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The map label for this gene is ilvD2 [H]

Identifier: 115352562

GI number: 115352562

Start: 2768068

End: 2769741

Strand: Direct

Name: ilvD2 [H]

Synonym: Bamb_2511

Alternate gene names: 115352562

Gene position: 2768068-2769741 (Clockwise)

Preceding gene: 115352559

Following gene: 115352563

Centisome position: 77.83

GC content: 67.86

Gene sequence:

>1674_bases
ATGCCGTACAACCGTCGCTCGAAGCACATCACGCAAGGCGTGGCCCGTTCGCCGAACCGCTCGATGTATTACGCCCTCGG
CTACCAGAAGGACGATTTCGACAAGCCGATGATCGGCATCGCGAACGGCCACTCGACGATCACGCCGTGCAACTCGGGCC
TGCAGCGGCTGTCGGACGCGGCCGTCGCGGCGGTCAAGGCGGCCGACGCGAACCCGCAGATCTTCGGCACGCCGACGATC
TCGGACGGCATGTCGATGGGCACCGAGGGGATGAAGTACTCGCTCGTGTCGCGTGAAGTGATCGCCGATTGCATCGAGAC
CTGCGTACAGGGCCAGTGGATGGACGGCGTGGTGGTGGTCGGCGGCTGCGACAAGAACATGCCGGGCGGGATGATCGCGC
TCGCGCGCCTGAACGTGCCGGGTATCTACGTGTACGGCGGCACGATCCGCCCCGGCCACTGGAAGGGCCGCGACCTGACG
ATCGTGTCGTCGTTCGAGGCGGTCGGCGAATTCACCGCGGGCCGGATGTCGCAGGAGGATTTCGAAGGGGTCGAGAAGAA
CGCGTGCCCGACCTCGGGGTCGTGCGGCGGGATGTACACGGCGAACACGATGAGCTCGTCGTTCGAGGCGCTCGGCATGT
CGCTGCTGTACTCGTCGACGATGGCGAACCCCGATCAGGAGAAGGTCGATTCGGCCGCCGAATCGGCGCGTGTGCTGGTC
GAGGCCGTGAAGCGCGACCTTAAGCCGCGCGACATCATCACGAAGGCATCGATCGAGAACGCGGTGTCGCTGATCATGGC
CACCGGCGGCTCGACCAACGCGGTGCTGCACTATCTCGCGATCGCGCACGCGGCCGAGATCGACTGGACGATCGACGACT
TCGAGCGCATCCGCAAGCGCGTGCCGGTGCTCTGCGACCTGAAGCCGTCGGGTCAGTACGTCGCGACCGATCTTCACCAG
GCGGGCGGCATCCCGCAGGTGCTGCGCATCCTGCTCGATGCGGGGCTGCTGCACGGCGACTGCATGACGATCACCGGCCG
CACGATCGCCGAGGAATTGAAGGACGTGCCGGGCGTGCCGCGCGCGGACCAGAAGGTGATCTTCCCGATCGATCGCGCGC
TGTACAAGGAAGGGCATCTCGCGATCCTGAAGGGCAACCTCGCGGAACACGGCGCGGTCGCGAAGATCACCGGCCTGAAG
AACCCGGTGATCACGGGCCCGGCCCGCGTGTTCGACGACGAGCAAAGCGCGATGGACGCGATCCTCGCCGACCGGATCCG
CGCGGGCGACGTGCTGGTGCTGCGCTATCTCGGCCCACAGGGCGGCCCCGGCATGCCGGAAATGCTCGCGCCGACGTCGG
CGATCATCGGCAAGGGGCTCGGCGAATCGGTCGGCTTCATCACGGACGGCCGCTTCTCGGGCGGCACCTGGGGGATGGTG
GTCGGCCACGTCGCGCCGGAGGCGTTCGTCGGCGGCACGATCGCGCTCGTGCAGGAAGGCGATTCGATCACGATCGATGC
GCACCGGCGGGTGCTGCAACTGAACGTCGACGACGCGGAGCTCGCGCGCCGCCGCGCCGCGTGGAAGCAGCCGGCGCCGC
GCTACACGCGCGGCGTGCTGGCCAAGTATGCGGCCCTCGCCCGCCCGGCGAACCAGGGCGCCGTCACCGGTTGA

Upstream 100 bases:

>100_bases
CAAATAATATATTGGACATCCCAAACCGGACACTCCATTCTTGATCGATCCGAACCGGCGCGCCGTTCGCGCGCGCCACC
ATACAACGATGGAGTCCCCC

Downstream 100 bases:

>100_bases
TGCGGCGCGCGAGTCATGCGACCCCACTTCACGCGGCCGCCCAGGAAACGCGCAAAACGCGTTTCCCCTTTGCTTTTATA
ATGCGCGGACCGTGAAGCCG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD 2 [H]

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MPYNRRSKHITQGVARSPNRSMYYALGYQKDDFDKPMIGIANGHSTITPCNSGLQRLSDAAVAAVKAADANPQIFGTPTI
SDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVVGGCDKNMPGGMIALARLNVPGIYVYGGTIRPGHWKGRDLT
IVSSFEAVGEFTAGRMSQEDFEGVEKNACPTSGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLV
EAVKRDLKPRDIITKASIENAVSLIMATGGSTNAVLHYLAIAHAAEIDWTIDDFERIRKRVPVLCDLKPSGQYVATDLHQ
AGGIPQVLRILLDAGLLHGDCMTITGRTIAEELKDVPGVPRADQKVIFPIDRALYKEGHLAILKGNLAEHGAVAKITGLK
NPVITGPARVFDDEQSAMDAILADRIRAGDVLVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGFITDGRFSGGTWGMV
VGHVAPEAFVGGTIALVQEGDSITIDAHRRVLQLNVDDAELARRRAAWKQPAPRYTRGVLAKYAALARPANQGAVTG

Sequences:

>Translated_557_residues
MPYNRRSKHITQGVARSPNRSMYYALGYQKDDFDKPMIGIANGHSTITPCNSGLQRLSDAAVAAVKAADANPQIFGTPTI
SDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVVGGCDKNMPGGMIALARLNVPGIYVYGGTIRPGHWKGRDLT
IVSSFEAVGEFTAGRMSQEDFEGVEKNACPTSGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLV
EAVKRDLKPRDIITKASIENAVSLIMATGGSTNAVLHYLAIAHAAEIDWTIDDFERIRKRVPVLCDLKPSGQYVATDLHQ
AGGIPQVLRILLDAGLLHGDCMTITGRTIAEELKDVPGVPRADQKVIFPIDRALYKEGHLAILKGNLAEHGAVAKITGLK
NPVITGPARVFDDEQSAMDAILADRIRAGDVLVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGFITDGRFSGGTWGMV
VGHVAPEAFVGGTIALVQEGDSITIDAHRRVLQLNVDDAELARRRAAWKQPAPRYTRGVLAKYAALARPANQGAVTG
>Mature_556_residues
PYNRRSKHITQGVARSPNRSMYYALGYQKDDFDKPMIGIANGHSTITPCNSGLQRLSDAAVAAVKAADANPQIFGTPTIS
DGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVVGGCDKNMPGGMIALARLNVPGIYVYGGTIRPGHWKGRDLTI
VSSFEAVGEFTAGRMSQEDFEGVEKNACPTSGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLVE
AVKRDLKPRDIITKASIENAVSLIMATGGSTNAVLHYLAIAHAAEIDWTIDDFERIRKRVPVLCDLKPSGQYVATDLHQA
GGIPQVLRILLDAGLLHGDCMTITGRTIAEELKDVPGVPRADQKVIFPIDRALYKEGHLAILKGNLAEHGAVAKITGLKN
PVITGPARVFDDEQSAMDAILADRIRAGDVLVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGFITDGRFSGGTWGMVV
GHVAPEAFVGGTIALVQEGDSITIDAHRRVLQLNVDDAELARRRAAWKQPAPRYTRGVLAKYAALARPANQGAVTG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=604, Percent_Identity=38.0794701986755, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI2367371, Length=577, Percent_Identity=31.8890814558059, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI1786464, Length=470, Percent_Identity=35.531914893617, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI1788157, Length=485, Percent_Identity=31.9587628865979, Blast_Score=192, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6322476, Length=560, Percent_Identity=44.6428571428571, Blast_Score=498, Evalue=1e-142,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 59299; Mature: 59167

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYNRRSKHITQGVARSPNRSMYYALGYQKDDFDKPMIGIANGHSTITPCNSGLQRLSDA
CCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEECCCCEECCHHHHHHHHHHH
AVAAVKAADANPQIFGTPTISDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVV
HHHHHEECCCCCEEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEE
GGCDKNMPGGMIALARLNVPGIYVYGGTIRPGHWKGRDLTIVSSFEAVGEFTAGRMSQED
ECCCCCCCCCEEEEEEECCCEEEEECCEECCCCCCCCCEEEEECHHHHHHHHHCCCCHHH
FEGVEKNACPTSGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLV
HHCHHHCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
EAVKRDLKPRDIITKASIENAVSLIMATGGSTNAVLHYLAIAHAAEIDWTIDDFERIRKR
HHHHHCCCCHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VPVLCDLKPSGQYVATDLHQAGGIPQVLRILLDAGLLHGDCMTITGRTIAEELKDVPGVP
CCEEEECCCCCCEEEHHHHHHCCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHCCCCC
RADQKVIFPIDRALYKEGHLAILKGNLAEHGAVAKITGLKNPVITGPARVFDDEQSAMDA
CCCCEEEEEHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCCEECCHHHCCCHHHHHHH
ILADRIRAGDVLVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGFITDGRFSGGTWGMV
HHHHHHCCCCEEEEEEECCCCCCCCCHHHCCHHHHHHCCCCCCCCEEECCCCCCCCHHEE
VGHVAPEAFVGGTIALVQEGDSITIDAHRRVLQLNVDDAELARRRAAWKQPAPRYTRGVL
EECCCCHHHCCCEEEEEECCCEEEEECCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHH
AKYAALARPANQGAVTG
HHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PYNRRSKHITQGVARSPNRSMYYALGYQKDDFDKPMIGIANGHSTITPCNSGLQRLSDA
CCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEECCCCEECCHHHHHHHHHHH
AVAAVKAADANPQIFGTPTISDGMSMGTEGMKYSLVSREVIADCIETCVQGQWMDGVVVV
HHHHHEECCCCCEEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEE
GGCDKNMPGGMIALARLNVPGIYVYGGTIRPGHWKGRDLTIVSSFEAVGEFTAGRMSQED
ECCCCCCCCCEEEEEEECCCEEEEECCEECCCCCCCCCEEEEECHHHHHHHHHCCCCHHH
FEGVEKNACPTSGSCGGMYTANTMSSSFEALGMSLLYSSTMANPDQEKVDSAAESARVLV
HHCHHHCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
EAVKRDLKPRDIITKASIENAVSLIMATGGSTNAVLHYLAIAHAAEIDWTIDDFERIRKR
HHHHHCCCCHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VPVLCDLKPSGQYVATDLHQAGGIPQVLRILLDAGLLHGDCMTITGRTIAEELKDVPGVP
CCEEEECCCCCCEEEHHHHHHCCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHCCCCC
RADQKVIFPIDRALYKEGHLAILKGNLAEHGAVAKITGLKNPVITGPARVFDDEQSAMDA
CCCCEEEEEHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCCEECCHHHCCCHHHHHHH
ILADRIRAGDVLVLRYLGPQGGPGMPEMLAPTSAIIGKGLGESVGFITDGRFSGGTWGMV
HHHHHHCCCCEEEEEEECCCCCCCCCHHHCCHHHHHHCCCCCCCCEEECCCCCCCCHHEE
VGHVAPEAFVGGTIALVQEGDSITIDAHRRVLQLNVDDAELARRRAAWKQPAPRYTRGVL
EECCCCHHHCCCEEEEEECCCEEEEECCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHH
AKYAALARPANQGAVTG
HHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA