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The map label for this gene is hpt [H]

Identifier: 116326964

GI number: 116326964

Start: 152388

End: 152921

Strand: Reverse

Name: hpt [H]

Synonym: LBL_0130

Alternate gene names: 116326964

Gene position: 152921-152388 (Counterclockwise)

Preceding gene: 116326965

Following gene: 116326963

Centisome position: 4.23

GC content: 36.33

Gene sequence:

>534_bases
ATGAACGAGATCGATTCAAATACTTTACGCCCTTGTTTTAATCGAGAAGAGATCTCTCAAAAAGTAAAATTTCTAGCTTC
CGAGATAACAAAGGATTATAAAAAGTTAAATCCGATTCTTATCTGTGTATTAAAAGGTGGAATGTATTTTTTCGCGGATT
TAACAAGAGCGATTCCTTTTTCGGTAGAAATCGATTTCATTCAAGCAAGGTCCTATTCCGGAACTTCTTCAACCGGAAAT
ATCGATTTATTAAAAGATATCGATACAGACCTTTCCAATCGTCACGTGATTCTTGTAGAAGACATTTTAGATACGGGTTT
TACCCTTCAATATCTCATACGACATATCTTTGCCCGTAATCCTGCAAGTTTGGAAATCGTAACTCTTCTTTTAAAGAAAA
GAAAGAGTATCTTAGAATTCCCTGTAAAGTATGTGGGTTGGAGAATTTCAGACGAGTTCGTTGTGGGTTATGGTATGGAT
TTCGACGGAAAATACAGAAACCTGCCGGACATTCACGTTTTGGAAACGGGATAA

Upstream 100 bases:

>100_bases
AATTTCCTACATCAGGTTTTCTCAGTATACGAATTGAAACGGAATCTTGGAAAGAATTAGGCAAAGTTCCCGGAAAAATA
ATTCGATTTTGGATACCCGG

Downstream 100 bases:

>100_bases
CTTTTCGTTTAAGACTTCCTGATTACCTTGAGTTTGAAGGAAACAATTCATCTTTTTAAGAAGTGTTTCTTTATGAACGA
TGTCGTTTTAAAATTTCGAA

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MNEIDSNTLRPCFNREEISQKVKFLASEITKDYKKLNPILICVLKGGMYFFADLTRAIPFSVEIDFIQARSYSGTSSTGN
IDLLKDIDTDLSNRHVILVEDILDTGFTLQYLIRHIFARNPASLEIVTLLLKKRKSILEFPVKYVGWRISDEFVVGYGMD
FDGKYRNLPDIHVLETG

Sequences:

>Translated_177_residues
MNEIDSNTLRPCFNREEISQKVKFLASEITKDYKKLNPILICVLKGGMYFFADLTRAIPFSVEIDFIQARSYSGTSSTGN
IDLLKDIDTDLSNRHVILVEDILDTGFTLQYLIRHIFARNPASLEIVTLLLKKRKSILEFPVKYVGWRISDEFVVGYGMD
FDGKYRNLPDIHVLETG
>Mature_177_residues
MNEIDSNTLRPCFNREEISQKVKFLASEITKDYKKLNPILICVLKGGMYFFADLTRAIPFSVEIDFIQARSYSGTSSTGN
IDLLKDIDTDLSNRHVILVEDILDTGFTLQYLIRHIFARNPASLEIVTLLLKKRKSILEFPVKYVGWRISDEFVVGYGMD
FDGKYRNLPDIHVLETG

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=173, Percent_Identity=35.8381502890173, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI9910262, Length=167, Percent_Identity=31.7365269461078, Blast_Score=90, Evalue=9e-19,
Organism=Escherichia coli, GI87081689, Length=166, Percent_Identity=40.3614457831325, Blast_Score=126, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17510817, Length=166, Percent_Identity=33.1325301204819, Blast_Score=90, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20303; Mature: 20303

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEIDSNTLRPCFNREEISQKVKFLASEITKDYKKLNPILICVLKGGMYFFADLTRAIPF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCC
SVEIDFIQARSYSGTSSTGNIDLLKDIDTDLSNRHVILVEDILDTGFTLQYLIRHIFARN
EEEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCEEEEEHHHHCCCCHHHHHHHHHHCCC
PASLEIVTLLLKKRKSILEFPVKYVGWRISDEFVVGYGMDFDGKYRNLPDIHVLETG
CCCHHHHHHHHHHHHHHHHCCHHHHCEEECCCEEEEECCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MNEIDSNTLRPCFNREEISQKVKFLASEITKDYKKLNPILICVLKGGMYFFADLTRAIPF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCC
SVEIDFIQARSYSGTSSTGNIDLLKDIDTDLSNRHVILVEDILDTGFTLQYLIRHIFARN
EEEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCEEEEEHHHHCCCCHHHHHHHHHHCCC
PASLEIVTLLLKKRKSILEFPVKYVGWRISDEFVVGYGMDFDGKYRNLPDIHVLETG
CCCHHHHHHHHHHHHHHHHCCHHHHCEEECCCEEEEECCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA