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The map label for this gene is ethA [H]

Identifier: 114800504

GI number: 114800504

Start: 3362042

End: 3363541

Strand: Direct

Name: ethA [H]

Synonym: HNE_3188

Alternate gene names: 114800504

Gene position: 3362042-3363541 (Clockwise)

Preceding gene: 114797941

Following gene: 114799920

Centisome position: 90.74

GC content: 60.67

Gene sequence:

>1500_bases
ATGACCCAGCTCGACACAGACATCCTCATCATCGGCGCCGGCCTCTCCGGCATTGGCGCCGCCGTCCACCTCACCAAGCG
CAGCCCCGGCAAGCGCTACCGCATCTATGAGGCGCGCGACGCCATCGGCGGCACCTGGGATCTCTTCCGCTATCCCGGCA
TCCGCTCGGATTCGGACATGCACACGCTGGGCTATAATTTCAAACCCTGGACGGACGCCAAAGCCATCGCAGACGGCCCC
TCCATCCGCCGCTATGTGAACACCACGGCCGATGAATACGGCGTCCGCAAGAACATCTCGTTCAATACCAAGATCGTGGC
CGCCGACTGGTCGAGCGCCGATCAGGCATGGACCGTCACCAGCGAGAACGTAAAGACCGGCGCGCAGGAGAAAACCACCT
GCCGGTTCCTCTTCATGTGCGGGGGCTATTACAGCTATGACAAAGGCTACCGCCCGGATTTCCCCGGCGAGGAAGCCTTC
CGGGGCCAGATCATCCACCCGCAACACTGGCCCGAAGATCTCGACTATTCGGGCAAGAAAGTTGTCGTGATTGGCTCTGG
CGCCACAGCGATGACGCTGGTGCCCTCGATGGCGGAGAAAGCCGGGCATGTCACGATGCTGCAACGCTCGCCCACCTATG
TGGTCTCGCGCCCGGCTATGGACGGCTTTGCCAACTTCCTGCGCAAGGTCCTGCCCGATCAGTGGGCCTATAATCTCATC
CGCTGGCGGAACGTTGCCTTCCAGCAATTCTTCTTCCGCCAGACGCGCACGAACCCGGCCAAGGCGCGTGAGCGCCTTCT
TGGCATGGTGCGCGAAGAGCTTGGCCCAGACTATGATGTCGATAAACACTTCACGCCCACCTACAATCCGTGGGAACAGC
GCCTCTGTCTCGTTCCGGACTCGGACCTTTTCAATTCCCTGAAATCGGGCAAGGCCAGCATCGAGACCGATCATATCGAG
CGGTTTACCGAAACCGGCATCCTGCTCAAATCCGGCAAGGAACTTCCCGCCGACATCATCGTGACGGCCACCGGCCTCAA
CCTCATTTTCATGAACGGGGTGAATGTCTCGCTGGACGGCGCCAAGGTCGATCCCGGCCGGCTGCTCAACTACAAAGGCG
TGATGCTGTCCAACGTGCCAAACCTGGCCGTCACCTTCGGTTACACCAACGCCTCCTGGACGCTGAAAGCCGACCTCACC
AGCGAATATGTCAGCCGCCTGATCAATCTGATGGACGAGAAAGGCGCAACCTCCGCGATGCCCTATCTCGCCGCCTTCCC
GAACGAGACCGAGCCGTTCGTGGACTTTTCCTCCGGCTACTTCCAGCGCGTCATGGACCAGTTCCCGCGCCAGCACACAG
AAGCGCCCTGGAAGCTGAACCAGAACTATTTCGTCGACCGGAAAAACCTGCGCGACCTCCCCATCGAGGACGGCGTGATG
CAGTTCCACATTCCTGCCGCCGCCACCAAGCCCAAACCGGCATTGCAAGCGGCGGAATAG

Upstream 100 bases:

>100_bases
CCGGACAGCCCCGATTATGACATGGCCCGTGCCCGATTATTTTCGGTGACGCGTGCGTCACCTATTTTAATCTGCGCAAA
ATCGCGTAGTCTCCCGGCCC

Downstream 100 bases:

>100_bases
CTGGCCAAGGAGGATAGGCGCGCGCCTATCCTCCGTCCGCACACCCCCTCAACGTGTCACCCCGGAATTTGCGCAGCAAA
TATCCGGGACCCAGAATCTA

Product: hypothetical protein

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MTQLDTDILIIGAGLSGIGAAVHLTKRSPGKRYRIYEARDAIGGTWDLFRYPGIRSDSDMHTLGYNFKPWTDAKAIADGP
SIRRYVNTTADEYGVRKNISFNTKIVAADWSSADQAWTVTSENVKTGAQEKTTCRFLFMCGGYYSYDKGYRPDFPGEEAF
RGQIIHPQHWPEDLDYSGKKVVVIGSGATAMTLVPSMAEKAGHVTMLQRSPTYVVSRPAMDGFANFLRKVLPDQWAYNLI
RWRNVAFQQFFFRQTRTNPAKARERLLGMVREELGPDYDVDKHFTPTYNPWEQRLCLVPDSDLFNSLKSGKASIETDHIE
RFTETGILLKSGKELPADIIVTATGLNLIFMNGVNVSLDGAKVDPGRLLNYKGVMLSNVPNLAVTFGYTNASWTLKADLT
SEYVSRLINLMDEKGATSAMPYLAAFPNETEPFVDFSSGYFQRVMDQFPRQHTEAPWKLNQNYFVDRKNLRDLPIEDGVM
QFHIPAAATKPKPALQAAE

Sequences:

>Translated_499_residues
MTQLDTDILIIGAGLSGIGAAVHLTKRSPGKRYRIYEARDAIGGTWDLFRYPGIRSDSDMHTLGYNFKPWTDAKAIADGP
SIRRYVNTTADEYGVRKNISFNTKIVAADWSSADQAWTVTSENVKTGAQEKTTCRFLFMCGGYYSYDKGYRPDFPGEEAF
RGQIIHPQHWPEDLDYSGKKVVVIGSGATAMTLVPSMAEKAGHVTMLQRSPTYVVSRPAMDGFANFLRKVLPDQWAYNLI
RWRNVAFQQFFFRQTRTNPAKARERLLGMVREELGPDYDVDKHFTPTYNPWEQRLCLVPDSDLFNSLKSGKASIETDHIE
RFTETGILLKSGKELPADIIVTATGLNLIFMNGVNVSLDGAKVDPGRLLNYKGVMLSNVPNLAVTFGYTNASWTLKADLT
SEYVSRLINLMDEKGATSAMPYLAAFPNETEPFVDFSSGYFQRVMDQFPRQHTEAPWKLNQNYFVDRKNLRDLPIEDGVM
QFHIPAAATKPKPALQAAE
>Mature_498_residues
TQLDTDILIIGAGLSGIGAAVHLTKRSPGKRYRIYEARDAIGGTWDLFRYPGIRSDSDMHTLGYNFKPWTDAKAIADGPS
IRRYVNTTADEYGVRKNISFNTKIVAADWSSADQAWTVTSENVKTGAQEKTTCRFLFMCGGYYSYDKGYRPDFPGEEAFR
GQIIHPQHWPEDLDYSGKKVVVIGSGATAMTLVPSMAEKAGHVTMLQRSPTYVVSRPAMDGFANFLRKVLPDQWAYNLIR
WRNVAFQQFFFRQTRTNPAKARERLLGMVREELGPDYDVDKHFTPTYNPWEQRLCLVPDSDLFNSLKSGKASIETDHIER
FTETGILLKSGKELPADIIVTATGLNLIFMNGVNVSLDGAKVDPGRLLNYKGVMLSNVPNLAVTFGYTNASWTLKADLTS
EYVSRLINLMDEKGATSAMPYLAAFPNETEPFVDFSSGYFQRVMDQFPRQHTEAPWKLNQNYFVDRKNLRDLPIEDGVMQ
FHIPAAATKPKPALQAAE

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI50541965, Length=375, Percent_Identity=22.9333333333333, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI50541961, Length=375, Percent_Identity=22.9333333333333, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4503757, Length=369, Percent_Identity=21.1382113821138, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI4503759, Length=370, Percent_Identity=22.7027027027027, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17555726, Length=391, Percent_Identity=23.0179028132992, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI193202226, Length=236, Percent_Identity=23.728813559322, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561948, Length=364, Percent_Identity=21.978021978022, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17541300, Length=261, Percent_Identity=22.9885057471264, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 56090; Mature: 55959

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLDTDILIIGAGLSGIGAAVHLTKRSPGKRYRIYEARDAIGGTWDLFRYPGIRSDSDM
CCCCCCCEEEEECCCCCCCEEEEEECCCCCCEEEEEEHHHCCCCCCHHHCCCCCCCCCCC
HTLGYNFKPWTDAKAIADGPSIRRYVNTTADEYGVRKNISFNTKIVAADWSSADQAWTVT
EECCCCCCCCCCCHHHCCCHHHHHHHHCCHHHCCCCCCCCCCEEEEEECCCCCCCEEEEE
SENVKTGAQEKTTCRFLFMCGGYYSYDKGYRPDFPGEEAFRGQIIHPQHWPEDLDYSGKK
CCCCCCCCCCCCEEEEEEEECCEECCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCE
VVVIGSGATAMTLVPSMAEKAGHVTMLQRSPTYVVSRPAMDGFANFLRKVLPDQWAYNLI
EEEEECCCCHHHHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHHHHCCHHHHHHHH
RWRNVAFQQFFFRQTRTNPAKARERLLGMVREELGPDYDVDKHFTPTYNPWEQRLCLVPD
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCEEEECCC
SDLFNSLKSGKASIETDHIERFTETGILLKSGKELPADIIVTATGLNLIFMNGVNVSLDG
HHHHHHHHCCCCCCCHHHHHHHHHCCEEEECCCCCCCEEEEEECCCEEEEEECCEEEECC
AKVDPGRLLNYKGVMLSNVPNLAVTFGYTNASWTLKADLTSEYVSRLINLMDEKGATSAM
CCCCCCCEEEECCEEECCCCCEEEEEEECCCEEEEEECCHHHHHHHHHHHHHCCCCCCCC
PYLAAFPNETEPFVDFSSGYFQRVMDQFPRQHTEAPWKLNQNYFVDRKNLRDLPIEDGVM
CHHEECCCCCCCCEECCCHHHHHHHHHCCHHHCCCCEEECCCEEEECCCCCCCCCCCCEE
QFHIPAAATKPKPALQAAE
EEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQLDTDILIIGAGLSGIGAAVHLTKRSPGKRYRIYEARDAIGGTWDLFRYPGIRSDSDM
CCCCCCEEEEECCCCCCCEEEEEECCCCCCEEEEEEHHHCCCCCCHHHCCCCCCCCCCC
HTLGYNFKPWTDAKAIADGPSIRRYVNTTADEYGVRKNISFNTKIVAADWSSADQAWTVT
EECCCCCCCCCCCHHHCCCHHHHHHHHCCHHHCCCCCCCCCCEEEEEECCCCCCCEEEEE
SENVKTGAQEKTTCRFLFMCGGYYSYDKGYRPDFPGEEAFRGQIIHPQHWPEDLDYSGKK
CCCCCCCCCCCCEEEEEEEECCEECCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCE
VVVIGSGATAMTLVPSMAEKAGHVTMLQRSPTYVVSRPAMDGFANFLRKVLPDQWAYNLI
EEEEECCCCHHHHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHHHHCCHHHHHHHH
RWRNVAFQQFFFRQTRTNPAKARERLLGMVREELGPDYDVDKHFTPTYNPWEQRLCLVPD
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCEEEECCC
SDLFNSLKSGKASIETDHIERFTETGILLKSGKELPADIIVTATGLNLIFMNGVNVSLDG
HHHHHHHHCCCCCCCHHHHHHHHHCCEEEECCCCCCCEEEEEECCCEEEEEECCEEEECC
AKVDPGRLLNYKGVMLSNVPNLAVTFGYTNASWTLKADLTSEYVSRLINLMDEKGATSAM
CCCCCCCEEEECCEEECCCCCEEEEEEECCCEEEEEECCHHHHHHHHHHHHHCCCCCCCC
PYLAAFPNETEPFVDFSSGYFQRVMDQFPRQHTEAPWKLNQNYFVDRKNLRDLPIEDGVM
CHHEECCCCCCCCEECCCHHHHHHHHHCCHHHCCCCEEECCCEEEECCCCCCCCCCCCEE
QFHIPAAATKPKPALQAAE
EEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]