCGTAGGTCGCGCCGCACTTGGATTCATAAGCTAT
CTATCCAAAAAAAACAAAAAGGCTTCCATTGTAATCGCCTACGATTCCAGAAGGAAGTCTAAAGAATTTGCGGAAGTCAC
AGCAGGAATTGCGGCATCTCTCGGAGTTAAAGTGATTTTATTCCAAGAAGTAACACCCACACCTCTTCTTTCTTACGCAA
TTCGTTACTACAAAGCGACGGGAGGAGTCGTCATCACCGCTTCTCACAATCCTCCCGAATATAACGGTTTTAAGGCGTAT
CTTTCCGACGGAGGACAACTCGTCCCCCCGGACGATCAAAAAATCATTTCGAAAATAGAGTCAATCCGGGACTGGAATAC
CATTTCTCTTCTTTCCCCCAAAGATCCTATTTATAAAAAGATGGTAAAACCCGCCGGAAAAGATTGTTTTTCTTCCTACA
AAAAAGAACTTTCTAAAGCGGGAATTCTTTCCGTCACTCTAAAACCAAAAGACAGGGCTGCGATGAAAATCGTCTATTCT
CCGTTACATGGAACAGGCGCCAAAAGTATGAAAGACCTCTTAAACGGATTCGGATACAAAAATGTATTTCTGGTTCCAGA
ACAAAAAGATCCGAATGGAGAATTCCCCACCGTAAAGTATCCGAATCCGGAAGAACCGGAAGCAATGGAACTTTCCAAAA
AATTTGCGATTCAAAAAAACGCTCACGCTTTTATCGTAAGCGACCCGGACGCGGATAGGCTCGGGATCGGAGTCAAAAAT
GTCCAAGGAGAATATGTTTTATTAAACGGAAATCAGATCGGTTCTATCATGGCGGCTTATCTTTGCGAAAACTATGCAAC
GAGCAAAAAAAAGAAAAAAGCAATTCTCGTAAAAACGATCGTCACCACCGATCTCCAAGAAATCATCGCTAAAAAGAACA
AGGTAAAGTATAAAAACGTTCTCACCGGATTTAAGTTCATCGCGCAAGTGATGGCAAAAATCGATAAGAATAAAACCGAC
TTTTTTTTGTTCGGAGGAGAAGAGTCCTTCGGTTATCTTCCCGTTTCTTTTGTGAGAGACAAAGATTCACTTTCTTCCGC
GCTGTTACTTTTGGAAATTCTCACGGAAAAAAAAGATCTCTTAAACTACATGGATGAGATTTATCTCAAATACGGTCTCT
TTCAAGAAAGTCTCAAATCACTTACGTTGGAAGGACGCGCAGGTAAAGAAAAAATCCGTAAATCCTTGGAATCTCTCCGA
ACCGCGGATCTGTTAGGAAAAAAAATTCATCAAAGAAAGATCATCGGGATTTTAGATTATAAAACTCGAGCTGCAAAGGG
AAATACATCGAAATCCGCATTTTCGGGTTGTCCTTTTTCGGACGTGATTCAAGTCATTTTGGAAGGAAATGCAAAACTTA
CGATCCGCCCCTCCGGCACGGAACCGAAAATTAAAATCTATTCTTCCTTTCAAAGCTTAAAAGCTCCTAATTCCAAAGGA
GAAATTCCAATCCTCATGAAAGATCTCCTTTCCGAAATCAAAGTATCCGAGGAAATATTTTTACGACTGGCGGAACTCTC
ATGA

Upstream 100 bases:

>100_bases
CAATTCCATACTTTAGGAATCGACCAAAATTAGGGTTGAACCTCAAAAGAAAGCCAATTTTTATGAATTTAATCCTCTTA
AAAAATTAAATCGGAACCCT

Downstream 100 bases:

>100_bases
ACGACACAGACATCCACAAAGAACTTTTCCAACATACTAAGGAATTAGCGGATCATTATCTACTCAATACGTATTCAAGA
TACGACGTAGCGTTTCGTTA

Product: phosphomannomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 587; Mature: 587

Protein sequence:

>587_residues
MNHPESFIHSWTQEPFPSTVREEANRVLEKFSKGESGPDVEAFSIPLEFGTGGMRGKLGNGIGRMNEFTVGRAALGFISY
LSKKNKKASIVIAYDSRRKSKEFAEVTAGIAASLGVKVILFQEVTPTPLLSYAIRYYKATGGVVITASHNPPEYNGFKAY
LSDGGQLVPPDDQKIISKIESIRDWNTISLLSPKDPIYKKMVKPAGKDCFSSYKKELSKAGILSVTLKPKDRAAMKIVYS
PLHGTGAKSMKDLLNGFGYKNVFLVPEQKDPNGEFPTVKYPNPEEPEAMELSKKFAIQKNAHAFIVSDPDADRLGIGVKN
VQGEYVLLNGNQIGSIMAAYLCENYATSKKKKKAILVKTIVTTDLQEIIAKKNKVKYKNVLTGFKFIAQVMAKIDKNKTD
FFLFGGEESFGYLPVSFVRDKDSLSSALLLLEILTEKKDLLNYMDEIYLKYGLFQESLKSLTLEGRAGKEKIRKSLESLR
TADLLGKKIHQRKIIGILDYKTRAAKGNTSKSAFSGCPFSDVIQVILEGNAKLTIRPSGTEPKIKIYSSFQSLKAPNSKG
EIPILMKDLLSEIKVSEEIFLRLAELS

Sequences:

>Translated_587_residues
MNHPESFIHSWTQEPFPSTVREEANRVLEKFSKGESGPDVEAFSIPLEFGTGGMRGKLGNGIGRMNEFTVGRAALGFISY
LSKKNKKASIVIAYDSRRKSKEFAEVTAGIAASLGVKVILFQEVTPTPLLSYAIRYYKATGGVVITASHNPPEYNGFKAY
LSDGGQLVPPDDQKIISKIESIRDWNTISLLSPKDPIYKKMVKPAGKDCFSSYKKELSKAGILSVTLKPKDRAAMKIVYS
PLHGTGAKSMKDLLNGFGYKNVFLVPEQKDPNGEFPTVKYPNPEEPEAMELSKKFAIQKNAHAFIVSDPDADRLGIGVKN
VQGEYVLLNGNQIGSIMAAYLCENYATSKKKKKAILVKTIVTTDLQEIIAKKNKVKYKNVLTGFKFIAQVMAKIDKNKTD
FFLFGGEESFGYLPVSFVRDKDSLSSALLLLEILTEKKDLLNYMDEIYLKYGLFQESLKSLTLEGRAGKEKIRKSLESLR
TADLLGKKIHQRKIIGILDYKTRAAKGNTSKSAFSGCPFSDVIQVILEGNAKLTIRPSGTEPKIKIYSSFQSLKAPNSKG
EIPILMKDLLSEIKVSEEIFLRLAELS
>Mature_587_residues
MNHPESFIHSWTQEPFPSTVREEANRVLEKFSKGESGPDVEAFSIPLEFGTGGMRGKLGNGIGRMNEFTVGRAALGFISY
LSKKNKKASIVIAYDSRRKSKEFAEVTAGIAASLGVKVILFQEVTPTPLLSYAIRYYKATGGVVITASHNPPEYNGFKAY
LSDGGQLVPPDDQKIISKIESIRDWNTISLLSPKDPIYKKMVKPAGKDCFSSYKKELSKAGILSVTLKPKDRAAMKIVYS
PLHGTGAKSMKDLLNGFGYKNVFLVPEQKDPNGEFPTVKYPNPEEPEAMELSKKFAIQKNAHAFIVSDPDADRLGIGVKN
VQGEYVLLNGNQIGSIMAAYLCENYATSKKKKKAILVKTIVTTDLQEIIAKKNKVKYKNVLTGFKFIAQVMAKIDKNKTD
FFLFGGEESFGYLPVSFVRDKDSLSSALLLLEILTEKKDLLNYMDEIYLKYGLFQESLKSLTLEGRAGKEKIRKSLESLR
TADLLGKKIHQRKIIGILDYKTRAAKGNTSKSAFSGCPFSDVIQVILEGNAKLTIRPSGTEPKIKIYSSFQSLKAPNSKG
EIPILMKDLLSEIKVSEEIFLRLAELS

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=571, Percent_Identity=31.8739054290718, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI31377548, Length=570, Percent_Identity=30, Blast_Score=224, Evalue=2e-58,
Organism=Escherichia coli, GI1786904, Length=531, Percent_Identity=24.2937853107345, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71993870, Length=520, Percent_Identity=30.1923076923077, Blast_Score=215, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI71993878, Length=283, Percent_Identity=33.9222614840989, Blast_Score=154, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6323934, Length=541, Percent_Identity=31.0536044362292, Blast_Score=230, Evalue=6e-61,
Organism=Drosophila melanogaster, GI20129809, Length=535, Percent_Identity=28.2242990654206, Blast_Score=205, Evalue=9e-53,
Organism=Drosophila melanogaster, GI24651977, Length=461, Percent_Identity=29.2841648590022, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24653722, Length=484, Percent_Identity=28.3057851239669, Blast_Score=193, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 65058; Mature: 65058

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHPESFIHSWTQEPFPSTVREEANRVLEKFSKGESGPDVEAFSIPLEFGTGGMRGKLGN
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCC
GIGRMNEFTVGRAALGFISYLSKKNKKASIVIAYDSRRKSKEFAEVTAGIAASLGVKVIL
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEE
FQEVTPTPLLSYAIRYYKATGGVVITASHNPPEYNGFKAYLSDGGQLVPPDDQKIISKIE
EECCCCCHHHHHHHHHHEECCCEEEEECCCCCCCCCCHHHCCCCCEECCCCHHHHHHHHH
SIRDWNTISLLSPKDPIYKKMVKPAGKDCFSSYKKELSKAGILSVTLKPKDRAAMKIVYS
HHCCCCEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCEEEEEEE
PLHGTGAKSMKDLLNGFGYKNVFLVPEQKDPNGEFPTVKYPNPEEPEAMELSKKFAIQKN
CCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEECC
AHAFIVSDPDADRLGIGVKNVQGEYVLLNGNQIGSIMAAYLCENYATSKKKKKAILVKTI
CCEEEEECCCCCHHCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTTDLQEIIAKKNKVKYKNVLTGFKFIAQVMAKIDKNKTDFFLFGGEESFGYLPVSFVRD
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEECC
KDSLSSALLLLEILTEKKDLLNYMDEIYLKYGLFQESLKSLTLEGRAGKEKIRKSLESLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHH
TADLLGKKIHQRKIIGILDYKTRAAKGNTSKSAFSGCPFSDVIQVILEGNAKLTIRPSGT
HHHHHHHHHHHHHEEEEECCCHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCC
EPKIKIYSSFQSLKAPNSKGEIPILMKDLLSEIKVSEEIFLRLAELS
CCCEEEEECHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure
MNHPESFIHSWTQEPFPSTVREEANRVLEKFSKGESGPDVEAFSIPLEFGTGGMRGKLGN
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCC
GIGRMNEFTVGRAALGFISYLSKKNKKASIVIAYDSRRKSKEFAEVTAGIAASLGVKVIL
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEE
FQEVTPTPLLSYAIRYYKATGGVVITASHNPPEYNGFKAYLSDGGQLVPPDDQKIISKIE
EECCCCCHHHHHHHHHHEECCCEEEEECCCCCCCCCCHHHCCCCCEECCCCHHHHHHHHH
SIRDWNTISLLSPKDPIYKKMVKPAGKDCFSSYKKELSKAGILSVTLKPKDRAAMKIVYS
HHCCCCEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCEEEEEEE
PLHGTGAKSMKDLLNGFGYKNVFLVPEQKDPNGEFPTVKYPNPEEPEAMELSKKFAIQKN
CCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEECC
AHAFIVSDPDADRLGIGVKNVQGEYVLLNGNQIGSIMAAYLCENYATSKKKKKAILVKTI
CCEEEEECCCCCHHCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTTDLQEIIAKKNKVKYKNVLTGFKFIAQVMAKIDKNKTDFFLFGGEESFGYLPVSFVRD
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEECC
KDSLSSALLLLEILTEKKDLLNYMDEIYLKYGLFQESLKSLTLEGRAGKEKIRKSLESLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHH
TADLLGKKIHQRKIIGILDYKTRAAKGNTSKSAFSGCPFSDVIQVILEGNAKLTIRPSGT
HHHHHHHHHHHHHEEEEECCCHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCC
EPKIKIYSSFQSLKAPNSKGEIPILMKDLLSEIKVSEEIFLRLAELS
CCCEEEEECHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]