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The map label for this gene is kefC [H]

Identifier: 116326963

GI number: 116326963

Start: 150363

End: 152138

Strand: Reverse

Name: kefC [H]

Synonym: LBL_0129

Alternate gene names: 116326963

Gene position: 152138-150363 (Counterclockwise)

Preceding gene: 116326964

Following gene: 116326962

Centisome position: 4.21

GC content: 39.98

Gene sequence:

>1776_bases
ATGGAGCATCATTCTCTCTCCCTTTTAAACGATATAGCTTTGAGTATCATTTTTGCTACGTTTTTTGCTCACATAGCCAG
GATTACGAAACAACCTTTAATTTTGGGTTATGTAGCGGGAGGGCTTTTACTTGGACCAAATTTAGGTTTAAGTCTTGTGG
TTAACAAGGAAAGTATCGAGTTAATTTCCGAGATCGGATTGATTCTTCTCTTGTTCATCATCGGTCTTGAAATTGATTTA
AAAGAACTAGCACGTATGGGAAAGTCGATGTTCATTCTTGGGATTGTTCAATTTGTGTTCTGCGTGCTGTTCGGGCTTTT
ATTTTTCAGGGAAATTCTTGCTAACTTCAGCGGTAAGTTCGATCTTTTATATTTCGCTATCGCATTGGCCATCAGTTCCA
CGATGATCGTTGTCAAACTTCTGCACGATAAATTCGAAGTGAGTACGATTGCAGGTCGTCTTACAATCGGAGTATTGGTT
CTACAGGACATTTGGGCGATCATCTTCATGGGTATCCAGCCGAGTCTTCAGGATCCGCAAATTTTAAAGATCGTGAGTTC
GCTTGGAGTCGGTTCGGTATTAGTCTGCGTTTCATTTTTAATCAGTAGATTCTTTTTATCCAGATTGTTTCAAGCGGCGG
CTTCCAAACCAGAGCTTATCTTGATTACTTCAATTGCTTGGTGTTTTTTACTTTGCGGTTTTGCGGAAAAGGCCGGTCTA
TCCAAAGAGATGGGAGCCTTGATTGCGGGAATTAGTATCGCCGCATTTCCTTACGGAGCCGACGTTATCGCAAAACTTTC
GGGGATTAGAGATTTTTTCATCACTCTTTTTTTCGTTGCGCTTGGAATGAAAATTCCGATTCCTTCGATTCAGATTATCA
GCGTTTCTTTAATAGCGGTAGTGTTCGTAATTTTTAGTAGAGTCCTCACTGTTGCAACTCCGGTTTATTTTTCCGGTAGA
GGACTTAGAGCTGGAATCGTGACCGGTTTGAACTTGGCTCAAATCAGTGAGTTTTCTCTTGTAATCCTCTCACTGGGAAT
GGGTTACGGCCATATCAGTAAAGAATTGGAATCCACAGTTTTGACTTCAATGATTCTTGCATCGGTAGTTTCCACTTATA
TCATTTTTTTCAATGATCCAATTTCAAGATTCGTTTTAAAGCTATTGGGAATGATCGGTCTAAAAGAAGAAAAAAGAACC
GAATCCTATACTAACGGTCGATCGAAAAGAGATATCGTAATTCTCGGTTATTTTAGAATTGCACAAAGTCTTTTAGAGGA
AATAGAACGTGAAAAACCGGAATGGTTCAATCGAATTTTGATCGTGGATTTTAATCCTGTCTTTCGCCGCTTTCTAGAAG
CGAAAGGGATTCGTTGGGCTTACGGAGATCTCGCAAATCTGGAAACTTTGCATCATCTTGGAATTGAAGATGCAAGATAT
GTAATTTGTACTATCTCTGATATGATTCTCAAAGGAACAACCAATCGTAGACTTTTGGAGTCAATCAAAGGAATTTGTCA
TCACACACAACCTTCCATCATTCTTACCACCGACGATGTACAAGAAGCAAAAGTTCTTATCGAAAGTGGCGCCGCTCACG
TAATCGTACCGGGAAGGATCAGTGGAATGTCTCTTTTTAAAGAAATGAAGACAATCGTGGATCATTCCGACAAAAGTCGC
GTAAAAACCGAGCCCGCACATCTTTCCCTTGAGACAAAGAAGAAAAAATCGATAGGAAAAAAAGCCCGCTCCAAATCCAA
AGTTAGAATGAAGTAA

Upstream 100 bases:

>100_bases
TAAGAATCTTTCATACCTTAGCATGCAGAACGATTTATAGAAGACTACCGAACGCTTGCCGTGAAAATTAAAGCGCGGTA
AAATTTAGGACAAACCGTAA

Downstream 100 bases:

>100_bases
ACAAATTGATTCGTTCACCATGCAATAAAATCTGTGTAATGGACTTTAAGTCCGGTTATTGTCAGGGATGTTTTAGAACC
ATTGATGAAATCGGAAACTG

Product: KefB related efflux transport protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MEHHSLSLLNDIALSIIFATFFAHIARITKQPLILGYVAGGLLLGPNLGLSLVVNKESIELISEIGLILLLFIIGLEIDL
KELARMGKSMFILGIVQFVFCVLFGLLFFREILANFSGKFDLLYFAIALAISSTMIVVKLLHDKFEVSTIAGRLTIGVLV
LQDIWAIIFMGIQPSLQDPQILKIVSSLGVGSVLVCVSFLISRFFLSRLFQAAASKPELILITSIAWCFLLCGFAEKAGL
SKEMGALIAGISIAAFPYGADVIAKLSGIRDFFITLFFVALGMKIPIPSIQIISVSLIAVVFVIFSRVLTVATPVYFSGR
GLRAGIVTGLNLAQISEFSLVILSLGMGYGHISKELESTVLTSMILASVVSTYIIFFNDPISRFVLKLLGMIGLKEEKRT
ESYTNGRSKRDIVILGYFRIAQSLLEEIEREKPEWFNRILIVDFNPVFRRFLEAKGIRWAYGDLANLETLHHLGIEDARY
VICTISDMILKGTTNRRLLESIKGICHHTQPSIILTTDDVQEAKVLIESGAAHVIVPGRISGMSLFKEMKTIVDHSDKSR
VKTEPAHLSLETKKKKSIGKKARSKSKVRMK

Sequences:

>Translated_591_residues
MEHHSLSLLNDIALSIIFATFFAHIARITKQPLILGYVAGGLLLGPNLGLSLVVNKESIELISEIGLILLLFIIGLEIDL
KELARMGKSMFILGIVQFVFCVLFGLLFFREILANFSGKFDLLYFAIALAISSTMIVVKLLHDKFEVSTIAGRLTIGVLV
LQDIWAIIFMGIQPSLQDPQILKIVSSLGVGSVLVCVSFLISRFFLSRLFQAAASKPELILITSIAWCFLLCGFAEKAGL
SKEMGALIAGISIAAFPYGADVIAKLSGIRDFFITLFFVALGMKIPIPSIQIISVSLIAVVFVIFSRVLTVATPVYFSGR
GLRAGIVTGLNLAQISEFSLVILSLGMGYGHISKELESTVLTSMILASVVSTYIIFFNDPISRFVLKLLGMIGLKEEKRT
ESYTNGRSKRDIVILGYFRIAQSLLEEIEREKPEWFNRILIVDFNPVFRRFLEAKGIRWAYGDLANLETLHHLGIEDARY
VICTISDMILKGTTNRRLLESIKGICHHTQPSIILTTDDVQEAKVLIESGAAHVIVPGRISGMSLFKEMKTIVDHSDKSR
VKTEPAHLSLETKKKKSIGKKARSKSKVRMK
>Mature_591_residues
MEHHSLSLLNDIALSIIFATFFAHIARITKQPLILGYVAGGLLLGPNLGLSLVVNKESIELISEIGLILLLFIIGLEIDL
KELARMGKSMFILGIVQFVFCVLFGLLFFREILANFSGKFDLLYFAIALAISSTMIVVKLLHDKFEVSTIAGRLTIGVLV
LQDIWAIIFMGIQPSLQDPQILKIVSSLGVGSVLVCVSFLISRFFLSRLFQAAASKPELILITSIAWCFLLCGFAEKAGL
SKEMGALIAGISIAAFPYGADVIAKLSGIRDFFITLFFVALGMKIPIPSIQIISVSLIAVVFVIFSRVLTVATPVYFSGR
GLRAGIVTGLNLAQISEFSLVILSLGMGYGHISKELESTVLTSMILASVVSTYIIFFNDPISRFVLKLLGMIGLKEEKRT
ESYTNGRSKRDIVILGYFRIAQSLLEEIEREKPEWFNRILIVDFNPVFRRFLEAKGIRWAYGDLANLETLHHLGIEDARY
VICTISDMILKGTTNRRLLESIKGICHHTQPSIILTTDDVQEAKVLIESGAAHVIVPGRISGMSLFKEMKTIVDHSDKSR
VKTEPAHLSLETKKKKSIGKKARSKSKVRMK

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=358, Percent_Identity=25.9776536312849, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1786232, Length=517, Percent_Identity=27.6595744680851, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1786685, Length=572, Percent_Identity=21.8531468531469, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789749, Length=514, Percent_Identity=23.1517509727626, Blast_Score=80, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 65334; Mature: 65334

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHHSLSLLNDIALSIIFATFFAHIARITKQPLILGYVAGGLLLGPNLGLSLVVNKESIE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEECCCCCEEEEECHHHHH
LISEIGLILLLFIIGLEIDLKELARMGKSMFILGIVQFVFCVLFGLLFFREILANFSGKF
HHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DLLYFAIALAISSTMIVVKLLHDKFEVSTIAGRLTIGVLVLQDIWAIIFMGIQPSLQDPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
ILKIVSSLGVGSVLVCVSFLISRFFLSRLFQAAASKPELILITSIAWCFLLCGFAEKAGL
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHCCC
SKEMGALIAGISIAAFPYGADVIAKLSGIRDFFITLFFVALGMKIPIPSIQIISVSLIAV
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
VFVIFSRVLTVATPVYFSGRGLRAGIVTGLNLAQISEFSLVILSLGMGYGHISKELESTV
HHHHHHHHHHHHCCCEECCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LTSMILASVVSTYIIFFNDPISRFVLKLLGMIGLKEEKRTESYTNGRSKRDIVILGYFRI
HHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEHHHH
AQSLLEEIEREKPEWFNRILIVDFNPVFRRFLEAKGIRWAYGDLANLETLHHLGIEDARY
HHHHHHHHHHCCCHHHCEEEEEECCHHHHHHHHHCCCEEECCCHHHHHHHHHCCCCCCCE
VICTISDMILKGTTNRRLLESIKGICHHTQPSIILTTDDVQEAKVLIESGAAHVIVPGRI
EEEEHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCCEEEECCCC
SGMSLFKEMKTIVDHSDKSRVKTEPAHLSLETKKKKSIGKKARSKSKVRMK
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MEHHSLSLLNDIALSIIFATFFAHIARITKQPLILGYVAGGLLLGPNLGLSLVVNKESIE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEECCCCCEEEEECHHHHH
LISEIGLILLLFIIGLEIDLKELARMGKSMFILGIVQFVFCVLFGLLFFREILANFSGKF
HHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DLLYFAIALAISSTMIVVKLLHDKFEVSTIAGRLTIGVLVLQDIWAIIFMGIQPSLQDPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
ILKIVSSLGVGSVLVCVSFLISRFFLSRLFQAAASKPELILITSIAWCFLLCGFAEKAGL
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHCCC
SKEMGALIAGISIAAFPYGADVIAKLSGIRDFFITLFFVALGMKIPIPSIQIISVSLIAV
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
VFVIFSRVLTVATPVYFSGRGLRAGIVTGLNLAQISEFSLVILSLGMGYGHISKELESTV
HHHHHHHHHHHHCCCEECCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LTSMILASVVSTYIIFFNDPISRFVLKLLGMIGLKEEKRTESYTNGRSKRDIVILGYFRI
HHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEHHHH
AQSLLEEIEREKPEWFNRILIVDFNPVFRRFLEAKGIRWAYGDLANLETLHHLGIEDARY
HHHHHHHHHHCCCHHHCEEEEEECCHHHHHHHHHCCCEEECCCHHHHHHHHHCCCCCCCE
VICTISDMILKGTTNRRLLESIKGICHHTQPSIILTTDDVQEAKVLIESGAAHVIVPGRI
EEEEHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCCEEEECCCC
SGMSLFKEMKTIVDHSDKSRVKTEPAHLSLETKKKKSIGKKARSKSKVRMK
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA