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The map label for this gene is zraR [H]

Identifier: 116326865

GI number: 116326865

Start: 17984

End: 18877

Strand: Direct

Name: zraR [H]

Synonym: LBL_0014

Alternate gene names: 116326865

Gene position: 17984-18877 (Clockwise)

Preceding gene: 116326864

Following gene: 116326867

Centisome position: 0.5

GC content: 36.8

Gene sequence:

>894_bases
TTGAATTCCGAAGAACATATTTTTATCACCAACGCTTCGAATTCGATTAAAGTATTAAATCGACTCAAGTCTTTATCACG
AAATACATTACCCTTATTTATTACGGGAGGTCCGGGTAGTGGGAAGACGTTTGTTTCCAATCTAATTGCCGATTTATCCG
GTTTAAATCCTCGCGTTCTCATTTTAGATTCCGACAATGTCGAGAGCGAAAGGGGTTTGGAATCGATACTTTCCGACGGA
AAAAATACGTATTTTATTTTTAAGAATTTCCCCAATTTTTCAAAACAGATCCAAGTTTATCTTCTGAAAAAAATTCGTGA
AAGTCAAAGCGATTCTCGTTTCATTTTTATTTCCGATAAAGAATGGAAACAAAAACTGGAAACAGGACAAATTCTAGAAT
CGCTTTATTTTGAAATTTCAAATTTTCGATTGGATCTTCCGGATCTCAGGGAAAGAAAAGAGGATATTCCTCCGTTAATT
CGACATTTTTTGGAAACTCTTTCCGAAAAATACAAACGAAAAGAAATCCGGTTAAGCGAAAAACTAGTTCAGTTTTTACT
TAATTACGATTTTCCGGGCAACGTTAGACAACTCAAAAACCTTTTGGAAGGTATGATTTCCCTGTTTGCCGTCCGTGTTC
TTGACGTAAAACATCTTCCGCCTCAGATGTTTGAAACATGTTACGTTTATTCGGAGTTTATAGAAGTGAAAACCGGGATT
CCTTTAAAGGATTACGAAAGGGAAATCATCAAAAGGAATTTGATTCTTGTGAACGGAAATCGGGAAAAGGCCGCCAAAAT
ACTCGGAATATCGGAAAGGACGATTTATAGAAAGATTATAGAATTCGGTCTTTCCGGCGAAGCTGAAGGAAAAAATCCTC
CATCCGGCGACTGA

Upstream 100 bases:

>100_bases
AACTATTTTCAGAATACGAATAAAAGTTCTTTTGATTGTATAATCCGAGGTAGAGTTCTGCAAGTCAAAGGGTTATAATT
TTTGGAGAAGGGATCCACAT

Downstream 100 bases:

>100_bases
AATAAAACTCCGCCCCTTCTTTTTCCGAACCGGTTTTGATTCGAATATTCATATCTATCATAAAATCGTAAAGTTCTCCG
ATGATTTTATCGGAAAAAAA

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MNSEEHIFITNASNSIKVLNRLKSLSRNTLPLFITGGPGSGKTFVSNLIADLSGLNPRVLILDSDNVESERGLESILSDG
KNTYFIFKNFPNFSKQIQVYLLKKIRESQSDSRFIFISDKEWKQKLETGQILESLYFEISNFRLDLPDLRERKEDIPPLI
RHFLETLSEKYKRKEIRLSEKLVQFLLNYDFPGNVRQLKNLLEGMISLFAVRVLDVKHLPPQMFETCYVYSEFIEVKTGI
PLKDYEREIIKRNLILVNGNREKAAKILGISERTIYRKIIEFGLSGEAEGKNPPSGD

Sequences:

>Translated_297_residues
MNSEEHIFITNASNSIKVLNRLKSLSRNTLPLFITGGPGSGKTFVSNLIADLSGLNPRVLILDSDNVESERGLESILSDG
KNTYFIFKNFPNFSKQIQVYLLKKIRESQSDSRFIFISDKEWKQKLETGQILESLYFEISNFRLDLPDLRERKEDIPPLI
RHFLETLSEKYKRKEIRLSEKLVQFLLNYDFPGNVRQLKNLLEGMISLFAVRVLDVKHLPPQMFETCYVYSEFIEVKTGI
PLKDYEREIIKRNLILVNGNREKAAKILGISERTIYRKIIEFGLSGEAEGKNPPSGD
>Mature_297_residues
MNSEEHIFITNASNSIKVLNRLKSLSRNTLPLFITGGPGSGKTFVSNLIADLSGLNPRVLILDSDNVESERGLESILSDG
KNTYFIFKNFPNFSKQIQVYLLKKIRESQSDSRFIFISDKEWKQKLETGQILESLYFEISNFRLDLPDLRERKEDIPPLI
RHFLETLSEKYKRKEIRLSEKLVQFLLNYDFPGNVRQLKNLLEGMISLFAVRVLDVKHLPPQMFETCYVYSEFIEVKTGI
PLKDYEREIIKRNLILVNGNREKAAKILGISERTIYRKIIEFGLSGEAEGKNPPSGD

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG3829

COG function: function code KT; Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=278, Percent_Identity=25.5395683453237, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1790299, Length=314, Percent_Identity=24.5222929936306, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1788550, Length=179, Percent_Identity=29.608938547486, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789233, Length=329, Percent_Identity=25.8358662613982, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787583, Length=299, Percent_Identity=27.4247491638796, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1789087, Length=305, Percent_Identity=24.9180327868852, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788905, Length=300, Percent_Identity=21.3333333333333, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786524, Length=176, Percent_Identity=31.25, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87082117, Length=185, Percent_Identity=26.4864864864865, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081858, Length=292, Percent_Identity=19.8630136986301, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 34269; Mature: 34269

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSEEHIFITNASNSIKVLNRLKSLSRNTLPLFITGGPGSGKTFVSNLIADLSGLNPRVL
CCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEE
ILDSDNVESERGLESILSDGKNTYFIFKNFPNFSKQIQVYLLKKIRESQSDSRFIFISDK
EEECCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECH
EWKQKLETGQILESLYFEISNFRLDLPDLRERKEDIPPLIRHFLETLSEKYKRKEIRLSE
HHHHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
KLVQFLLNYDFPGNVRQLKNLLEGMISLFAVRVLDVKHLPPQMFETCYVYSEFIEVKTGI
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
PLKDYEREIIKRNLILVNGNREKAAKILGISERTIYRKIIEFGLSGEAEGKNPPSGD
CHHHHHHHHHHCCEEEEECCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNSEEHIFITNASNSIKVLNRLKSLSRNTLPLFITGGPGSGKTFVSNLIADLSGLNPRVL
CCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEE
ILDSDNVESERGLESILSDGKNTYFIFKNFPNFSKQIQVYLLKKIRESQSDSRFIFISDK
EEECCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECH
EWKQKLETGQILESLYFEISNFRLDLPDLRERKEDIPPLIRHFLETLSEKYKRKEIRLSE
HHHHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
KLVQFLLNYDFPGNVRQLKNLLEGMISLFAVRVLDVKHLPPQMFETCYVYSEFIEVKTGI
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
PLKDYEREIIKRNLILVNGNREKAAKILGISERTIYRKIIEFGLSGEAEGKNPPSGD
CHHHHHHHHHHCCEEEEECCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]