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The map label for this gene is acsA [H]

Identifier: 116326959

GI number: 116326959

Start: 145894

End: 147858

Strand: Reverse

Name: acsA [H]

Synonym: LBL_0125

Alternate gene names: 116326959

Gene position: 147858-145894 (Counterclockwise)

Preceding gene: 116326960

Following gene: 116326958

Centisome position: 4.09

GC content: 42.24

Gene sequence:

>1965_bases
ATGGCAAAAGAACGAATAGTTTTACCATCCGCGGAATTTAAAAAGAATTCAAACATTACCCTTAAGGATTATAAATCTCT
TTATAAAGAATCCATTGAGAACCCGAACAAATTTTGGGCAAAAGAAGCGAATCGACTGACCTGGTTTAAAAAATGGACCA
AGGTTTTAAATCACGATTTTAAAAATGCAAAAGTGGAATGGTTCAAAGGCGGAAAACTCAACGTTTCCTACAATTGTCTA
GATCGTCACATCAGTACTCCTTTGAAAAACAAAGCCGCTTTGATCTGGGAAGGAGATAATCCTTCGGAATCCAAAGTCCT
TACGTATTACGACGTTTACAGAGAGGTAAATCGTTTTGCGAACGTTCTCAAAAAATATGGAGTAAAAAAAGGAGATCGGG
TTCTTGTTTATCTCCCTATGATCCCGGAATTAGCAATTACGATTCTTGCATGTACTCGAATTGGCGCAATTCATTCCGTT
GTTTTCGGAGGTTTTTCTCCGGAAGCGCTTCAAAGTAGAATCGACGATTGTAAACCGAAGTTGATCGTCACCGCCGACGG
AGGTTTCCGAGGCGGTAAACCCATCGAACTCAAAAGAAACGTCGACATTGCTCTCGAAAAGTCCAAAGAGGATGTTAAAA
CGGTAATTGTTGTTCGTCGTACAGGAAACGAATCCGGTCTAGTTTGGAAAGACGGCCGGGATTATTGGTATCATTTTTTG
ATCAGCGATCCCGATTTATCCCCTTATTGTAAACCGGAGTCCATGGATGCGGAAGATCCTCTTTTTATTCTTTATACTTC
CGGTTCAACGGGAAAACCGAAAGGAGTTTTACATACTACGGGCGGTTATCTTCTCGGAGTTAATTTAACATTTCATTATG
TATTCGATATAAAACCGGAAGACACATATTGGTGCACTGCGGACATAGGTTGGGTGACGGGTCATTCTTACTTAGTTTAT
GGTCCCTTGTCCAACGGAGCCTCTTCTGTGATGTTTGAAGGAGTGCCTTCGTATCCGGACGCAGGAAGATTTTGGGACGT
TATCGATAAGTACGGAGTGAATATCTTTTATACGGCTCCAACCGCGATTCGTGCTTTGATGAGAGAAGGGTTGACTCACG
TTCAAAAAAGAAATTTGAGTTCTTTACGTCTTCTAGGTTCCGTCGGAGAACCGATCAACCCCGAAGCTTGGGAATGGTAT
TTTAAAATTATCGGAAAAGAAAAATGTCCAATCGTGGATACCTGGTGGCAAACCGAAACCGGATCCATTATGATCACTGC
GTTACCCGGAGCCATCCCACAAAAACCGGGTTCGGCTACTTTACCGTTTTTCGGAGTTCAGCCCGTATTAGTGGACAACG
ACGGAAAAGAAATAAACGACAAAGGAGAAGTTTCCGGAAATTTGTGTATCAAAAGTCCTTGGCCGTCGATGATGCGTGGA
GTTTACGGAGATTCGAAACGATTTTTTGATACATATTTCTCTCAATTCAAAGGATATTATTTTACAGGAGATGGAGCGCG
CAGAGATAAAGACGGTTACTATTGGATTACCGGGCGTGTAGATGACGTAATTAATGTTTCCGGTCATAGAATCGGAAGTG
CAGAAGTCGAAAGTGCGCTCGTTGAAAATAGATCCGTTGCCGAGGCCGCTGTAGTCGGATTCCCTCACGACATCAAAGGA
CAGGGGATATATGCTTATGTAACCGTAAAGGAAGGTATTGCGACTAATGATACCTTGAAAAAAGAACTCGTTGCAATTGT
TGAAAAGGTAATCGGCAAAATTGCGAGACCGGACGTGATTCATTGGGCGCCGAGTCTTCCAAAAACTCGTTCCGGAAAAA
TTATGAGAAGAATTTTAAGAAAGATTGCTTCGGGAGAATTCGAAGGCCTCGGTGATACTTCGACTCTCGCGGATCCGTCG
GTGGTTCAAAAATTGATCGAAGATAAAAGAAAATTCCACAGTTAA

Upstream 100 bases:

>100_bases
CTTCGGGCGATTTTCCTAAGAGAAAGGTTCGGATTTCCTTTTCTGCAATTTGGTAGACAGAGAGAAAAAAAAGAACATTC
TTTGCGAATCGGAGGAAGTT

Downstream 100 bases:

>100_bases
GGATCGGATTCCTTGCAAGAACCTTCGAAACAAAAGTAAAAAGTGAGTGAATCATTATGCCAAATTCAAATAAACTTTGT
TTGAACTCGATGAACGATTT

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 654; Mature: 653

Protein sequence:

>654_residues
MAKERIVLPSAEFKKNSNITLKDYKSLYKESIENPNKFWAKEANRLTWFKKWTKVLNHDFKNAKVEWFKGGKLNVSYNCL
DRHISTPLKNKAALIWEGDNPSESKVLTYYDVYREVNRFANVLKKYGVKKGDRVLVYLPMIPELAITILACTRIGAIHSV
VFGGFSPEALQSRIDDCKPKLIVTADGGFRGGKPIELKRNVDIALEKSKEDVKTVIVVRRTGNESGLVWKDGRDYWYHFL
ISDPDLSPYCKPESMDAEDPLFILYTSGSTGKPKGVLHTTGGYLLGVNLTFHYVFDIKPEDTYWCTADIGWVTGHSYLVY
GPLSNGASSVMFEGVPSYPDAGRFWDVIDKYGVNIFYTAPTAIRALMREGLTHVQKRNLSSLRLLGSVGEPINPEAWEWY
FKIIGKEKCPIVDTWWQTETGSIMITALPGAIPQKPGSATLPFFGVQPVLVDNDGKEINDKGEVSGNLCIKSPWPSMMRG
VYGDSKRFFDTYFSQFKGYYFTGDGARRDKDGYYWITGRVDDVINVSGHRIGSAEVESALVENRSVAEAAVVGFPHDIKG
QGIYAYVTVKEGIATNDTLKKELVAIVEKVIGKIARPDVIHWAPSLPKTRSGKIMRRILRKIASGEFEGLGDTSTLADPS
VVQKLIEDKRKFHS

Sequences:

>Translated_654_residues
MAKERIVLPSAEFKKNSNITLKDYKSLYKESIENPNKFWAKEANRLTWFKKWTKVLNHDFKNAKVEWFKGGKLNVSYNCL
DRHISTPLKNKAALIWEGDNPSESKVLTYYDVYREVNRFANVLKKYGVKKGDRVLVYLPMIPELAITILACTRIGAIHSV
VFGGFSPEALQSRIDDCKPKLIVTADGGFRGGKPIELKRNVDIALEKSKEDVKTVIVVRRTGNESGLVWKDGRDYWYHFL
ISDPDLSPYCKPESMDAEDPLFILYTSGSTGKPKGVLHTTGGYLLGVNLTFHYVFDIKPEDTYWCTADIGWVTGHSYLVY
GPLSNGASSVMFEGVPSYPDAGRFWDVIDKYGVNIFYTAPTAIRALMREGLTHVQKRNLSSLRLLGSVGEPINPEAWEWY
FKIIGKEKCPIVDTWWQTETGSIMITALPGAIPQKPGSATLPFFGVQPVLVDNDGKEINDKGEVSGNLCIKSPWPSMMRG
VYGDSKRFFDTYFSQFKGYYFTGDGARRDKDGYYWITGRVDDVINVSGHRIGSAEVESALVENRSVAEAAVVGFPHDIKG
QGIYAYVTVKEGIATNDTLKKELVAIVEKVIGKIARPDVIHWAPSLPKTRSGKIMRRILRKIASGEFEGLGDTSTLADPS
VVQKLIEDKRKFHS
>Mature_653_residues
AKERIVLPSAEFKKNSNITLKDYKSLYKESIENPNKFWAKEANRLTWFKKWTKVLNHDFKNAKVEWFKGGKLNVSYNCLD
RHISTPLKNKAALIWEGDNPSESKVLTYYDVYREVNRFANVLKKYGVKKGDRVLVYLPMIPELAITILACTRIGAIHSVV
FGGFSPEALQSRIDDCKPKLIVTADGGFRGGKPIELKRNVDIALEKSKEDVKTVIVVRRTGNESGLVWKDGRDYWYHFLI
SDPDLSPYCKPESMDAEDPLFILYTSGSTGKPKGVLHTTGGYLLGVNLTFHYVFDIKPEDTYWCTADIGWVTGHSYLVYG
PLSNGASSVMFEGVPSYPDAGRFWDVIDKYGVNIFYTAPTAIRALMREGLTHVQKRNLSSLRLLGSVGEPINPEAWEWYF
KIIGKEKCPIVDTWWQTETGSIMITALPGAIPQKPGSATLPFFGVQPVLVDNDGKEINDKGEVSGNLCIKSPWPSMMRGV
YGDSKRFFDTYFSQFKGYYFTGDGARRDKDGYYWITGRVDDVINVSGHRIGSAEVESALVENRSVAEAAVVGFPHDIKGQ
GIYAYVTVKEGIATNDTLKKELVAIVEKVIGKIARPDVIHWAPSLPKTRSGKIMRRILRKIASGEFEGLGDTSTLADPSV
VQKLIEDKRKFHS

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=671, Percent_Identity=50.9687034277198, Blast_Score=684, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=684, Percent_Identity=50, Blast_Score=679, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=631, Percent_Identity=48.811410459588, Blast_Score=623, Evalue=1e-178,
Organism=Homo sapiens, GI13375727, Length=627, Percent_Identity=37.3205741626794, Blast_Score=418, Evalue=1e-116,
Organism=Homo sapiens, GI38505220, Length=520, Percent_Identity=30.9615384615385, Blast_Score=203, Evalue=4e-52,
Organism=Homo sapiens, GI42544132, Length=572, Percent_Identity=29.3706293706294, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI31982927, Length=621, Percent_Identity=25.6038647342995, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI115511026, Length=524, Percent_Identity=29.5801526717557, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI122937307, Length=505, Percent_Identity=31.0891089108911, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI58082049, Length=566, Percent_Identity=26.5017667844523, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI157311624, Length=566, Percent_Identity=26.1484098939929, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI157311622, Length=566, Percent_Identity=26.1484098939929, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI42544134, Length=388, Percent_Identity=26.0309278350515, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI195947378, Length=453, Percent_Identity=24.9448123620309, Blast_Score=97, Evalue=7e-20,
Organism=Homo sapiens, GI187761345, Length=389, Percent_Identity=26.2210796915167, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI187761343, Length=389, Percent_Identity=26.2210796915167, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI156151445, Length=383, Percent_Identity=23.7597911227154, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI227499619, Length=531, Percent_Identity=23.5404896421846, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1790505, Length=637, Percent_Identity=58.5557299843014, Blast_Score=771, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=634, Percent_Identity=37.8548895899054, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI1788107, Length=571, Percent_Identity=25.569176882662, Blast_Score=118, Evalue=2e-27,
Organism=Escherichia coli, GI221142682, Length=547, Percent_Identity=23.9488117001828, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI145693145, Length=521, Percent_Identity=24.3761996161228, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI1786810, Length=524, Percent_Identity=22.5190839694656, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71982997, Length=661, Percent_Identity=51.285930408472, Blast_Score=649, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71983001, Length=660, Percent_Identity=51.2121212121212, Blast_Score=649, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17569507, Length=652, Percent_Identity=22.6993865030675, Blast_Score=151, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI17557194, Length=557, Percent_Identity=23.8779174147217, Blast_Score=105, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17558820, Length=517, Percent_Identity=23.7911025145068, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI32563687, Length=516, Percent_Identity=23.2558139534884, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17538037, Length=584, Percent_Identity=25, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17559526, Length=555, Percent_Identity=23.963963963964, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17560140, Length=532, Percent_Identity=21.9924812030075, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI115534440, Length=558, Percent_Identity=22.2222222222222, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=641, Percent_Identity=50.7020280811232, Blast_Score=647, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319264, Length=644, Percent_Identity=50.6211180124224, Blast_Score=620, Evalue=1e-178,
Organism=Saccharomyces cerevisiae, GI6319699, Length=379, Percent_Identity=26.3852242744063, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24667955, Length=668, Percent_Identity=54.4910179640719, Blast_Score=716, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=566, Percent_Identity=59.0106007067138, Blast_Score=660, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=524, Percent_Identity=59.3511450381679, Blast_Score=616, Evalue=1e-176,
Organism=Drosophila melanogaster, GI21355225, Length=643, Percent_Identity=35.9253499222395, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI21355181, Length=513, Percent_Identity=24.1715399610136, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI18859661, Length=509, Percent_Identity=23.3791748526523, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24581924, Length=538, Percent_Identity=22.6765799256506, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24648260, Length=385, Percent_Identity=25.4545454545455, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356947, Length=378, Percent_Identity=24.0740740740741, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 73403; Mature: 73272

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKERIVLPSAEFKKNSNITLKDYKSLYKESIENPNKFWAKEANRLTWFKKWTKVLNHDF
CCCCEEECCCHHHCCCCCEEHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHCCCC
KNAKVEWFKGGKLNVSYNCLDRHISTPLKNKAALIWEGDNPSESKVLTYYDVYREVNRFA
CCCEEEEEECCEEEEEHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHH
NVLKKYGVKKGDRVLVYLPMIPELAITILACTRIGAIHSVVFGGFSPEALQSRIDDCKPK
HHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
LIVTADGGFRGGKPIELKRNVDIALEKSKEDVKTVIVVRRTGNESGLVWKDGRDYWYHFL
EEEEECCCCCCCCCEEEECCCEEEEECCCCCEEEEEEEEECCCCCCEEEECCCCEEEEEE
ISDPDLSPYCKPESMDAEDPLFILYTSGSTGKPKGVLHTTGGYLLGVNLTFHYVFDIKPE
EECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEEEEEEEEEEECCC
DTYWCTADIGWVTGHSYLVYGPLSNGASSVMFEGVPSYPDAGRFWDVIDKYGVNIFYTAP
CCEEEEEECCEEECCCEEEEECCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCEEEEECH
TAIRALMREGLTHVQKRNLSSLRLLGSVGEPINPEAWEWYFKIIGKEKCPIVDTWWQTET
HHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCC
GSIMITALPGAIPQKPGSATLPFFGVQPVLVDNDGKEINDKGEVSGNLCIKSPWPSMMRG
CCEEEEECCCCCCCCCCCCCCCEECCCEEEECCCCCCCCCCCCCCCCEEEECCCHHHHHH
VYGDSKRFFDTYFSQFKGYYFTGDGARRDKDGYYWITGRVDDVINVSGHRIGSAEVESAL
HCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHH
VENRSVAEAAVVGFPHDIKGQGIYAYVTVKEGIATNDTLKKELVAIVEKVIGKIARPDVI
HCCCCHHHHHEECCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEE
HWAPSLPKTRSGKIMRRILRKIASGEFEGLGDTSTLADPSVVQKLIEDKRKFHS
EECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKERIVLPSAEFKKNSNITLKDYKSLYKESIENPNKFWAKEANRLTWFKKWTKVLNHDF
CCCEEECCCHHHCCCCCEEHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHCCCC
KNAKVEWFKGGKLNVSYNCLDRHISTPLKNKAALIWEGDNPSESKVLTYYDVYREVNRFA
CCCEEEEEECCEEEEEHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHH
NVLKKYGVKKGDRVLVYLPMIPELAITILACTRIGAIHSVVFGGFSPEALQSRIDDCKPK
HHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
LIVTADGGFRGGKPIELKRNVDIALEKSKEDVKTVIVVRRTGNESGLVWKDGRDYWYHFL
EEEEECCCCCCCCCEEEECCCEEEEECCCCCEEEEEEEEECCCCCCEEEECCCCEEEEEE
ISDPDLSPYCKPESMDAEDPLFILYTSGSTGKPKGVLHTTGGYLLGVNLTFHYVFDIKPE
EECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEEEEEEEEEEECCC
DTYWCTADIGWVTGHSYLVYGPLSNGASSVMFEGVPSYPDAGRFWDVIDKYGVNIFYTAP
CCEEEEEECCEEECCCEEEEECCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCEEEEECH
TAIRALMREGLTHVQKRNLSSLRLLGSVGEPINPEAWEWYFKIIGKEKCPIVDTWWQTET
HHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCC
GSIMITALPGAIPQKPGSATLPFFGVQPVLVDNDGKEINDKGEVSGNLCIKSPWPSMMRG
CCEEEEECCCCCCCCCCCCCCCEECCCEEEECCCCCCCCCCCCCCCCEEEECCCHHHHHH
VYGDSKRFFDTYFSQFKGYYFTGDGARRDKDGYYWITGRVDDVINVSGHRIGSAEVESAL
HCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHH
VENRSVAEAAVVGFPHDIKGQGIYAYVTVKEGIATNDTLKKELVAIVEKVIGKIARPDVI
HCCCCHHHHHEECCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEE
HWAPSLPKTRSGKIMRRILRKIASGEFEGLGDTSTLADPSVVQKLIEDKRKFHS
EECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA