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The map label for this gene is lrp [H]

Identifier: 116248721

GI number: 116248721

Start: 45110

End: 45607

Strand: Reverse

Name: lrp [H]

Synonym: pRL120045

Alternate gene names: 116248721

Gene position: 45607-45110 (Counterclockwise)

Preceding gene: 116248732

Following gene: 116248720

Centisome position: 5.24

GC content: 64.26

Gene sequence:

>498_bases
ATGAAGCTCGACGCCATCGACCTGCGCATTCTCGACGCCGTCCAGCGCGACGGCCGCATCACCAAACTGGCGCTCGCCGA
AAAGGCCGGCCTGTCGCCGACGCCATGCTGGATGCGGCTGCGCAAGCTCGAAAAGGCCGGGATCATCACCGGCTATCACG
CACGCATCGCGCCGCGGCGCATCGCGCCGGTCGCCAGCGTGATGATGGAAGTGACGCTCGCCAACCATCGCCAGGCGGAT
TTCGAGCGCTTCGAGCGCGCCATCAGCGCAGTCCCGGAGGTCGTCTCCTGCTGGTCGGTCGGCGGCGGCGTCGATTATAT
CCTGAAGATCATCGCACCCGATATCGACGCCTATCAGCGGCTGGTCGACGGGCTTCTCGACCGCGAACTCGGCATCGACC
GCTACTTCACCTACATCGTCACCAAGACGGTGAAGGAGGACACCGTCCTTCCGGTCTCTTCCTTCACTGCCACCGATGAA
GAACAGAGCGCGCCGTAG

Upstream 100 bases:

>100_bases
ATTTCAACACTGCTGAAAATCAGTTCAATTGACAATGCCAAAATGCGCTCCCATTGTCTTTTCCCTGCGTTTGAAATGAA
TTCTTTCTAAAGAAAGCACC

Downstream 100 bases:

>100_bases
ACAATCTCTCTGCCAGGCCGCCGTCCTTTAGACCATCTCTCTCTTTTCGCATCCGCCAACAGACAATCTCTCGCCCGCTC
CCGTGGAAGACTGACGTCAA

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MKLDAIDLRILDAVQRDGRITKLALAEKAGLSPTPCWMRLRKLEKAGIITGYHARIAPRRIAPVASVMMEVTLANHRQAD
FERFERAISAVPEVVSCWSVGGGVDYILKIIAPDIDAYQRLVDGLLDRELGIDRYFTYIVTKTVKEDTVLPVSSFTATDE
EQSAP

Sequences:

>Translated_165_residues
MKLDAIDLRILDAVQRDGRITKLALAEKAGLSPTPCWMRLRKLEKAGIITGYHARIAPRRIAPVASVMMEVTLANHRQAD
FERFERAISAVPEVVSCWSVGGGVDYILKIIAPDIDAYQRLVDGLLDRELGIDRYFTYIVTKTVKEDTVLPVSSFTATDE
EQSAP
>Mature_165_residues
MKLDAIDLRILDAVQRDGRITKLALAEKAGLSPTPCWMRLRKLEKAGIITGYHARIAPRRIAPVASVMMEVTLANHRQAD
FERFERAISAVPEVVSCWSVGGGVDYILKIIAPDIDAYQRLVDGLLDRELGIDRYFTYIVTKTVKEDTVLPVSSFTATDE
EQSAP

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=152, Percent_Identity=38.8157894736842, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=29.3333333333333, Blast_Score=87, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18374; Mature: 18374

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDAIDLRILDAVQRDGRITKLALAEKAGLSPTPCWMRLRKLEKAGIITGYHARIAPRR
CCCCHHHHHHHHHHHCCCCEEHHHHHHHCCCCCCHHHHHHHHHHHHCCEECHHHHCCCHH
IAPVASVMMEVTLANHRQADFERFERAISAVPEVVSCWSVGGGVDYILKIIAPDIDAYQR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHH
LVDGLLDRELGIDRYFTYIVTKTVKEDTVLPVSSFTATDEEQSAP
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKLDAIDLRILDAVQRDGRITKLALAEKAGLSPTPCWMRLRKLEKAGIITGYHARIAPRR
CCCCHHHHHHHHHHHCCCCEEHHHHHHHCCCCCCHHHHHHHHHHHHCCEECHHHHCCCHH
IAPVASVMMEVTLANHRQADFERFERAISAVPEVVSCWSVGGGVDYILKIIAPDIDAYQR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHH
LVDGLLDRELGIDRYFTYIVTKTVKEDTVLPVSSFTATDEEQSAP
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]