Click here to switch to the map view.

The map label for this gene is kynU [H]

Identifier: 115352677

GI number: 115352677

Start: 2888417

End: 2889670

Strand: Direct

Name: kynU [H]

Synonym: Bamb_2626

Alternate gene names: 115352677

Gene position: 2888417-2889670 (Clockwise)

Preceding gene: 115352676

Following gene: 115352678

Centisome position: 81.21

GC content: 70.1

Gene sequence:

>1254_bases
ATGATCAAGACCCGTGAAGACGCGCTCGCCCTCGACCGCGACGACCCGCTCGCCGCGCTGCGCGACCAGTTCGCGCTGCC
CGACGGCGTGATCTATCTCGACGGCAACTCGCTCGGCGCCCAGCCGCGCGCGTCGGCCGCCCGCGCGCAACAGGTGATCG
GCGCCGAATGGGGCGAAGGCCTGATCCGCAGCTGGAACACCGCCGGCTGGTTCGCGCTGCCGCGCCGCCTCGGCGACAAG
CTCGCGACGCTGATAGGCGGCGCACCGGGGGAGACCGTCGTGACCGACACCATCTCGATCAACCTGTTCAAGCTGCTGTC
GGCGATGCTGCGTCACCAGGCCGCGCGCGCGCCGGAGCGCCGCGTGATCGTGTCGGAGCGCTCGAACTTCCCGACCGACC
TGTACATCGCGCAAGGGCTGATCGAGCAGCTCGGCGGCGGCTACGAGCTGCGCCTGATCGACGATCCGGCCGACCTGCCC
GACGCGCTCGGCGCGGACACGGCCGTCGCGATGATCACGCACGTGAACTACCGCACCGGCTACATGCACGACATGCCGGC
CGTCACGCAACTCGTGCACGACGCGGGCGCGCTGATGCTGTGGGATCTCGCGCACTCGGCCGGCGCGGTGCCGGTCGACC
TGAACGGCGCGCATGCGGACGGCGCGGTCGGTTGCACGTACAAGTATCTGAACGGCGGCCCCGGTTCGCCGGCGTTCGTG
TGGGTGCCGCAGCGCCATCACGCGCATTTCTCGCAGCCGCTGTCGGGCTGGTGGGGCCACCGCGCACCGTTCGCGATGCA
GCCGGGCTTCGCGCCCGATCCGGGCATCGCGCGCTTCCTGTGCGGCACGCAGCCGATCGTGTCGATGTCGATGGTCGAAT
GCGGGCTCGACGTGTTCCTGCAGACCGACATGCACGCGATCCGCCGCAAGTCGCTCGCGCTCACCGATGCGTTCATCGCA
CTCGTCGAAGCGCGCTGCGCGGGCCTGTCGCTGAAGCTCGTCACGCCGCGCGCGCATCACCAGCGCGGCTCGCAGGCGAG
CTTCGAGCATCCGCACGGCTACGAGGTGATGCAGGCGCTGATCGCGCGTGGCGTGATCGGCGACTACCGCGAGCCGTACG
TGCTGCGCTTCGGCTTCACGCCGCTCTATACGCGCTTCGTCGACGTGTGGGATGCCGTCGAGACGCTGCGCGACATCCTG
GCCACCGATGCGTGGAAGGCACCCGAATTCGCCGAGCGCGGCGCGGTGACCTGA

Upstream 100 bases:

>100_bases
CCGCTGAAGTTCGCGACGCTCGACGCAAGCCCCGTGCGTGCGGTGCTGCGCGCGCTGCCCGGCCACTCCTCCTGATTACC
CGACCCACTGACCCGACATC

Downstream 100 bases:

>100_bases
TCGGCGTCGACCGGCGCGCGCAGGCCGCGCGCCGCGCCCCCCGTCATTCAAATCTGGAGAGAGTCGTGAATTCTGGTCAT
ATGCAGCCACCCGGCGACAA

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MIKTREDALALDRDDPLAALRDQFALPDGVIYLDGNSLGAQPRASAARAQQVIGAEWGEGLIRSWNTAGWFALPRRLGDK
LATLIGGAPGETVVTDTISINLFKLLSAMLRHQAARAPERRVIVSERSNFPTDLYIAQGLIEQLGGGYELRLIDDPADLP
DALGADTAVAMITHVNYRTGYMHDMPAVTQLVHDAGALMLWDLAHSAGAVPVDLNGAHADGAVGCTYKYLNGGPGSPAFV
WVPQRHHAHFSQPLSGWWGHRAPFAMQPGFAPDPGIARFLCGTQPIVSMSMVECGLDVFLQTDMHAIRRKSLALTDAFIA
LVEARCAGLSLKLVTPRAHHQRGSQASFEHPHGYEVMQALIARGVIGDYREPYVLRFGFTPLYTRFVDVWDAVETLRDIL
ATDAWKAPEFAERGAVT

Sequences:

>Translated_417_residues
MIKTREDALALDRDDPLAALRDQFALPDGVIYLDGNSLGAQPRASAARAQQVIGAEWGEGLIRSWNTAGWFALPRRLGDK
LATLIGGAPGETVVTDTISINLFKLLSAMLRHQAARAPERRVIVSERSNFPTDLYIAQGLIEQLGGGYELRLIDDPADLP
DALGADTAVAMITHVNYRTGYMHDMPAVTQLVHDAGALMLWDLAHSAGAVPVDLNGAHADGAVGCTYKYLNGGPGSPAFV
WVPQRHHAHFSQPLSGWWGHRAPFAMQPGFAPDPGIARFLCGTQPIVSMSMVECGLDVFLQTDMHAIRRKSLALTDAFIA
LVEARCAGLSLKLVTPRAHHQRGSQASFEHPHGYEVMQALIARGVIGDYREPYVLRFGFTPLYTRFVDVWDAVETLRDIL
ATDAWKAPEFAERGAVT
>Mature_417_residues
MIKTREDALALDRDDPLAALRDQFALPDGVIYLDGNSLGAQPRASAARAQQVIGAEWGEGLIRSWNTAGWFALPRRLGDK
LATLIGGAPGETVVTDTISINLFKLLSAMLRHQAARAPERRVIVSERSNFPTDLYIAQGLIEQLGGGYELRLIDDPADLP
DALGADTAVAMITHVNYRTGYMHDMPAVTQLVHDAGALMLWDLAHSAGAVPVDLNGAHADGAVGCTYKYLNGGPGSPAFV
WVPQRHHAHFSQPLSGWWGHRAPFAMQPGFAPDPGIARFLCGTQPIVSMSMVECGLDVFLQTDMHAIRRKSLALTDAFIA
LVEARCAGLSLKLVTPRAHHQRGSQASFEHPHGYEVMQALIARGVIGDYREPYVLRFGFTPLYTRFVDVWDAVETLRDIL
ATDAWKAPEFAERGAVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=444, Percent_Identity=28.3783783783784, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI74101437, Length=285, Percent_Identity=26.6666666666667, Blast_Score=86, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17550466, Length=430, Percent_Identity=26.9767441860465, Blast_Score=147, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6323261, Length=456, Percent_Identity=29.1666666666667, Blast_Score=145, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 45421; Mature: 45421

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKTREDALALDRDDPLAALRDQFALPDGVIYLDGNSLGAQPRASAARAQQVIGAEWGEG
CCCCCCCHHCCCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCH
LIRSWNTAGWFALPRRLGDKLATLIGGAPGETVVTDTISINLFKLLSAMLRHQAARAPER
HHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCC
RVIVSERSNFPTDLYIAQGLIEQLGGGYELRLIDDPADLPDALGADTAVAMITHVNYRTG
EEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHCCCCHHHHHHEECCCCCC
YMHDMPAVTQLVHDAGALMLWDLAHSAGAVPVDLNGAHADGAVGCTYKYLNGGPGSPAFV
CCCCHHHHHHHHHHCCHHEEEHHHHCCCCCEEECCCCCCCCCCEEEEEECCCCCCCCEEE
WVPQRHHAHFSQPLSGWWGHRAPFAMQPGFAPDPGIARFLCGTQPIVSMSMVECGLDVFL
ECCCHHCCCCCCCHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCHHHHH
QTDMHAIRRKSLALTDAFIALVEARCAGLSLKLVTPRAHHQRGSQASFEHPHGYEVMQAL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCCCCCCCCHHHHHHH
IARGVIGDYREPYVLRFGFTPLYTRFVDVWDAVETLRDILATDAWKAPEFAERGAVT
HHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCC
>Mature Secondary Structure
MIKTREDALALDRDDPLAALRDQFALPDGVIYLDGNSLGAQPRASAARAQQVIGAEWGEG
CCCCCCCHHCCCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCH
LIRSWNTAGWFALPRRLGDKLATLIGGAPGETVVTDTISINLFKLLSAMLRHQAARAPER
HHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCC
RVIVSERSNFPTDLYIAQGLIEQLGGGYELRLIDDPADLPDALGADTAVAMITHVNYRTG
EEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHCCCCHHHHHHEECCCCCC
YMHDMPAVTQLVHDAGALMLWDLAHSAGAVPVDLNGAHADGAVGCTYKYLNGGPGSPAFV
CCCCHHHHHHHHHHCCHHEEEHHHHCCCCCEEECCCCCCCCCCEEEEEECCCCCCCCEEE
WVPQRHHAHFSQPLSGWWGHRAPFAMQPGFAPDPGIARFLCGTQPIVSMSMVECGLDVFL
ECCCHHCCCCCCCHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCHHHHH
QTDMHAIRRKSLALTDAFIALVEARCAGLSLKLVTPRAHHQRGSQASFEHPHGYEVMQAL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCCCCCCCCHHHHHHH
IARGVIGDYREPYVLRFGFTPLYTRFVDVWDAVETLRDILATDAWKAPEFAERGAVT
HHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA