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The map label for this gene is degS [H]

Identifier: 116248952

GI number: 116248952

Start: 299776

End: 301014

Strand: Reverse

Name: degS [H]

Synonym: pRL120283

Alternate gene names: 116248952

Gene position: 301014-299776 (Counterclockwise)

Preceding gene: 116248958

Following gene: 116248951

Centisome position: 34.6

GC content: 66.18

Gene sequence:

>1239_bases
ATGCTGCATCTCGTACCCGCAGCCATGTTCGACCACTATCTCGGCATTTCCCGGCTGCTCGCGGGCCAGCTCGACTTCCG
CTCGGCTATCCGTTCCGTTGCGGCCGAGGTCGCCCATATCATCCCGCACGACCACCTCGATGTCTGCGTGCTGCTTGAGG
GCGGCAACTACCACACGGCCTATGAGACCGGCATCGAGACCGCCTGGGGCGGCCTTGCCGGCGCGCCTGTTGTCAACAGC
CCCATCCGTTCGCTGCTCTGGGGCGAGGTGGATTTTCTGCTGGCGGACGACGCCATGACCGACCCGCGTTTCCACTTCGA
GGGCGCCTTCAAGCGGCCGATCGTCGAACAGTCGCTGAGGAGCCGCTTGCATGTGCCGATGAAGGTGCAGGGCACGATCA
TCGCGGCGCTTTCCTGTTCGTCGCACAGGGCGAGCGTTTATACGATGGAGGATATCGAACGCGCCCGCATCATCGCCGAC
CTGCTGACGCCCTATTTCTTCGCGCTGCAGGCAGCCGAGCAGGCGCAACGCTCGGCCATTGTCGAGGCAGAGGCCCGCGC
CCGCGAGGAGGGCTTGCGGCAAGGTGCGCTGAAGCTTACCGAAGCGCTGGAGCAGGAACGCCAGCGCATCGGCATGGACC
TGCACGACCAGACGCTCGCCGACCTGACGCGGCTCGCCCGCCGGATCGATCGGCTGTCGCGCAACGGCGAGTTGGCGCCC
GAGGCGCTGGAGCCGATCTCCCGTTCCCTGCAGCATTGCATGCAGGATCTGCGGCAGATCATCGAGCAGGCAAAACCCTC
CGTGCTCCAGCTCTTCGGCCTCGCTCAGGCGATCGAACATCATCTGGACCGATCGACCCGCGACACGGGGTCGGGGATCG
AGTGGGGCCTTGTCGACGAGACGCACTGCGCACTGGAGCGACTGGAACCGACCGTCAGCGTCGCGCTGTTCCGGATCGCC
CAGGAGGCGATCAACAATGCGGTACGCCATGCCGCGCCGCTGGCCGTCACGGTGCGGCTCGAGGCCGATGACGACCGGCT
ATCGATCGAAATCTCCGACGACGGAACCGGGCTCGCCAAGGCCCGGGGCCGGATCGGCGGCGGCATCGACAATATGAAGA
CCCGTGCGCGGCTGATTTCAGCGCGGTTCACGACCGGCCCCGGCCACAACAATCGCGGCACTGTGGTGCGCGTCGTGCTA
CCGCTCGTACCGAACGACCCGCCGAGCGGGCCAAACTGA

Upstream 100 bases:

>100_bases
GCTGCGGGTTTACGCAAGACGGCGGCGCTTCCGCGGGCGCTTACTGCGAAGGGTCGCGGCGGGTTGAGGAGCCTGCTGCC
GCCTCGGGGAGGAACTGACG

Downstream 100 bases:

>100_bases
GGAGAAGGGCATGATGAAGGTTCTGATCGTCGAGGACGACCCGCTGCACCGGTCCTATCTGCACGAGGCGGTCAACGCGG
CTCTGCCGGAATGCGACACG

Product: putative two-component sensor histidine kinase transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MLHLVPAAMFDHYLGISRLLAGQLDFRSAIRSVAAEVAHIIPHDHLDVCVLLEGGNYHTAYETGIETAWGGLAGAPVVNS
PIRSLLWGEVDFLLADDAMTDPRFHFEGAFKRPIVEQSLRSRLHVPMKVQGTIIAALSCSSHRASVYTMEDIERARIIAD
LLTPYFFALQAAEQAQRSAIVEAEARAREEGLRQGALKLTEALEQERQRIGMDLHDQTLADLTRLARRIDRLSRNGELAP
EALEPISRSLQHCMQDLRQIIEQAKPSVLQLFGLAQAIEHHLDRSTRDTGSGIEWGLVDETHCALERLEPTVSVALFRIA
QEAINNAVRHAAPLAVTVRLEADDDRLSIEISDDGTGLAKARGRIGGGIDNMKTRARLISARFTTGPGHNNRGTVVRVVL
PLVPNDPPSGPN

Sequences:

>Translated_412_residues
MLHLVPAAMFDHYLGISRLLAGQLDFRSAIRSVAAEVAHIIPHDHLDVCVLLEGGNYHTAYETGIETAWGGLAGAPVVNS
PIRSLLWGEVDFLLADDAMTDPRFHFEGAFKRPIVEQSLRSRLHVPMKVQGTIIAALSCSSHRASVYTMEDIERARIIAD
LLTPYFFALQAAEQAQRSAIVEAEARAREEGLRQGALKLTEALEQERQRIGMDLHDQTLADLTRLARRIDRLSRNGELAP
EALEPISRSLQHCMQDLRQIIEQAKPSVLQLFGLAQAIEHHLDRSTRDTGSGIEWGLVDETHCALERLEPTVSVALFRIA
QEAINNAVRHAAPLAVTVRLEADDDRLSIEISDDGTGLAKARGRIGGGIDNMKTRARLISARFTTGPGHNNRGTVVRVVL
PLVPNDPPSGPN
>Mature_412_residues
MLHLVPAAMFDHYLGISRLLAGQLDFRSAIRSVAAEVAHIIPHDHLDVCVLLEGGNYHTAYETGIETAWGGLAGAPVVNS
PIRSLLWGEVDFLLADDAMTDPRFHFEGAFKRPIVEQSLRSRLHVPMKVQGTIIAALSCSSHRASVYTMEDIERARIIAD
LLTPYFFALQAAEQAQRSAIVEAEARAREEGLRQGALKLTEALEQERQRIGMDLHDQTLADLTRLARRIDRLSRNGELAP
EALEPISRSLQHCMQDLRQIIEQAKPSVLQLFGLAQAIEHHLDRSTRDTGSGIEWGLVDETHCALERLEPTVSVALFRIA
QEAINNAVRHAAPLAVTVRLEADDDRLSIEISDDGTGLAKARGRIGGGIDNMKTRARLISARFTTGPGHNNRGTVVRVVL
PLVPNDPPSGPN

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=210, Percent_Identity=28.0952380952381, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 45286; Mature: 45286

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHLVPAAMFDHYLGISRLLAGQLDFRSAIRSVAAEVAHIIPHDHLDVCVLLEGGNYHTA
CCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCH
YETGIETAWGGLAGAPVVNSPIRSLLWGEVDFLLADDAMTDPRFHFEGAFKRPIVEQSLR
HHHCCHHHCCCCCCCCCHHHHHHHHHHCCHHEEEECCCCCCCCEECCCCCCCHHHHHHHH
SRLHVPMKVQGTIIAALSCSSHRASVYTMEDIERARIIADLLTPYFFALQAAEQAQRSAI
HHCCCCEEECCEEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEAEARAREEGLRQGALKLTEALEQERQRIGMDLHDQTLADLTRLARRIDRLSRNGELAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
EALEPISRSLQHCMQDLRQIIEQAKPSVLQLFGLAQAIEHHLDRSTRDTGSGIEWGLVDE
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCH
THCALERLEPTVSVALFRIAQEAINNAVRHAAPLAVTVRLEADDDRLSIEISDDGTGLAK
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEEECCCCCCHHH
ARGRIGGGIDNMKTRARLISARFTTGPGHNNRGTVVRVVLPLVPNDPPSGPN
HCCCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MLHLVPAAMFDHYLGISRLLAGQLDFRSAIRSVAAEVAHIIPHDHLDVCVLLEGGNYHTA
CCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCH
YETGIETAWGGLAGAPVVNSPIRSLLWGEVDFLLADDAMTDPRFHFEGAFKRPIVEQSLR
HHHCCHHHCCCCCCCCCHHHHHHHHHHCCHHEEEECCCCCCCCEECCCCCCCHHHHHHHH
SRLHVPMKVQGTIIAALSCSSHRASVYTMEDIERARIIADLLTPYFFALQAAEQAQRSAI
HHCCCCEEECCEEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEAEARAREEGLRQGALKLTEALEQERQRIGMDLHDQTLADLTRLARRIDRLSRNGELAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
EALEPISRSLQHCMQDLRQIIEQAKPSVLQLFGLAQAIEHHLDRSTRDTGSGIEWGLVDE
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCH
THCALERLEPTVSVALFRIAQEAINNAVRHAAPLAVTVRLEADDDRLSIEISDDGTGLAK
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEEECCCCCCHHH
ARGRIGGGIDNMKTRARLISARFTTGPGHNNRGTVVRVVLPLVPNDPPSGPN
HCCCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]