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The map label for this gene is hemH

Identifier: 115350694

GI number: 115350694

Start: 722967

End: 724031

Strand: Direct

Name: hemH

Synonym: Bamb_0640

Alternate gene names: 115350694

Gene position: 722967-724031 (Clockwise)

Preceding gene: 115350693

Following gene: 115350695

Centisome position: 20.33

GC content: 67.98

Gene sequence:

>1065_bases
ATGCGTTTCGATCTTGAGCCGCCTTCGAGCGTCGCGGCCGCCCATCGTACCGGCGTGCTGCTGATCAATCTCGGCACGCC
CGACGCCCCGACGCCGCGCGCGGTGCGGCGCTATCTGGCCGAATTCCTGTCGGATCCTCGCGTCGTCGAAATCCCGCAGG
TCGTCTGGCAGGTACTGCTGCGCACGCTGATCCTGCCGCTGCGCGGCCGCGCGTCCGCGAAGAAATACGCGGCCGTCTGG
ATGCCGGAGGGTTCGCCGCTGCGCGTCTACACCGAGCGGCAGACCGAGGGCGTGCGCCATCTGCTCGCATCGAACGCCTA
TCAGGTGACGGTCGATTACGCGATGCGCTACGGCAGCCCGAACATTGCGCAGGCGCTCGCGCAGTTCAAGCGGGCGGGCG
TCGAGCGCGTGCTGCTGATGCCGATGTATCCGCAATACTCGGCGTCCACCACCGCGACGGCATTCGATGCCGCGTTCGCC
GCGCTCGCGCGGATGCGCAACCAGCCGGAAGTGCGCACGGTGCGGCAGTACGCCGACCATCCGGCCTATATCCACGCGCT
TGCCGAGCAGGTGCGCCAATACTGGGCGCAGCACGGCCGGCCCGATTTCGCGGCCGGCGACAAGCTCGTGCTGAGCTTTC
ACGGCGTGCCGAAACGCACGCTCGACCTGGGCGACCCCTATCACGACCAGTGCCAGCAGACGGGCGCGCTGCTGATGGCC
GCGCTCGGGCTGTCGACGCTCGAATGCCGCGTGACGTTCCAGTCACGCTTCGGCAAGGCCGAATGGCTGCAGCCGTACAC
GGCGCCGACGCTGCGTGAGCTCGGCGCGGCCGGCGTGCGACGAGCAGATGTGTTCTGTCCCGGTTTTACGGCCGATTGCC
TGGAGACGATCGAGGAAATCGGGATGGAGGTGCGCGACGAATTCATCGCGGGCGGCGGCCAGGCGTTCCACCGGATTCCA
TGCCTGAATGGCGCGCACGCATGGATCGGCGCGCTCGGCGAGATCGTCGCCGAGAATCTGCAGGGCTGGCCGGTGAAGGC
CGCGCAGCCCGACATGGTGAACTGA

Upstream 100 bases:

>100_bases
GCGCGCGCCGCCATTCGGCCGAACGGCCAGCCGACCCGAGCGGGGCGGCCCGCTATAATTGAGAGCCGTCCGACTGCGTG
CCCCGAGCACGTTCCTGCCC

Downstream 100 bases:

>100_bases
AGGTGAACTGAAATGACGGCCCAGCCCCTATGCGCACTGCGTTCGCCGTTCGAGCGGGCGGTCGGTCGCGATGGGGCGGC
ACGGCGGAGGCTGGCATGAA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MRFDLEPPSSVAAAHRTGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQVVWQVLLRTLILPLRGRASAKKYAAVW
MPEGSPLRVYTERQTEGVRHLLASNAYQVTVDYAMRYGSPNIAQALAQFKRAGVERVLLMPMYPQYSASTTATAFDAAFA
ALARMRNQPEVRTVRQYADHPAYIHALAEQVRQYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMA
ALGLSTLECRVTFQSRFGKAEWLQPYTAPTLRELGAAGVRRADVFCPGFTADCLETIEEIGMEVRDEFIAGGGQAFHRIP
CLNGAHAWIGALGEIVAENLQGWPVKAAQPDMVN

Sequences:

>Translated_354_residues
MRFDLEPPSSVAAAHRTGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQVVWQVLLRTLILPLRGRASAKKYAAVW
MPEGSPLRVYTERQTEGVRHLLASNAYQVTVDYAMRYGSPNIAQALAQFKRAGVERVLLMPMYPQYSASTTATAFDAAFA
ALARMRNQPEVRTVRQYADHPAYIHALAEQVRQYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMA
ALGLSTLECRVTFQSRFGKAEWLQPYTAPTLRELGAAGVRRADVFCPGFTADCLETIEEIGMEVRDEFIAGGGQAFHRIP
CLNGAHAWIGALGEIVAENLQGWPVKAAQPDMVN
>Mature_354_residues
MRFDLEPPSSVAAAHRTGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQVVWQVLLRTLILPLRGRASAKKYAAVW
MPEGSPLRVYTERQTEGVRHLLASNAYQVTVDYAMRYGSPNIAQALAQFKRAGVERVLLMPMYPQYSASTTATAFDAAFA
ALARMRNQPEVRTVRQYADHPAYIHALAEQVRQYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMA
ALGLSTLECRVTFQSRFGKAEWLQPYTAPTLRELGAAGVRRADVFCPGFTADCLETIEEIGMEVRDEFIAGGGQAFHRIP
CLNGAHAWIGALGEIVAENLQGWPVKAAQPDMVN

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=333, Percent_Identity=25.5255255255255, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI60499025, Length=333, Percent_Identity=25.5255255255255, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1786681, Length=322, Percent_Identity=45.6521739130435, Blast_Score=281, Evalue=6e-77,
Organism=Saccharomyces cerevisiae, GI6324750, Length=336, Percent_Identity=25, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17864156, Length=341, Percent_Identity=25.2199413489736, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24651774, Length=270, Percent_Identity=25.5555555555556, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 39156; Mature: 39156

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFDLEPPSSVAAAHRTGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQVVWQVLL
CCCCCCCCHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
RTLILPLRGRASAKKYAAVWMPEGSPLRVYTERQTEGVRHLLASNAYQVTVDYAMRYGSP
HHHHHHCCCCCCCCCEEEEECCCCCCEEEEECHHHHHHHHHHHCCCEEEEEHHHHHCCCC
NIAQALAQFKRAGVERVLLMPMYPQYSASTTATAFDAAFAALARMRNQPEVRTVRQYADH
HHHHHHHHHHHCCHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PAYIHALAEQVRQYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMA
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
ALGLSTLECRVTFQSRFGKAEWLQPYTAPTLRELGAAGVRRADVFCPGFTADCLETIEEI
HHCCCCEEEEEEHHHHCCCHHHCCCCCCHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHH
GMEVRDEFIAGGGQAFHRIPCLNGAHAWIGALGEIVAENLQGWPVKAAQPDMVN
HHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRFDLEPPSSVAAAHRTGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQVVWQVLL
CCCCCCCCHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
RTLILPLRGRASAKKYAAVWMPEGSPLRVYTERQTEGVRHLLASNAYQVTVDYAMRYGSP
HHHHHHCCCCCCCCCEEEEECCCCCCEEEEECHHHHHHHHHHHCCCEEEEEHHHHHCCCC
NIAQALAQFKRAGVERVLLMPMYPQYSASTTATAFDAAFAALARMRNQPEVRTVRQYADH
HHHHHHHHHHHCCHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PAYIHALAEQVRQYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMA
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
ALGLSTLECRVTFQSRFGKAEWLQPYTAPTLRELGAAGVRRADVFCPGFTADCLETIEEI
HHCCCCEEEEEEHHHHCCCHHHCCCCCCHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHH
GMEVRDEFIAGGGQAFHRIPCLNGAHAWIGALGEIVAENLQGWPVKAAQPDMVN
HHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA