Click here to switch to the map view.

The map label for this gene is purR [H]

Identifier: 115351559

GI number: 115351559

Start: 1650142

End: 1651173

Strand: Direct

Name: purR [H]

Synonym: Bamb_1506

Alternate gene names: 115351559

Gene position: 1650142-1651173 (Clockwise)

Preceding gene: 115351558

Following gene: 115351560

Centisome position: 46.4

GC content: 68.8

Gene sequence:

>1032_bases
ATGGCGACGATCAAGGATGTGGCGGCCATGGCGGGCGTGTCGTTTACGACCGTGTCGCACGTGGTGAACAATTCGCGGCC
GGTGTCCGCGGACGTGCGTGCGAAGGTCGAGGGCGCGATCCGTGAGCTGAATTACGTGCCGTCGGCCGTGGCGCGCTCGC
TCAAGGCGCGTTCGACGGCGACCATCGGACTCGTCGTGCCGAACAGTACGAATCCGTACTTCGCGGAGCTTGCGCGCGGC
ATCGAGGATCAGTGCGCGGCCAACGGCTATTGCGTGTTCTTCTGCAACTCGGACGACGATCCCGTGAAGCAGCGCAACTA
CTTGCGCGTGCTGCAGGAAAAGCGCATCGACGGGCTGATCGTCGCATCGGCCGGCGAGGACGCGGTGCTCGCGCAGACGC
TCGCGCACGCGCATGCGCCGCTCGTCGTCGTCGACCGCAACATCGAGGGGCTCGCGGCCGACCTCGTGCAGATCGATCAC
GAACGCGGCGCGTATCTGGCGACGCGCCACCTGCTCGAACTCGGGCACGCGAAGATCGGCTGCATCACCGGGCCGACCGA
CACGGCCGTCAGCGCGATGCGCGTGCACGGCTTCATCCGCGCGATGGCCGAGCGCGGGATCGACATCGTGCCGGGCGCGA
TCGCGGAAAGCGATTTCTCGTGCCTCGGCGGCTATCACGCGGCGTCGCGGCTGTTCGAGTCGGTGCATCCGAGCGCGATT
TTCGCGGGCAACGACCTGATGGGCGTCGGTGCGCTGCGCGCGGCGGCCGAGCGCGGATTGCGCGTGCCGGACGACTGCTC
GATCATCGGCTTCGACGACATCGAATTCTCCCGCTACACGTATCCGGCACTGTCGACGGTCGGCCAGTCGGTGCGCGCGC
TCGGCGAAATGGCCGCGCAGACGCTGATCGAGCGGATCGGCGGCGGCTCGACCGCTGCGCCGAGCCGTCGCCGCGTCGTG
TCGCCGCGCCTCGTGCTGCGCGAATCCACGGCGATCTACCGCGAGCCGGCCGCGCCCGGCGCTCGCGCATGA

Upstream 100 bases:

>100_bases
GGCGGTGATCGTGGTGGCGGTCGTGCTCGATACGTATCGCAGCCGGCGCGCCCGCGCCCGGTAAGAACTACACAGAAAGC
AGACCAGAGAGAAACGGGAA

Downstream 100 bases:

>100_bases
CGGCGCGCACGACGGGCGCCGGCCGCGTGACGGTGGTCGGCAGCCTCAACATGGATCTCGTCGTGCGGGCGCCGCGGCTG
CCGCTGCCGGGCGAAACGCT

Product: LacI family transcription regulator

Products: NA

Alternate protein names: Pur regulon repressor; Purine nucleotide synthesis repressor [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MATIKDVAAMAGVSFTTVSHVVNNSRPVSADVRAKVEGAIRELNYVPSAVARSLKARSTATIGLVVPNSTNPYFAELARG
IEDQCAANGYCVFFCNSDDDPVKQRNYLRVLQEKRIDGLIVASAGEDAVLAQTLAHAHAPLVVVDRNIEGLAADLVQIDH
ERGAYLATRHLLELGHAKIGCITGPTDTAVSAMRVHGFIRAMAERGIDIVPGAIAESDFSCLGGYHAASRLFESVHPSAI
FAGNDLMGVGALRAAAERGLRVPDDCSIIGFDDIEFSRYTYPALSTVGQSVRALGEMAAQTLIERIGGGSTAAPSRRRVV
SPRLVLRESTAIYREPAAPGARA

Sequences:

