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The map label for this gene is panC

Identifier: 116249028

GI number: 116249028

Start: 388343

End: 389254

Strand: Direct

Name: panC

Synonym: pRL120359

Alternate gene names: 116249028

Gene position: 388343-389254 (Clockwise)

Preceding gene: 116249025

Following gene: 116249029

Centisome position: 44.64

GC content: 62.72

Gene sequence:

>912_bases
ATGCGGGTTTTCTCGAGCATTGACGAGCTGCGCCACACGCTCGACGCGCTGAGGCGGCAGGGGCGAACCGTCGGCCTCGT
TCCGACGATGGGTTATCTCCATGCCGGTCATATGGAGCTCGTCTCGCGCGCTCGCGCCGAGAACGACATCGTCGTCGTCT
CGATTTTCGTCAATCCGCTGCAGTTCGGCCCGGCGGAAGATCTCAGCAAATATCCGCGCGATCTGGAACGCGATGCCGCC
ATGCTGAGGCAAGCCGGCGTCAATTTCCTTTTTTCGCCTGGTGTCGAGGACATGTATTCCCGCCCGATGTTGACCGTCGT
CGACGTTCCAGATCTCGGGCGCGAACTCGAAGGGGCGGTACGGCCTGGGCATTTCGCCGGCGTCGCCACTGTCGTCTGCA
AGCTTTTCAACATCGTGCAGCCGCAGACCGCCTATTTTGGAGCGAAGGATTACCAGCAGGTCGTCATCATCAAGCGCATG
GTGGACGATCTGGCCTTGCCGGTGCGCCTGATATCGGTGCCGACCGTCAGGGATAGCGACGGCCTCGCATTGTCGTCGCG
CAACGTCTATCTCAGCGAGGCGGAGCGGCGTGCCGCGGTGATCGTCCCTCAGACCCTTGACGAGGCCGAGCGCCTGGTCG
CCGACGGCCTGACCGATCCGGTGGAACTAGAGGCACGGCTCACGGCATTTCTTAGTCGCGAGCCTCTGGCAAAGCCCGAG
GTCGTCGCCGTCAGAGATGCCGCAACGCTGCAGCCAGTCACGTCGATCGCAGACCCTGTCGTCGTGGCGCTCTTCGTTCG
GGTCGGCTCGACACGGCTTCTCGACAACAGGGTCGTTGGGAGCAACCGGTTTGTCGGGAACAACAGGGTTGCCGGCGGGC
AGAGCTTGCCGGGAAAGGGAGTGACCAGATGA

Upstream 100 bases:

>100_bases
TTCATCTAATCGTCTTTATCGAGGAATATGCATTGACCTGCCGCATCGATTACACTTCTTATCCGCGCCCAAGATGGAGT
GACCGGCCAGGGGAGGATAT

Downstream 100 bases:

>100_bases
GCGCGGCCGGAATTCAGAAGCGCATTACGCCAGCGCGCATCTCAGCCATGAAGGGCGGCAAGCCGATCGTCTGCCTGACC
GCCTATACGACGCCGATGGC

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MRVFSSIDELRHTLDALRRQGRTVGLVPTMGYLHAGHMELVSRARAENDIVVVSIFVNPLQFGPAEDLSKYPRDLERDAA
MLRQAGVNFLFSPGVEDMYSRPMLTVVDVPDLGRELEGAVRPGHFAGVATVVCKLFNIVQPQTAYFGAKDYQQVVIIKRM
VDDLALPVRLISVPTVRDSDGLALSSRNVYLSEAERRAAVIVPQTLDEAERLVADGLTDPVELEARLTAFLSREPLAKPE
VVAVRDAATLQPVTSIADPVVVALFVRVGSTRLLDNRVVGSNRFVGNNRVAGGQSLPGKGVTR

Sequences:

>Translated_303_residues
MRVFSSIDELRHTLDALRRQGRTVGLVPTMGYLHAGHMELVSRARAENDIVVVSIFVNPLQFGPAEDLSKYPRDLERDAA
MLRQAGVNFLFSPGVEDMYSRPMLTVVDVPDLGRELEGAVRPGHFAGVATVVCKLFNIVQPQTAYFGAKDYQQVVIIKRM
VDDLALPVRLISVPTVRDSDGLALSSRNVYLSEAERRAAVIVPQTLDEAERLVADGLTDPVELEARLTAFLSREPLAKPE
VVAVRDAATLQPVTSIADPVVVALFVRVGSTRLLDNRVVGSNRFVGNNRVAGGQSLPGKGVTR
>Mature_303_residues
MRVFSSIDELRHTLDALRRQGRTVGLVPTMGYLHAGHMELVSRARAENDIVVVSIFVNPLQFGPAEDLSKYPRDLERDAA
MLRQAGVNFLFSPGVEDMYSRPMLTVVDVPDLGRELEGAVRPGHFAGVATVVCKLFNIVQPQTAYFGAKDYQQVVIIKRM
VDDLALPVRLISVPTVRDSDGLALSSRNVYLSEAERRAAVIVPQTLDEAERLVADGLTDPVELEARLTAFLSREPLAKPE
VVAVRDAATLQPVTSIADPVVVALFVRVGSTRLLDNRVVGSNRFVGNNRVAGGQSLPGKGVTR

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=281, Percent_Identity=42.3487544483986, Blast_Score=220, Evalue=8e-59,
Organism=Saccharomyces cerevisiae, GI6322046, Length=314, Percent_Identity=37.8980891719745, Blast_Score=177, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_RHIL3 (Q1M4A1)

Other databases:

- EMBL:   AM236086
- RefSeq:   YP_764869.1
- ProteinModelPortal:   Q1M4A1
- SMR:   Q1M4A1
- STRING:   Q1M4A1
- GeneID:   4398332
- GenomeReviews:   AM236086_GR
- KEGG:   rle:pRL120359
- NMPDR:   fig|216596.1.peg.6066
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   YRAYFGQ
- PhylomeDB:   Q1M4A1
- ProtClustDB:   PRK00380
- BioCyc:   RLEG216596:PRL120359-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 33080; Mature: 33080

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 153-153 BINDING 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVFSSIDELRHTLDALRRQGRTVGLVPTMGYLHAGHMELVSRARAENDIVVVSIFVNPL
CCHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCC
QFGPAEDLSKYPRDLERDAAMLRQAGVNFLFSPGVEDMYSRPMLTVVDVPDLGRELEGAV
CCCCHHHHHHCHHHHHHHHHHHHHHCCCEEECCCHHHHHCCCCEEEECCCCCCHHHHCCC
RPGHFAGVATVVCKLFNIVQPQTAYFGAKDYQQVVIIKRMVDDLALPVRLISVPTVRDSD
CCCHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHCCHHEEECCCEECCC
GLALSSRNVYLSEAERRAAVIVPQTLDEAERLVADGLTDPVELEARLTAFLSREPLAKPE
CCEEECCCEEEEHHCCCEEEEECHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCC
VVAVRDAATLQPVTSIADPVVVALFVRVGSTRLLDNRVVGSNRFVGNNRVAGGQSLPGKG
EEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCEECCCCCCCCCCCCCCCCCCCCCC
VTR
CCC
>Mature Secondary Structure
MRVFSSIDELRHTLDALRRQGRTVGLVPTMGYLHAGHMELVSRARAENDIVVVSIFVNPL
CCHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCC
QFGPAEDLSKYPRDLERDAAMLRQAGVNFLFSPGVEDMYSRPMLTVVDVPDLGRELEGAV
CCCCHHHHHHCHHHHHHHHHHHHHHCCCEEECCCHHHHHCCCCEEEECCCCCCHHHHCCC
RPGHFAGVATVVCKLFNIVQPQTAYFGAKDYQQVVIIKRMVDDLALPVRLISVPTVRDSD
CCCHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHCCHHEEECCCEECCC
GLALSSRNVYLSEAERRAAVIVPQTLDEAERLVADGLTDPVELEARLTAFLSREPLAKPE
CCEEECCCEEEEHHCCCEEEEECHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCC
VVAVRDAATLQPVTSIADPVVVALFVRVGSTRLLDNRVVGSNRFVGNNRVAGGQSLPGKG
EEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCEECCCCCCCCCCCCCCCCCCCCCC
VTR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA