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The map label for this gene is paaJ-5 [C]

Identifier: 116326993

GI number: 116326993

Start: 193342

End: 194607

Strand: Direct

Name: paaJ-5 [C]

Synonym: LBL_0162

Alternate gene names: 116326993

Gene position: 193342-194607 (Clockwise)

Preceding gene: 116326992

Following gene: 116326994

Centisome position: 5.35

GC content: 46.68

Gene sequence:

>1266_bases
ATGAGCGATAAAATTTACGTCCTCGGCGGGGAACAAACCGATTTTCAAAGAAACTGGACTAAGGAAGGAAAAACCTTTAT
GTCCTTGATGCGTGAAGCCGTTCAAGACGGTCTCGCTGCCGTCGGAATCACTCCCGATGAAATCAAAAAACTGAACAAAC
AAAATAGAATCGGAATTTTCGTTGGAAACTTCGATGCGGAACAGTATGCAACTCAAGGTCACTTGGGCGCATTTTTAACC
GAAGTCGATCCTGCGTTCTCCGGAATTCCGGGCGGACGTTTTGAAGCCGCTTGCGCTTCCGGTTCCATCGCACTCGACGC
GGCTGCGACAAAAATTCGCGCAAAAGACTACGACGTTGCGATCGTTCTCGGAATCGAGATCATGAAAACCGTAAGTTCTT
CCGTAGGGGGCGATTTTTTAGGAACAGCCGCTTATTACGAAAAAGAAGCAAAAGGAGTTCAATTTCCTTTCCCGAAACTT
TTCGGAAAACTCGCGGACGTGATTCTCGAAAGATATAAACTTCCGGAACAAAGATTTATGGGAGCGTTAGCCGAAATTTC
CAGAATCAACTATGATAACGCAAAGAAAAATCCAAAGGCTCAAACCCGTTCTTGGTTCATGAACAAAGAACACGCAAACG
CAAGAGGCGGAGAATACAATATGGCGGTCGGAGGAAGACTCTGCATCACCGATTGTTCTCAAGTTACCGACGGTGCGGCT
ATGGTGGTTCTCGCGAATAAATCTTATACCGAAGAATACGCGAAAAAAAGAGGAAAGAAGATCAACACGATCCCAAGACT
GAAAGGCTGGGGACACAGAGTGGCTCCGATCACTTTTGAAGCGAAGGTCGCCGAATCCAAAGGGGACAAATACATTCTCC
CTTGGACCAGACAAACCGTAAAAGACGCTTATGATAGAGCGGAACTCGGAGTAAAAGATATTGACGTTTTCGAAACTCAC
GATTGTTTTACTTCCTCTGAATACGCGGCGATTTCTGCATTCGGAATTTCTCAACCGGGAAAAGAACACGAAGCCATCGA
GGAAGGGATTATCGATTTCAAAGGTAAAAAACCGATCAACCCATCCGGCGGACTTATCGGAGTGGGACATCCGGTTGGAG
CTTCCGGAGTGAGAATGATGCTCGACCTCTACAAACAAGTTACCGGAACTGCGGGCAACTACCAAGTGGAAGGCGCTAAG
AACGGGCTGATGCTGAATATCGGCGGGTCCGCAACGACTAACGTAGTGTTCATTGTAGGAAAATAA

Upstream 100 bases:

>100_bases
ATTAGCAAAAGCGAAACCAGGGAAGCCGTTTTACGAGCTGAAGGAAAAGCTGGATGCTCGTTCACTTTTCAAAGGATAAT
TTAGGGGAGAAGGTATCACC

Downstream 100 bases:

>100_bases
AAATGAGTCTAAAGACTGCGAAAGATTGGAATCAGTTTCTTCTAAGGTTGTTTATCGCTTTCGGTTTTTGGGAGGTGATC
TCCGTACCGCTTCGCAGTCT

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSDKIYVLGGEQTDFQRNWTKEGKTFMSLMREAVQDGLAAVGITPDEIKKLNKQNRIGIFVGNFDAEQYATQGHLGAFLT
EVDPAFSGIPGGRFEAACASGSIALDAAATKIRAKDYDVAIVLGIEIMKTVSSSVGGDFLGTAAYYEKEAKGVQFPFPKL
FGKLADVILERYKLPEQRFMGALAEISRINYDNAKKNPKAQTRSWFMNKEHANARGGEYNMAVGGRLCITDCSQVTDGAA
MVVLANKSYTEEYAKKRGKKINTIPRLKGWGHRVAPITFEAKVAESKGDKYILPWTRQTVKDAYDRAELGVKDIDVFETH
DCFTSSEYAAISAFGISQPGKEHEAIEEGIIDFKGKKPINPSGGLIGVGHPVGASGVRMMLDLYKQVTGTAGNYQVEGAK
NGLMLNIGGSATTNVVFIVGK

Sequences:

>Translated_421_residues
MSDKIYVLGGEQTDFQRNWTKEGKTFMSLMREAVQDGLAAVGITPDEIKKLNKQNRIGIFVGNFDAEQYATQGHLGAFLT
EVDPAFSGIPGGRFEAACASGSIALDAAATKIRAKDYDVAIVLGIEIMKTVSSSVGGDFLGTAAYYEKEAKGVQFPFPKL
FGKLADVILERYKLPEQRFMGALAEISRINYDNAKKNPKAQTRSWFMNKEHANARGGEYNMAVGGRLCITDCSQVTDGAA
MVVLANKSYTEEYAKKRGKKINTIPRLKGWGHRVAPITFEAKVAESKGDKYILPWTRQTVKDAYDRAELGVKDIDVFETH
DCFTSSEYAAISAFGISQPGKEHEAIEEGIIDFKGKKPINPSGGLIGVGHPVGASGVRMMLDLYKQVTGTAGNYQVEGAK
NGLMLNIGGSATTNVVFIVGK
>Mature_420_residues
SDKIYVLGGEQTDFQRNWTKEGKTFMSLMREAVQDGLAAVGITPDEIKKLNKQNRIGIFVGNFDAEQYATQGHLGAFLTE
VDPAFSGIPGGRFEAACASGSIALDAAATKIRAKDYDVAIVLGIEIMKTVSSSVGGDFLGTAAYYEKEAKGVQFPFPKLF
GKLADVILERYKLPEQRFMGALAEISRINYDNAKKNPKAQTRSWFMNKEHANARGGEYNMAVGGRLCITDCSQVTDGAAM
VVLANKSYTEEYAKKRGKKINTIPRLKGWGHRVAPITFEAKVAESKGDKYILPWTRQTVKDAYDRAELGVKDIDVFETHD
CFTSSEYAAISAFGISQPGKEHEAIEEGIIDFKGKKPINPSGGLIGVGHPVGASGVRMMLDLYKQVTGTAGNYQVEGAKN
GLMLNIGGSATTNVVFIVGK

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=430, Percent_Identity=27.2093023255814, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI302344767, Length=348, Percent_Identity=28.735632183908, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI302344760, Length=348, Percent_Identity=28.735632183908, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI302344762, Length=265, Percent_Identity=29.811320754717, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI55956775, Length=220, Percent_Identity=28.6363636363636, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17537653, Length=418, Percent_Identity=27.511961722488, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24585051, Length=431, Percent_Identity=24.3619489559165, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19921506, Length=431, Percent_Identity=23.8979118329466, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 45716; Mature: 45584

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKIYVLGGEQTDFQRNWTKEGKTFMSLMREAVQDGLAAVGITPDEIKKLNKQNRIGIF
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHCCCCCEEEE
VGNFDAEQYATQGHLGAFLTEVDPAFSGIPGGRFEAACASGSIALDAAATKIRAKDYDVA
EECCCHHHHHHCCCHHHHHHHCCHHHCCCCCCCEEHHHCCCCEEEEHHHHEEECCCCCEE
IVLGIEIMKTVSSSVGGDFLGTAAYYEKEAKGVQFPFPKLFGKLADVILERYKLPEQRFM
EEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHH
GALAEISRINYDNAKKNPKAQTRSWFMNKEHANARGGEYNMAVGGRLCITDCSQVTDGAA
HHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEEECCEEEEECHHHCCCCEE
MVVLANKSYTEEYAKKRGKKINTIPRLKGWGHRVAPITFEAKVAESKGDKYILPWTRQTV
EEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCEECEEEEEEEECCCCCCEEEECCCHHHH
KDAYDRAELGVKDIDVFETHDCFTSSEYAAISAFGISQPGKEHEAIEEGIIDFKGKKPIN
HHHHHHHHCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCEECCCCCCCC
PSGGLIGVGHPVGASGVRMMLDLYKQVTGTAGNYQVEGAKNGLMLNIGGSATTNVVFIVG
CCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEECCCCCCEEEEEEE
K
C
>Mature Secondary Structure 
SDKIYVLGGEQTDFQRNWTKEGKTFMSLMREAVQDGLAAVGITPDEIKKLNKQNRIGIF
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHCCCCCEEEE
VGNFDAEQYATQGHLGAFLTEVDPAFSGIPGGRFEAACASGSIALDAAATKIRAKDYDVA
EECCCHHHHHHCCCHHHHHHHCCHHHCCCCCCCEEHHHCCCCEEEEHHHHEEECCCCCEE
IVLGIEIMKTVSSSVGGDFLGTAAYYEKEAKGVQFPFPKLFGKLADVILERYKLPEQRFM
EEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHH
GALAEISRINYDNAKKNPKAQTRSWFMNKEHANARGGEYNMAVGGRLCITDCSQVTDGAA
HHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEEECCEEEEECHHHCCCCEE
MVVLANKSYTEEYAKKRGKKINTIPRLKGWGHRVAPITFEAKVAESKGDKYILPWTRQTV
EEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCEECEEEEEEEECCCCCCEEEECCCHHHH
KDAYDRAELGVKDIDVFETHDCFTSSEYAAISAFGISQPGKEHEAIEEGIIDFKGKKPIN
HHHHHHHHCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCEECCCCCCCC
PSGGLIGVGHPVGASGVRMMLDLYKQVTGTAGNYQVEGAKNGLMLNIGGSATTNVVFIVG
CCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEECCCCCCEEEEEEE
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]