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The map label for this gene is hisA

Identifier: 115350403

GI number: 115350403

Start: 391838

End: 392593

Strand: Direct

Name: hisA

Synonym: Bamb_0348

Alternate gene names: 115350403

Gene position: 391838-392593 (Clockwise)

Preceding gene: 115350402

Following gene: 115350404

Centisome position: 11.02

GC content: 64.29

Gene sequence:

>756_bases
ATGCTGCTGATTCCGGCCATCGATCTCAAAGACGGTCAGTGTGTGCGCCTCAAACAGGGCGATATGGACCAGGCCACGAT
TTTCTCCGAGGACCCGGCGGCGATGGCCCGCAAGTGGGTCGATCTCGGCGCCCGGCGGCTGCATCTGGTCGACCTGAACG
GCGCATTCGCCGGCAAGCCGAAGAACCTCGATGCGATCGAAGCGATCCTCGACGAAGTCGGCGACGAAATCCCCGTACAG
CTCGGCGGCGGCATCCGCAGCCTCGAGACGGTCGAGAAGTATCTCGACGCCGGCCTGTCCTACGTGATCATCGGCACGGC
GGCCGTGAAGGACCCGGGCTTCCTGCGGGATGCGTGCACCGCGTTCGCGGGCAACATCATCGTCGGCCTCGATGCGAAGG
ACGGCAAGGTCGCGACCGACGGCTGGAGCAAGCTGACGGGCCACGAAGTGATCGATCTCGCGCTGAAGTTCGAGGACTAC
GGCGTCGAATCGATCGTCTACACCGACATCGGCCGCGACGGGATGCTGCAGGGCATCAATATCGAGGCGACCGTGAAGCT
CGCTCAGGCGGTCGGCATTCCGGTGATCGCCAGCGGCGGCCTGTCGAACCTCGCGGACATCGACAGCCTGTGCGAAGTGG
AAGAGCACGGCGTCGAAGGCGTGATCTGCGGCCGTGCGATCTACTCCGGCGATCTCGATTTCGCGGCCGCGCAAAAGCGC
GCGGACGAACTGAACGGCGAACTCGACAACGCGTAA

Upstream 100 bases:

>100_bases
AGCGCCGAAAGAGTTGTACTAAACTAGCGAGGCGGCGCGGTACCGGATCGACCGGTGCGCGCCCGATTCTTTTCTTCTTC
CACGACGACACCCGATTGCT

Downstream 100 bases:

>100_bases
GCGCGGTTGTCCCGTTCGCCGGGGCTGCCTGCTGGCGGCCCCGACCGGAAGCCTCGCGCGAGGCTTCCGTAACCGGCCGT
CCCATCGCGGCCTTTGGCGC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKPKNLDAIEAILDEVGDEIPVQ
LGGGIRSLETVEKYLDAGLSYVIIGTAAVKDPGFLRDACTAFAGNIIVGLDAKDGKVATDGWSKLTGHEVIDLALKFEDY
GVESIVYTDIGRDGMLQGINIEATVKLAQAVGIPVIASGGLSNLADIDSLCEVEEHGVEGVICGRAIYSGDLDFAAAQKR
ADELNGELDNA

Sequences:

>Translated_251_residues
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKPKNLDAIEAILDEVGDEIPVQ
LGGGIRSLETVEKYLDAGLSYVIIGTAAVKDPGFLRDACTAFAGNIIVGLDAKDGKVATDGWSKLTGHEVIDLALKFEDY
GVESIVYTDIGRDGMLQGINIEATVKLAQAVGIPVIASGGLSNLADIDSLCEVEEHGVEGVICGRAIYSGDLDFAAAQKR
ADELNGELDNA
>Mature_251_residues
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKPKNLDAIEAILDEVGDEIPVQ
LGGGIRSLETVEKYLDAGLSYVIIGTAAVKDPGFLRDACTAFAGNIIVGLDAKDGKVATDGWSKLTGHEVIDLALKFEDY
GVESIVYTDIGRDGMLQGINIEATVKLAQAVGIPVIASGGLSNLADIDSLCEVEEHGVEGVICGRAIYSGDLDFAAAQKR
ADELNGELDNA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=242, Percent_Identity=32.6446280991736, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788336, Length=213, Percent_Identity=25.8215962441315, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_BURA4 (B1YRW0)

Other databases:

- EMBL:   CP001025
- RefSeq:   YP_001807074.1
- ProteinModelPortal:   B1YRW0
- SMR:   B1YRW0
- GeneID:   6178259
- GenomeReviews:   CP001025_GR
- KEGG:   bac:BamMC406_0357
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- ProtClustDB:   PRK00748
- BioCyc:   BAMB398577:BAMMC406_0357-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 26541; Mature: 26541

Theoretical pI: Translated: 4.15; Mature: 4.15

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKP
CEEEEEEECCCCCEEEECCCCCCCEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
KNLDAIEAILDEVGDEIPVQLGGGIRSLETVEKYLDAGLSYVIIGTAAVKDPGFLRDACT
CCHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHH
AFAGNIIVGLDAKDGKVATDGWSKLTGHEVIDLALKFEDYGVESIVYTDIGRDGMLQGIN
HHHCCEEEEEECCCCEEECCCCHHCCCCCEEEEEEEECCCCCCEEEEEECCCCCCEECCC
IEATVKLAQAVGIPVIASGGLSNLADIDSLCEVEEHGVEGVICGRAIYSGDLDFAAAQKR
CHHHEEHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCCCEEEECCEEECCCCCHHHHHHH
ADELNGELDNA
HHHHCCCCCCC
>Mature Secondary Structure
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKP
CEEEEEEECCCCCEEEECCCCCCCEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
KNLDAIEAILDEVGDEIPVQLGGGIRSLETVEKYLDAGLSYVIIGTAAVKDPGFLRDACT
CCHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHH
AFAGNIIVGLDAKDGKVATDGWSKLTGHEVIDLALKFEDYGVESIVYTDIGRDGMLQGIN
HHHCCEEEEEECCCCEEECCCCHHCCCCCEEEEEEEECCCCCCEEEEEECCCCCCEECCC
IEATVKLAQAVGIPVIASGGLSNLADIDSLCEVEEHGVEGVICGRAIYSGDLDFAAAQKR
CHHHEEHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCCCEEEECCEEECCCCCHHHHHHH
ADELNGELDNA
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA