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The map label for this gene is kynA [H]

Identifier: 115352678

GI number: 115352678

Start: 2889736

End: 2890677

Strand: Direct

Name: kynA [H]

Synonym: Bamb_2627

Alternate gene names: 115352678

Gene position: 2889736-2890677 (Clockwise)

Preceding gene: 115352677

Following gene: 115352683

Centisome position: 81.25

GC content: 66.99

Gene sequence:

>942_bases
GTGAATTCTGGTCATATGCAGCCACCCGGCGACAATGCGCCGGCGGGCTGCCCGTTCTCGGGCGCACACGCGGCCCAACC
CGCGCATGAAGCGCCGCACGTGCCGGGCGACGCGGCAGGCGAAGCCGGCTGGCACGACGCGCAGCTCGATTTCTCGAAGT
CGATGAGCTACGGCGACTATCTGTCGCTGAATTCGATCCTCGACGCGCAACATCCGCTGTCGCCCGATCACAACGAGATG
CTGTTCATCATCCAGCATCAGACGAGCGAGCTGTGGATGAAGCTCGCGCTGTTCGAGCTGCGCGGCGCGCTCGACGCGGT
GCGCGGCGACGCGCTGCCGCCCGCGTTCAAGATGCTCGCGCGGGTGTCACGGATCCTCGAGCAGCTCGTGCAGGCGTGGA
ACGTGCTGTCGACGATGACGCCGTCCGAGTATTCGGCGATGCGCCCGTATCTCGGCCAGTCGTCGGGCTTCCAGTCGTAC
CAGTACCGGCAGCTCGAATTCCTGCTCGGCAACAAGAACGTGCAGATGCTGCAGCCGCATGCGCACCGGCCCGACATCCT
CGAGCAGGTGCGCGCGACGCTCGAGGCGCCGTCGTTCTACGACGAGGTCGTGCGCCTGCTCGCGCGGCGCGGTTTCCCGA
TCGCGCCCGAGCGGCTCGAGCGCGACTGGACGCAGCCGATGCGTCACGACGAAACGGTCGAGGCCGCGTGGCTCGAGGTC
TACCGTCACCCGCAGCAGCACTGGGAGCTGTACGAGATGGCCGAGGAACTCGTCGATCTCGAGGATGCGTTCCGCCAGTG
GCGCTTCCGCCACGTGACGACCGTCGAGCGCATCATCGGCTTCAAGCAGGGCACGGGCGGCACGAGCGGCGCGCCGTATC
TGCGCAAGATGCTCGACGTCGTGCTGTTCCCCGAGCTCTGGCACGTGCGCACCACGCTGTAA

Upstream 100 bases:

>100_bases
CACCCGAATTCGCCGAGCGCGGCGCGGTGACCTGATCGGCGTCGACCGGCGCGCGCAGGCCGCGCGCCGCGCCCCCCGTC
ATTCAAATCTGGAGAGAGTC

Downstream 100 bases:

>100_bases
CGCACGGCATGCGCCCGCGCGTCACGACGACGTGCGGGCCAGCTCCTCTCCTTCGCGCGGCAACGCCCGTTCGCGCGCGA
ACCGCGGAATGTGGCGCCGC

Product: tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MNSGHMQPPGDNAPAGCPFSGAHAAQPAHEAPHVPGDAAGEAGWHDAQLDFSKSMSYGDYLSLNSILDAQHPLSPDHNEM
LFIIQHQTSELWMKLALFELRGALDAVRGDALPPAFKMLARVSRILEQLVQAWNVLSTMTPSEYSAMRPYLGQSSGFQSY
QYRQLEFLLGNKNVQMLQPHAHRPDILEQVRATLEAPSFYDEVVRLLARRGFPIAPERLERDWTQPMRHDETVEAAWLEV
YRHPQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL

Sequences:

>Translated_313_residues
MNSGHMQPPGDNAPAGCPFSGAHAAQPAHEAPHVPGDAAGEAGWHDAQLDFSKSMSYGDYLSLNSILDAQHPLSPDHNEM
LFIIQHQTSELWMKLALFELRGALDAVRGDALPPAFKMLARVSRILEQLVQAWNVLSTMTPSEYSAMRPYLGQSSGFQSY
QYRQLEFLLGNKNVQMLQPHAHRPDILEQVRATLEAPSFYDEVVRLLARRGFPIAPERLERDWTQPMRHDETVEAAWLEV
YRHPQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL
>Mature_313_residues
MNSGHMQPPGDNAPAGCPFSGAHAAQPAHEAPHVPGDAAGEAGWHDAQLDFSKSMSYGDYLSLNSILDAQHPLSPDHNEM
LFIIQHQTSELWMKLALFELRGALDAVRGDALPPAFKMLARVSRILEQLVQAWNVLSTMTPSEYSAMRPYLGQSSGFQSY
QYRQLEFLLGNKNVQMLQPHAHRPDILEQVRATLEAPSFYDEVVRLLARRGFPIAPERLERDWTQPMRHDETVEAAWLEV
YRHPQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring [H]

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI5032165, Length=169, Percent_Identity=36.094674556213, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17552370, Length=372, Percent_Identity=25.5376344086022, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI32564651, Length=177, Percent_Identity=29.3785310734463, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17530891, Length=372, Percent_Identity=29.5698924731183, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017485
- InterPro:   IPR004981 [H]

Pfam domain/function: PF03301 Trp_dioxygenase [H]

EC number: =1.13.11.11 [H]

Molecular weight: Translated: 35694; Mature: 35694

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSGHMQPPGDNAPAGCPFSGAHAAQPAHEAPHVPGDAAGEAGWHDAQLDFSKSMSYGDY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCH
LSLNSILDAQHPLSPDHNEMLFIIQHQTSELWMKLALFELRGALDAVRGDALPPAFKMLA
HHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
RVSRILEQLVQAWNVLSTMTPSEYSAMRPYLGQSSGFQSYQYRQLEFLLGNKNVQMLQPH
HHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCC
AHRPDILEQVRATLEAPSFYDEVVRLLARRGFPIAPERLERDWTQPMRHDETVEAAWLEV
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
YRHPQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDV
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
VLFPELWHVRTTL
HHHHHHHHHHHCC
>Mature Secondary Structure
MNSGHMQPPGDNAPAGCPFSGAHAAQPAHEAPHVPGDAAGEAGWHDAQLDFSKSMSYGDY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCH
LSLNSILDAQHPLSPDHNEMLFIIQHQTSELWMKLALFELRGALDAVRGDALPPAFKMLA
HHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
RVSRILEQLVQAWNVLSTMTPSEYSAMRPYLGQSSGFQSYQYRQLEFLLGNKNVQMLQPH
HHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCC
AHRPDILEQVRATLEAPSFYDEVVRLLARRGFPIAPERLERDWTQPMRHDETVEAAWLEV
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
YRHPQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDV
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
VLFPELWHVRTTL
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA