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The map label for this gene is exuR [H]

Identifier: 116249065

GI number: 116249065

Start: 431734

End: 432492

Strand: Direct

Name: exuR [H]

Synonym: pRL120399

Alternate gene names: 116249065

Gene position: 431734-432492 (Clockwise)

Preceding gene: 116249064

Following gene: 116249066

Centisome position: 49.62

GC content: 64.56

Gene sequence:

>759_bases
ATGTTTTCGCCTGTTGAATCACGCCGCCTTTACCGGCAGGTCGCCGATCAGATTCGCTTGATGATCGCCAGCGGCGAGCT
TGCCGTCGGCCAGCGGCTGCCGGCCGAGCGCGACCTGGCGGAGCAACTGTCGGTTTCACGCCCGACCGTCCGCGAGGCGC
TGATCGTCCTGGAGGTCGAAGGCCTCGTCAACATCCGCATGGGATCCGGCATCTATGTGGTGCGCCAGCATGCTGCGACC
GTCACTGGGGCCGAGCGAGAGCCGGTGGAGGGCCCGTTCGAGCTGCTGCAGGCGCGCGCCCTCATCGAATGCGCCATTGC
CGAAGAAGCTGCAGGCCGCGCCAAACCGGACGATATCGCGCTGCTCGATGAAGCTCTGACGCGCATGGGTGGTGTGGTCA
ACGATGCGATCGCAGTGCTCGATGCCGATCGCGCCTTCCACACCGGCATTGCCGCCATCGTCGGCAATGCGACATTGATC
CGCGTCACGGGCGAGATGTTCGACATGCGCATGACGCCTTATTTCGCAAGGCTCGCCAGCCACTTCGAGGGGCCTACGAC
ATGGCGTAGCGCCCTGGACGAGCATCGCGCCATTCGCGACGCGATCGCCGCCGGCGATGCAGCCGGCGCCAAGGCTGCCA
TGCGCGCTCATCTCACCATGTCGCAGAAGAGGTTTTCCGAGAGCTTCGGGGAGGAGTTCTCGGGGGAAGAGGAGCGCGGA
CGCAACAAGCGGCCGTCGAAAGGAACTGCCAAGACTTAA

Upstream 100 bases:

>100_bases
CGGATTGACGCACAACTCCAGCAATGCTATTCAAGTACTAATTGGTCAGGCCAGTTGACCAGCTGCGCGCTTGAGGAGAA
GCTCGCCTAGGGAGGCCACG

Downstream 100 bases:

>100_bases
CCCAAGCTCGGGAGGAGAGAGCAATGAAAAGCAGACTGGCAACGATACTTTGCACCGCAGCCGTAATCATGGCGAGTAGC
GCAATCGCGCAGGCCCAGAC

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MFSPVESRRLYRQVADQIRLMIASGELAVGQRLPAERDLAEQLSVSRPTVREALIVLEVEGLVNIRMGSGIYVVRQHAAT
VTGAEREPVEGPFELLQARALIECAIAEEAAGRAKPDDIALLDEALTRMGGVVNDAIAVLDADRAFHTGIAAIVGNATLI
RVTGEMFDMRMTPYFARLASHFEGPTTWRSALDEHRAIRDAIAAGDAAGAKAAMRAHLTMSQKRFSESFGEEFSGEEERG
RNKRPSKGTAKT

Sequences:

>Translated_252_residues
MFSPVESRRLYRQVADQIRLMIASGELAVGQRLPAERDLAEQLSVSRPTVREALIVLEVEGLVNIRMGSGIYVVRQHAAT
VTGAEREPVEGPFELLQARALIECAIAEEAAGRAKPDDIALLDEALTRMGGVVNDAIAVLDADRAFHTGIAAIVGNATLI
RVTGEMFDMRMTPYFARLASHFEGPTTWRSALDEHRAIRDAIAAGDAAGAKAAMRAHLTMSQKRFSESFGEEFSGEEERG
RNKRPSKGTAKT
>Mature_252_residues
MFSPVESRRLYRQVADQIRLMIASGELAVGQRLPAERDLAEQLSVSRPTVREALIVLEVEGLVNIRMGSGIYVVRQHAAT
VTGAEREPVEGPFELLQARALIECAIAEEAAGRAKPDDIALLDEALTRMGGVVNDAIAVLDADRAFHTGIAAIVGNATLI
RVTGEMFDMRMTPYFARLASHFEGPTTWRSALDEHRAIRDAIAAGDAAGAKAAMRAHLTMSQKRFSESFGEEFSGEEERG
RNKRPSKGTAKT

Specific function: Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the exuT, uxaCA and uxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082208, Length=242, Percent_Identity=36.3636363636364, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1790780, Length=233, Percent_Identity=36.480686695279, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790032, Length=237, Percent_Identity=35.4430379746835, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1789621, Length=227, Percent_Identity=29.9559471365639, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1789353, Length=231, Percent_Identity=26.8398268398268, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786303, Length=237, Percent_Identity=28.6919831223629, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI48994955, Length=216, Percent_Identity=27.7777777777778, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 27418; Mature: 27418

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSPVESRRLYRQVADQIRLMIASGELAVGQRLPAERDLAEQLSVSRPTVREALIVLEVE
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHCCCCHHHHHEEEEEEC
GLVNIRMGSGIYVVRQHAATVTGAEREPVEGPFELLQARALIECAIAEEAAGRAKPDDIA
CEEEEEECCCEEEEEHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LLDEALTRMGGVVNDAIAVLDADRAFHTGIAAIVGNATLIRVTGEMFDMRMTPYFARLAS
HHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEHHHHHHHCCHHHHHHHH
HFEGPTTWRSALDEHRAIRDAIAAGDAAGAKAAMRAHLTMSQKRFSESFGEEFSGEEERG
HCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHC
RNKRPSKGTAKT
CCCCCCCCCCCC
>Mature Secondary Structure
MFSPVESRRLYRQVADQIRLMIASGELAVGQRLPAERDLAEQLSVSRPTVREALIVLEVE
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHCCCCHHHHHEEEEEEC
GLVNIRMGSGIYVVRQHAATVTGAEREPVEGPFELLQARALIECAIAEEAAGRAKPDDIA
CEEEEEECCCEEEEEHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LLDEALTRMGGVVNDAIAVLDADRAFHTGIAAIVGNATLIRVTGEMFDMRMTPYFARLAS
HHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEHHHHHHHCCHHHHHHHH
HFEGPTTWRSALDEHRAIRDAIAAGDAAGAKAAMRAHLTMSQKRFSESFGEEFSGEEERG
HCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHC
RNKRPSKGTAKT
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA