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The map label for this gene is nhaK [H]

Identifier: 116248859

GI number: 116248859

Start: 194028

End: 195569

Strand: Direct

Name: nhaK [H]

Synonym: pRL120188

Alternate gene names: 116248859

Gene position: 194028-195569 (Clockwise)

Preceding gene: 116248856

Following gene: 116248861

Centisome position: 22.3

GC content: 63.04

Gene sequence:

>1542_bases
ATGACGTTCTTCGAAACACTTGTTGCATTGCTGGCGGTTGCCATCCTGCTGCTGCAGGTCACGCGTCGTATGCGCCTGCC
CTACCCCGGCATTCTGGCTGCCGCCGGCGTCGCCGTGGCGATGTTGCCCGGCGCGCCCACGATTCCGATCGATCCGCCGA
CGGCGCTCGCTCTGTTCATCGCGCCCGTTCTTGTCGATTCGGCCTATGACTTCCCGGTGGGCGCGGCGCGGCGCATGCTG
CTGCCGTTGTTCTTCTATGCCGTCGTCGCTGTTCTTGTTACGACAGGCGTGGTCGTGTCGATCAGCATGCTGACGGTCGG
GCTTCCGATTGCGGTTGCGGTCACACTTGGCGCAATTGTTTCGCCGCCCGATGCCGCAGCCGCCACGGCAGTCCTTTCCA
ATTTGCCGGTCGCCCGCCGTGTGGATGCTTTGCTCAAGGGAGAAAGCCTGTTCAACGACGCAACCGCGCTGCTGCTTTTT
GGCGCCGCGCTGACTGTCCAGGCGCGTGGCGGACTGGATGCCGGGACGGCGCTTCAGGTGGGGTTTGCCGCACCTGGAGG
GATCCTGTTCGGCATCGCGTTCGGTTTTTTTGTCTCGCGGCTTCGTCCGATAACCGAAAACACGGTCGGCGGGACCCTGC
TTCAATTCGTCTACGCTTTTTCGACCTGGCTGATCGCCGAACATCTGCACCTGTCGGCTGTCCTTGCCACCGTGGCGAGC
GCAATGACGCTCGCCACTCTCTCTTCGGTCAAGGATTCGCCACGGATGCGGGTGCATTCCTTCGCCGTCTGGACGACTGT
CGTCTTCCTGTTGAACGTGGTGGCTTTCCTGCTGATGGGCCTGCAGGCGCGCCGCATCCTTGAGGCGATGTCGGCCGAAG
AGCTCCAGCGGGCGATGGGATTTGCCGCCATCGTGGTGGTCGGCGTCATCCTGGCGCGCATGGCAATGGCGTTCCTGCTT
CACGCCGTCGTCGCGTCTCGCCACCGGCGCGGCGGTGAACTGGCACCTTTCACATCCGGGGAGACCTTGCTGGTGGGTTG
GGCCGGTATGCGCGGCCTCGTTACGCTGGCGACGGCCTTCGCACTCCCCGCCGATTTTCCGGAACGAGACCTGGTCGTGC
TCACGGCCTTTACGGTGGTGCTCGCAACCCTGGTCATTCAAGGAGCGACCCTGGCACCGATGATCCATTTCCTGAAACTC
GGTCGGCAGGCAGAAGTCCGCGATGAACTCAAGGCGGCCCGAAGATCGCTCGCCGAAGCTGCCTTTCTGCGGCTCGAGAA
GGAAGACGGCACTGAGGCCGAAGCGATCCGGACGATCTGCAAGGATCATTGGACCGCATCAACCGATGCAAACGAGACCT
CGCCGCTCGATCGCCGCCGTCACCTGACGATCGCGGCCGTTCTCGCCCAGCGCCAGCGCCTCGAGGAATTGCGCGACGCA
GATCAGATCGGCGCGACGCAATATCTCGAGCTGCAGGAAGACCTGGACTGGAAGCAGCTTTCCGTCGACTCGGATGAAGA
TCGCCGCATCACAGAAAGCTAG

Upstream 100 bases:

>100_bases
CTCGTAGTCCATCGTCGCCCTCATCAGCTTGATACGACACAAGCTTTACATCGGGGCGGCACCCGCTTCAATGTGCTCGA
AAGCCTGCTAGTATGCTGAA

Downstream 100 bases:

>100_bases
ATCCGATAAGGCAATTGTTGATGCCAACGCGATCGGGCATCAAAGGGTCTGTTCTCCGTCAGCCCAGCGTTTCCAACGAG
GCGGCGCGCGCTACTCGATA

Product: putative transmembrane Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MTFFETLVALLAVAILLLQVTRRMRLPYPGILAAAGVAVAMLPGAPTIPIDPPTALALFIAPVLVDSAYDFPVGAARRML
LPLFFYAVVAVLVTTGVVVSISMLTVGLPIAVAVTLGAIVSPPDAAAATAVLSNLPVARRVDALLKGESLFNDATALLLF
GAALTVQARGGLDAGTALQVGFAAPGGILFGIAFGFFVSRLRPITENTVGGTLLQFVYAFSTWLIAEHLHLSAVLATVAS
AMTLATLSSVKDSPRMRVHSFAVWTTVVFLLNVVAFLLMGLQARRILEAMSAEELQRAMGFAAIVVVGVILARMAMAFLL
HAVVASRHRRGGELAPFTSGETLLVGWAGMRGLVTLATAFALPADFPERDLVVLTAFTVVLATLVIQGATLAPMIHFLKL
GRQAEVRDELKAARRSLAEAAFLRLEKEDGTEAEAIRTICKDHWTASTDANETSPLDRRRHLTIAAVLAQRQRLEELRDA
DQIGATQYLELQEDLDWKQLSVDSDEDRRITES

Sequences:

>Translated_513_residues
MTFFETLVALLAVAILLLQVTRRMRLPYPGILAAAGVAVAMLPGAPTIPIDPPTALALFIAPVLVDSAYDFPVGAARRML
LPLFFYAVVAVLVTTGVVVSISMLTVGLPIAVAVTLGAIVSPPDAAAATAVLSNLPVARRVDALLKGESLFNDATALLLF
GAALTVQARGGLDAGTALQVGFAAPGGILFGIAFGFFVSRLRPITENTVGGTLLQFVYAFSTWLIAEHLHLSAVLATVAS
AMTLATLSSVKDSPRMRVHSFAVWTTVVFLLNVVAFLLMGLQARRILEAMSAEELQRAMGFAAIVVVGVILARMAMAFLL
HAVVASRHRRGGELAPFTSGETLLVGWAGMRGLVTLATAFALPADFPERDLVVLTAFTVVLATLVIQGATLAPMIHFLKL
GRQAEVRDELKAARRSLAEAAFLRLEKEDGTEAEAIRTICKDHWTASTDANETSPLDRRRHLTIAAVLAQRQRLEELRDA
DQIGATQYLELQEDLDWKQLSVDSDEDRRITES
>Mature_512_residues
TFFETLVALLAVAILLLQVTRRMRLPYPGILAAAGVAVAMLPGAPTIPIDPPTALALFIAPVLVDSAYDFPVGAARRMLL
PLFFYAVVAVLVTTGVVVSISMLTVGLPIAVAVTLGAIVSPPDAAAATAVLSNLPVARRVDALLKGESLFNDATALLLFG
AALTVQARGGLDAGTALQVGFAAPGGILFGIAFGFFVSRLRPITENTVGGTLLQFVYAFSTWLIAEHLHLSAVLATVASA
MTLATLSSVKDSPRMRVHSFAVWTTVVFLLNVVAFLLMGLQARRILEAMSAEELQRAMGFAAIVVVGVILARMAMAFLLH
AVVASRHRRGGELAPFTSGETLLVGWAGMRGLVTLATAFALPADFPERDLVVLTAFTVVLATLVIQGATLAPMIHFLKLG
RQAEVRDELKAARRSLAEAAFLRLEKEDGTEAEAIRTICKDHWTASTDANETSPLDRRRHLTIAAVLAQRQRLEELRDAD
QIGATQYLELQEDLDWKQLSVDSDEDRRITES

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=406, Percent_Identity=25.1231527093596, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI194239733, Length=380, Percent_Identity=25, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4759144, Length=399, Percent_Identity=25.5639097744361, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790501, Length=539, Percent_Identity=26.1595547309833, Blast_Score=133, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71980847, Length=427, Percent_Identity=20.1405152224824, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25147678, Length=439, Percent_Identity=22.0956719817768, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71999817, Length=514, Percent_Identity=20.2334630350195, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71999821, Length=483, Percent_Identity=19.8757763975155, Blast_Score=65, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI71999819, Length=468, Percent_Identity=20.2991452991453, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI281360447, Length=424, Percent_Identity=21.2264150943396, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221510738, Length=389, Percent_Identity=21.8508997429306, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI221510734, Length=389, Percent_Identity=22.107969151671, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI221510736, Length=389, Percent_Identity=21.8508997429306, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221510732, Length=389, Percent_Identity=21.8508997429306, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24585580, Length=389, Percent_Identity=21.8508997429306, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24585578, Length=389, Percent_Identity=21.8508997429306, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221510740, Length=389, Percent_Identity=21.8508997429306, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 54868; Mature: 54737

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCHHHHHHHHCCCHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TFFETLVALLAVAILLLQVTRRMRLPYPGILAAAGVAVAMLPGAPTIPIDPPTALALFI
CHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH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HHCCCHHHHHHHHCCCHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA