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The map label for this gene is yngG [H]

Identifier: 115351653

GI number: 115351653

Start: 1775754

End: 1776716

Strand: Direct

Name: yngG [H]

Synonym: Bamb_1600

Alternate gene names: 115351653

Gene position: 1775754-1776716 (Clockwise)

Preceding gene: 115351652

Following gene: 115351654

Centisome position: 49.93

GC content: 69.26

Gene sequence:

>963_bases
ATGAGCCAGCACCCCCAACGACTCTATATCCACGAAGTCGCGACACGCGACGGTTTCCAGAATGAAGCGGCGTTCGTCGA
CACCGACGACAAGATCGCGCTCGTCGACGCATTGAGCGCGTGCGGTTACGCGAAGATCGAGGTCACGTCATTCACGTCGC
CGAAGGCGATCCCCGCGCTGCGCGACGCCGAGGCCGTGATGCACGGCATCGTGCGCGCGCCGGGCGTCGTCTATACGGTG
CTCGTGCCGAACGTGCGGGGCGCGCAGCGCGCGCTGTCGTGCGGCGTCGACGAGGTAAACCTCGTGATGTCGATGAGCGA
GAGCCACAACCGCGCGAACCTGCGGATGAGCCGCGAGCAGTCGTTCGCCCAGCTGCGCGACGTGATCGACGCGGTGCGCG
GCACCGGCGTCGCGATCAACGTGTCGCTGTCGACCGCGATGGGGTGTCCGATGGAAGGCGACGTGCGCGACGAAACCGTG
CTCGCGTGGATGCAGCGCTTCGCGGATCTCGGCGTGCACGGTTTCACGCTGTGCGACACGACCGGCATGGCGTATCCGTC
GCAGGTGCGCGCGCTGGCCGAACGCGCGCGCGAACGCTTCGGCGCGCTGCAGCTCACACTGCACTTTCACAACACGCGCG
GGATGGCGCTCGCGAACACGCTCGCCGCGCTCGACGCCGGCATCGAGCGCTTCGACGCGTCGCTCGGCGGGCTCGGCGGC
TGTCCGTACGCGCCGGGCGCGACCGGCAATGCATGCACCGAGGAACTCGTGCACATGCTCGCGCTCGACGGCTACGATAC
CGGCATCGATCTCGCGGCCGTGCTCGCCGCGGCCGCACGGCTGCCCGCGCTGATCGGGCATGACGTGCCGAGCCAGATCC
TGAAGGCCGGGCGCCGCTCGGACCTGCATCCGGCACCGCGCGCCGAAGCCGGCGACATGCCGGCGCAGCGGGCTTTCTCG
TGA

Upstream 100 bases:

>100_bases
CGATACCGAGGCGGTACTCGAATCGATCGGCATCGATACTGCGACGCGCGACGCGTGGCGCACGCGCGGCGTGATCTGAA
CTGGCCAGCAGAGCGACGAC

Downstream 100 bases:

>100_bases
ACAGTCGTCAACAGGAGCGAATCACATGGCGCTGATCGACCACCTCGACCATCTCGTCCTGACTTGCGTCGATCCGGAGC
GGACGAAGCATTTCTATACC

Product: pyruvate carboxyltransferase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MSQHPQRLYIHEVATRDGFQNEAAFVDTDDKIALVDALSACGYAKIEVTSFTSPKAIPALRDAEAVMHGIVRAPGVVYTV
LVPNVRGAQRALSCGVDEVNLVMSMSESHNRANLRMSREQSFAQLRDVIDAVRGTGVAINVSLSTAMGCPMEGDVRDETV
LAWMQRFADLGVHGFTLCDTTGMAYPSQVRALAERARERFGALQLTLHFHNTRGMALANTLAALDAGIERFDASLGGLGG
CPYAPGATGNACTEELVHMLALDGYDTGIDLAAVLAAAARLPALIGHDVPSQILKAGRRSDLHPAPRAEAGDMPAQRAFS

Sequences:

>Translated_320_residues
MSQHPQRLYIHEVATRDGFQNEAAFVDTDDKIALVDALSACGYAKIEVTSFTSPKAIPALRDAEAVMHGIVRAPGVVYTV
LVPNVRGAQRALSCGVDEVNLVMSMSESHNRANLRMSREQSFAQLRDVIDAVRGTGVAINVSLSTAMGCPMEGDVRDETV
LAWMQRFADLGVHGFTLCDTTGMAYPSQVRALAERARERFGALQLTLHFHNTRGMALANTLAALDAGIERFDASLGGLGG
CPYAPGATGNACTEELVHMLALDGYDTGIDLAAVLAAAARLPALIGHDVPSQILKAGRRSDLHPAPRAEAGDMPAQRAFS
>Mature_319_residues
SQHPQRLYIHEVATRDGFQNEAAFVDTDDKIALVDALSACGYAKIEVTSFTSPKAIPALRDAEAVMHGIVRAPGVVYTVL
VPNVRGAQRALSCGVDEVNLVMSMSESHNRANLRMSREQSFAQLRDVIDAVRGTGVAINVSLSTAMGCPMEGDVRDETVL
AWMQRFADLGVHGFTLCDTTGMAYPSQVRALAERARERFGALQLTLHFHNTRGMALANTLAALDAGIERFDASLGGLGGC
PYAPGATGNACTEELVHMLALDGYDTGIDLAAVLAAAARLPALIGHDVPSQILKAGRRSDLHPAPRAEAGDMPAQRAFS

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=296, Percent_Identity=37.5, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI109150422, Length=296, Percent_Identity=36.8243243243243, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI109150427, Length=296, Percent_Identity=36.8243243243243, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI260654708, Length=135, Percent_Identity=37.037037037037, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17510563, Length=289, Percent_Identity=36.3321799307958, Blast_Score=198, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6320019, Length=229, Percent_Identity=28.82096069869, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320071, Length=229, Percent_Identity=28.82096069869, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24582381, Length=293, Percent_Identity=34.8122866894198, Blast_Score=192, Evalue=4e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 34084; Mature: 33953

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQHPQRLYIHEVATRDGFQNEAAFVDTDDKIALVDALSACGYAKIEVTSFTSPKAIPAL
CCCCCCEEHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCH
RDAEAVMHGIVRAPGVVYTVLVPNVRGAQRALSCGVDEVNLVMSMSESHNRANLRMSREQ
HHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHCCCHHHHHHHHHHCCCCCHHEEEHHHH
SFAQLRDVIDAVRGTGVAINVSLSTAMGCPMEGDVRDETVLAWMQRFADLGVHGFTLCDT
HHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECC
TGMAYPSQVRALAERARERFGALQLTLHFHNTRGMALANTLAALDAGIERFDASLGGLGG
CCCCCHHHHHHHHHHHHHHHCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
CPYAPGATGNACTEELVHMLALDGYDTGIDLAAVLAAAARLPALIGHDVPSQILKAGRRS
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCC
DLHPAPRAEAGDMPAQRAFS
CCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
SQHPQRLYIHEVATRDGFQNEAAFVDTDDKIALVDALSACGYAKIEVTSFTSPKAIPAL
CCCCCEEHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCH
RDAEAVMHGIVRAPGVVYTVLVPNVRGAQRALSCGVDEVNLVMSMSESHNRANLRMSREQ
HHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHCCCHHHHHHHHHHCCCCCHHEEEHHHH
SFAQLRDVIDAVRGTGVAINVSLSTAMGCPMEGDVRDETVLAWMQRFADLGVHGFTLCDT
HHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECC
TGMAYPSQVRALAERARERFGALQLTLHFHNTRGMALANTLAALDAGIERFDASLGGLGG
CCCCCHHHHHHHHHHHHHHHCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
CPYAPGATGNACTEELVHMLALDGYDTGIDLAAVLAAAARLPALIGHDVPSQILKAGRRS
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCC
DLHPAPRAEAGDMPAQRAFS
CCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]