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The map label for this gene is uppS [H]

Identifier: 116327677

GI number: 116327677

Start: 1065373

End: 1066098

Strand: Direct

Name: uppS [H]

Synonym: LBL_0923

Alternate gene names: 116327677

Gene position: 1065373-1066098 (Clockwise)

Preceding gene: 116327676

Following gene: 116327678

Centisome position: 29.48

GC content: 44.21

Gene sequence:

>726_bases
GTGGGCTTATTCGAGTCCAAGTTTCCTCAACATATCGCCGTTATCATGGACGGTAACGGTCGATGGGCCGTTTCTCTGGG
GAAACCCCGATCGGAAGGACATAGGGAAGGGGCAAACGCAATCGATCGTTTGATGGATGCAAGCCTCGAGTTCGGTCTGA
AAAATGTTTCTCTTTACGCATTTTCCACCGAAAATTGGAGACGCCCGATCACCGAAATTCGATCCATTTTCAATCTGCTT
GTGGAGTTTATCGATACTCGTTTGGATACGATTCATACGAGGGGAATTCGAATTCATCACTCGGGAAGCAGAAAGCGTTT
GACACGGAATGTTTTGGATAAGATCGACTTTGCGATCGAAAAGACCAAGAAGAACAAGAATCTTAACGTAAATTTTTGTT
TGAATTACGGTTCCAAAGACGAACTACTCAGAGCGGCTCAAGAAGCTTTTTTACGCCGAAAAAAGGAAAAGGTCTCTTTC
GAAAAGCCGTTGAAAGAGAAGGAACTTGAAAAATTTTTATATACGTCCACCCTTCCTCCCGTAGATTTACTGATCAGAAC
GGCCGGGGAGCAAAGACTTTCCAATTTTTTGCTTTGGCAATCCGCTTATGCGGAGTTGTATTTTACGGATACTCTTTGGC
CCGACTTCGATAAAAATTCCCTGGTAGATTCCCTGAAGTGGTACGAAACCAGAACCCGAAAATTCGGAGGATTGGAAAAT
GGGTGA

Upstream 100 bases:

>100_bases
AAAACAATTCAAGACCGGATTCAAAAAACCACCGATTCTTATATCGATAAAATTTCCGCTCTGACCGCAGAGAAGGAAAA
GGAAATCACTACGATCTAAC

Downstream 100 bases:

>100_bases
AACATCCAAGAGGCTCGCTTCCGCCGCGGCGCTGATTGTATTTTATCTTTTTATGATATTTTATGCGGATTTTTATTATC
TGCAGACGTATCTAATTCTT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MGLFESKFPQHIAVIMDGNGRWAVSLGKPRSEGHREGANAIDRLMDASLEFGLKNVSLYAFSTENWRRPITEIRSIFNLL
VEFIDTRLDTIHTRGIRIHHSGSRKRLTRNVLDKIDFAIEKTKKNKNLNVNFCLNYGSKDELLRAAQEAFLRRKKEKVSF
EKPLKEKELEKFLYTSTLPPVDLLIRTAGEQRLSNFLLWQSAYAELYFTDTLWPDFDKNSLVDSLKWYETRTRKFGGLEN
G

Sequences:

>Translated_241_residues
MGLFESKFPQHIAVIMDGNGRWAVSLGKPRSEGHREGANAIDRLMDASLEFGLKNVSLYAFSTENWRRPITEIRSIFNLL
VEFIDTRLDTIHTRGIRIHHSGSRKRLTRNVLDKIDFAIEKTKKNKNLNVNFCLNYGSKDELLRAAQEAFLRRKKEKVSF
EKPLKEKELEKFLYTSTLPPVDLLIRTAGEQRLSNFLLWQSAYAELYFTDTLWPDFDKNSLVDSLKWYETRTRKFGGLEN
G
>Mature_240_residues
GLFESKFPQHIAVIMDGNGRWAVSLGKPRSEGHREGANAIDRLMDASLEFGLKNVSLYAFSTENWRRPITEIRSIFNLLV
EFIDTRLDTIHTRGIRIHHSGSRKRLTRNVLDKIDFAIEKTKKNKNLNVNFCLNYGSKDELLRAAQEAFLRRKKEKVSFE
KPLKEKELEKFLYTSTLPPVDLLIRTAGEQRLSNFLLWQSAYAELYFTDTLWPDFDKNSLVDSLKWYETRTRKFGGLENG

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=212, Percent_Identity=33.4905660377358, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI45580742, Length=212, Percent_Identity=33.4905660377358, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI1786371, Length=233, Percent_Identity=39.0557939914163, Blast_Score=186, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71993029, Length=237, Percent_Identity=30.379746835443, Blast_Score=107, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=35.2112676056338, Blast_Score=134, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6323748, Length=221, Percent_Identity=32.579185520362, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI18857969, Length=209, Percent_Identity=35.8851674641148, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28034; Mature: 27903

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLFESKFPQHIAVIMDGNGRWAVSLGKPRSEGHREGANAIDRLMDASLEFGLKNVSLYA
CCCCCCCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEE
FSTENWRRPITEIRSIFNLLVEFIDTRLDTIHTRGIRIHHSGSRKRLTRNVLDKIDFAIE
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHH
KTKKNKNLNVNFCLNYGSKDELLRAAQEAFLRRKKEKVSFEKPLKEKELEKFLYTSTLPP
HHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHCCCCH
VDLLIRTAGEQRLSNFLLWQSAYAELYFTDTLWPDFDKNSLVDSLKWYETRTRKFGGLEN
HHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
G
C
>Mature Secondary Structure 
GLFESKFPQHIAVIMDGNGRWAVSLGKPRSEGHREGANAIDRLMDASLEFGLKNVSLYA
CCCCCCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEE
FSTENWRRPITEIRSIFNLLVEFIDTRLDTIHTRGIRIHHSGSRKRLTRNVLDKIDFAIE
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHH
KTKKNKNLNVNFCLNYGSKDELLRAAQEAFLRRKKEKVSFEKPLKEKELEKFLYTSTLPP
HHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHCCCCH
VDLLIRTAGEQRLSNFLLWQSAYAELYFTDTLWPDFDKNSLVDSLKWYETRTRKFGGLEN
HHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA