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The map label for this gene is metC [H]

Identifier: 116326890

GI number: 116326890

Start: 50652

End: 52145

Strand: Direct

Name: metC [H]

Synonym: LBL_0043

Alternate gene names: 116326890

Gene position: 50652-52145 (Clockwise)

Preceding gene: 116326889

Following gene: 116326892

Centisome position: 1.4

GC content: 39.09

Gene sequence:

>1494_bases
ATGTTACAAGAAATCAACGAACCTCATCGAACACTTTGCGGGGAAAGAATTCCCTTTGAGAATATTCACGCAGTTTCTGT
AAGTCTTCCCCAATTGTCGGACGTGATCGGTTACGAAGAAAAAAGAACAGAAACCCTTTCTAGATTGAAATCGGGTTATC
CTAGATTTGTCGCGCATTCCTATATCGCGAGAATTTTAGACTACAATCGAGAAACAAAAAAAATAGATACTCCTCAGTTC
ATCGTATCTTCCCGAAAAGCGGCAAATACAATCGTTCAAAAATTCTCGATTCAAAAACATGAAATTTTCGAAGATGAAGG
AATCGTAACCTTAGTGATTCCGAACTTGAAAAATTTAGAAAAAGAAATTCTTTCTTTTATTCAACATACCGGATGTCTTG
CATCTTCCAGAATGGCGGAGGATTTCCTTTTAAAGAAAGGAATTCTACGGGAAATTTTCAGAGAGAAAGTCGAGAAAGAA
AATCCGGTTCAAAAAATTCTATCCACGTTATCTTCTTTCTATGGAGATCTAAATCCTGAAATTCTTCTTTCCGTTTCAGG
TATGAACGGAGTCTATTCCGCTTTCGAAGCCTTAGATCGTATCCAAAGAAACAAAGGAAAAACGATCTGGATTAGATTGG
GTTGGCTTTATGTAGATAATATTAGAATTTTAGAAAAATATACGAAAGACTCCTACGTGATCCATAACGCGATGGATCTG
GAAAATTTAGAACAATTCCTAAGACAAAACTCGGAACAAGTTGCGGGGATCATCACCGAGTGTCCCACAAATCCCCTTCT
TTTAGTCCCTAACTATGAAAAATTAAAATCCATCGTGGATCAATATCGGATTCCATTGATTGCGGATATTTCCGTCGCGG
GTTCGGCGGTGATCAACGTTCTTCCTTACGTGGACGTCGTCGTGGAAAGTTTAACCAAGTTCGCCTGCGGAAACGGAGAT
CTCATAATGGGATCCGTCATTTTAAACAAAGACTCACATTGGTTTTCCGAAATTTTTTCGATGTGTAAAGAATCAATCGA
AGCGCCGTATCTCAGAGATTGCGAAAGGCTCGCCTACGAAATCCAAGGATACGAGGAAAGAGTTCTTAAGATCAGTGCGA
ATGTTAAAACACTCGCAGAATATTTTTCACAACAGCCGGGTATTAGAAACGTATTCTGGACGGGTTCTTCCAAAAATTTC
GAAAAGATCACGAGACTTTCGGGCATACAGGCGGGAGTTCTATCGATTGAACTTTCGATTCCATTAGAAAAGTTTTATGA
TCGACTGGCTCTATTGAAAGGACCAAGTTTCGGGACCGAGTTTACTCTCAATATGTTATATGTTTATCTGGCTCATTACG
AATTAGTAACTCAGGAGGAAGGAAGAAAATTCCTAAAAGAAAATGGACTGGATCCAAACTTGATTCGAATCTCTGTTGGT
ATCGAAAGCCCGGATCTTCTGATTCAAGAATACAAGAAAGCCCTCAAAGCTTAA

Upstream 100 bases:

>100_bases
AGAGCCCGAAAAATTTCAGAAACACAAGTCCATTGAGAGTTTTCGGTCGAATTTAGGGGTTGAAAAATCGACGATCGATC
CCGGAGTAGAATCAATAGAA

Downstream 100 bases:

>100_bases
GTTTTTGCTCGGAGCAAATTTCGAACTTTGCACCGACTTCAGAGGCAGCAAAAGAAACGTATAAAATAAGTTATAAATTT
AAGAATACTTAAAGTACGTC

Product: Cys/Met metabolism PLP-dependent protein

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MLQEINEPHRTLCGERIPFENIHAVSVSLPQLSDVIGYEEKRTETLSRLKSGYPRFVAHSYIARILDYNRETKKIDTPQF
IVSSRKAANTIVQKFSIQKHEIFEDEGIVTLVIPNLKNLEKEILSFIQHTGCLASSRMAEDFLLKKGILREIFREKVEKE
NPVQKILSTLSSFYGDLNPEILLSVSGMNGVYSAFEALDRIQRNKGKTIWIRLGWLYVDNIRILEKYTKDSYVIHNAMDL
ENLEQFLRQNSEQVAGIITECPTNPLLLVPNYEKLKSIVDQYRIPLIADISVAGSAVINVLPYVDVVVESLTKFACGNGD
LIMGSVILNKDSHWFSEIFSMCKESIEAPYLRDCERLAYEIQGYEERVLKISANVKTLAEYFSQQPGIRNVFWTGSSKNF
EKITRLSGIQAGVLSIELSIPLEKFYDRLALLKGPSFGTEFTLNMLYVYLAHYELVTQEEGRKFLKENGLDPNLIRISVG
IESPDLLIQEYKKALKA

Sequences:

>Translated_497_residues
MLQEINEPHRTLCGERIPFENIHAVSVSLPQLSDVIGYEEKRTETLSRLKSGYPRFVAHSYIARILDYNRETKKIDTPQF
IVSSRKAANTIVQKFSIQKHEIFEDEGIVTLVIPNLKNLEKEILSFIQHTGCLASSRMAEDFLLKKGILREIFREKVEKE
NPVQKILSTLSSFYGDLNPEILLSVSGMNGVYSAFEALDRIQRNKGKTIWIRLGWLYVDNIRILEKYTKDSYVIHNAMDL
ENLEQFLRQNSEQVAGIITECPTNPLLLVPNYEKLKSIVDQYRIPLIADISVAGSAVINVLPYVDVVVESLTKFACGNGD
LIMGSVILNKDSHWFSEIFSMCKESIEAPYLRDCERLAYEIQGYEERVLKISANVKTLAEYFSQQPGIRNVFWTGSSKNF
EKITRLSGIQAGVLSIELSIPLEKFYDRLALLKGPSFGTEFTLNMLYVYLAHYELVTQEEGRKFLKENGLDPNLIRISVG
IESPDLLIQEYKKALKA
>Mature_497_residues
MLQEINEPHRTLCGERIPFENIHAVSVSLPQLSDVIGYEEKRTETLSRLKSGYPRFVAHSYIARILDYNRETKKIDTPQF
IVSSRKAANTIVQKFSIQKHEIFEDEGIVTLVIPNLKNLEKEILSFIQHTGCLASSRMAEDFLLKKGILREIFREKVEKE
NPVQKILSTLSSFYGDLNPEILLSVSGMNGVYSAFEALDRIQRNKGKTIWIRLGWLYVDNIRILEKYTKDSYVIHNAMDL
ENLEQFLRQNSEQVAGIITECPTNPLLLVPNYEKLKSIVDQYRIPLIADISVAGSAVINVLPYVDVVVESLTKFACGNGD
LIMGSVILNKDSHWFSEIFSMCKESIEAPYLRDCERLAYEIQGYEERVLKISANVKTLAEYFSQQPGIRNVFWTGSSKNF
EKITRLSGIQAGVLSIELSIPLEKFYDRLALLKGPSFGTEFTLNMLYVYLAHYELVTQEEGRKFLKENGLDPNLIRISVG
IESPDLLIQEYKKALKA

Specific function: The enzymatic degradation of amino acids in cheese is believed to generate aroma compounds and therefore to be essential for flavor development. Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine but is also able to catalyze an alpha

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322970, Length=392, Percent_Identity=29.8469387755102, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6322590, Length=354, Percent_Identity=27.4011299435028, Blast_Score=131, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323557, Length=347, Percent_Identity=25.9365994236311, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 56727; Mature: 56727

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQEINEPHRTLCGERIPFENIHAVSVSLPQLSDVIGYEEKRTETLSRLKSGYPRFVAHS
CCCCCCCCHHHHCCCCCCCCCCEEEEEECHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHH
YIARILDYNRETKKIDTPQFIVSSRKAANTIVQKFSIQKHEIFEDEGIVTLVIPNLKNLE
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEECCCHHHHH
KEILSFIQHTGCLASSRMAEDFLLKKGILREIFREKVEKENPVQKILSTLSSFYGDLNPE
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCE
ILLSVSGMNGVYSAFEALDRIQRNKGKTIWIRLGWLYVDNIRILEKYTKDSYVIHNAMDL
EEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCHHHHHHHCCCCEEEECCCCH
ENLEQFLRQNSEQVAGIITECPTNPLLLVPNYEKLKSIVDQYRIPLIADISVAGSAVINV
HHHHHHHHCCCHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHCCCEEEECHHHHHHHHHH
LPYVDVVVESLTKFACGNGDLIMGSVILNKDSHWFSEIFSMCKESIEAPYLRDCERLAYE
HHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IQGYEERVLKISANVKTLAEYFSQQPGIRNVFWTGSSKNFEKITRLSGIQAGVLSIELSI
HCCHHHHHHEEECCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHCCCCCCEEEEEEEC
PLEKFYDRLALLKGPSFGTEFTLNMLYVYLAHYELVTQEEGRKFLKENGLDPNLIRISVG
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
IESPDLLIQEYKKALKA
CCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLQEINEPHRTLCGERIPFENIHAVSVSLPQLSDVIGYEEKRTETLSRLKSGYPRFVAHS
CCCCCCCCHHHHCCCCCCCCCCEEEEEECHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHH
YIARILDYNRETKKIDTPQFIVSSRKAANTIVQKFSIQKHEIFEDEGIVTLVIPNLKNLE
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEECCCHHHHH
KEILSFIQHTGCLASSRMAEDFLLKKGILREIFREKVEKENPVQKILSTLSSFYGDLNPE
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCE
ILLSVSGMNGVYSAFEALDRIQRNKGKTIWIRLGWLYVDNIRILEKYTKDSYVIHNAMDL
EEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCHHHHHHHCCCCEEEECCCCH
ENLEQFLRQNSEQVAGIITECPTNPLLLVPNYEKLKSIVDQYRIPLIADISVAGSAVINV
HHHHHHHHCCCHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHCCCEEEECHHHHHHHHHH
LPYVDVVVESLTKFACGNGDLIMGSVILNKDSHWFSEIFSMCKESIEAPYLRDCERLAYE
HHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IQGYEERVLKISANVKTLAEYFSQQPGIRNVFWTGSSKNFEKITRLSGIQAGVLSIELSI
HCCHHHHHHEEECCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHCCCCCCEEEEEEEC
PLEKFYDRLALLKGPSFGTEFTLNMLYVYLAHYELVTQEEGRKFLKENGLDPNLIRISVG
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
IESPDLLIQEYKKALKA
CCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]