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The map label for this gene is mrdA [H]

Identifier: 115353219

GI number: 115353219

Start: 3501731

End: 3504025

Strand: Direct

Name: mrdA [H]

Synonym: Bamb_3168

Alternate gene names: 115353219

Gene position: 3501731-3504025 (Clockwise)

Preceding gene: 115353218

Following gene: 115353220

Centisome position: 98.46

GC content: 68.19

Gene sequence:

>2295_bases
ATGGGCCGGATCAAATGTAACCGCATGACCGAATTCAACGACACCCAACAGCAGCTCTCGAAGTTCCGCCTGCGCGTCGC
GGCGGCGGGCGTGTTCGTGTTCGTCTGCTTCGGGCTGCTCGCGAGCCGCTTCTTCTACCTGCAGCTGATGCAGCACGGCA
AATATGCGCTGCAGGCTGAGGAAAACCGCATCTCGGTCGCACCGATCGTGCCGAACCGCGGGATCATCACCGACCGCAAC
GGCGTGGTCCTCGCGAAGAACTATTCGGCGTACACGCTCGAGATCACGCCGTCGAAGCTCGACGACACGCTCGACAACAC
GATCGACAAGCTGTCCGAGATCATCCCGATCGACGCGCGCGACCGCCGCCGCTTCAAGAAGCTGCAGGAAGACTCGAAGA
ACTTCGAGAGCCTGCCGATCCGCACGCGCCTCACCGACGCGGAAGTCGCGCGCTTCACCGCGCAGCGCTTCCGCTTCCCC
GGCGTCGACGTGCGCGCGCGGCTGTTCCGCCAGTACCCGCTCGGCATGACGGCCGCGCACGTGATCGGCTACATCGGCCG
GATCTCGAAGCGCGACCAGGATCGCATCGATGCGATGAGCGACGAGAACGACAGCGACCAGGAACATTACGATCCGCGTC
GCGACGCGAACAACTACAAGGGCACCGACTACATCGGCAAGATCGGCGTCGAGCAGAGCTACGAAGCCGACCTGCATGGC
CTCACGGGCTTCGAGGAAGTCGAGGTGACGGCCGGCGGCCGGCCCGTGCGCACGCTGTCGCGCACGCAGGCGACGCCCGG
CAACAACCTGGTGCTGTCGCTCGACATCGGGCTGCAGCAGGTCGCCGAGCAGGCGTTCGCCGGCAAGCGCGGCGCGCTCG
TCGCGATCGAGCCGAAGACGGGCGACGTGCTCGCGTTCGTGTCGTCGCCGAGCTTCGACCCGAACTCGTTCGTCGACGGC
ATCGACCAGCAGACCTGGGACGAGCTGAACAACTCGCCCGACAAGCCGCTGCTGAACCGGCCGCTGCACGGCACCTACCC
GCCCGGCTCGACGTACAAGCCGTTCATGGCGCTGGCCGGCCTGACGCTCGGCAAGCGCACGCCGGGCTGGGGCTTCCAGG
ATCCCGGCTACTTCACGTTCGGCGGCCACACGTTCCGCAACGACGTGCGCTCGGGCCAGGGCTGGGTCGACATGAACAAG
GCGATCATGGTGTCGAACGACACCTACTTCTACATGCTCGCGCGCGACCTCGGCGTGAACGCGATCGCGAACTTCATGAA
GCCGTTCGGCTTCGGCCAGATCACCGGCATCGACATCCAGGGCGAGGCGCGCGGGATCCTGCCGTCGACCGACTGGAAGA
AGAAGGCGTTCAAGAAGGCCGCGCAGCAGAAGTGGTTCGACGGCGAAACGATCAGCCTCGGGATCGGCCAGGGCTACAAC
TCGTACACGATCCTGCAGCTCGCGCACGCCACCGCGACGCTCGCGAACAACGGCGTCGTGATGAAGCCTCACCTCGTGAA
GGAAGTCGAGGATCCGATCTCGCGCGCGCGCCACCTGACCGTGCCGAAGGAAAGCGAAGTGATTCCGCTCAAGCAGGGCG
ACATCGACGTCGTGAAGCGCGGGATGGAAAACGTGATCGAGAATCCGTCCGGCACCGCGTACAAGGTGTTCCGCGGCGCG
CCGTACCTCGCGGCCGGCAAGACCGGTACCGCGCAGGTGTTCTCGCTGCAGGGCTCGAACTACAAGGGCCACCTGCTCGC
CGAGCACCTGCGCGACCACGCGCTGTTCATCGCGTACGCGCCGGTCGACCATCCGCAGATCGCCGTCGCGCTGGTCGTCG
AGAACGGCGGCTGGGGCGCGCAGGCCGCGGGCCCGATCGCGCGCCGCGTGCTCGACTACTACCTCGTCGAACGTCAGAAC
CCGAACAACGAGGCCGCGGCCGTGGCCGCCGCCGCGTCGGCGACCGAGCCGGTGAGCGCGCCCGTGGTCGGCGACGCATC
GAAGCCCGCCGCCGTCGCGGCCGGCTTCACCGCGCTGCCGCAGCCGGTCGTGCCGACCGCGGCGAGCGCGGCAAGTGCGG
CGGACGCCGCGTCGGCACCCGATGCATCGAGCGCGGCGCAGCCGTCCGACGCGAGCGCCGCGGCGCCGATGGCCGCGAGC
CTGCCGCCGATCCGGCGCCCGCACCGGCCCCACCGGCCCGCGAGCGGCGCACAGCCGGTCGCCACCGGGCCGCGCGACGA
CAACTTCCGTGCCTCGGCCACCGCGAAAGCGGTGAACGCCGGCACCGCTCATTAA

Upstream 100 bases:

>100_bases
ATCTGAGCCGCACCGGGACCGACCTTGAACACCCGCCGCCCCCACGCCCGCCGCGCGCCGCGCTCCGGGGCGGCCCCTCG
TCCGCGCGCGCTCGCCGTGC

Downstream 100 bases:

>100_bases
CGGAGAAAGGCATGCAATTCGACAAGCGCGCCTGGCTCGACAAGATCAAGCAGATGTTCGCGGGTTTCGACCGCCCGCTC
GCCCTCATCGTGTTCCTGCT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 764; Mature: 763

Protein sequence:

>764_residues
MGRIKCNRMTEFNDTQQQLSKFRLRVAAAGVFVFVCFGLLASRFFYLQLMQHGKYALQAEENRISVAPIVPNRGIITDRN
GVVLAKNYSAYTLEITPSKLDDTLDNTIDKLSEIIPIDARDRRRFKKLQEDSKNFESLPIRTRLTDAEVARFTAQRFRFP
GVDVRARLFRQYPLGMTAAHVIGYIGRISKRDQDRIDAMSDENDSDQEHYDPRRDANNYKGTDYIGKIGVEQSYEADLHG
LTGFEEVEVTAGGRPVRTLSRTQATPGNNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVSSPSFDPNSFVDG
IDQQTWDELNNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNK
AIMVSNDTYFYMLARDLGVNAIANFMKPFGFGQITGIDIQGEARGILPSTDWKKKAFKKAAQQKWFDGETISLGIGQGYN
SYTILQLAHATATLANNGVVMKPHLVKEVEDPISRARHLTVPKESEVIPLKQGDIDVVKRGMENVIENPSGTAYKVFRGA
PYLAAGKTGTAQVFSLQGSNYKGHLLAEHLRDHALFIAYAPVDHPQIAVALVVENGGWGAQAAGPIARRVLDYYLVERQN
PNNEAAAVAAAASATEPVSAPVVGDASKPAAVAAGFTALPQPVVPTAASAASAADAASAPDASSAAQPSDASAAAPMAAS
LPPIRRPHRPHRPASGAQPVATGPRDDNFRASATAKAVNAGTAH

Sequences:

>Translated_764_residues
MGRIKCNRMTEFNDTQQQLSKFRLRVAAAGVFVFVCFGLLASRFFYLQLMQHGKYALQAEENRISVAPIVPNRGIITDRN
GVVLAKNYSAYTLEITPSKLDDTLDNTIDKLSEIIPIDARDRRRFKKLQEDSKNFESLPIRTRLTDAEVARFTAQRFRFP
GVDVRARLFRQYPLGMTAAHVIGYIGRISKRDQDRIDAMSDENDSDQEHYDPRRDANNYKGTDYIGKIGVEQSYEADLHG
LTGFEEVEVTAGGRPVRTLSRTQATPGNNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVSSPSFDPNSFVDG
IDQQTWDELNNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNK
AIMVSNDTYFYMLARDLGVNAIANFMKPFGFGQITGIDIQGEARGILPSTDWKKKAFKKAAQQKWFDGETISLGIGQGYN
SYTILQLAHATATLANNGVVMKPHLVKEVEDPISRARHLTVPKESEVIPLKQGDIDVVKRGMENVIENPSGTAYKVFRGA
PYLAAGKTGTAQVFSLQGSNYKGHLLAEHLRDHALFIAYAPVDHPQIAVALVVENGGWGAQAAGPIARRVLDYYLVERQN
PNNEAAAVAAAASATEPVSAPVVGDASKPAAVAAGFTALPQPVVPTAASAASAADAASAPDASSAAQPSDASAAAPMAAS
LPPIRRPHRPHRPASGAQPVATGPRDDNFRASATAKAVNAGTAH
>Mature_763_residues
GRIKCNRMTEFNDTQQQLSKFRLRVAAAGVFVFVCFGLLASRFFYLQLMQHGKYALQAEENRISVAPIVPNRGIITDRNG
VVLAKNYSAYTLEITPSKLDDTLDNTIDKLSEIIPIDARDRRRFKKLQEDSKNFESLPIRTRLTDAEVARFTAQRFRFPG
VDVRARLFRQYPLGMTAAHVIGYIGRISKRDQDRIDAMSDENDSDQEHYDPRRDANNYKGTDYIGKIGVEQSYEADLHGL
TGFEEVEVTAGGRPVRTLSRTQATPGNNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVSSPSFDPNSFVDGI
DQQTWDELNNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLTLGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKA
IMVSNDTYFYMLARDLGVNAIANFMKPFGFGQITGIDIQGEARGILPSTDWKKKAFKKAAQQKWFDGETISLGIGQGYNS
YTILQLAHATATLANNGVVMKPHLVKEVEDPISRARHLTVPKESEVIPLKQGDIDVVKRGMENVIENPSGTAYKVFRGAP
YLAAGKTGTAQVFSLQGSNYKGHLLAEHLRDHALFIAYAPVDHPQIAVALVVENGGWGAQAAGPIARRVLDYYLVERQNP
NNEAAAVAAAASATEPVSAPVVGDASKPAAVAAGFTALPQPVVPTAASAASAADAASAPDASSAAQPSDASAAAPMAASL
PPIRRPHRPHRPASGAQPVATGPRDDNFRASATAKAVNAGTAH

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=645, Percent_Identity=39.6899224806202, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI1786272, Length=651, Percent_Identity=23.3486943164363, Blast_Score=120, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 82805; Mature: 82674

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRIKCNRMTEFNDTQQQLSKFRLRVAAAGVFVFVCFGLLASRFFYLQLMQHGKYALQAE
CCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
ENRISVAPIVPNRGIITDRNGVVLAKNYSAYTLEITPSKLDDTLDNTIDKLSEIIPIDAR
CCEEEEEEECCCCCEEECCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCH
DRRRFKKLQEDSKNFESLPIRTRLTDAEVARFTAQRFRFPGVDVRARLFRQYPLGMTAAH
HHHHHHHHHHHCCCHHCCCCEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHH
VIGYIGRISKRDQDRIDAMSDENDSDQEHYDPRRDANNYKGTDYIGKIGVEQSYEADLHG
HHHHHHHHCCCCHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCHHEECCCCCCCCCCCCC
LTGFEEVEVTAGGRPVRTLSRTQATPGNNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKT
CCCCCEEEEECCCCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEEECCC
GDVLAFVSSPSFDPNSFVDGIDQQTWDELNNSPDKPLLNRPLHGTYPPGSTYKPFMALAG
CCEEEEECCCCCCCHHHHCCCCHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHC
LTLGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDTYFYMLARDLGVN
CCCCCCCCCCCCCCCCEEEECCHHHHHHHCCCCCEEECCCEEEEECCCEEEEEECHHCHH
AIANFMKPFGFGQITGIDIQGEARGILPSTDWKKKAFKKAAQQKWFDGETISLGIGQGYN
HHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCC
SYTILQLAHATATLANNGVVMKPHLVKEVEDPISRARHLTVPKESEVIPLKQGDIDVVKR
CEEEEEEHHHHHHHCCCCEEECCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHH
GMENVIENPSGTAYKVFRGAPYLAAGKTGTAQVFSLQGSNYKGHLLAEHLRDHALFIAYA
HHHHHHCCCCCCEEEEECCCCEEECCCCCCEEEEEECCCCCCCHHHHHHHCCCEEEEEEC
PVDHPQIAVALVVENGGWGAQAAGPIARRVLDYYLVERQNPNNEAAAVAAAASATEPVSA
CCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCC
PVVGDASKPAAVAAGFTALPQPVVPTAASAASAADAASAPDASSAAQPSDASAAAPMAAS
CCCCCCCCCHHHHCCCHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHC
LPPIRRPHRPHRPASGAQPVATGPRDDNFRASATAKAVNAGTAH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCC
>Mature Secondary Structure 
GRIKCNRMTEFNDTQQQLSKFRLRVAAAGVFVFVCFGLLASRFFYLQLMQHGKYALQAE
CCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
ENRISVAPIVPNRGIITDRNGVVLAKNYSAYTLEITPSKLDDTLDNTIDKLSEIIPIDAR
CCEEEEEEECCCCCEEECCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCH
DRRRFKKLQEDSKNFESLPIRTRLTDAEVARFTAQRFRFPGVDVRARLFRQYPLGMTAAH
HHHHHHHHHHHCCCHHCCCCEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHH
VIGYIGRISKRDQDRIDAMSDENDSDQEHYDPRRDANNYKGTDYIGKIGVEQSYEADLHG
HHHHHHHHCCCCHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCHHEECCCCCCCCCCCCC
LTGFEEVEVTAGGRPVRTLSRTQATPGNNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKT
CCCCCEEEEECCCCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEEECCC
GDVLAFVSSPSFDPNSFVDGIDQQTWDELNNSPDKPLLNRPLHGTYPPGSTYKPFMALAG
CCEEEEECCCCCCCHHHHCCCCHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHC
LTLGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDTYFYMLARDLGVN
CCCCCCCCCCCCCCCCEEEECCHHHHHHHCCCCCEEECCCEEEEECCCEEEEEECHHCHH
AIANFMKPFGFGQITGIDIQGEARGILPSTDWKKKAFKKAAQQKWFDGETISLGIGQGYN
HHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCC
SYTILQLAHATATLANNGVVMKPHLVKEVEDPISRARHLTVPKESEVIPLKQGDIDVVKR
CEEEEEEHHHHHHHCCCCEEECCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHH
GMENVIENPSGTAYKVFRGAPYLAAGKTGTAQVFSLQGSNYKGHLLAEHLRDHALFIAYA
HHHHHHCCCCCCEEEEECCCCEEECCCCCCEEEEEECCCCCCCHHHHHHHCCCEEEEEEC
PVDHPQIAVALVVENGGWGAQAAGPIARRVLDYYLVERQNPNNEAAAVAAAASATEPVSA
CCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCC
PVVGDASKPAAVAAGFTALPQPVVPTAASAASAADAASAPDASSAAQPSDASAAAPMAAS
CCCCCCCCCHHHHCCCHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHC
LPPIRRPHRPHRPASGAQPVATGPRDDNFRASATAKAVNAGTAH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]