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The map label for this gene is betA [H]

Identifier: 116248958

GI number: 116248958

Start: 306748

End: 308379

Strand: Reverse

Name: betA [H]

Synonym: pRL120289

Alternate gene names: 116248958

Gene position: 308379-306748 (Counterclockwise)

Preceding gene: 116248959

Following gene: 116248952

Centisome position: 35.45

GC content: 61.09

Gene sequence:

>1632_bases
GTGAAGCTGAATAGTCATGACCAAAATGCACCCGAAAATCCGCCTATTCCTCAGCACGAGGTCGGTGATGTTTTCGACTT
CATCGTCTGCGGCGCCGGGTCCAGCGGCTCCGTTGTCGCTGCGCGACTGGCAGAGGATGGGAACGCGAGCGTTCTGCTGC
TCGAGGCGGGTGGGGACGATGCGGCCGAAACCGTTACGAACCCTGCGCAGTGGCCGCTCAATCTCGGCTCGAGCCGCGAC
TGGGGCTTTGTTGGACAACCGACCCCCGGCCTGGACGGACGACGTCTTCCTCTCAGCATGGGCAAGGGGCTCGGTGGCGG
TTCGAGCATCAATGTCATGGTGTGGGCCAGAGGACACAAGGGGGACTGGGACCACTTTGCCGCTGAAGCCGGCGATGACG
CGTGGGGCTACCAGTCGATCCTCGGCTACTATCGCCGGATCGAAGACTGGCACGGCGCTCCGGACCCAACGCGTCGCGGC
GTGGGAGGACCGGTCTACGTAGCGCAGCCGCAGGCGCCCCAACCGATCGCAGAGGCCCTGTTGCGTGCGGCATCCACTAT
CGGCATTCCCGTCTACGATAGCTCGAACGGTGAAATGATGGAGGGGCCAGGAGGGGCATCGATCGCTGAACTGCGGATCC
GCGATGGCAAGCGGGAATCCGTGTTCGGATCGTATGTCCGTCCGCTCATGTCGCGGCCGAACCTGACGGTGCTGACCGAC
GCACTGGTCACGCGGCTCATCTTCGATGGCAAGCGCGTGACGGGGATCGAGGCTCTCGTCGGTGATCAACGACGTCAATT
CATTGCGCGTTGCGAAACGGTACTGTCGCTCGGCGCGATCAACACACCGAAAGTGTTGATGCAGTCGGGCATAGGGCCGG
AAGATGATCTGCAAGCCCACGGCATTCCCGTGGTTCAACATTTACCTGGCGTTGGGCGCAATCATCAGGATCACCTCGCA
TTCGGCAGCACCTGGGCATATCGAAAACCAGAAGCCGTCGGTGGCAGTGGCTGCGAAGCAAAACTCTACTGGAAAAGCGA
CGCGCGTCTCGCCCAGCCGGACATTCTTCAGTGCCAGCTGGAGTTCGCCGTGCCGTCGCCCTTCGAGACGGGTCTCGAAA
CGCCGGAACATGGCTGGACGATGTTTAACGGCCTCGCCCAGCCGAAAAGCCGTGGTTGGCTTCGGCTCTCCGGCCCCAAC
GCAAGTGACCCTATCCTCATCGAACCCAATTCGTTGAGCGAACCAGAAGACATGGCTGCTGCCCTGGCCGCGGTGGAGCT
ATGCCGGGAATTGGGAAATAGCGACGCTTTCAAGCCGTTGGTAACGGCCGAGACTGCTCCGGGCGCGCGCAACAGATCAG
GGATGATCGACTTTATCCGGCGTTCGGCGGTCACCTACTGGCATCAATCCTGCACAGCCAAGATGGGACGCGACAGCATG
TCGGTGGTCGATAACGAGCTCAAAGTGTACGGTATTGATGGCCTTCGCATCGCAGACTCCTCGATCATGCCTCGCATCAC
CACCGGCAACACGATGGCGCCCTGTGTTGTCATCGGAGAGCGGGCGGCCGATCTGATCCGGGAAATGCATGGTCTTACGG
ACTCGAGCGGAGGGTTCAATCAGCCTATATGA

Upstream 100 bases:

>100_bases
AAATGCCGCACGATCGCTGAATTAGAACTATTGCGCGGCTTCGCCGTGAAATCCCCAGCACTTTCGCAATTTCTTTCAAT
CCATTCACGGAGGTAGTCAC

Downstream 100 bases:

>100_bases
TGAAGAGATTTATGTGGAGCTCGGCGGCCAGCATACGTGGGCCGCCGAGCTTTTTGTAGAAACGGTTTGTATATTGGTTC
AAGGCGACCAACCTCACGGC

Product: putative choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 543; Mature: 543

Protein sequence:

>543_residues
MKLNSHDQNAPENPPIPQHEVGDVFDFIVCGAGSSGSVVAARLAEDGNASVLLLEAGGDDAAETVTNPAQWPLNLGSSRD
WGFVGQPTPGLDGRRLPLSMGKGLGGGSSINVMVWARGHKGDWDHFAAEAGDDAWGYQSILGYYRRIEDWHGAPDPTRRG
VGGPVYVAQPQAPQPIAEALLRAASTIGIPVYDSSNGEMMEGPGGASIAELRIRDGKRESVFGSYVRPLMSRPNLTVLTD
ALVTRLIFDGKRVTGIEALVGDQRRQFIARCETVLSLGAINTPKVLMQSGIGPEDDLQAHGIPVVQHLPGVGRNHQDHLA
FGSTWAYRKPEAVGGSGCEAKLYWKSDARLAQPDILQCQLEFAVPSPFETGLETPEHGWTMFNGLAQPKSRGWLRLSGPN
ASDPILIEPNSLSEPEDMAAALAAVELCRELGNSDAFKPLVTAETAPGARNRSGMIDFIRRSAVTYWHQSCTAKMGRDSM
SVVDNELKVYGIDGLRIADSSIMPRITTGNTMAPCVVIGERAADLIREMHGLTDSSGGFNQPI

Sequences:

>Translated_543_residues
MKLNSHDQNAPENPPIPQHEVGDVFDFIVCGAGSSGSVVAARLAEDGNASVLLLEAGGDDAAETVTNPAQWPLNLGSSRD
WGFVGQPTPGLDGRRLPLSMGKGLGGGSSINVMVWARGHKGDWDHFAAEAGDDAWGYQSILGYYRRIEDWHGAPDPTRRG
VGGPVYVAQPQAPQPIAEALLRAASTIGIPVYDSSNGEMMEGPGGASIAELRIRDGKRESVFGSYVRPLMSRPNLTVLTD
ALVTRLIFDGKRVTGIEALVGDQRRQFIARCETVLSLGAINTPKVLMQSGIGPEDDLQAHGIPVVQHLPGVGRNHQDHLA
FGSTWAYRKPEAVGGSGCEAKLYWKSDARLAQPDILQCQLEFAVPSPFETGLETPEHGWTMFNGLAQPKSRGWLRLSGPN
ASDPILIEPNSLSEPEDMAAALAAVELCRELGNSDAFKPLVTAETAPGARNRSGMIDFIRRSAVTYWHQSCTAKMGRDSM
SVVDNELKVYGIDGLRIADSSIMPRITTGNTMAPCVVIGERAADLIREMHGLTDSSGGFNQPI
>Mature_543_residues
MKLNSHDQNAPENPPIPQHEVGDVFDFIVCGAGSSGSVVAARLAEDGNASVLLLEAGGDDAAETVTNPAQWPLNLGSSRD
WGFVGQPTPGLDGRRLPLSMGKGLGGGSSINVMVWARGHKGDWDHFAAEAGDDAWGYQSILGYYRRIEDWHGAPDPTRRG
VGGPVYVAQPQAPQPIAEALLRAASTIGIPVYDSSNGEMMEGPGGASIAELRIRDGKRESVFGSYVRPLMSRPNLTVLTD
ALVTRLIFDGKRVTGIEALVGDQRRQFIARCETVLSLGAINTPKVLMQSGIGPEDDLQAHGIPVVQHLPGVGRNHQDHLA
FGSTWAYRKPEAVGGSGCEAKLYWKSDARLAQPDILQCQLEFAVPSPFETGLETPEHGWTMFNGLAQPKSRGWLRLSGPN
ASDPILIEPNSLSEPEDMAAALAAVELCRELGNSDAFKPLVTAETAPGARNRSGMIDFIRRSAVTYWHQSCTAKMGRDSM
SVVDNELKVYGIDGLRIADSSIMPRITTGNTMAPCVVIGERAADLIREMHGLTDSSGGFNQPI

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=560, Percent_Identity=35.5357142857143, Blast_Score=293, Evalue=3e-79,
Organism=Escherichia coli, GI1786503, Length=553, Percent_Identity=35.4430379746835, Blast_Score=288, Evalue=9e-79,
Organism=Caenorhabditis elegans, GI17532301, Length=554, Percent_Identity=33.0324909747292, Blast_Score=264, Evalue=8e-71,
Organism=Drosophila melanogaster, GI24642048, Length=590, Percent_Identity=33.3898305084746, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI45551458, Length=596, Percent_Identity=31.7114093959732, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI45549471, Length=586, Percent_Identity=32.0819112627986, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24642042, Length=589, Percent_Identity=30.8998302207131, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24642059, Length=585, Percent_Identity=32.991452991453, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24650267, Length=570, Percent_Identity=31.2280701754386, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI17137792, Length=563, Percent_Identity=31.2611012433393, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24642037, Length=589, Percent_Identity=32.597623089983, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24642039, Length=572, Percent_Identity=32.3426573426573, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24642035, Length=572, Percent_Identity=31.6433566433566, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI18859995, Length=572, Percent_Identity=30.7692307692308, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24642051, Length=576, Percent_Identity=30.5555555555556, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI18859993, Length=566, Percent_Identity=30.3886925795053, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24642055, Length=313, Percent_Identity=38.6581469648562, Blast_Score=195, Evalue=8e-50,
Organism=Drosophila melanogaster, GI24645930, Length=319, Percent_Identity=29.4670846394984, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24642057, Length=328, Percent_Identity=27.7439024390244, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 58191; Mature: 58191

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNSHDQNAPENPPIPQHEVGDVFDFIVCGAGSSGSVVAARLAEDGNASVLLLEAGGDD
CCCCCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCCEEEEEECCCCCCEEEEEECCCCH
AAETVTNPAQWPLNLGSSRDWGFVGQPTPGLDGRRLPLSMGKGLGGGSSINVMVWARGHK
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCEEEEEEEECCCC
GDWDHFAAEAGDDAWGYQSILGYYRRIEDWHGAPDPTRRGVGGPVYVAQPQAPQPIAEAL
CCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCCCEEEECCCCCCHHHHHH
LRAASTIGIPVYDSSNGEMMEGPGGASIAELRIRDGKRESVFGSYVRPLMSRPNLTVLTD
HHHHHHCCEEEEECCCCCEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEHHH
ALVTRLIFDGKRVTGIEALVGDQRRQFIARCETVLSLGAINTPKVLMQSGIGPEDDLQAH
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCC
GIPVVQHLPGVGRNHQDHLAFGSTWAYRKPEAVGGSGCEAKLYWKSDARLAQPDILQCQL
CCCHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEE
EFAVPSPFETGLETPEHGWTMFNGLAQPKSRGWLRLSGPNASDPILIEPNSLSEPEDMAA
EECCCCCHHHCCCCCCCCHHHHHCCCCCCCCCEEEECCCCCCCCEEECCCCCCCHHHHHH
ALAAVELCRELGNSDAFKPLVTAETAPGARNRSGMIDFIRRSAVTYWHQSCTAKMGRDSM
HHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
SVVDNELKVYGIDGLRIADSSIMPRITTGNTMAPCVVIGERAADLIREMHGLTDSSGGFN
HHHCCCEEEEECCCEEEECCCCCCEEECCCCCCCEEEECHHHHHHHHHHHCCCCCCCCCC
QPI
CCC
>Mature Secondary Structure
MKLNSHDQNAPENPPIPQHEVGDVFDFIVCGAGSSGSVVAARLAEDGNASVLLLEAGGDD
CCCCCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCCEEEEEECCCCCCEEEEEECCCCH
AAETVTNPAQWPLNLGSSRDWGFVGQPTPGLDGRRLPLSMGKGLGGGSSINVMVWARGHK
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCEEEEEEEECCCC
GDWDHFAAEAGDDAWGYQSILGYYRRIEDWHGAPDPTRRGVGGPVYVAQPQAPQPIAEAL
CCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCCCEEEECCCCCCHHHHHH
LRAASTIGIPVYDSSNGEMMEGPGGASIAELRIRDGKRESVFGSYVRPLMSRPNLTVLTD
HHHHHHCCEEEEECCCCCEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEHHH
ALVTRLIFDGKRVTGIEALVGDQRRQFIARCETVLSLGAINTPKVLMQSGIGPEDDLQAH
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCC
GIPVVQHLPGVGRNHQDHLAFGSTWAYRKPEAVGGSGCEAKLYWKSDARLAQPDILQCQL
CCCHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEE
EFAVPSPFETGLETPEHGWTMFNGLAQPKSRGWLRLSGPNASDPILIEPNSLSEPEDMAA
EECCCCCHHHCCCCCCCCHHHHHCCCCCCCCCEEEECCCCCCCCEEECCCCCCCHHHHHH
ALAAVELCRELGNSDAFKPLVTAETAPGARNRSGMIDFIRRSAVTYWHQSCTAKMGRDSM
HHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
SVVDNELKVYGIDGLRIADSSIMPRITTGNTMAPCVVIGERAADLIREMHGLTDSSGGFN
HHHCCCEEEEECCCEEEECCCCCCEEECCCCCCCEEEECHHHHHHHHHHHCCCCCCCCCC
QPI
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA