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The map label for this gene is 116327589

Identifier: 116327589

GI number: 116327589

Start: 948549

End: 949454

Strand: Direct

Name: 116327589

Synonym: LBL_0820

Alternate gene names: NA

Gene position: 948549-949454 (Clockwise)

Preceding gene: 116327586

Following gene: 116327590

Centisome position: 26.24

GC content: 41.5

Gene sequence:

>906_bases
TTGGAGAAGCAGTTAGAACGAATTGGTTTAGTTTATCATCCGGATTATAATATAGATCTGGGACCTCATATATTTCCGGC
AAGGAAATATCAAATGATTTACGATCTTGTAAAACAGGATCGTAAGCTCGCAGATCTTTATGTATACAGACCCGAGCCCG
CTAAGGATAAAGATTTGACATTGGTTCATACTAAGGAGTTTTTAAAGGATTTTTTTTCTCTCAAAATCACCGAAAGAACC
CAGTATTCGGAACTTCCACTTACGAAACAAATCGTTCAAAGTTTTGTTTTAGCGGTCGGAGGTACGATACTCGCCACCGA
ACTGACCCAAAAATACAAGTTCGTTTATCATATCGGTGGCGGTTTTCATCATAGTATGCCCGATCGGGCGGAAGGATTTT
GTTATTTGAACGATGCGGCGATCGCGGTTAAATTGTATCAAAGGACGTATCCTGGTAGAAAAATTCTCTTCATCGATTTG
GATCTTCATCAAGGCAACGGAAATTCCGTCGTATTTCAAGAAGACTCGGACGTGTTTACGTTTTCCATGCATCAGGAAAA
TTTGTATCCTAAGAAAGAAAAATCGGGACTTGATATCCCTCTTGAAGAAGGTACGGAGGATGGAAAGTATCTGGAGCTTT
TGACGGAATCTCTACACAAGATCAAATCCGATTTCAAACCGGATTTGATTTTTTATATTGCTGGAGCCGATCCATTTGAA
GGAGATTCCCTCGGAGATTTAAAACTCACGCTTCAAGGGTTACGAAAGAGGGATAAGATCGTCAGAGACTTCGTTCGTGC
GTTAGACGTGCCTGCCGTGATTCTTCCGGCGGGAGGATATGCGAAGGACTTTTACGATACGGTGACGATTCACTACAACA
CGATCAAAGTATTTGCGACCGATTGA

Upstream 100 bases:

>100_bases
CGGTAATTATAGATAAATGCCTTCCATTGTTCCAGCTAATATTTCCTCTTTACGAACGGAAACCGAAAAATAGAATGAAC
CAAAAATAGGCGTCCTCTTC

Downstream 100 bases:

>100_bases
CTATGAGCATGTTTTCCGATAAGAAAAAAGGAAATCCCGAATTTTGGGACGGTCAAGATCTGGGAATGATCGACATTTCC
AGAGAGTTTCAGACTTCTCT

Product: deacetylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MEKQLERIGLVYHPDYNIDLGPHIFPARKYQMIYDLVKQDRKLADLYVYRPEPAKDKDLTLVHTKEFLKDFFSLKITERT
QYSELPLTKQIVQSFVLAVGGTILATELTQKYKFVYHIGGGFHHSMPDRAEGFCYLNDAAIAVKLYQRTYPGRKILFIDL
DLHQGNGNSVVFQEDSDVFTFSMHQENLYPKKEKSGLDIPLEEGTEDGKYLELLTESLHKIKSDFKPDLIFYIAGADPFE
GDSLGDLKLTLQGLRKRDKIVRDFVRALDVPAVILPAGGYAKDFYDTVTIHYNTIKVFATD

Sequences:

>Translated_301_residues
MEKQLERIGLVYHPDYNIDLGPHIFPARKYQMIYDLVKQDRKLADLYVYRPEPAKDKDLTLVHTKEFLKDFFSLKITERT
QYSELPLTKQIVQSFVLAVGGTILATELTQKYKFVYHIGGGFHHSMPDRAEGFCYLNDAAIAVKLYQRTYPGRKILFIDL
DLHQGNGNSVVFQEDSDVFTFSMHQENLYPKKEKSGLDIPLEEGTEDGKYLELLTESLHKIKSDFKPDLIFYIAGADPFE
GDSLGDLKLTLQGLRKRDKIVRDFVRALDVPAVILPAGGYAKDFYDTVTIHYNTIKVFATD
>Mature_301_residues
MEKQLERIGLVYHPDYNIDLGPHIFPARKYQMIYDLVKQDRKLADLYVYRPEPAKDKDLTLVHTKEFLKDFFSLKITERT
QYSELPLTKQIVQSFVLAVGGTILATELTQKYKFVYHIGGGFHHSMPDRAEGFCYLNDAAIAVKLYQRTYPGRKILFIDL
DLHQGNGNSVVFQEDSDVFTFSMHQENLYPKKEKSGLDIPLEEGTEDGKYLELLTESLHKIKSDFKPDLIFYIAGADPFE
GDSLGDLKLTLQGLRKRDKIVRDFVRALDVPAVILPAGGYAKDFYDTVTIHYNTIKVFATD

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI217272877, Length=292, Percent_Identity=33.5616438356164, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI209862883, Length=265, Percent_Identity=32.4528301886792, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI13128860, Length=286, Percent_Identity=25.8741258741259, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI8923769, Length=295, Percent_Identity=25.4237288135593, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI293336691, Length=270, Percent_Identity=25.5555555555556, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI13128862, Length=302, Percent_Identity=24.1721854304636, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI262073088, Length=173, Percent_Identity=30.0578034682081, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI13128864, Length=270, Percent_Identity=24.4444444444444, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI262073092, Length=212, Percent_Identity=25.9433962264151, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI153085395, Length=141, Percent_Identity=31.2056737588652, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI30795204, Length=179, Percent_Identity=28.4916201117318, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI30795202, Length=179, Percent_Identity=28.4916201117318, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI17158039, Length=179, Percent_Identity=28.4916201117318, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI148539870, Length=141, Percent_Identity=31.2056737588652, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI169234807, Length=141, Percent_Identity=31.2056737588652, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI62750349, Length=168, Percent_Identity=27.9761904761905, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI62750347, Length=168, Percent_Identity=27.9761904761905, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI193207430, Length=296, Percent_Identity=28.3783783783784, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17561978, Length=283, Percent_Identity=27.5618374558304, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17508561, Length=283, Percent_Identity=23.321554770318, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17537347, Length=284, Percent_Identity=26.7605633802817, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193206283, Length=232, Percent_Identity=28.0172413793103, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17540332, Length=232, Percent_Identity=28.0172413793103, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17540334, Length=262, Percent_Identity=27.4809160305344, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17534739, Length=212, Percent_Identity=26.8867924528302, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193209491, Length=147, Percent_Identity=32.6530612244898, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI25154020, Length=235, Percent_Identity=25.1063829787234, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25154022, Length=235, Percent_Identity=25.1063829787234, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323999, Length=296, Percent_Identity=24.3243243243243, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321244, Length=213, Percent_Identity=29.1079812206573, Blast_Score=99, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6325325, Length=214, Percent_Identity=27.1028037383178, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6324307, Length=274, Percent_Identity=25.5474452554745, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24649807, Length=303, Percent_Identity=33.003300330033, Blast_Score=160, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24657891, Length=286, Percent_Identity=25.8741258741259, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24644244, Length=301, Percent_Identity=25.5813953488372, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI281360899, Length=247, Percent_Identity=25.1012145748988, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24642146, Length=247, Percent_Identity=25.1012145748988, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24642144, Length=247, Percent_Identity=25.1012145748988, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24642142, Length=247, Percent_Identity=25.1012145748988, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 34545; Mature: 34545

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKQLERIGLVYHPDYNIDLGPHIFPARKYQMIYDLVKQDRKLADLYVYRPEPAKDKDLT
CCCCHHHCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEE
LVHTKEFLKDFFSLKITERTQYSELPLTKQIVQSFVLAVGGTILATELTQKYKFVYHIGG
EEEHHHHHHHHHCEEEECCCCCCCCCHHHHHHHHHHHHHCCHHEEHHHHHHEEEEEEECC
GFHHSMPDRAEGFCYLNDAAIAVKLYQRTYPGRKILFIDLDLHQGNGNSVVFQEDSDVFT
CCCCCCCCCCCCEEEECCCEEEEEEEHHCCCCCEEEEEEEEEECCCCCEEEEECCCCEEE
FSMHQENLYPKKEKSGLDIPLEEGTEDGKYLELLTESLHKIKSDFKPDLIFYIAGADPFE
EEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
GDSLGDLKLTLQGLRKRDKIVRDFVRALDVPAVILPAGGYAKDFYDTVTIHYNTIKVFAT
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEEEEEEEEC
D
C
>Mature Secondary Structure
MEKQLERIGLVYHPDYNIDLGPHIFPARKYQMIYDLVKQDRKLADLYVYRPEPAKDKDLT
CCCCHHHCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEE
LVHTKEFLKDFFSLKITERTQYSELPLTKQIVQSFVLAVGGTILATELTQKYKFVYHIGG
EEEHHHHHHHHHCEEEECCCCCCCCCHHHHHHHHHHHHHCCHHEEHHHHHHEEEEEEECC
GFHHSMPDRAEGFCYLNDAAIAVKLYQRTYPGRKILFIDLDLHQGNGNSVVFQEDSDVFT
CCCCCCCCCCCCEEEECCCEEEEEEEHHCCCCCEEEEEEEEEECCCCCEEEEECCCCEEE
FSMHQENLYPKKEKSGLDIPLEEGTEDGKYLELLTESLHKIKSDFKPDLIFYIAGADPFE
EEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
GDSLGDLKLTLQGLRKRDKIVRDFVRALDVPAVILPAGGYAKDFYDTVTIHYNTIKVFAT
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEEEEEEEEC
D
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7678591 [H]