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The map label for this gene is 116249199

Identifier: 116249199

GI number: 116249199

Start: 580451

End: 581449

Strand: Direct

Name: 116249199

Synonym: pRL120535

Alternate gene names: NA

Gene position: 580451-581449 (Clockwise)

Preceding gene: 116249198

Following gene: 116249200

Centisome position: 66.72

GC content: 61.06

Gene sequence:

>999_bases
ATGAGAAACAGCTTCTTCTGTATCGATGCGCATACCTGCGGCAATCCCGTCCGGCTCGTCGCCGGAGGCGGTCCGCTGCT
TCTGCATGCGCCGATCAGCGAGCGACGGGAGATTTTTGTCCGGGACCATGACTGGGTACGCCAGGCGCTGATGTTCGAGC
CAAGGGGGCACGACATCATGTCAGGCGCGATCATCTATCCGGCCTATCGGGAGGATTGCGATTTCGCCGTGCTTTTCATC
GAAGTGAGTGGCTGTCTGCCGATGTGCGGCGCCGGCACCATCGGCACCGTGACCGCCGCGATCGAGGAGGGGCTCGTCAA
GCCGCGGGAGCCCGGCCGGGTTGCCATCGAGACGCCTGCAGGAAGGGTCGACGTCACTTATGAGGAGAAGGGCGGATATG
TCGAAACCGTTCGTCTCCACAATGTTGCGAGCTATCTTCATGAGGCTGATGTCGAGGTCGATGTGCCGGGAATGGGCCGT
CTGCGCGTCGACCTCTCATATGGCGGCAACTATTATGCAGTCATCGAACCTCAGGAAAACTGGAGCGGGCTCGACGGCAT
GACCGCATCCGACATCGTCGGTTGCAGCCAGAAGCTCAGGTCAGCGCTTGCCGATATCTGCGATCCCATTCATCCCGACG
ACGCCAGGATCCGCGGCGTGCATCATGCCATCTGGTGTGATCTCCCCGTCAACGACACTTCGGATGGGCGTTGCGCGGTC
TTCTATGGCGAGAAGGCCATCGATCGCTCGCCGGGCGGCACCGGCACTTCCGCCCGCATGGCCCAGCTCTATGGGAAGGG
ACGGCTTACCGTCGGGTCGAGATTCCGGCATGAAAGCCTGATCGGAACCGTCTTCGAGGGCCGGGTCGAAGCCGAGGCAC
GCATTGGGCCTTATAGCGGTATTCTTCCAAGCATCGGAGGCTGGGCACGCGTCATCGGGCACAACACCATTTTCGTTGAC
GATCGGGATCCGCTAGCGCATGGCTTTCAGATCCGATGA

Upstream 100 bases:

>100_bases
CTGGCGATCGTTGCAGTCGCCCTCCTGCTCGACCGACTGTCCCGCGGCCTGCTCGACCGCGACAGGCCACGGAAGGCAGG
ATGAGCAAGGACATGAAAAG

Downstream 100 bases:

>100_bases
GCGCGTTTCGTCTGAAAAGACGGGCGGCGCGGTAAGAGGCGGCAAGGAGATGACTATGCGACCCGAGCAGCATCGACGGG
CAGATGACGCCGCGAAGTCG

Product: hydroxyproline-2-epimerase

Products: NA

Alternate protein names: Hydroxyproline-2-epimerase; HyPRE [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MRNSFFCIDAHTCGNPVRLVAGGGPLLLHAPISERREIFVRDHDWVRQALMFEPRGHDIMSGAIIYPAYREDCDFAVLFI
EVSGCLPMCGAGTIGTVTAAIEEGLVKPREPGRVAIETPAGRVDVTYEEKGGYVETVRLHNVASYLHEADVEVDVPGMGR
LRVDLSYGGNYYAVIEPQENWSGLDGMTASDIVGCSQKLRSALADICDPIHPDDARIRGVHHAIWCDLPVNDTSDGRCAV
FYGEKAIDRSPGGTGTSARMAQLYGKGRLTVGSRFRHESLIGTVFEGRVEAEARIGPYSGILPSIGGWARVIGHNTIFVD
DRDPLAHGFQIR

Sequences:

>Translated_332_residues
MRNSFFCIDAHTCGNPVRLVAGGGPLLLHAPISERREIFVRDHDWVRQALMFEPRGHDIMSGAIIYPAYREDCDFAVLFI
EVSGCLPMCGAGTIGTVTAAIEEGLVKPREPGRVAIETPAGRVDVTYEEKGGYVETVRLHNVASYLHEADVEVDVPGMGR
LRVDLSYGGNYYAVIEPQENWSGLDGMTASDIVGCSQKLRSALADICDPIHPDDARIRGVHHAIWCDLPVNDTSDGRCAV
FYGEKAIDRSPGGTGTSARMAQLYGKGRLTVGSRFRHESLIGTVFEGRVEAEARIGPYSGILPSIGGWARVIGHNTIFVD
DRDPLAHGFQIR
>Mature_332_residues
MRNSFFCIDAHTCGNPVRLVAGGGPLLLHAPISERREIFVRDHDWVRQALMFEPRGHDIMSGAIIYPAYREDCDFAVLFI
EVSGCLPMCGAGTIGTVTAAIEEGLVKPREPGRVAIETPAGRVDVTYEEKGGYVETVRLHNVASYLHEADVEVDVPGMGR
LRVDLSYGGNYYAVIEPQENWSGLDGMTASDIVGCSQKLRSALADICDPIHPDDARIRGVHHAIWCDLPVNDTSDGRCAV
FYGEKAIDRSPGGTGTSARMAQLYGKGRLTVGSRFRHESLIGTVFEGRVEAEARIGPYSGILPSIGGWARVIGHNTIFVD
DRDPLAHGFQIR

Specific function: Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4- hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell

COG id: COG3938

COG function: function code E; Proline racemase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the proline racemase family. 4- hydroxyproline epimerase subfamily [H]

Homologues:

Organism=Homo sapiens, GI21389361, Length=333, Percent_Identity=31.5315315315315, Blast_Score=162, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008794 [H]

Pfam domain/function: PF05544 Pro_racemase [H]

EC number: =5.1.1.8 [H]

Molecular weight: Translated: 36208; Mature: 36208

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNSFFCIDAHTCGNPVRLVAGGGPLLLHAPISERREIFVRDHDWVRQALMFEPRGHDIM
CCCCEEEEECCCCCCCEEEEECCCCEEEECCCCCCCEEEEECHHHHHHHHEECCCCCCEE
SGAIIYPAYREDCDFAVLFIEVSGCLPMCGAGTIGTVTAAIEEGLVKPREPGRVAIETPA
CCEEEECCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCC
GRVDVTYEEKGGYVETVRLHNVASYLHEADVEVDVPGMGRLRVDLSYGGNYYAVIEPQEN
CEEEEEEECCCCEEEEEEHHHHHHHHHHCCCEEECCCCCEEEEEEEECCCEEEEEECCCC
WSGLDGMTASDIVGCSQKLRSALADICDPIHPDDARIRGVHHAIWCDLPVNDTSDGRCAV
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEEEEEEEEECCCCCCCCCEEEE
FYGEKAIDRSPGGTGTSARMAQLYGKGRLTVGSRFRHESLIGTVFEGRVEAEARIGPYSG
EECCHHCCCCCCCCCCHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCEEEEEEEECCCCC
ILPSIGGWARVIGHNTIFVDDRDPLAHGFQIR
CCCCCCCCEEEEECCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MRNSFFCIDAHTCGNPVRLVAGGGPLLLHAPISERREIFVRDHDWVRQALMFEPRGHDIM
CCCCEEEEECCCCCCCEEEEECCCCEEEECCCCCCCEEEEECHHHHHHHHEECCCCCCEE
SGAIIYPAYREDCDFAVLFIEVSGCLPMCGAGTIGTVTAAIEEGLVKPREPGRVAIETPA
CCEEEECCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCC
GRVDVTYEEKGGYVETVRLHNVASYLHEADVEVDVPGMGRLRVDLSYGGNYYAVIEPQEN
CEEEEEEECCCCEEEEEEHHHHHHHHHHCCCEEECCCCCEEEEEEEECCCEEEEEECCCC
WSGLDGMTASDIVGCSQKLRSALADICDPIHPDDARIRGVHHAIWCDLPVNDTSDGRCAV
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEEEEEEEEECCCCCCCCCEEEE
FYGEKAIDRSPGGTGTSARMAQLYGKGRLTVGSRFRHESLIGTVFEGRVEAEARIGPYSG
EECCHHCCCCCCCCCCHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCEEEEEEEECCCCC
ILPSIGGWARVIGHNTIFVDDRDPLAHGFQIR
CCCCCCCCEEEEECCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA