Click here to switch to the map view.

The map label for this gene is hbpA [H]

Identifier: 116248805

GI number: 116248805

Start: 131542

End: 133221

Strand: Reverse

Name: hbpA [H]

Synonym: pRL120131

Alternate gene names: 116248805

Gene position: 133221-131542 (Counterclockwise)

Preceding gene: 116248806

Following gene: 116248804

Centisome position: 15.31

GC content: 58.15

Gene sequence:

>1680_bases
ATGACTACCGTGGACAAGTCTCAGCATTCCTATATCCCGACTCTGGTCGAACAGATGTCGAGCGGCTCGATCGGCCGCCG
AGAATTTCTGCGTAAAGCGACGCTTCTTGGTGTTTCGGCCGCAGCCGCATATTCTCTGGCCGGCGTTCCAATGCCGGGCG
ACGGCGCCCGGGCCGACGATATGCCCAAGGGCGGAAACCTGCGCATCGGCATGCGTTGCATGGAAATCAAGGATCCGCAT
CTGGCGGATTTCGCCGAAAAGTCGAACGTGATCCGCCAGGTCTGCGAGTATCTCACCCTCACGGACCGCAACAACATCAC
TCATCCCTACCTGCTGGAAAAATGGGAAGTCAGCGACGACCTGAAGACGTGGACCCTACACGTGCGCAAGGACGTCAAGT
GGCGCAAGGGCAGGCCGCTGACGGCTGACGATGTGATCTGGAACCTGAAGCGCGTCTGCGATCCAGCCATCGGCTCGTCG
ATGCTCGGGCTCTTCACCGGCTACCTCATGCAGGAATACGAAACCGGCGAAAAGGACGAGAAGGGCAATCCCAAGAAGTC
GAGCAAGCTCTGGGCCGACAACGCCATCGAGAAGGTCGACGATCACACTGTCCGCCTCAACTGCTCCTCGCCGCAAATTG
CCGTGCCCGAGCATCTCTATCACTACCCGATGTTCATCATCGATCCGGAAGAAAATGGCGCCTTCGGTGCGGATGCGAAC
GGCACGGGTCCCTTCGTTATCACCGAGTATGTCGTCGGCAAAGGTGCCAAGTACAAAGCGCGCACCGACTATTGGGGCAC
TGGCCCCTATCTCGACACGTTCGAATATGTCGACCTCGGCGACAATCCAGGTGCAGGTATCGCGGCAATGGCCTCCAAGC
AGGTCGATGGCCTGTCGGAAGCCGATGCCGTTCAGATCAATGCGATGAAAAATTTCCCGCATGTCGCCGTTTATCAGGTC
GAGACGACCCAGACGGTCGTCGCCCGCATGCATCCCGATATCGACCAGTTCAAGGACAAACGCGTGCGCCAGGCGATGCG
TTATGCGATCGACCGCGATAAGGTCATTCAGACGGCACTTCTCGGTGCCGGCATTCCTGCCGAAGATCATCACGTCGCGC
CCTCGCATCCGGAATATGCGGCGTTGCCGAAATACCCCCGCGACATCGAGAAAGCGAAGAAGCTTCTGGCCGATGCCGGC
TATCCGGATGGTTTCGAATTCGACATGGTCACGCGTCCCGATCCGATCTGGGAACTGAACACGGCGCAGGTCCTCGCCGA
ACAGTTCAAGGACATCGGTGTCAAGATCAACATCAAGTCCCTGCCCAGCGCCCAATATTGGGAAGTCTGGACGACTGCTC
CCTTCAGCCTGACCGCGTGGGGCCACCGGCCGCTGGCAATCATGACACTGTCGCTTGCCTATCGTTCGAATGCCGCCTGG
AACGAGTCCAACTATTCCAACGCGGATTTCGACAAGCTGCTGACCGAGGCCGAGGGTATCCTTGATCCAAAGGAACGCAG
CAAGGTGATGGCGAAAATCGAGGCGATCATGCAGGACGACGGGCCGATCGTTCAGCCCTTCTGGCGTGTTTTCTCGACCG
TCATGGACAAGAAGGTCAAGGGCTTTGAGCTCCATCCTTCGCAATACATCTTCGCGCATCAGTACGCGATCTCGGCGTAA

Upstream 100 bases:

>100_bases
GTGACGGACAAAAGTCCGCTGCGACCGAGCCTGGGGCGAGTGTCTTGCCGGCCGGTCCGACCAACAAAAATTCGGAACAG
TTAAAGCGCTAAACTAGGAG

Downstream 100 bases:

>100_bases
CCTCCCGGCTGGCGCCTGGCCGCGTTCGCGCGGTCGGGTGCTAGGCCCAGTCAGCGGATTCCTCCGGCTATGGCGACATT
TCTCCTGAAACGCTTGGCGA

Product: putative substrate binding component of ABC transporter

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Hemin-binding lipoprotein [H]

Number of amino acids: Translated: 559; Mature: 558

Protein sequence:

>559_residues
MTTVDKSQHSYIPTLVEQMSSGSIGRREFLRKATLLGVSAAAAYSLAGVPMPGDGARADDMPKGGNLRIGMRCMEIKDPH
LADFAEKSNVIRQVCEYLTLTDRNNITHPYLLEKWEVSDDLKTWTLHVRKDVKWRKGRPLTADDVIWNLKRVCDPAIGSS
MLGLFTGYLMQEYETGEKDEKGNPKKSSKLWADNAIEKVDDHTVRLNCSSPQIAVPEHLYHYPMFIIDPEENGAFGADAN
GTGPFVITEYVVGKGAKYKARTDYWGTGPYLDTFEYVDLGDNPGAGIAAMASKQVDGLSEADAVQINAMKNFPHVAVYQV
ETTQTVVARMHPDIDQFKDKRVRQAMRYAIDRDKVIQTALLGAGIPAEDHHVAPSHPEYAALPKYPRDIEKAKKLLADAG
YPDGFEFDMVTRPDPIWELNTAQVLAEQFKDIGVKINIKSLPSAQYWEVWTTAPFSLTAWGHRPLAIMTLSLAYRSNAAW
NESNYSNADFDKLLTEAEGILDPKERSKVMAKIEAIMQDDGPIVQPFWRVFSTVMDKKVKGFELHPSQYIFAHQYAISA

Sequences:

>Translated_559_residues
MTTVDKSQHSYIPTLVEQMSSGSIGRREFLRKATLLGVSAAAAYSLAGVPMPGDGARADDMPKGGNLRIGMRCMEIKDPH
LADFAEKSNVIRQVCEYLTLTDRNNITHPYLLEKWEVSDDLKTWTLHVRKDVKWRKGRPLTADDVIWNLKRVCDPAIGSS
MLGLFTGYLMQEYETGEKDEKGNPKKSSKLWADNAIEKVDDHTVRLNCSSPQIAVPEHLYHYPMFIIDPEENGAFGADAN
GTGPFVITEYVVGKGAKYKARTDYWGTGPYLDTFEYVDLGDNPGAGIAAMASKQVDGLSEADAVQINAMKNFPHVAVYQV
ETTQTVVARMHPDIDQFKDKRVRQAMRYAIDRDKVIQTALLGAGIPAEDHHVAPSHPEYAALPKYPRDIEKAKKLLADAG
YPDGFEFDMVTRPDPIWELNTAQVLAEQFKDIGVKINIKSLPSAQYWEVWTTAPFSLTAWGHRPLAIMTLSLAYRSNAAW
NESNYSNADFDKLLTEAEGILDPKERSKVMAKIEAIMQDDGPIVQPFWRVFSTVMDKKVKGFELHPSQYIFAHQYAISA
>Mature_558_residues
TTVDKSQHSYIPTLVEQMSSGSIGRREFLRKATLLGVSAAAAYSLAGVPMPGDGARADDMPKGGNLRIGMRCMEIKDPHL
ADFAEKSNVIRQVCEYLTLTDRNNITHPYLLEKWEVSDDLKTWTLHVRKDVKWRKGRPLTADDVIWNLKRVCDPAIGSSM
LGLFTGYLMQEYETGEKDEKGNPKKSSKLWADNAIEKVDDHTVRLNCSSPQIAVPEHLYHYPMFIIDPEENGAFGADANG
TGPFVITEYVVGKGAKYKARTDYWGTGPYLDTFEYVDLGDNPGAGIAAMASKQVDGLSEADAVQINAMKNFPHVAVYQVE
TTQTVVARMHPDIDQFKDKRVRQAMRYAIDRDKVIQTALLGAGIPAEDHHVAPSHPEYAALPKYPRDIEKAKKLLADAGY
PDGFEFDMVTRPDPIWELNTAQVLAEQFKDIGVKINIKSLPSAQYWEVWTTAPFSLTAWGHRPLAIMTLSLAYRSNAAWN
ESNYSNADFDKLLTEAEGILDPKERSKVMAKIEAIMQDDGPIVQPFWRVFSTVMDKKVKGFELHPSQYIFAHQYAISA

Specific function: Important role in heme acquisition or metabolism [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=465, Percent_Identity=26.2365591397849, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1787495, Length=549, Percent_Identity=24.408014571949, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1789397, Length=505, Percent_Identity=22.7722772277228, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI1787052, Length=493, Percent_Identity=22.7180527383367, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787762, Length=457, Percent_Identity=21.2253829321663, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1787551, Length=273, Percent_Identity=21.978021978022, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081878, Length=487, Percent_Identity=21.5605749486653, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 62573; Mature: 62441

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVDKSQHSYIPTLVEQMSSGSIGRREFLRKATLLGVSAAAAYSLAGVPMPGDGARADD
CCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
MPKGGNLRIGMRCMEIKDPHLADFAEKSNVIRQVCEYLTLTDRNNITHPYLLEKWEVSDD
CCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHEEECCCCCC
LKTWTLHVRKDVKWRKGRPLTADDVIWNLKRVCDPAIGSSMLGLFTGYLMQEYETGEKDE
CEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCC
KGNPKKSSKLWADNAIEKVDDHTVRLNCSSPQIAVPEHLYHYPMFIIDPEENGAFGADAN
CCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCEECCHHHHHCCEEEEECCCCCCCCCCCC
GTGPFVITEYVVGKGAKYKARTDYWGTGPYLDTFEYVDLGDNPGAGIAAMASKQVDGLSE
CCCCEEEEEHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCC
ADAVQINAMKNFPHVAVYQVETTQTVVARMHPDIDQFKDKRVRQAMRYAIDRDKVIQTAL
CCEEEEEEECCCCCEEEEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHH
LGAGIPAEDHHVAPSHPEYAALPKYPRDIEKAKKLLADAGYPDGFEFDMVTRPDPIWELN
HHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEECC
TAQVLAEQFKDIGVKINIKSLPSAQYWEVWTTAPFSLTAWGHRPLAIMTLSLAYRSNAAW
HHHHHHHHHHHCCEEEEECCCCCCCCEEEEECCCCEEECCCCCCEEEEEEEHHHHCCCCC
NESNYSNADFDKLLTEAEGILDPKERSKVMAKIEAIMQDDGPIVQPFWRVFSTVMDKKVK
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
GFELHPSQYIFAHQYAISA
CEEECCCCEEEEEEEEECC
>Mature Secondary Structure 
TTVDKSQHSYIPTLVEQMSSGSIGRREFLRKATLLGVSAAAAYSLAGVPMPGDGARADD
CCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
MPKGGNLRIGMRCMEIKDPHLADFAEKSNVIRQVCEYLTLTDRNNITHPYLLEKWEVSDD
CCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHEEECCCCCC
LKTWTLHVRKDVKWRKGRPLTADDVIWNLKRVCDPAIGSSMLGLFTGYLMQEYETGEKDE
CEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCC
KGNPKKSSKLWADNAIEKVDDHTVRLNCSSPQIAVPEHLYHYPMFIIDPEENGAFGADAN
CCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCEECCHHHHHCCEEEEECCCCCCCCCCCC
GTGPFVITEYVVGKGAKYKARTDYWGTGPYLDTFEYVDLGDNPGAGIAAMASKQVDGLSE
CCCCEEEEEHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCC
ADAVQINAMKNFPHVAVYQVETTQTVVARMHPDIDQFKDKRVRQAMRYAIDRDKVIQTAL
CCEEEEEEECCCCCEEEEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHH
LGAGIPAEDHHVAPSHPEYAALPKYPRDIEKAKKLLADAGYPDGFEFDMVTRPDPIWELN
HHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEECC
TAQVLAEQFKDIGVKINIKSLPSAQYWEVWTTAPFSLTAWGHRPLAIMTLSLAYRSNAAW
HHHHHHHHHHHCCEEEEECCCCCCCCEEEEECCCCEEECCCCCCEEEEEEEHHHHCCCCC
NESNYSNADFDKLLTEAEGILDPKERSKVMAKIEAIMQDDGPIVQPFWRVFSTVMDKKVK
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
GFELHPSQYIFAHQYAISA
CEEECCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339409; 7542800; 2041470 [H]