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The map label for this gene is purM [H]

Identifier: 116327586

GI number: 116327586

Start: 943929

End: 944963

Strand: Direct

Name: purM [H]

Synonym: LBL_0817

Alternate gene names: 116327586

Gene position: 943929-944963 (Clockwise)

Preceding gene: 116327585

Following gene: 116327589

Centisome position: 26.12

GC content: 43.0

Gene sequence:

>1035_bases
ATGGAAGAAAAGATCACATACAAAAGTGTCGGTGTGGATACTGAAAAGGGAAGAGAGTTCGTACAAAAGATCAAACGAAA
CGTAGAATCTACCCATGGTCCCAGAGTTCTTGGCGGCCTCGGCGGCTTTGCGGGAGCTTACGATGTAAGTATTCTTAAAA
AATACAACCAACCCGTTCTTCTTTCCGGTACCGACGGTGTCGGAACAAAAATAGAACTTGCACGATTATTGAACACTTTC
GACACGATCGGAATCGATTTAGTTGCGATGTGTGTGAACGACATTCTTGTTTGCGGGGGGGAACCTCTTTTCTTTTTGGA
TTATATAGCATGCGGAAAATTGGATATTGAGAAAATGGATCGAATCGTTGCCGGAATCGTCCATGGATGTAAGTTGTCTA
ACACAGCTTTGCTGGGGGGAGAGACTGCGGAACATCCCGGAACGATGAAGGAAGACGAGTTTGATCTTGCCGGTTTTGTG
GTGGGTGTGGTCGAAAGGGATTTGATGATAGACGGTTCCATGATTCGACCGGGAGATAAGATTTTAGGACTCGAATCCAG
TGGACCTCATAGCAACGGATTTTCGCTCATTCGTAAACTTCTTTTGAAAGACGGAAAACATCTTCCATCCGATCCCGAAC
AAATAAAGTTTTTAAAGGATTACGCTCTCAAGCCGACTCGAATTTACGTTCAAAGTATATTGAAACTTTTGCAAAAGGTC
CCGGTCAAAGGAATGGTACATATCACCGGAGGTGGATATCAGGAAAATGTTCCAAGGGTTCTTCCGAAAGGATCTCAGGC
AAAATTCTATAAGGACAAAATTCCTTCGGGATATTTTTTCGAGAAGATCAAAAGGGATTATAAACTCGACGAATTGGAAC
TATTCGGAACGTTCAATATGGGGATTGGTTATATGTTGGTCGTTTCTAAAGAACACGTCGATATTGCCGAAGAATTTTTA
GAATCTACGGGGGAGTCTGTCCACAAAATCGGAGAGATTGTTTCCGGTAATCGGGAAGAGATTCAGCTCGTCTAA

Upstream 100 bases:

>100_bases
TCGTCCTTAAGTGCCGGATTTCCTTGTGAGTCCGGTTTTTTTTGTGTGCAGGGATTTTGACTTTTTCAAGCTATTCTAAA
AAAGAATCGGAACTTTGAGA

Downstream 100 bases:

>100_bases
TTGAACGTGAGTTCGGTGAAAGAAAATCGAAGCTCGGTTCCAATGTGGAGATTTTCGAATCTACGGAACTTTATACAAAG
CTGATCGTAAGTCTAAAAAC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MEEKITYKSVGVDTEKGREFVQKIKRNVESTHGPRVLGGLGGFAGAYDVSILKKYNQPVLLSGTDGVGTKIELARLLNTF
DTIGIDLVAMCVNDILVCGGEPLFFLDYIACGKLDIEKMDRIVAGIVHGCKLSNTALLGGETAEHPGTMKEDEFDLAGFV
VGVVERDLMIDGSMIRPGDKILGLESSGPHSNGFSLIRKLLLKDGKHLPSDPEQIKFLKDYALKPTRIYVQSILKLLQKV
PVKGMVHITGGGYQENVPRVLPKGSQAKFYKDKIPSGYFFEKIKRDYKLDELELFGTFNMGIGYMLVVSKEHVDIAEEFL
ESTGESVHKIGEIVSGNREEIQLV

Sequences:

>Translated_344_residues
MEEKITYKSVGVDTEKGREFVQKIKRNVESTHGPRVLGGLGGFAGAYDVSILKKYNQPVLLSGTDGVGTKIELARLLNTF
DTIGIDLVAMCVNDILVCGGEPLFFLDYIACGKLDIEKMDRIVAGIVHGCKLSNTALLGGETAEHPGTMKEDEFDLAGFV
VGVVERDLMIDGSMIRPGDKILGLESSGPHSNGFSLIRKLLLKDGKHLPSDPEQIKFLKDYALKPTRIYVQSILKLLQKV
PVKGMVHITGGGYQENVPRVLPKGSQAKFYKDKIPSGYFFEKIKRDYKLDELELFGTFNMGIGYMLVVSKEHVDIAEEFL
ESTGESVHKIGEIVSGNREEIQLV
>Mature_344_residues
MEEKITYKSVGVDTEKGREFVQKIKRNVESTHGPRVLGGLGGFAGAYDVSILKKYNQPVLLSGTDGVGTKIELARLLNTF
DTIGIDLVAMCVNDILVCGGEPLFFLDYIACGKLDIEKMDRIVAGIVHGCKLSNTALLGGETAEHPGTMKEDEFDLAGFV
VGVVERDLMIDGSMIRPGDKILGLESSGPHSNGFSLIRKLLLKDGKHLPSDPEQIKFLKDYALKPTRIYVQSILKLLQKV
PVKGMVHITGGGYQENVPRVLPKGSQAKFYKDKIPSGYFFEKIKRDYKLDELELFGTFNMGIGYMLVVSKEHVDIAEEFL
ESTGESVHKIGEIVSGNREEIQLV

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=337, Percent_Identity=45.6973293768546, Blast_Score=263, Evalue=1e-70,
Organism=Homo sapiens, GI209869995, Length=337, Percent_Identity=45.6973293768546, Blast_Score=263, Evalue=1e-70,
Organism=Homo sapiens, GI209869993, Length=337, Percent_Identity=45.6973293768546, Blast_Score=263, Evalue=1e-70,
Organism=Escherichia coli, GI1788845, Length=341, Percent_Identity=46.3343108504399, Blast_Score=305, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI17567511, Length=349, Percent_Identity=38.9684813753582, Blast_Score=213, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6321203, Length=338, Percent_Identity=39.6449704142012, Blast_Score=229, Evalue=6e-61,
Organism=Drosophila melanogaster, GI24582400, Length=297, Percent_Identity=37.7104377104377, Blast_Score=181, Evalue=6e-46,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37899; Mature: 37899

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEKITYKSVGVDTEKGREFVQKIKRNVESTHGPRVLGGLGGFAGAYDVSILKKYNQPVL
CCCCEEHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCCEE
LSGTDGVGTKIELARLLNTFDTIGIDLVAMCVNDILVCGGEPLFFLDYIACGKLDIEKMD
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCCHHHHH
RIVAGIVHGCKLSNTALLGGETAEHPGTMKEDEFDLAGFVVGVVERDLMIDGSMIRPGDK
HHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCEECCCCC
ILGLESSGPHSNGFSLIRKLLLKDGKHLPSDPEQIKFLKDYALKPTRIYVQSILKLLQKV
EEECCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
PVKGMVHITGGGYQENVPRVLPKGSQAKFYKDKIPSGYFFEKIKRDYKLDELELFGTFNM
CCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHCCCCCCEEEEEEECC
GIGYMLVVSKEHVDIAEEFLESTGESVHKIGEIVSGNREEIQLV
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEC
>Mature Secondary Structure
MEEKITYKSVGVDTEKGREFVQKIKRNVESTHGPRVLGGLGGFAGAYDVSILKKYNQPVL
CCCCEEHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCCEE
LSGTDGVGTKIELARLLNTFDTIGIDLVAMCVNDILVCGGEPLFFLDYIACGKLDIEKMD
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCCHHHHH
RIVAGIVHGCKLSNTALLGGETAEHPGTMKEDEFDLAGFVVGVVERDLMIDGSMIRPGDK
HHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCEECCCCC
ILGLESSGPHSNGFSLIRKLLLKDGKHLPSDPEQIKFLKDYALKPTRIYVQSILKLLQKV
EEECCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
PVKGMVHITGGGYQENVPRVLPKGSQAKFYKDKIPSGYFFEKIKRDYKLDELELFGTFNM
CCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHCCCCCCEEEEEEECC
GIGYMLVVSKEHVDIAEEFLESTGESVHKIGEIVSGNREEIQLV
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA