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The map label for this gene is uvrD [H]

Identifier: 115351375

GI number: 115351375

Start: 1452257

End: 1454779

Strand: Direct

Name: uvrD [H]

Synonym: Bamb_1322

Alternate gene names: 115351375

Gene position: 1452257-1454779 (Clockwise)

Preceding gene: 115351372

Following gene: 115351376

Centisome position: 40.83

GC content: 67.7

Gene sequence:

>2523_bases
ATGGATGCACATCGGCCAGCCATTGCGGGGTCCGCGCCGGCCCGTCGGGCGGCCCTCACTGCGCCGCGGCGGCGCGAGGC
CGAACGGATCGGAAACGGCATCGCGCCGCCGACTTATAATGTCGGGTCCGCATTTTTCTCGCACGCCCGCTGCCGCTCCA
TGCCCGATCTGCTCGCCAATCTGAACCCTGAACAATACGCCGCCGTCACGTTGCCGAACGAACCGGCGCTGATCCTCGCG
GGGGCGGGCAGCGGCAAGACCCGCGTGCTGATCACCCGCATCGCGTGGCTGATCCAGCAAGGCTACGCGTCGCCGCCCAC
CGTGCTGGCCGTCACCTTCACGAACAAGGCCGCGCGCGAGATGATGGCGCGCCTGTCGGCGATGATGCCGATCGACACGC
GCGGAATGTGGATCGGCACGTTCCACGGGCTGTGCAACCGGATGCTGCGCACCCACTGGCGCGACGCCGGCCTGCCGCAG
ACCTTCCAGATCCTCGACACGGCCGATCAGTTGTCGGCGATCAAGCGGTTGATGAAGGCGGCGAACGTCGACGACGAGAA
GTACCCGCCGAAGAATGTCCAGTACTTCATCAACAACGCGAAGGAGCAGGGGCTGCGTCCCGACAAGGTCGACGCGACCG
ACAACTTCAACCGCAAGTTCGTCGAGCTGTACCAGGCGTACGACCAGCAGTGCCAGCGCGAGGGCGTGGTCGACTTCCCC
GAGCTGCTGCTGCGCTGCTACGAGCTGCTCGCGTACAACGCGCCGCTGCGCGCGCACTACCAGGCACGCTTCCGGCACAT
CCTCGTCGACGAGTTCCAGGACACCAACAAGCTGCAGTACGCGTGGCTCAAGATGCTCGCGGGCGGCGAGAACGCGATCT
TCGCGGTCGGCGACGACGACCAGTCGATCTACGCGTTCCGCGGCGCGAACGTCGGCAACATGCGCGACTTCGAAGACGAA
TTCCGCGTGCGCAACCTGATCAAGCTCGAGCAGAACTACCGGTCGCACGGCAACATCCTCGACGCGGCGAACCAGCTGAT
CTCGAACAACGCGCACCGCCTCGGCAAGAACCTGCGCACCGACGCCGGCCACGGTGAGCCCGTGCGCGTGTACGAGGCGA
GCACCGATGCGCAGGAAGCCGGCTGGATCGTCGAGGAGATCCGCTCGCTGATCAACACCGGAATGTCGCGCAGCGAAGTC
GCCGTCCTGTATCGCAGCAACGCGCAATCGCGCGCGATCGAGCACACGCTGATGACCTCGGGCATTCCGTATCGCGTGTA
CGGCGGCCTGCGCTTCTTCGAGCGCCAGGAAGTGAAGCATGCGCTCGCGTACCTGCGCCTGATCGACAACCCGAACGACG
ACACCGCGTTCGTGCGCGTCGTGAACTTCCCGACGCGCGGGATCGGCGCGCGCTCCATCGAGCAGCTCGCGGATGCCGCG
CGCCTGTACGACTGTTCGATGGCCGCCGCGATTCCGTACGTGACCGGCAAGGCCGGCACGAGCCTCGGCGGGTTCGCGAC
GCTGATCGCGAAGATGCGCGCCGAGACGCAGCAGATGAGCCTGCCCGAGACGGTCGAGTACGTCGTGCGCGCGAGCGGCC
TCGCCGATTTCTACCAGGGCGAGCGCGAAGGCCAGGACCGCCTCGAGAACTTGCAGGAACTCGTGAACGCGGCCACCGCG
TTCGTCAGCGAGGAAGGCTACGGGCTCGACGCGCCGGCCCGCTCGATCCCGCTGCGCGCGGGGGCGATCGCGGCGCCGGA
GCTCGGCGTGGATGCGAACGATCCGTCGGTCGACGTGCTCGATCCGGCGCCGCTCGACGACCCCGCGCAGAACCCCGACA
CGATGACGCCGCTCGCGGGCTTCCTGTCGCACGCATCGCTCGAAGCCGGCGACAACCAGGCGCAGGCCGGCCAGGACGCC
GTGCAGCTGATGACGGTGCACGCGGCGAAGGGCCTCGAATTCTCGGCCGTGTTCATCACCGGCCTGGAGGAAGGGCTGTT
CCCGCACGAGAACAGCGTGCTCGAATCGGACGGCCTCGAGGAAGAGCGCCGGCTGATGTACGTCGCGATCACGCGGGCGA
AGGAGCGGCTCTACCTGTCGTTCGCGCAGAGCCGGATGCTGCACGGCCAGACGCGCTACAACGTGCGCTCGCGCTTCTTC
GACGAATTGCCGGAGCACGTGCTGAAGTGGCTGACGCCGAAGGTCGAGGCGGGCGCGCGTTGGGGCGGCCGTTCGGACAA
TGCCGGCTGGGGGCGCGACTGGTTCTCGCGGCCGGGCGGCGGCAGTCGCGAGCAGGTCGTCGACGCGGCGGTTTCCGCGC
CGCTGCCGGCGTTCGCGAACAAGCAGCGCGCGGCCGACACCGGCTTTCGCGTCGGCCAGCAGGTATTTCATACCAAGTTC
GGCGAGGGCACGGTCACCGCGCTCGAAGGCAACGGCGCCGATGCGAAGGCGCAGGTGAAGTTCAAGCGGCACGGCGAGAA
GTGGCTCGCGCTGGCGGTCGCGAAACTGCAGGCGGTGGAATGA

Upstream 100 bases:

>100_bases
GATGGTGTGGGGTTCGAAACTCTTCGCAAGCGTGCTGTCGCTCATGGTTGGAAATCTGCCGAAAAATGCGTGAATTGGAT
GCCGAATCCGGCAATTATAA

Downstream 100 bases:

>100_bases
TGAGCATCGACATGGTCGGAACGGTTTCGACGCGCCCGCTCGGCATTCTGGCCGCGCTGCCCGAGGAGCTCGGCGACCTG
ATCGCCGCGATGCGCGCCGA

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 840; Mature: 840

Protein sequence:

>840_residues
MDAHRPAIAGSAPARRAALTAPRRREAERIGNGIAPPTYNVGSAFFSHARCRSMPDLLANLNPEQYAAVTLPNEPALILA
GAGSGKTRVLITRIAWLIQQGYASPPTVLAVTFTNKAAREMMARLSAMMPIDTRGMWIGTFHGLCNRMLRTHWRDAGLPQ
TFQILDTADQLSAIKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPDKVDATDNFNRKFVELYQAYDQQCQREGVVDFP
ELLLRCYELLAYNAPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGGENAIFAVGDDDQSIYAFRGANVGNMRDFEDE
FRVRNLIKLEQNYRSHGNILDAANQLISNNAHRLGKNLRTDAGHGEPVRVYEASTDAQEAGWIVEEIRSLINTGMSRSEV
AVLYRSNAQSRAIEHTLMTSGIPYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFVRVVNFPTRGIGARSIEQLADAA
RLYDCSMAAAIPYVTGKAGTSLGGFATLIAKMRAETQQMSLPETVEYVVRASGLADFYQGEREGQDRLENLQELVNAATA
FVSEEGYGLDAPARSIPLRAGAIAAPELGVDANDPSVDVLDPAPLDDPAQNPDTMTPLAGFLSHASLEAGDNQAQAGQDA
VQLMTVHAAKGLEFSAVFITGLEEGLFPHENSVLESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRYNVRSRFF
DELPEHVLKWLTPKVEAGARWGGRSDNAGWGRDWFSRPGGGSREQVVDAAVSAPLPAFANKQRAADTGFRVGQQVFHTKF
GEGTVTALEGNGADAKAQVKFKRHGEKWLALAVAKLQAVE

Sequences:

>Translated_840_residues
MDAHRPAIAGSAPARRAALTAPRRREAERIGNGIAPPTYNVGSAFFSHARCRSMPDLLANLNPEQYAAVTLPNEPALILA
GAGSGKTRVLITRIAWLIQQGYASPPTVLAVTFTNKAAREMMARLSAMMPIDTRGMWIGTFHGLCNRMLRTHWRDAGLPQ
TFQILDTADQLSAIKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPDKVDATDNFNRKFVELYQAYDQQCQREGVVDFP
ELLLRCYELLAYNAPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGGENAIFAVGDDDQSIYAFRGANVGNMRDFEDE
FRVRNLIKLEQNYRSHGNILDAANQLISNNAHRLGKNLRTDAGHGEPVRVYEASTDAQEAGWIVEEIRSLINTGMSRSEV
AVLYRSNAQSRAIEHTLMTSGIPYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFVRVVNFPTRGIGARSIEQLADAA
RLYDCSMAAAIPYVTGKAGTSLGGFATLIAKMRAETQQMSLPETVEYVVRASGLADFYQGEREGQDRLENLQELVNAATA
FVSEEGYGLDAPARSIPLRAGAIAAPELGVDANDPSVDVLDPAPLDDPAQNPDTMTPLAGFLSHASLEAGDNQAQAGQDA
VQLMTVHAAKGLEFSAVFITGLEEGLFPHENSVLESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRYNVRSRFF
DELPEHVLKWLTPKVEAGARWGGRSDNAGWGRDWFSRPGGGSREQVVDAAVSAPLPAFANKQRAADTGFRVGQQVFHTKF
GEGTVTALEGNGADAKAQVKFKRHGEKWLALAVAKLQAVE
>Mature_840_residues
MDAHRPAIAGSAPARRAALTAPRRREAERIGNGIAPPTYNVGSAFFSHARCRSMPDLLANLNPEQYAAVTLPNEPALILA
GAGSGKTRVLITRIAWLIQQGYASPPTVLAVTFTNKAAREMMARLSAMMPIDTRGMWIGTFHGLCNRMLRTHWRDAGLPQ
TFQILDTADQLSAIKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPDKVDATDNFNRKFVELYQAYDQQCQREGVVDFP
ELLLRCYELLAYNAPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGGENAIFAVGDDDQSIYAFRGANVGNMRDFEDE
FRVRNLIKLEQNYRSHGNILDAANQLISNNAHRLGKNLRTDAGHGEPVRVYEASTDAQEAGWIVEEIRSLINTGMSRSEV
AVLYRSNAQSRAIEHTLMTSGIPYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFVRVVNFPTRGIGARSIEQLADAA
RLYDCSMAAAIPYVTGKAGTSLGGFATLIAKMRAETQQMSLPETVEYVVRASGLADFYQGEREGQDRLENLQELVNAATA
FVSEEGYGLDAPARSIPLRAGAIAAPELGVDANDPSVDVLDPAPLDDPAQNPDTMTPLAGFLSHASLEAGDNQAQAGQDA
VQLMTVHAAKGLEFSAVFITGLEEGLFPHENSVLESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRYNVRSRFF
DELPEHVLKWLTPKVEAGARWGGRSDNAGWGRDWFSRPGGGSREQVVDAAVSAPLPAFANKQRAADTGFRVGQQVFHTKF
GEGTVTALEGNGADAKAQVKFKRHGEKWLALAVAKLQAVE

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=792, Percent_Identity=44.5707070707071, Blast_Score=647, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=684, Percent_Identity=34.9415204678363, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1787196, Length=340, Percent_Identity=27.9411764705882, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6322369, Length=741, Percent_Identity=27.9352226720648, Blast_Score=220, Evalue=8e-58,
Organism=Saccharomyces cerevisiae, GI6324477, Length=557, Percent_Identity=23.3393177737882, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 92850; Mature: 92850

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAHRPAIAGSAPARRAALTAPRRREAERIGNGIAPPTYNVGSAFFSHARCRSMPDLLAN
CCCCCCCCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHC
LNPEQYAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGYASPPTVLAVTFTNKAARE
CCHHHEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHH
MMARLSAMMPIDTRGMWIGTFHGLCNRMLRTHWRDAGLPQTFQILDTADQLSAIKRLMKA
HHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
ANVDDEKYPPKNVQYFINNAKEQGLRPDKVDATDNFNRKFVELYQAYDQQCQREGVVDFP
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHH
ELLLRCYELLAYNAPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGGENAIFAVGDDD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEECCCC
QSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANQLISNNAHRLGKNLRT
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHCCCCC
DAGHGEPVRVYEASTDAQEAGWIVEEIRSLINTGMSRSEVAVLYRSNAQSRAIEHTLMTS
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHC
GIPYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFVRVVNFPTRGIGARSIEQLADAA
CCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHH
RLYDCSMAAAIPYVTGKAGTSLGGFATLIAKMRAETQQMSLPETVEYVVRASGLADFYQG
HHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHCC
EREGQDRLENLQELVNAATAFVSEEGYGLDAPARSIPLRAGAIAAPELGVDANDPSVDVL
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECC
DPAPLDDPAQNPDTMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFSAVFIT
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEE
GLEEGLFPHENSVLESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRYNVRSRFF
CHHHCCCCCCCCCCCCCCCCHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
DELPEHVLKWLTPKVEAGARWGGRSDNAGWGRDWFSRPGGGSREQVVDAAVSAPLPAFAN
HHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHCCCCHHCC
KQRAADTGFRVGQQVFHTKFGEGTVTALEGNGADAKAQVKFKRHGEKWLALAVAKLQAVE
CHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEHHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDAHRPAIAGSAPARRAALTAPRRREAERIGNGIAPPTYNVGSAFFSHARCRSMPDLLAN
CCCCCCCCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHC
LNPEQYAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGYASPPTVLAVTFTNKAARE
CCHHHEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHH
MMARLSAMMPIDTRGMWIGTFHGLCNRMLRTHWRDAGLPQTFQILDTADQLSAIKRLMKA
HHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
ANVDDEKYPPKNVQYFINNAKEQGLRPDKVDATDNFNRKFVELYQAYDQQCQREGVVDFP
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHH
ELLLRCYELLAYNAPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGGENAIFAVGDDD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEECCCC
QSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANQLISNNAHRLGKNLRT
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHCCCCC
DAGHGEPVRVYEASTDAQEAGWIVEEIRSLINTGMSRSEVAVLYRSNAQSRAIEHTLMTS
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHC
GIPYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFVRVVNFPTRGIGARSIEQLADAA
CCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHH
RLYDCSMAAAIPYVTGKAGTSLGGFATLIAKMRAETQQMSLPETVEYVVRASGLADFYQG
HHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHCC
EREGQDRLENLQELVNAATAFVSEEGYGLDAPARSIPLRAGAIAAPELGVDANDPSVDVL
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECC
DPAPLDDPAQNPDTMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFSAVFIT
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEE
GLEEGLFPHENSVLESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRYNVRSRFF
CHHHCCCCCCCCCCCCCCCCHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
DELPEHVLKWLTPKVEAGARWGGRSDNAGWGRDWFSRPGGGSREQVVDAAVSAPLPAFAN
HHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHCCCCHHCC
KQRAADTGFRVGQQVFHTKFGEGTVTALEGNGADAKAQVKFKRHGEKWLALAVAKLQAVE
CHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEHHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]