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The map label for this gene is cobT

Identifier: 116327072

GI number: 116327072

Start: 294154

End: 295188

Strand: Reverse

Name: cobT

Synonym: LBL_0245

Alternate gene names: 116327072

Gene position: 295188-294154 (Counterclockwise)

Preceding gene: 116327073

Following gene: 116327071

Centisome position: 8.17

GC content: 40.0

Gene sequence:

>1035_bases
TTGAATCCAAATGAACTAATCGTAAAATTACAAAGTAAAATCGATCTAAAAACAAAACCTCCCGGTTCTTTAGGAACTTT
AGAGTCTCTCGCTCTTCAAATCGGTTTAATTCAAAACACTGATTCACCCGAGTTAAAAAGTCCTCATATCCTGGTTTTTG
CCGGAGATCATGGTCTTGCCAATTCTGGAGTCAGCGCTTATCCGAAAGAAGTCACTTATCAAATGGTATTCAATTTCTTG
AATGGAGGTGCGGCAATCAACGCATTCTGCAAACAGAATTCTATCCGACTCAAAGTGGTGGATGCAGGCGTGGATTTCTC
GTTTTCGGATGATTCCACTTTCCTTCATCCCGATTTTATCGATGCCAAAGTAGGATTTGGAACAAAAAACATCCTAATAG
AATCGGCAATGACAAAAGAAGAATGTAATCAAGCTTTGGAAAAAGGAGCTTTTATTTCCACAAAAAAGGTATCAAGTAAT
TGTAATGTAATCGGATTCGGAGAAATGGGAATCGGAAATACTTCTTCCGCGAGTCTTATCACCGCAAGCGTTTTGAAAAA
AGATTTAAGAGAAGTTACCGGAAAAGGAACAGGACTAAACGACCAAAAATTTCAGAAAAAGATCACGATTTTGGAAGAAT
GTCTTTGCAAACATCAATCTTCGCTACGAACTCCCTTCGAAGTCTTACAAACCTTCGGAGGATTCGAAATCGCGATGATG
ATCGGGGCGATGATCGATTCTGCGAAAAAAGGAAGAATTATCCTAGTCGACGGTTTTATCGCTACGTCAGCGTTTTTAAT
CGCTCACAAAATGGAGCCTACAATTTTAAAAAACGCAGTCTTCTGTCACAAATCGGTAGAACCCGGTCACATACATTTAT
TAGAAGAATGGAATGCAAAACCTCTTCTTGATTTGGGACTCCGACTTGGGGAAGGAGCCGGATGTGCGATCGCGTTTCCG
ATTCTATTATCCGCGATCGCTTTCTTAAACGATATGGCTTCCTTTGAATCCGCAAAAGTAGACCAAAAACTTTGA

Upstream 100 bases:

>100_bases
ATTTGATTTATACCTCGATTCTTTTCGGGATTTTAGACCGAGTCGAATTAAAAGTGAAAGCGAATTTTATAAAAAACGAA
ACAAAGGAGGAACTTTCCGT

Downstream 100 bases:

>100_bases
TTCTCTCTATAATCCGAGAGGAGTGGAATCGTTTCTGCGCCTCTTGGACGTTCAGTACAAGACTTCCCATTCCTCCTTTT
TACGTTTATTCCGAATCTAC

Product: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Products: NA

Alternate protein names: NN:DBI PRT; N(1)-alpha-phosphoribosyltransferase

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MNPNELIVKLQSKIDLKTKPPGSLGTLESLALQIGLIQNTDSPELKSPHILVFAGDHGLANSGVSAYPKEVTYQMVFNFL
NGGAAINAFCKQNSIRLKVVDAGVDFSFSDDSTFLHPDFIDAKVGFGTKNILIESAMTKEECNQALEKGAFISTKKVSSN
CNVIGFGEMGIGNTSSASLITASVLKKDLREVTGKGTGLNDQKFQKKITILEECLCKHQSSLRTPFEVLQTFGGFEIAMM
IGAMIDSAKKGRIILVDGFIATSAFLIAHKMEPTILKNAVFCHKSVEPGHIHLLEEWNAKPLLDLGLRLGEGAGCAIAFP
ILLSAIAFLNDMASFESAKVDQKL

Sequences:

>Translated_344_residues
MNPNELIVKLQSKIDLKTKPPGSLGTLESLALQIGLIQNTDSPELKSPHILVFAGDHGLANSGVSAYPKEVTYQMVFNFL
NGGAAINAFCKQNSIRLKVVDAGVDFSFSDDSTFLHPDFIDAKVGFGTKNILIESAMTKEECNQALEKGAFISTKKVSSN
CNVIGFGEMGIGNTSSASLITASVLKKDLREVTGKGTGLNDQKFQKKITILEECLCKHQSSLRTPFEVLQTFGGFEIAMM
IGAMIDSAKKGRIILVDGFIATSAFLIAHKMEPTILKNAVFCHKSVEPGHIHLLEEWNAKPLLDLGLRLGEGAGCAIAFP
ILLSAIAFLNDMASFESAKVDQKL
>Mature_344_residues
MNPNELIVKLQSKIDLKTKPPGSLGTLESLALQIGLIQNTDSPELKSPHILVFAGDHGLANSGVSAYPKEVTYQMVFNFL
NGGAAINAFCKQNSIRLKVVDAGVDFSFSDDSTFLHPDFIDAKVGFGTKNILIESAMTKEECNQALEKGAFISTKKVSSN
CNVIGFGEMGIGNTSSASLITASVLKKDLREVTGKGTGLNDQKFQKKITILEECLCKHQSSLRTPFEVLQTFGGFEIAMM
IGAMIDSAKKGRIILVDGFIATSAFLIAHKMEPTILKNAVFCHKSVEPGHIHLLEEWNAKPLLDLGLRLGEGAGCAIAFP
ILLSAIAFLNDMASFESAKVDQKL

Specific function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)

COG id: COG2038

COG function: function code H; NaMN:DMB phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobT family

Homologues:

Organism=Escherichia coli, GI1788300, Length=333, Percent_Identity=30.6306306306306, Blast_Score=168, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBT_LEPBJ (Q04PD9)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_801989.1
- ProteinModelPortal:   Q04PD9
- SMR:   Q04PD9
- STRING:   Q04PD9
- GeneID:   4412095
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_2826
- eggNOG:   COG2038
- HOGENOM:   HBG634399
- OMA:   NEMATFS
- PhylomeDB:   Q04PD9
- ProtClustDB:   PRK00105
- BioCyc:   LBOR355277:LBJ_2826-MONOMER
- HAMAP:   MF_00230
- InterPro:   IPR003200
- InterPro:   IPR023195
- InterPro:   IPR017846
- Gene3D:   G3DSA:1.10.1610.10
- TIGRFAMs:   TIGR03160

Pfam domain/function: PF02277 DBI_PRT; SSF52733 NN:DBI_PRT

EC number: =2.4.2.21

Molecular weight: Translated: 37096; Mature: 37096

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: ACT_SITE 311-311

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPNELIVKLQSKIDLKTKPPGSLGTLESLALQIGLIQNTDSPELKSPHILVFAGDHGLA
CCCHHEEEEEECCCCCCCCCCCCCHHHHHHHHHEEEEECCCCCCCCCCEEEEEECCCCCC
NSGVSAYPKEVTYQMVFNFLNGGAAINAFCKQNSIRLKVVDAGVDFSFSDDSTFLHPDFI
CCCCCCCHHHHHHHHHHHHHCCCCEEEHHHCCCCEEEEEEECCCCEEECCCCCEECCCCC
DAKVGFGTKNILIESAMTKEECNQALEKGAFISTKKVSSNCNVIGFGEMGIGNTSSASLI
CCCCCCCHHHHHHHHHHCHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCCCCCHHHH
TASVLKKDLREVTGKGTGLNDQKFQKKITILEECLCKHQSSLRTPFEVLQTFGGFEIAMM
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHH
IGAMIDSAKKGRIILVDGFIATSAFLIAHKMEPTILKNAVFCHKSVEPGHIHLLEEWNAK
HHHHHHCCCCCEEEEEECHHHHHHHHHHHCCCCHHHHHHHHEECCCCCCEEEEEECCCCC
PLLDLGLRLGEGAGCAIAFPILLSAIAFLNDMASFESAKVDQKL
CHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNPNELIVKLQSKIDLKTKPPGSLGTLESLALQIGLIQNTDSPELKSPHILVFAGDHGLA
CCCHHEEEEEECCCCCCCCCCCCCHHHHHHHHHEEEEECCCCCCCCCCEEEEEECCCCCC
NSGVSAYPKEVTYQMVFNFLNGGAAINAFCKQNSIRLKVVDAGVDFSFSDDSTFLHPDFI
CCCCCCCHHHHHHHHHHHHHCCCCEEEHHHCCCCEEEEEEECCCCEEECCCCCEECCCCC
DAKVGFGTKNILIESAMTKEECNQALEKGAFISTKKVSSNCNVIGFGEMGIGNTSSASLI
CCCCCCCHHHHHHHHHHCHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCCCCCHHHH
TASVLKKDLREVTGKGTGLNDQKFQKKITILEECLCKHQSSLRTPFEVLQTFGGFEIAMM
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHH
IGAMIDSAKKGRIILVDGFIATSAFLIAHKMEPTILKNAVFCHKSVEPGHIHLLEEWNAK
HHHHHHCCCCCEEEEEECHHHHHHHHHHHCCCCHHHHHHHHEECCCCCCEEEEEECCCCC
PLLDLGLRLGEGAGCAIAFPILLSAIAFLNDMASFESAKVDQKL
CHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA