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The map label for this gene is mucB [H]

Identifier: 115351059

GI number: 115351059

Start: 1092886

End: 1093938

Strand: Direct

Name: mucB [H]

Synonym: Bamb_1005

Alternate gene names: 115351059

Gene position: 1092886-1093938 (Clockwise)

Preceding gene: 115351058

Following gene: 115351060

Centisome position: 30.73

GC content: 68.0

Gene sequence:

>1053_bases
ATGCGGACATTGCAGTTGAATCACGCCATCTCCGGATGGAAGCGGCTGCCGGCCCTCCTGCTTTGCGCAGCCGCCCTGTT
GTCCGTTCAATCCCTCCCTGCCAGCGCCCAGCAACCGGACGATCCCGTCGCGACCCGCAAGGGTGCGGCGGAGTGGCTCG
ACCGCATCCAGCAGGCGGCGCAGCAGCAGAGCTACGAGGGCACGTTCGTCTACCAGCGCGGCGCGTATGTCCAGTCGTCG
CGCATCGCGCACGTGGCGTCCCGCGACGGCGAGTTCGAGCGGATCGAAACGCTCGACGGCAAGCCGCGCAAGGTGCTGCG
GCATAACGACGAGCTGTACACGTTCGTGCCGGAGCGCAAGCTGTGCGTGGTCGAGCGCCGCCAGACGCGCGACTCGTTTC
CTTCGCTGCTCGGCGCGGGCGGCGAGCACGTGATGTCCGTCTACGACGCGAAGCTGCTCGGCAAGGACCGCGTGGCGGGG
CTCGACGCGCAAGTCGTCGAACTCGTGCCGAAGGATGCGTACCGCTTCACGTACAAGCTGTGGGCCGACGCCCGGACGGG
GCTGCTGCTGCGTTCGCAGACGCTCGACGCGAGCGATCACGTGCTCGAGCAGATCGCGTTCTCGCAAGTCCAGACGGGCG
GCACGTCCGGCGACAAGGCCGCGATCGCGGCCGGCATGCGCAATTTGAGCGGCTGGACGGTCGTCCGCCCGCCGGTCGCG
ACGGTCGACATGGAAGCGCAGGGCTGGCAGATCGCGCCGAACGTCGCCGGCTTCCGGAAGATTCGCGAGGTGCGCCGCCC
GATGGCCGCGCGCGACGCCGGCGATCCGCCGATTCCGGTCGACCAGGCCGTCTTCACCGACGGGCTCGCGACGATCTCCG
TCTTCATCGAGCCGGCTGAAAAGAACACGCGCAAGGAAGGCGCGGGCAGCACCGGTGCGACCCACGTTCTCGTGAAGCGT
CGCGGCGACTACTGGATCACCGTGCTCGGCGAAGTGCCGCCGGCCACGTTGCAGCAGTTCGCGGCTGCCATAGAATACAA
GGCTTCCAAGTAA

Upstream 100 bases:

>100_bases
ACCTTGAAGCGCACCAGCAATTCGCGCAGCAGCCCGTCGTCACAGGCTCGATGCCGCTGATCCGCGCTGCCGTGACCACC
ACGCCAGGCCAATAAACTCG

Downstream 100 bases:

>100_bases
CGCTACGGCTTCCGACATGACGAAACTCACGCTGCGCAACGTGTTCGCGGCGGCGGTGCTGTGTGCCTGCCTGCCCCTCA
TCCCGCATACCGCGGTGGCG

Product: sigma E regulatory protein, MucB/RseB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MRTLQLNHAISGWKRLPALLLCAAALLSVQSLPASAQQPDDPVATRKGAAEWLDRIQQAAQQQSYEGTFVYQRGAYVQSS
RIAHVASRDGEFERIETLDGKPRKVLRHNDELYTFVPERKLCVVERRQTRDSFPSLLGAGGEHVMSVYDAKLLGKDRVAG
LDAQVVELVPKDAYRFTYKLWADARTGLLLRSQTLDASDHVLEQIAFSQVQTGGTSGDKAAIAAGMRNLSGWTVVRPPVA
TVDMEAQGWQIAPNVAGFRKIREVRRPMAARDAGDPPIPVDQAVFTDGLATISVFIEPAEKNTRKEGAGSTGATHVLVKR
RGDYWITVLGEVPPATLQQFAAAIEYKASK

Sequences:

>Translated_350_residues
MRTLQLNHAISGWKRLPALLLCAAALLSVQSLPASAQQPDDPVATRKGAAEWLDRIQQAAQQQSYEGTFVYQRGAYVQSS
RIAHVASRDGEFERIETLDGKPRKVLRHNDELYTFVPERKLCVVERRQTRDSFPSLLGAGGEHVMSVYDAKLLGKDRVAG
LDAQVVELVPKDAYRFTYKLWADARTGLLLRSQTLDASDHVLEQIAFSQVQTGGTSGDKAAIAAGMRNLSGWTVVRPPVA
TVDMEAQGWQIAPNVAGFRKIREVRRPMAARDAGDPPIPVDQAVFTDGLATISVFIEPAEKNTRKEGAGSTGATHVLVKR
RGDYWITVLGEVPPATLQQFAAAIEYKASK
>Mature_350_residues
MRTLQLNHAISGWKRLPALLLCAAALLSVQSLPASAQQPDDPVATRKGAAEWLDRIQQAAQQQSYEGTFVYQRGAYVQSS
RIAHVASRDGEFERIETLDGKPRKVLRHNDELYTFVPERKLCVVERRQTRDSFPSLLGAGGEHVMSVYDAKLLGKDRVAG
LDAQVVELVPKDAYRFTYKLWADARTGLLLRSQTLDASDHVLEQIAFSQVQTGGTSGDKAAIAAGMRNLSGWTVVRPPVA
TVDMEAQGWQIAPNVAGFRKIREVRRPMAARDAGDPPIPVDQAVFTDGLATISVFIEPAEKNTRKEGAGSTGATHVLVKR
RGDYWITVLGEVPPATLQQFAAAIEYKASK

Specific function: Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate- producing form. Inactivation of mucB causes conversion to mucoidy [H]

COG id: COG3026

COG function: function code T; Negative regulator of sigma E activity

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rseB family [H]

Homologues:

Organism=Escherichia coli, GI1788924, Length=304, Percent_Identity=25.9868421052632, Blast_Score=104, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005588 [H]

Pfam domain/function: PF03888 MucB_RseB [H]

EC number: NA

Molecular weight: Translated: 38375; Mature: 38375

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLQLNHAISGWKRLPALLLCAAALLSVQSLPASAQQPDDPVATRKGAAEWLDRIQQAA
CCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCHHHHHHHHHHHH
QQQSYEGTFVYQRGAYVQSSRIAHVASRDGEFERIETLDGKPRKVLRHNDELYTFVPERK
HHCCCCCEEEEECCCEECCCHHHHHHHCCCCHHHHHCCCCCCHHHHHCCCCEEEECCCCC
LCVVERRQTRDSFPSLLGAGGEHVMSVYDAKLLGKDRVAGLDAQVVELVPKDAYRFTYKL
EEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHCCCCHHHHHHCCCCHHHEEEEE
WADARTGLLLRSQTLDASDHVLEQIAFSQVQTGGTSGDKAAIAAGMRNLSGWTVVRPPVA
ECCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEECCCCE
TVDMEAQGWQIAPNVAGFRKIREVRRPMAARDAGDPPIPVDQAVFTDGLATISVFIEPAE
EEEECCCCCEECCCHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHCCCEEEEEEEECCH
KNTRKEGAGSTGATHVLVKRRGDYWITVLGEVPPATLQQFAAAIEYKASK
HCCHHCCCCCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRTLQLNHAISGWKRLPALLLCAAALLSVQSLPASAQQPDDPVATRKGAAEWLDRIQQAA
CCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCHHHHHHHHHHHH
QQQSYEGTFVYQRGAYVQSSRIAHVASRDGEFERIETLDGKPRKVLRHNDELYTFVPERK
HHCCCCCEEEEECCCEECCCHHHHHHHCCCCHHHHHCCCCCCHHHHHCCCCEEEECCCCC
LCVVERRQTRDSFPSLLGAGGEHVMSVYDAKLLGKDRVAGLDAQVVELVPKDAYRFTYKL
EEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHCCCCHHHHHHCCCCHHHEEEEE
WADARTGLLLRSQTLDASDHVLEQIAFSQVQTGGTSGDKAAIAAGMRNLSGWTVVRPPVA
ECCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEECCCCE
TVDMEAQGWQIAPNVAGFRKIREVRRPMAARDAGDPPIPVDQAVFTDGLATISVFIEPAE
EEEECCCCCEECCCHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHCCCEEEEEEEECCH
KNTRKEGAGSTGATHVLVKRRGDYWITVLGEVPPATLQQFAAAIEYKASK
HCCHHCCCCCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8412698; 8378309; 8444793; 10984043 [H]