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The map label for this gene is fabG [C]

Identifier: 114800537

GI number: 114800537

Start: 3274957

End: 3275874

Strand: Direct

Name: fabG [C]

Synonym: HNE_3099

Alternate gene names: 114800537

Gene position: 3274957-3275874 (Clockwise)

Preceding gene: 114798533

Following gene: 114799815

Centisome position: 88.39

GC content: 63.62

Gene sequence:

>918_bases
ATGGGTGTTCTCGACGGGAAGGTCGTTCTGGTTACAGGCGGCGGCAACGGCATCGGCAAGGAAACAGCGCTTCTGGCCGC
GCGCGAAGGCGCCAAAGTGCTGGTCAACGATCTCGGCGGCGGCCTGAAAGGCGGCGACGAGGGCGATGCAGGCCCGGCAG
AGGCGGTCGCAGCGGAAATCCGCGCCGCAGGCGGGGAAGCGGCCTCCAACTCCGAAAGCGTGACCGAATACAGCGCCGTC
GCCAATATGGTGACCCAGGCGCTCGACACGTTCGGCCGCCTCGATTCGATCATCAACCCGGCCGGCATCCTGCGTGACGG
CATGTTCCACAAGATGAGCGAAGCCGACTGGAAAGCCGTGATCGATGTTCACCTGCATGGCTCCTACAATGTCGGCCGCG
CGGCGGTTGAATATTTCCGCGAGAGCGAGCGCGGCTCTTACGTGTTCTTCACCTCCACCTCCGGCCTGATCGGCAATATC
GGCCAGGCAAACTATGCCGCCGCCAAGCTCGGCATTGTTGGCCTTTCCCGCATTCTGGCGATGGAAGGGGCGGCGAAAAA
CATCCGCTCCAACGTGATTGCGCCGTTTGCCTGGACGCGGATGATTGCCTCGATCCCGGTGAAGGATGAAGCCAGCGCCC
AGCGGGTTGAGCGGATGAAGAACGGCATGCGCGCCGATCAGGTGGCGCAGCTGGCCGTGGCGCTCTGCTCGGATCAGTCG
TCCAACGTCTCGGGTCAGATTTTCGGCGTGCGCGGCAATGAAGTGATCCTCTTCGACCAGCCCCGCCCGGTGAAATCGCT
GGCGCGGATGGAGGGGTGGAACCCCGAAAGCCTGATCAGCCAGGCCTTCCCGGCGATGAGCCCGGACTTTACCGATCTGG
GGGCGACGGCGAGCGTGTTTCCTTACGAGCCGATCTGA

Upstream 100 bases:

>100_bases
GCCCGGCCTGCGCGGTATTTCAAACCTTGATTTTCTCCCCGCCCCTTGCGGGCCCGCTTCTGGCCGGTAGTGTCCCGCCC
GAACCAATAAGGAGGAAGTC

Downstream 100 bases:

>100_bases
TCGGCAGCAGTTTTGGCCGGCGCAGCCCTTGGGCTGTCCGGCGAAAACCTCTCTCCCCGGTGATCCGGGGACGGAAAATT
GCTTCAAGACGTATCGGGGT

Product: short chain dehydrogenase/reductase family oxidoreductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MGVLDGKVVLVTGGGNGIGKETALLAAREGAKVLVNDLGGGLKGGDEGDAGPAEAVAAEIRAAGGEAASNSESVTEYSAV
ANMVTQALDTFGRLDSIINPAGILRDGMFHKMSEADWKAVIDVHLHGSYNVGRAAVEYFRESERGSYVFFTSTSGLIGNI
GQANYAAAKLGIVGLSRILAMEGAAKNIRSNVIAPFAWTRMIASIPVKDEASAQRVERMKNGMRADQVAQLAVALCSDQS
SNVSGQIFGVRGNEVILFDQPRPVKSLARMEGWNPESLISQAFPAMSPDFTDLGATASVFPYEPI

Sequences:

>Translated_305_residues
MGVLDGKVVLVTGGGNGIGKETALLAAREGAKVLVNDLGGGLKGGDEGDAGPAEAVAAEIRAAGGEAASNSESVTEYSAV
ANMVTQALDTFGRLDSIINPAGILRDGMFHKMSEADWKAVIDVHLHGSYNVGRAAVEYFRESERGSYVFFTSTSGLIGNI
GQANYAAAKLGIVGLSRILAMEGAAKNIRSNVIAPFAWTRMIASIPVKDEASAQRVERMKNGMRADQVAQLAVALCSDQS
SNVSGQIFGVRGNEVILFDQPRPVKSLARMEGWNPESLISQAFPAMSPDFTDLGATASVFPYEPI
>Mature_304_residues
GVLDGKVVLVTGGGNGIGKETALLAAREGAKVLVNDLGGGLKGGDEGDAGPAEAVAAEIRAAGGEAASNSESVTEYSAVA
NMVTQALDTFGRLDSIINPAGILRDGMFHKMSEADWKAVIDVHLHGSYNVGRAAVEYFRESERGSYVFFTSTSGLIGNIG
QANYAAAKLGIVGLSRILAMEGAAKNIRSNVIAPFAWTRMIASIPVKDEASAQRVERMKNGMRADQVAQLAVALCSDQSS
NVSGQIFGVRGNEVILFDQPRPVKSLARMEGWNPESLISQAFPAMSPDFTDLGATASVFPYEPI

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=247, Percent_Identity=44.5344129554656, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI15277342, Length=259, Percent_Identity=32.4324324324324, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI40254992, Length=201, Percent_Identity=35.8208955223881, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4758504, Length=220, Percent_Identity=30, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI10190704, Length=282, Percent_Identity=28.7234042553192, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI4503817, Length=192, Percent_Identity=27.6041666666667, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI66933014, Length=253, Percent_Identity=26.8774703557312, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI83715985, Length=221, Percent_Identity=28.0542986425339, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI19923817, Length=276, Percent_Identity=26.0869565217391, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI32483357, Length=257, Percent_Identity=24.9027237354086, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=252, Percent_Identity=30.5555555555556, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=31.0077519379845, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786812, Length=264, Percent_Identity=29.1666666666667, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=26.3779527559055, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787905, Length=252, Percent_Identity=30.5555555555556, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI2367175, Length=258, Percent_Identity=32.1705426356589, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790717, Length=252, Percent_Identity=27.7777777777778, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87082160, Length=256, Percent_Identity=25, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787526, Length=199, Percent_Identity=29.6482412060301, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788459, Length=259, Percent_Identity=25.0965250965251, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789057, Length=269, Percent_Identity=25.2788104089219, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=246, Percent_Identity=42.2764227642276, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25147288, Length=255, Percent_Identity=32.156862745098, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17555706, Length=254, Percent_Identity=33.0708661417323, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17560676, Length=256, Percent_Identity=28.515625, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17538182, Length=216, Percent_Identity=34.7222222222222, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17564282, Length=196, Percent_Identity=26.530612244898, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17544670, Length=223, Percent_Identity=29.1479820627803, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=266, Percent_Identity=27.0676691729323, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=272, Percent_Identity=25.7352941176471, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=193, Percent_Identity=27.4611398963731, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17567345, Length=203, Percent_Identity=27.5862068965517, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=192, Percent_Identity=25.5208333333333, Blast_Score=64, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=192, Percent_Identity=25.5208333333333, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=286, Percent_Identity=39.1608391608392, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324126, Length=255, Percent_Identity=27.843137254902, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI18859837, Length=287, Percent_Identity=39.0243902439024, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24639444, Length=258, Percent_Identity=36.046511627907, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17737361, Length=221, Percent_Identity=31.6742081447964, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI23397609, Length=256, Percent_Identity=28.125, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640492, Length=199, Percent_Identity=26.6331658291457, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI281364892, Length=195, Percent_Identity=27.1794871794872, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24644339, Length=190, Percent_Identity=27.3684210526316, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21356301, Length=192, Percent_Identity=27.6041666666667, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 31983; Mature: 31851

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVLDGKVVLVTGGGNGIGKETALLAAREGAKVLVNDLGGGLKGGDEGDAGPAEAVAAEI
CCCCCCEEEEEECCCCCCCCHHHHEECCCCCEEEHHHCCCCCCCCCCCCCCHHHHHHHHH
RAAGGEAASNSESVTEYSAVANMVTQALDTFGRLDSIINPAGILRDGMFHKMSEADWKAV
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEE
IDVHLHGSYNVGRAAVEYFRESERGSYVFFTSTSGLIGNIGQANYAAAKLGIVGLSRILA
EEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
MEGAAKNIRSNVIAPFAWTRMIASIPVKDEASAQRVERMKNGMRADQVAQLAVALCSDQS
HHCHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
SNVSGQIFGVRGNEVILFDQPRPVKSLARMEGWNPESLISQAFPAMSPDFTDLGATASVF
CCCCEEEEEECCCEEEEECCCCCHHHHHHHCCCCHHHHHHHHCCCCCCCCHHCCCCCCCC
PYEPI
CCCCC
>Mature Secondary Structure 
GVLDGKVVLVTGGGNGIGKETALLAAREGAKVLVNDLGGGLKGGDEGDAGPAEAVAAEI
CCCCCEEEEEECCCCCCCCHHHHEECCCCCEEEHHHCCCCCCCCCCCCCCHHHHHHHHH
RAAGGEAASNSESVTEYSAVANMVTQALDTFGRLDSIINPAGILRDGMFHKMSEADWKAV
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEE
IDVHLHGSYNVGRAAVEYFRESERGSYVFFTSTSGLIGNIGQANYAAAKLGIVGLSRILA
EEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
MEGAAKNIRSNVIAPFAWTRMIASIPVKDEASAQRVERMKNGMRADQVAQLAVALCSDQS
HHCHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
SNVSGQIFGVRGNEVILFDQPRPVKSLARMEGWNPESLISQAFPAMSPDFTDLGATASVF
CCCCEEEEEECCCEEEEECCCCCHHHHHHHCCCCHHHHHHHHCCCCCCCCHHCCCCCCCC
PYEPI
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]