>Translated_343_residues
MATIKDVAAMAGVSFTTVSHVVNNSRPVSADVRAKVEGAIRELNYVPSAVARSLKARSTATIGLVVPNSTNPYFAELARG
IEDQCAANGYCVFFCNSDDDPVKQRNYLRVLQEKRIDGLIVASAGEDAVLAQTLAHAHAPLVVVDRNIEGLAADLVQIDH
ERGAYLATRHLLELGHAKIGCITGPTDTAVSAMRVHGFIRAMAERGIDIVPGAIAESDFSCLGGYHAASRLFESVHPSAI
FAGNDLMGVGALRAAAERGLRVPDDCSIIGFDDIEFSRYTYPALSTVGQSVRALGEMAAQTLIERIGGGSTAAPSRRRVV
SPRLVLRESTAIYREPAAPGARA
>Mature_342_residues
ATIKDVAAMAGVSFTTVSHVVNNSRPVSADVRAKVEGAIRELNYVPSAVARSLKARSTATIGLVVPNSTNPYFAELARGI
EDQCAANGYCVFFCNSDDDPVKQRNYLRVLQEKRIDGLIVASAGEDAVLAQTLAHAHAPLVVVDRNIEGLAADLVQIDHE
RGAYLATRHLLELGHAKIGCITGPTDTAVSAMRVHGFIRAMAERGIDIVPGAIAESDFSCLGGYHAASRLFESVHPSAIF
AGNDLMGVGALRAAAERGLRVPDDCSIIGFDDIEFSRYTYPALSTVGQSVRALGEMAAQTLIERIGGGSTAAPSRRRVVS
PRLVLRESTAIYREPAAPGARA

Specific function: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepre

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787948, Length=334, Percent_Identity=42.814371257485, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1790194, Length=331, Percent_Identity=40.4833836858006, Blast_Score=248, Evalue=6e-67,
Organism=Escherichia coli, GI1790369, Length=332, Percent_Identity=33.7349397590361, Blast_Score=194, Evalue=7e-51,
Organism=Escherichia coli, GI1788474, Length=342, Percent_Identity=36.2573099415205, Blast_Score=174, Evalue=7e-45,
Organism=Escherichia coli, GI1789202, Length=334, Percent_Identity=33.8323353293413, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI1789068, Length=333, Percent_Identity=31.8318318318318, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1786540, Length=345, Percent_Identity=31.0144927536232, Blast_Score=150, Evalue=9e-38,
Organism=Escherichia coli, GI1787580, Length=314, Percent_Identity=29.9363057324841, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI48994940, Length=309, Percent_Identity=27.831715210356, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790715, Length=316, Percent_Identity=25.9493670886076, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787906, Length=343, Percent_Identity=26.8221574344023, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1789456, Length=320, Percent_Identity=27.5, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1786268, Length=328, Percent_Identity=26.219512195122, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790689, Length=316, Percent_Identity=24.6835443037975, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790192, Length=248, Percent_Identity=28.2258064516129, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36395; Mature: 36264

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIKDVAAMAGVSFTTVSHVVNNSRPVSADVRAKVEGAIRELNYVPSAVARSLKARSTA
CCCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCE
TIGLVVPNSTNPYFAELARGIEDQCAANGYCVFFCNSDDDPVKQRNYLRVLQEKRIDGLI
EEEEEECCCCCHHHHHHHCCHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEE
VASAGEDAVLAQTLAHAHAPLVVVDRNIEGLAADLVQIDHERGAYLATRHLLELGHAKIG
EECCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEE
CITGPTDTAVSAMRVHGFIRAMAERGIDIVPGAIAESDFSCLGGYHAASRLFESVHPSAI
EECCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEE
FAGNDLMGVGALRAAAERGLRVPDDCSIIGFDDIEFSRYTYPALSTVGQSVRALGEMAAQ
EECCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TLIERIGGGSTAAPSRRRVVSPRLVLRESTAIYREPAAPGARA
HHHHHHCCCCCCCCCCCCCCCCHHHEECCHHHHCCCCCCCCCC
>Mature Secondary Structure 
ATIKDVAAMAGVSFTTVSHVVNNSRPVSADVRAKVEGAIRELNYVPSAVARSLKARSTA
CCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCE
TIGLVVPNSTNPYFAELARGIEDQCAANGYCVFFCNSDDDPVKQRNYLRVLQEKRIDGLI
EEEEEECCCCCHHHHHHHCCHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEE
VASAGEDAVLAQTLAHAHAPLVVVDRNIEGLAADLVQIDHERGAYLATRHLLELGHAKIG
EECCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEE
CITGPTDTAVSAMRVHGFIRAMAERGIDIVPGAIAESDFSCLGGYHAASRLFESVHPSAI
EECCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEE
FAGNDLMGVGALRAAAERGLRVPDDCSIIGFDDIEFSRYTYPALSTVGQSVRALGEMAAQ
EECCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TLIERIGGGSTAAPSRRRVVSPRLVLRESTAIYREPAAPGARA
HHHHHHCCCCCCCCCCCCCCCCHHHEECCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA