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The map label for this gene is hisB

Identifier: 116326882

GI number: 116326882

Start: 41992

End: 42612

Strand: Reverse

Name: hisB

Synonym: LBL_0034

Alternate gene names: 116326882

Gene position: 42612-41992 (Counterclockwise)

Preceding gene: 116326887

Following gene: 116326881

Centisome position: 1.18

GC content: 40.58

Gene sequence:

>621_bases
TTGACACGGAGGTTGATCCGATTCTATGATCCAGTTAGAATGAAAGCAGAAAGAAAAACCTCCGAAACCGAGATCAAATT
AGAAATGAATCTCCACGGAACTGGTCAGTATCGATTCGATACAGAGATTCCTTTTTTTGAACACATGCTTTCTCATATCT
CCAAACACGGATTAATTGATCTAAATCTTTGGTTGAGAGGGGATATCGAAATCGACTGTCACCATTCCGTAGAAGATACT
GCGATCTTAATGGGAACTACGATTCACAAACAGTTAGGTGACAAGGCCGGGATCTTTCGATACGGACATTTTACTCTTAC
TATGGATGAAGTTCTTACAACCGTAGCCGTGGATCTAGGCGGTAGGTATTTTTTTAAATACACCGGTCCCGAGCTAACGG
GTAAGTTCGGAATTTATGATGCGGAACTTTCTTTGGAATTTTTACAAAAACTTGCATTAAATGCAAAGATGAATCTGCAC
GTATTTGTTCATTACGGAGATAACAAACATCATGTTCACGAATCTATTTTTAAGGCTCTAGGTAAAGCTCTTAGAATGGC
GATCGCACAAGACTCGGCGACTGCAGGCGCGATTCCTTCCACAAAAGGAGTTTTGGAATGA

Upstream 100 bases:

>100_bases
AGTGCGTCTACCAATTCCGCCACTTCGGCAATACAGTGAGAAACCGCTCTTACAATCTCGGAAGGTTTGGGTTTTCCGTC
ATTCATTATTTTGGAATTCA

Downstream 100 bases:

>100_bases
TAGCTATTCTAGATTACGGAATGGGAAACATTCATTCCTGTATCAAAGCTGTATCTCTTTATACAAAAGATTTCGTTTAT
ACGAACAATAAAACAACGAT

Product: imidazoleglycerol-phosphate dehydratase or histidinol-phosphatase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MTRRLIRFYDPVRMKAERKTSETEIKLEMNLHGTGQYRFDTEIPFFEHMLSHISKHGLIDLNLWLRGDIEIDCHHSVEDT
AILMGTTIHKQLGDKAGIFRYGHFTLTMDEVLTTVAVDLGGRYFFKYTGPELTGKFGIYDAELSLEFLQKLALNAKMNLH
VFVHYGDNKHHVHESIFKALGKALRMAIAQDSATAGAIPSTKGVLE

Sequences:

>Translated_206_residues
MTRRLIRFYDPVRMKAERKTSETEIKLEMNLHGTGQYRFDTEIPFFEHMLSHISKHGLIDLNLWLRGDIEIDCHHSVEDT
AILMGTTIHKQLGDKAGIFRYGHFTLTMDEVLTTVAVDLGGRYFFKYTGPELTGKFGIYDAELSLEFLQKLALNAKMNLH
VFVHYGDNKHHVHESIFKALGKALRMAIAQDSATAGAIPSTKGVLE
>Mature_205_residues
TRRLIRFYDPVRMKAERKTSETEIKLEMNLHGTGQYRFDTEIPFFEHMLSHISKHGLIDLNLWLRGDIEIDCHHSVEDTA
ILMGTTIHKQLGDKAGIFRYGHFTLTMDEVLTTVAVDLGGRYFFKYTGPELTGKFGIYDAELSLEFLQKLALNAKMNLHV
FVHYGDNKHHVHESIFKALGKALRMAIAQDSATAGAIPSTKGVLE

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=188, Percent_Identity=38.8297872340425, Blast_Score=127, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6324776, Length=165, Percent_Identity=35.7575757575758, Blast_Score=95, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_LEPBJ (Q04W74)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_799604.1
- ProteinModelPortal:   Q04W74
- SMR:   Q04W74
- STRING:   Q04W74
- GeneID:   4410678
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_0101
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   RQAVEYD
- ProtClustDB:   CLSK573360
- BioCyc:   LBOR355277:LBJ_0101-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 23423; Mature: 23292

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRLIRFYDPVRMKAERKTSETEIKLEMNLHGTGQYRFDTEIPFFEHMLSHISKHGLID
CCCCHHHHCCCHHHHHHCCCCCEEEEEEEEECCCCCEEECCCCCHHHHHHHHHHHCCEEE
LNLWLRGDIEIDCHHSVEDTAILMGTTIHKQLGDKAGIFRYGHFTLTMDEVLTTVAVDLG
EEEEEEECEEEEECCCCCCCEEEEECHHHHHCCCCCCEEEEEEEEEEHHHHHHHHHHHCC
GRYFFKYTGPELTGKFGIYDAELSLEFLQKLALNAKMNLHVFVHYGDNKHHVHESIFKAL
CEEEEEEECCCCCCEECEEEHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHH
GKALRMAIAQDSATAGAIPSTKGVLE
HHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TRRLIRFYDPVRMKAERKTSETEIKLEMNLHGTGQYRFDTEIPFFEHMLSHISKHGLID
CCCHHHHCCCHHHHHHCCCCCEEEEEEEEECCCCCEEECCCCCHHHHHHHHHHHCCEEE
LNLWLRGDIEIDCHHSVEDTAILMGTTIHKQLGDKAGIFRYGHFTLTMDEVLTTVAVDLG
EEEEEEECEEEEECCCCCCCEEEEECHHHHHCCCCCCEEEEEEEEEEHHHHHHHHHHHCC
GRYFFKYTGPELTGKFGIYDAELSLEFLQKLALNAKMNLHVFVHYGDNKHHVHESIFKAL
CEEEEEEECCCCCCEECEEEHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHH
GKALRMAIAQDSATAGAIPSTKGVLE
HHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA