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The map label for this gene is gloB [H]

Identifier: 115351217

GI number: 115351217

Start: 1271606

End: 1272388

Strand: Direct

Name: gloB [H]

Synonym: Bamb_1164

Alternate gene names: 115351217

Gene position: 1271606-1272388 (Clockwise)

Preceding gene: 115351213

Following gene: 115351218

Centisome position: 35.75

GC content: 69.35

Gene sequence:

>783_bases
GTGCCGGCATTCGAAGACAACTACATCTGGCTCGTGTCGGACGGCCGCGATGCGATCGCCGTCGATCCGGGTGAAGCCGC
GCCGGTACGCCGTGTTCTTGCGGAACGCGGCTGGCGGTTGACCGCTATTTTACTCACGCACCACCACGCCGACCATGTCG
GCGGTGTCGCCGCACTGCGAGATAGCCAACCGGACGATGCGCCGCTCGTGGTTTACGGCCCCGCAGCCGAGGCGATCGGC
GTGGTCACCCGGCCGCTCGCGGGCGGCGATCGCGTGATGCTCGACGCACCGGCGCTCGCATTCGACGTGCTCGACGTGCC
CGGTCACACGCGCGGCCACATCGCGTATTTTCAGGCGGCCGGCGTAGGCGCGGCCACGCCGCACGTGTTCTGCGGCGACA
CGCTGTTCTCGTGCGGCTGCGGCCGCCTGTTCGAAGGCACGCCCGCGCAGATGCTCGCGTCGCTCGACGCGCTCGCGGCG
CTGCCCGGCGACACGCGCGTGCATTGCGCACACGAATACACACTGTCGAACATCCGCTTCGCGCTCGCGTGCGAACCGGG
CAATGCGGCGCTCGCCGCGTGGCGCGACGACGCGCAGGCGCTGCGCGCGCGCGGCGTGCCGACGCTGCCCACCACGATCG
CGCACGAACGTGCGGTCAACCCGTTCATGCGCGCGGACAGCGCGGCGATCCATGCGACGCTCGAAGCCGAGCTGCACGAA
ACGGTGCCGGATCGTCTGGCGGCATTCACGCTGATGCGCGAGTGGAAAAATCGTTTCCGATGA

Upstream 100 bases:

>100_bases
AGCGGCCGGGCGGCGAGTCGGTCCAGGCGGGCCAGTCTATAATTTGTGGATCGGACATAACGTTGATTGCGCGCCCATGA
ACGAGCTGGAATACGTGCCG

Downstream 100 bases:

>100_bases
CGCATTCCGGAGGACTCCAAACCTCAGGTGGCGCCTGTAAAAATTGCTCCAAATGTAGGATTTCGCTGAGTTTTCGGTGT
TTTTATTGACGTGAAGCACG

Product: hydroxyacylglutathione hydrolase

Products: NA

Alternate protein names: Glyoxalase II; Glx II [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MPAFEDNYIWLVSDGRDAIAVDPGEAAPVRRVLAERGWRLTAILLTHHHADHVGGVAALRDSQPDDAPLVVYGPAAEAIG
VVTRPLAGGDRVMLDAPALAFDVLDVPGHTRGHIAYFQAAGVGAATPHVFCGDTLFSCGCGRLFEGTPAQMLASLDALAA
LPGDTRVHCAHEYTLSNIRFALACEPGNAALAAWRDDAQALRARGVPTLPTTIAHERAVNPFMRADSAAIHATLEAELHE
TVPDRLAAFTLMREWKNRFR

Sequences:

>Translated_260_residues
MPAFEDNYIWLVSDGRDAIAVDPGEAAPVRRVLAERGWRLTAILLTHHHADHVGGVAALRDSQPDDAPLVVYGPAAEAIG
VVTRPLAGGDRVMLDAPALAFDVLDVPGHTRGHIAYFQAAGVGAATPHVFCGDTLFSCGCGRLFEGTPAQMLASLDALAA
LPGDTRVHCAHEYTLSNIRFALACEPGNAALAAWRDDAQALRARGVPTLPTTIAHERAVNPFMRADSAAIHATLEAELHE
TVPDRLAAFTLMREWKNRFR
>Mature_259_residues
PAFEDNYIWLVSDGRDAIAVDPGEAAPVRRVLAERGWRLTAILLTHHHADHVGGVAALRDSQPDDAPLVVYGPAAEAIGV
VTRPLAGGDRVMLDAPALAFDVLDVPGHTRGHIAYFQAAGVGAATPHVFCGDTLFSCGCGRLFEGTPAQMLASLDALAAL
PGDTRVHCAHEYTLSNIRFALACEPGNAALAAWRDDAQALRARGVPTLPTTIAHERAVNPFMRADSAAIHATLEAELHET
VPDRLAAFTLMREWKNRFR

Specific function: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid [H]

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family [H]

Homologues:

Organism=Homo sapiens, GI94538320, Length=266, Percent_Identity=38.3458646616541, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI94538322, Length=266, Percent_Identity=38.3458646616541, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI14150041, Length=226, Percent_Identity=40.2654867256637, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI116642887, Length=236, Percent_Identity=36.864406779661, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI21703352, Length=236, Percent_Identity=36.864406779661, Blast_Score=134, Evalue=6e-32,
Organism=Homo sapiens, GI46361987, Length=190, Percent_Identity=41.0526315789474, Blast_Score=122, Evalue=3e-28,
Organism=Escherichia coli, GI1786406, Length=261, Percent_Identity=43.2950191570881, Blast_Score=195, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17536925, Length=261, Percent_Identity=35.632183908046, Blast_Score=143, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6320478, Length=270, Percent_Identity=30, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324614, Length=237, Percent_Identity=29.957805907173, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667711, Length=235, Percent_Identity=40.4255319148936, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI21356335, Length=234, Percent_Identity=40.5982905982906, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24667703, Length=234, Percent_Identity=40.5982905982906, Blast_Score=165, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR017782 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.2.6 [H]

Molecular weight: Translated: 27835; Mature: 27704

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAFEDNYIWLVSDGRDAIAVDPGEAAPVRRVLAERGWRLTAILLTHHHADHVGGVAALR
CCCCCCCEEEEEECCCCEEEECCCCCHHHHHHHHHCCCEEEEEEEEECCCHHHCCEEEEC
DSQPDDAPLVVYGPAAEAIGVVTRPLAGGDRVMLDAPALAFDVLDVPGHTRGHIAYFQAA
CCCCCCCCEEEECCCHHHHHHHCCCCCCCCEEEEECCCEEEEEEECCCCCCCEEEEEEEC
GVGAATPHVFCGDTLFSCGCGRLFEGTPAQMLASLDALAALPGDTRVHCAHEYTLSNIRF
CCCCCCCCEEECCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEEECCEEE
ALACEPGNAALAAWRDDAQALRARGVPTLPTTIAHERAVNPFMRADSAAIHATLEAELHE
EEEECCCCCEEEEECHHHHHHHHCCCCCCCHHHHHHHHCCHHHHCCCCEEEEEEHHHHHH
TVPDRLAAFTLMREWKNRFR
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PAFEDNYIWLVSDGRDAIAVDPGEAAPVRRVLAERGWRLTAILLTHHHADHVGGVAALR
CCCCCCEEEEEECCCCEEEECCCCCHHHHHHHHHCCCEEEEEEEEECCCHHHCCEEEEC
DSQPDDAPLVVYGPAAEAIGVVTRPLAGGDRVMLDAPALAFDVLDVPGHTRGHIAYFQAA
CCCCCCCCEEEECCCHHHHHHHCCCCCCCCEEEEECCCEEEEEEECCCCCCCEEEEEEEC
GVGAATPHVFCGDTLFSCGCGRLFEGTPAQMLASLDALAALPGDTRVHCAHEYTLSNIRF
CCCCCCCCEEECCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEEECCEEE
ALACEPGNAALAAWRDDAQALRARGVPTLPTTIAHERAVNPFMRADSAAIHATLEAELHE
EEEECCCCCEEEEECHHHHHHHHCCCCCCCHHHHHHHHCCHHHHCCCCEEEEEEHHHHHH
TVPDRLAAFTLMREWKNRFR
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA