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The map label for this gene is yphC [C]

Identifier: 116327521

GI number: 116327521

Start: 848669

End: 849703

Strand: Reverse

Name: yphC [C]

Synonym: LBL_0749

Alternate gene names: 116327521

Gene position: 849703-848669 (Counterclockwise)

Preceding gene: 116327523

Following gene: 116327520

Centisome position: 23.51

GC content: 43.38

Gene sequence:

>1035_bases
ATGAAAGCCGCAATTTTAGAATCCGGTAAAAAAATCTTAGACATCAGAGAAGTTCCAGTTCCAGAACTCAAACCCGGACA
AGTAAAAGTAAAAATCAAAGCCTGCGGAATTTGCGGATCCGATGTCCATCTCGTGATCCACGGTACTCTCAAATGTAAAC
ATTTTCCAAGAATTCCCGGCCACGAATCGTCGGGAATAATCGAGGAAGTAGGTGAAAACGTAAGTCGTTTTCAAAAAGGA
GATCGTGTCGTAATCGCTGCCGGAACCTCCTGCGGAGTTTGTTCTTACTGCAAAGCGGGATACGAAAACTTATGTAAAGA
CGTAGGAGTTTTCGGTTTTGATCGAGACGGAGGTTTTGCGGAATATAATATCGCGGAAGAACGTTATTTGTATTCTCTTC
CGGATACGATTCCGTTCGATCAAGGAGCAATTCTTGCAGACGCGGTTTCCACACCGTATCACGCGATTCGATACAGAGGA
AATATTCAAAACGGTGATACGGTTGCCATATTCGGTTGCGGCGGCCTTGGAATCCATGCGGTCGCGATTGCAAGAGCTAT
GACCGACGGAAAAGTAATCGCTTTAGACGTGGAAAGAGGACCATTGGAAAATGCGGCTAAGTACGGAGCCGATGAAATCA
TCAATTTGAAAGAAATTCGAAACCCGGGAAAAACTCTCAAAGAAATTACAAAGGGAGTGGATCTACTTGCGGATTTTTCG
GGATATATGTCCAACATTGAAGAATCTCTACGCGCTATGAATCCCGGAGGTAGAATCGTTCTCGTGGGAATCGGAAGACA
ACCTTTGAAGTTTCAGATTCCTTTTATTTTAATCGGGAGAATGATTTCAGTCTTGGGTTCGTACGGTTCCGATCGTAGGG
CAATTCCCGAACTGATCGAATTATACCTTAAAGGGAAAATCAATCTTTCTCATTCGATCACTTCCCATCATACATTAGAG
GAATTGAATCAATGCCTGGAAGACTTGGACGAAAGAAAAGGAAATCCGATTCGGTTTATCATTCAACCTGGATGA

Upstream 100 bases:

>100_bases
GTCAGAAAATCAAGCGCAAAGTTCTGTTCCAGTTTTGGGACAGAACCTTATATCAAATTTACGTTTTTTTACATCGTGTT
TCATTAAAGGAGAACAAAAT

Downstream 100 bases:

>100_bases
AATCCGGAATTTTTTATTCCCGCATCGAAATCAGAACCCGTGTGCTAGTCCAAAAACCGTCGTTTGTATAGTATGTTAGA
ATTTGACAAAATGCAAAAAA

Product: Zn-dependent alcohol dehydrogenase

Products: NA

Alternate protein names: ADH-HT [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MKAAILESGKKILDIREVPVPELKPGQVKVKIKACGICGSDVHLVIHGTLKCKHFPRIPGHESSGIIEEVGENVSRFQKG
DRVVIAAGTSCGVCSYCKAGYENLCKDVGVFGFDRDGGFAEYNIAEERYLYSLPDTIPFDQGAILADAVSTPYHAIRYRG
NIQNGDTVAIFGCGGLGIHAVAIARAMTDGKVIALDVERGPLENAAKYGADEIINLKEIRNPGKTLKEITKGVDLLADFS
GYMSNIEESLRAMNPGGRIVLVGIGRQPLKFQIPFILIGRMISVLGSYGSDRRAIPELIELYLKGKINLSHSITSHHTLE
ELNQCLEDLDERKGNPIRFIIQPG

Sequences:

>Translated_344_residues
MKAAILESGKKILDIREVPVPELKPGQVKVKIKACGICGSDVHLVIHGTLKCKHFPRIPGHESSGIIEEVGENVSRFQKG
DRVVIAAGTSCGVCSYCKAGYENLCKDVGVFGFDRDGGFAEYNIAEERYLYSLPDTIPFDQGAILADAVSTPYHAIRYRG
NIQNGDTVAIFGCGGLGIHAVAIARAMTDGKVIALDVERGPLENAAKYGADEIINLKEIRNPGKTLKEITKGVDLLADFS
GYMSNIEESLRAMNPGGRIVLVGIGRQPLKFQIPFILIGRMISVLGSYGSDRRAIPELIELYLKGKINLSHSITSHHTLE
ELNQCLEDLDERKGNPIRFIIQPG
>Mature_344_residues
MKAAILESGKKILDIREVPVPELKPGQVKVKIKACGICGSDVHLVIHGTLKCKHFPRIPGHESSGIIEEVGENVSRFQKG
DRVVIAAGTSCGVCSYCKAGYENLCKDVGVFGFDRDGGFAEYNIAEERYLYSLPDTIPFDQGAILADAVSTPYHAIRYRG
NIQNGDTVAIFGCGGLGIHAVAIARAMTDGKVIALDVERGPLENAAKYGADEIINLKEIRNPGKTLKEITKGVDLLADFS
GYMSNIEESLRAMNPGGRIVLVGIGRQPLKFQIPFILIGRMISVLGSYGSDRRAIPELIELYLKGKINLSHSITSHHTLE
ELNQCLEDLDERKGNPIRFIIQPG

Specific function: Thermophilic NAD(+)-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=30.3523035230352, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4501933, Length=368, Percent_Identity=29.6195652173913, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI156523966, Length=371, Percent_Identity=28.0323450134771, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI34577061, Length=368, Percent_Identity=29.6195652173913, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI4501939, Length=363, Percent_Identity=27.8236914600551, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI262073058, Length=367, Percent_Identity=28.6103542234332, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI71743840, Length=367, Percent_Identity=28.6103542234332, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI71565154, Length=374, Percent_Identity=26.2032085561497, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI156627571, Length=348, Percent_Identity=27.5862068965517, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI71565152, Length=372, Percent_Identity=26.3440860215054, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI194239674, Length=261, Percent_Identity=29.5019157088123, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI13236495, Length=261, Percent_Identity=29.5019157088123, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI194239676, Length=216, Percent_Identity=30.0925925925926, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI87082125, Length=332, Percent_Identity=30.7228915662651, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1787863, Length=338, Percent_Identity=30.4733727810651, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI87081918, Length=334, Percent_Identity=30.8383233532934, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1790045, Length=346, Percent_Identity=28.6127167630058, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1788407, Length=342, Percent_Identity=26.6081871345029, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1786552, Length=368, Percent_Identity=28.2608695652174, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1788073, Length=333, Percent_Identity=27.027027027027, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788075, Length=343, Percent_Identity=27.6967930029155, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI226510992, Length=336, Percent_Identity=25.5952380952381, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786825, Length=393, Percent_Identity=25.9541984732824, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790718, Length=291, Percent_Identity=28.8659793814433, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1786518, Length=318, Percent_Identity=28.3018867924528, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87082401, Length=304, Percent_Identity=25.3289473684211, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=343, Percent_Identity=34.1107871720117, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17562878, Length=318, Percent_Identity=31.4465408805031, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI25146526, Length=372, Percent_Identity=27.9569892473118, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71997431, Length=374, Percent_Identity=27.5401069518717, Blast_Score=127, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17565904, Length=348, Percent_Identity=27.2988505747126, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI71988145, Length=332, Percent_Identity=27.4096385542169, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17562582, Length=313, Percent_Identity=26.1980830670927, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17562584, Length=333, Percent_Identity=27.3273273273273, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=27.4932614555256, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323099, Length=351, Percent_Identity=29.0598290598291, Blast_Score=136, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6319955, Length=356, Percent_Identity=29.7752808988764, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6322619, Length=352, Percent_Identity=28.9772727272727, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319258, Length=363, Percent_Identity=26.7217630853994, Blast_Score=126, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6319621, Length=310, Percent_Identity=30.9677419354839, Blast_Score=123, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6324486, Length=330, Percent_Identity=29.3939393939394, Blast_Score=119, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6323729, Length=330, Percent_Identity=27.8787878787879, Blast_Score=119, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6323961, Length=330, Percent_Identity=28.7878787878788, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319257, Length=356, Percent_Identity=26.123595505618, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6319949, Length=287, Percent_Identity=31.0104529616725, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323980, Length=252, Percent_Identity=30.952380952381, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737895, Length=370, Percent_Identity=27.5675675675676, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17737897, Length=345, Percent_Identity=29.8550724637681, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17137530, Length=339, Percent_Identity=28.023598820059, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI221457811, Length=317, Percent_Identity=23.0283911671924, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45551930, Length=317, Percent_Identity=23.0283911671924, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45550770, Length=317, Percent_Identity=23.0283911671924, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37430; Mature: 37430

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAILESGKKILDIREVPVPELKPGQVKVKIKACGICGSDVHLVIHGTLKCKHFPRIPG
CCCHHHHCCCCEEEEECCCCCCCCCCEEEEEEEEECCCCCCEEEEEEEEEEECCCCCCCC
HESSGIIEEVGENVSRFQKGDRVVIAAGTSCGVCSYCKAGYENLCKDVGVFGFDRDGGFA
CCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEECCCCCEE
EYNIAEERYLYSLPDTIPFDQGAILADAVSTPYHAIRYRGNIQNGDTVAIFGCGGLGIHA
EEECCCHHEEEECCCCCCCCCCCEEEHHHCCCCEEEEEECCCCCCCEEEEEECCCCHHHH
VAIARAMTDGKVIALDVERGPLENAAKYGADEIINLKEIRNPGKTLKEITKGVDLLADFS
HHHHHHHCCCEEEEEECCCCCCHHHHHCCHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHH
GYMSNIEESLRAMNPGGRIVLVGIGRQPLKFQIPFILIGRMISVLGSYGSDRRAIPELIE
HHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECHHHHHHHHHHHHHCCCCCCHHHHHHHH
LYLKGKINLSHSITSHHTLEELNQCLEDLDERKGNPIRFIIQPG
HHHCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
>Mature Secondary Structure
MKAAILESGKKILDIREVPVPELKPGQVKVKIKACGICGSDVHLVIHGTLKCKHFPRIPG
CCCHHHHCCCCEEEEECCCCCCCCCCEEEEEEEEECCCCCCEEEEEEEEEEECCCCCCCC
HESSGIIEEVGENVSRFQKGDRVVIAAGTSCGVCSYCKAGYENLCKDVGVFGFDRDGGFA
CCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEECCCCCEE
EYNIAEERYLYSLPDTIPFDQGAILADAVSTPYHAIRYRGNIQNGDTVAIFGCGGLGIHA
EEECCCHHEEEECCCCCCCCCCCEEEHHHCCCCEEEEEECCCCCCCEEEEEECCCCHHHH
VAIARAMTDGKVIALDVERGPLENAAKYGADEIINLKEIRNPGKTLKEITKGVDLLADFS
HHHHHHHCCCEEEEEECCCCCCHHHHHCCHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHH
GYMSNIEESLRAMNPGGRIVLVGIGRQPLKFQIPFILIGRMISVLGSYGSDRRAIPELIE
HHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECHHHHHHHHHHHHHCCCCCCHHHHHHHH
LYLKGKINLSHSITSHHTLEELNQCLEDLDERKGNPIRFIIQPG
HHHCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020473 [H]