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The map label for this gene is hbd [H]

Identifier: 115351196

GI number: 115351196

Start: 1253430

End: 1254347

Strand: Direct

Name: hbd [H]

Synonym: Bamb_1143

Alternate gene names: 115351196

Gene position: 1253430-1254347 (Clockwise)

Preceding gene: 115351193

Following gene: 115351198

Centisome position: 35.24

GC content: 69.28

Gene sequence:

>918_bases
ATGGACATTCAACGCATCGCGATCGTTGGTGCCGGCGTGATCGGCGCGAGCTGGGCGGCTTTCTATCTGTCGCAGGGCTT
CGACGTCGTCGCGACCGATCCCGCGCCGCAGGCCGACGCGCGGCTGCGCGACGCACTCGCCGGGTTTCTCGGCGAACGCG
CCGCCGAGCTTTCCGCGCGGCTGTCGTTCGACGCGGATCTCGTGCGCGCGCTCGGCGGCGTCGATTTCGTGCAGGAGAAC
GGCCCCGAACGGCTCGACCTGAAGCGCGCGTTGTACCGGCAGATGGACGACGTGCTGCCGGCGCGCGTGCCGATCGCGTC
GAGTTCGTCGGGCCTGAAGATGTCGGAGATCCAGACCGCGTGCGACAAGCATCCGGAACGCTGCCTGATCGCGCATCCGT
TCAACCCGCCGCACCTGATTCCGCTCGTCGAGCTGGTCGGCGGCGACGCGACCGACCCGGCCGTGATCGCGCGCGTGAAG
GCGTTCTACGACGCGCTCGGCAAGCAGACCATCGTGCTCAACAAGGAAATGACCGGCCACGTTGCGAACCGGCTCGCCGC
CGCGCTGTTTCGCGAGGTGTATCACCTGGTCGGCGAAGGCGTGGTGAGCGTCGCCGATGCGGACAAGGCCGTCGCGTGGG
GGCCGGGCTTGCGCTGGGGGCTGATGGGGCAGTGCCTGACCTATCACCTCGGCGGCGGCGCGGGCGGGATCGCGCACTTC
CTCGAACACCTGTCGGGGCCGATCACGACGTGGTGGGACGACCTCGGCACGCCGTCGTTCGATCCGGCCGTCGATCGCAA
GCTGAACGACGAACTGCGCGCGATCCAGGGCGAGCGTTCGATGCAGGAACTGGCGGCCGAGCGCGACCGGCTGCTCGTCG
AGCTGATCGACGCGCGGCGGCGCAGCTTCCTGCCCTGA

Upstream 100 bases:

>100_bases
CGGTTTTCAAGAGGGAAATTGCAACCGGCATCAATACGTGGCGATGCGAATCGATGCGACAATCGTCGCGCTATCCACAG
ACCACGGAGACGGGACGGAC

Downstream 100 bases:

>100_bases
GCGCTCGCTACAGTTCGGCGGCCGCCGTGATCAGCGTCGCCTCGAGCGCGAGCGTCGAGCGTGATGCAGCAGCGGGCCGG
TCGATCACATATTCGAGTTC

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MDIQRIAIVGAGVIGASWAAFYLSQGFDVVATDPAPQADARLRDALAGFLGERAAELSARLSFDADLVRALGGVDFVQEN
GPERLDLKRALYRQMDDVLPARVPIASSSSGLKMSEIQTACDKHPERCLIAHPFNPPHLIPLVELVGGDATDPAVIARVK
AFYDALGKQTIVLNKEMTGHVANRLAAALFREVYHLVGEGVVSVADADKAVAWGPGLRWGLMGQCLTYHLGGGAGGIAHF
LEHLSGPITTWWDDLGTPSFDPAVDRKLNDELRAIQGERSMQELAAERDRLLVELIDARRRSFLP

Sequences:

>Translated_305_residues
MDIQRIAIVGAGVIGASWAAFYLSQGFDVVATDPAPQADARLRDALAGFLGERAAELSARLSFDADLVRALGGVDFVQEN
GPERLDLKRALYRQMDDVLPARVPIASSSSGLKMSEIQTACDKHPERCLIAHPFNPPHLIPLVELVGGDATDPAVIARVK
AFYDALGKQTIVLNKEMTGHVANRLAAALFREVYHLVGEGVVSVADADKAVAWGPGLRWGLMGQCLTYHLGGGAGGIAHF
LEHLSGPITTWWDDLGTPSFDPAVDRKLNDELRAIQGERSMQELAAERDRLLVELIDARRRSFLP
>Mature_305_residues
MDIQRIAIVGAGVIGASWAAFYLSQGFDVVATDPAPQADARLRDALAGFLGERAAELSARLSFDADLVRALGGVDFVQEN
GPERLDLKRALYRQMDDVLPARVPIASSSSGLKMSEIQTACDKHPERCLIAHPFNPPHLIPLVELVGGDATDPAVIARVK
AFYDALGKQTIVLNKEMTGHVANRLAAALFREVYHLVGEGVVSVADADKAVAWGPGLRWGLMGQCLTYHLGGGAGGIAHF
LEHLSGPITTWWDDLGTPSFDPAVDRKLNDELRAIQGERSMQELAAERDRLLVELIDARRRSFLP

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=282, Percent_Identity=35.1063829787234, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI20127408, Length=210, Percent_Identity=28.0952380952381, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI68989263, Length=208, Percent_Identity=24.0384615384615, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI261878539, Length=208, Percent_Identity=24.0384615384615, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI296179429, Length=233, Percent_Identity=24.4635193133047, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1787661, Length=243, Percent_Identity=27.9835390946502, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790281, Length=127, Percent_Identity=31.496062992126, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI115533614, Length=249, Percent_Identity=31.7269076305221, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI193203623, Length=249, Percent_Identity=31.7269076305221, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17553560, Length=229, Percent_Identity=25.3275109170306, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17549919, Length=233, Percent_Identity=24.0343347639485, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25144276, Length=209, Percent_Identity=26.7942583732057, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17508951, Length=211, Percent_Identity=26.5402843601896, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17508953, Length=210, Percent_Identity=25.7142857142857, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI20129993, Length=318, Percent_Identity=33.0188679245283, Blast_Score=154, Evalue=5e-38,
Organism=Drosophila melanogaster, GI45549573, Length=304, Percent_Identity=32.2368421052632, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 33008; Mature: 33008

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIQRIAIVGAGVIGASWAAFYLSQGFDVVATDPAPQADARLRDALAGFLGERAAELSAR
CCCCEEEEEECCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LSFDADLVRALGGVDFVQENGPERLDLKRALYRQMDDVLPARVPIASSSSGLKMSEIQTA
CCCCHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
CDKHPERCLIAHPFNPPHLIPLVELVGGDATDPAVIARVKAFYDALGKQTIVLNKEMTGH
HHCCCCCEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHH
VANRLAAALFREVYHLVGEGVVSVADADKAVAWGPGLRWGLMGQCLTYHLGGGAGGIAHF
HHHHHHHHHHHHHHHHHCCCCEEECCCCCCEECCCCCCHHHHHHHHHHHCCCCCCHHHHH
LEHLSGPITTWWDDLGTPSFDPAVDRKLNDELRAIQGERSMQELAAERDRLLVELIDARR
HHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
RSFLP
HCCCC
>Mature Secondary Structure
MDIQRIAIVGAGVIGASWAAFYLSQGFDVVATDPAPQADARLRDALAGFLGERAAELSAR
CCCCEEEEEECCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LSFDADLVRALGGVDFVQENGPERLDLKRALYRQMDDVLPARVPIASSSSGLKMSEIQTA
CCCCHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
CDKHPERCLIAHPFNPPHLIPLVELVGGDATDPAVIARVKAFYDALGKQTIVLNKEMTGH
HHCCCCCEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHH
VANRLAAALFREVYHLVGEGVVSVADADKAVAWGPGLRWGLMGQCLTYHLGGGAGGIAHF
HHHHHHHHHHHHHHHHHCCCCEEECCCCCCEECCCCCCHHHHHHHHHHHCCCCCCHHHHH
LEHLSGPITTWWDDLGTPSFDPAVDRKLNDELRAIQGERSMQELAAERDRLLVELIDARR
HHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
RSFLP
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]