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The map label for this gene is fadB [H]

Identifier: 116326992

GI number: 116326992

Start: 192010

End: 193320

Strand: Direct

Name: fadB [H]

Synonym: LBL_0161

Alternate gene names: 116326992

Gene position: 192010-193320 (Clockwise)

Preceding gene: 116326991

Following gene: 116326993

Centisome position: 5.31

GC content: 45.0

Gene sequence:

>1311_bases
ATGAGAGAAATAAAAACAGTAACAGTATTGGGCGCGAACGGTACCATGGGCGCCGGATCGGCGGCAATTGTTGCCTCATT
CGGAAAGGCAAAAGTTCACATGCTCGCAAGGGATACAAACAAAGCGAAAGAAGGAATTGAAAAGGCGATCGGTTCCGTTA
AAACCGATACAATTCGGCCAAGACTGATTCCGGGTTCGTATGATGCGGATTTGGAAAAAGCGGTAGCGGAATCCGATTGG
GTTTTCGAACTCGTTGCGGAAAGCTACGAAGTAAAAGAACCGATCAACAAAAGAATCGCAAGTTCAAGAAGACCTGGAAC
CATCGTTTCAACGGTTTCTTCCGGTCTTTCCATCGAAAGACTTTCTAAAGCGTTCGATGAAGACGGACAAAAGCGTTATT
TCGGAACTCATTTCTTTAATCCTCCTTATAAAATGATTCTTTGTGAATTAGTTTCTCATAAAGGATCGGATAAGAAAGTT
CTTAAACAACTCGGAGAGTATCTGGATAAGGTTTTAGGCCGCGCGGTCGTTTACACAAACGATACTCCCGCATTTGCCGG
AAACAGAATCGGATTTCAGCTCATCAACGAAGTCGCTCAAATCGCGGAAAAATATTCCGATAAAGGCGGGATTGCTTTGA
TGGATACGATTATGAGCGGTTACACCGGAAGAGCGATGGCTCCTTTGGACACTGCGGACTTCGTAGGTCTCGACGTTCAC
AAAGCGATCGTGGATAACCTCTACGAGATGACAAAAGACGTCGCTCATTCTACGTTTAAAATGCCGGGTTACTTCCAAAA
GCTCATTGATAAAGGCGACCTAGGAAGAAAAACGGGCGGCGGTCTTTATAAGATGTCCAAAACTCCGGACGGTAAGAAAG
AAAAATTAGTCTATAATATAGGCGCGGATCTGTACGAACCCGTGCCAAAATTCGATATCGATTTTATTCGTCAGGCGAAC
AAAAAGATTTCCGAAGCGGACTACATCGGCGCGATGAACATCGTAAAAGAAGCAAAAGGTTTCGAAGCGGACTTAGCGAG
ATACTTCATCGCAAGATACGTTAGTTACTCTCTTTCGATCGTTGGCGAAGTCGTTGACACAAAAGAAATGGCGGACCTCG
CTATGGGAACAGGATTCAATTGGGCTCCCGCTTCCGCATTCGTCGATTTTTTAGGCGGACCTAAGGACGCGATTCAACTG
ATCGAAAAAGCAAAACTTCCGGTTCCTGACGTATTAGCAAAAGCGAAACCAGGGAAGCCGTTTTACGAGCTGAAGGAAAA
GCTGGATGCTCGTTCACTTTTCAAAGGATAA

Upstream 100 bases:

>100_bases
GATTCCTATACTTAAGCAGGGTGAAAAAAACTTTCCTCCCCACCCGGTTGTTTTAAACAAGTCCTATTCCATTGGGAAAT
CCAAGAATCGGTATAGTTTC

Downstream 100 bases:

>100_bases
TTTAGGGGAGAAGGTATCACCATGAGCGATAAAATTTACGTCCTCGGCGGGGAACAAACCGATTTTCAAAGAAACTGGAC
TAAGGAAGGAAAAACCTTTA

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MREIKTVTVLGANGTMGAGSAAIVASFGKAKVHMLARDTNKAKEGIEKAIGSVKTDTIRPRLIPGSYDADLEKAVAESDW
VFELVAESYEVKEPINKRIASSRRPGTIVSTVSSGLSIERLSKAFDEDGQKRYFGTHFFNPPYKMILCELVSHKGSDKKV
LKQLGEYLDKVLGRAVVYTNDTPAFAGNRIGFQLINEVAQIAEKYSDKGGIALMDTIMSGYTGRAMAPLDTADFVGLDVH
KAIVDNLYEMTKDVAHSTFKMPGYFQKLIDKGDLGRKTGGGLYKMSKTPDGKKEKLVYNIGADLYEPVPKFDIDFIRQAN
KKISEADYIGAMNIVKEAKGFEADLARYFIARYVSYSLSIVGEVVDTKEMADLAMGTGFNWAPASAFVDFLGGPKDAIQL
IEKAKLPVPDVLAKAKPGKPFYELKEKLDARSLFKG

Sequences:

>Translated_436_residues
MREIKTVTVLGANGTMGAGSAAIVASFGKAKVHMLARDTNKAKEGIEKAIGSVKTDTIRPRLIPGSYDADLEKAVAESDW
VFELVAESYEVKEPINKRIASSRRPGTIVSTVSSGLSIERLSKAFDEDGQKRYFGTHFFNPPYKMILCELVSHKGSDKKV
LKQLGEYLDKVLGRAVVYTNDTPAFAGNRIGFQLINEVAQIAEKYSDKGGIALMDTIMSGYTGRAMAPLDTADFVGLDVH
KAIVDNLYEMTKDVAHSTFKMPGYFQKLIDKGDLGRKTGGGLYKMSKTPDGKKEKLVYNIGADLYEPVPKFDIDFIRQAN
KKISEADYIGAMNIVKEAKGFEADLARYFIARYVSYSLSIVGEVVDTKEMADLAMGTGFNWAPASAFVDFLGGPKDAIQL
IEKAKLPVPDVLAKAKPGKPFYELKEKLDARSLFKG
>Mature_436_residues
MREIKTVTVLGANGTMGAGSAAIVASFGKAKVHMLARDTNKAKEGIEKAIGSVKTDTIRPRLIPGSYDADLEKAVAESDW
VFELVAESYEVKEPINKRIASSRRPGTIVSTVSSGLSIERLSKAFDEDGQKRYFGTHFFNPPYKMILCELVSHKGSDKKV
LKQLGEYLDKVLGRAVVYTNDTPAFAGNRIGFQLINEVAQIAEKYSDKGGIALMDTIMSGYTGRAMAPLDTADFVGLDVH
KAIVDNLYEMTKDVAHSTFKMPGYFQKLIDKGDLGRKTGGGLYKMSKTPDGKKEKLVYNIGADLYEPVPKFDIDFIRQAN
KKISEADYIGAMNIVKEAKGFEADLARYFIARYVSYSLSIVGEVVDTKEMADLAMGTGFNWAPASAFVDFLGGPKDAIQL
IEKAKLPVPDVLAKAKPGKPFYELKEKLDARSLFKG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=297, Percent_Identity=31.3131313131313, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI296179427, Length=311, Percent_Identity=30.2250803858521, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI20127408, Length=302, Percent_Identity=25.4966887417219, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1787661, Length=294, Percent_Identity=29.5918367346939, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790281, Length=248, Percent_Identity=26.2096774193548, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17549919, Length=301, Percent_Identity=28.2392026578073, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17553560, Length=302, Percent_Identity=26.8211920529801, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17508951, Length=298, Percent_Identity=26.1744966442953, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508953, Length=301, Percent_Identity=26.2458471760797, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25144276, Length=301, Percent_Identity=26.2458471760797, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17563036, Length=295, Percent_Identity=27.7966101694915, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17558304, Length=409, Percent_Identity=24.4498777506112, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24583077, Length=450, Percent_Identity=25.1111111111111, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24583079, Length=450, Percent_Identity=25.1111111111111, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19921000, Length=450, Percent_Identity=24.8888888888889, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 47784; Mature: 47784

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREIKTVTVLGANGTMGAGSAAIVASFGKAKVHMLARDTNKAKEGIEKAIGSVKTDTIRP
CCCEEEEEEECCCCCCCCCCHHHHHHCCCHHEEHHHHCCHHHHHHHHHHHCCCCCCCCCC
RLIPGSYDADLEKAVAESDWVFELVAESYEVKEPINKRIASSRRPGTIVSTVSSGLSIER
EECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHH
LSKAFDEDGQKRYFGTHFFNPPYKMILCELVSHKGSDKKVLKQLGEYLDKVLGRAVVYTN
HHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEC
DTPAFAGNRIGFQLINEVAQIAEKYSDKGGIALMDTIMSGYTGRAMAPLDTADFVGLDVH
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHCCHHHH
KAIVDNLYEMTKDVAHSTFKMPGYFQKLIDKGDLGRKTGGGLYKMSKTPDGKKEKLVYNI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCEEEECCCCCCCHHHEEEEC
GADLYEPVPKFDIDFIRQANKKISEADYIGAMNIVKEAKGFEADLARYFIARYVSYSLSI
CCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VGEVVDTKEMADLAMGTGFNWAPASAFVDFLGGPKDAIQLIEKAKLPVPDVLAKAKPGKP
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHCCCCCCC
FYELKEKLDARSLFKG
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MREIKTVTVLGANGTMGAGSAAIVASFGKAKVHMLARDTNKAKEGIEKAIGSVKTDTIRP
CCCEEEEEEECCCCCCCCCCHHHHHHCCCHHEEHHHHCCHHHHHHHHHHHCCCCCCCCCC
RLIPGSYDADLEKAVAESDWVFELVAESYEVKEPINKRIASSRRPGTIVSTVSSGLSIER
EECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHH
LSKAFDEDGQKRYFGTHFFNPPYKMILCELVSHKGSDKKVLKQLGEYLDKVLGRAVVYTN
HHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEC
DTPAFAGNRIGFQLINEVAQIAEKYSDKGGIALMDTIMSGYTGRAMAPLDTADFVGLDVH
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHCCHHHH
KAIVDNLYEMTKDVAHSTFKMPGYFQKLIDKGDLGRKTGGGLYKMSKTPDGKKEKLVYNI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCEEEECCCCCCCHHHEEEEC
GADLYEPVPKFDIDFIRQANKKISEADYIGAMNIVKEAKGFEADLARYFIARYVSYSLSI
CCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VGEVVDTKEMADLAMGTGFNWAPASAFVDFLGGPKDAIQLIEKAKLPVPDVLAKAKPGKP
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHCCCCCCC
FYELKEKLDARSLFKG
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]