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The map label for this gene is ampC [C]

Identifier: 114800442

GI number: 114800442

Start: 1140464

End: 1141603

Strand: Direct

Name: ampC [C]

Synonym: HNE_1129

Alternate gene names: 114800442

Gene position: 1140464-1141603 (Clockwise)

Preceding gene: 114797107

Following gene: 114799701

Centisome position: 30.78

GC content: 65.44

Gene sequence:

>1140_bases
ATGAGCCAGACCGAAATCCACGGCAGCGTGGAGGCGCGCTTTGCGCCCGTCCGCGACGCCTTCGCGCAGAACTTCACCAA
TGGCGGCGAAAACGGCGCCGCCTTCTGCATGACGCTGGAGGGCAAGCCCATCGTCGACATCTGGGGCGGCTACGCAGACG
AAGAACAGACCAGGCCCTGGCAGAAGGGCACGCTCGTCAACGTCTACTCCACCACCAAGACGATGACCGCCCTCACCGCC
CTCTTTCTGGCAGACAAGGGCGCGCTGAAGTTTGAAGACCCCGTCGCCAAATACTGGCCCGAATTTGCCGCCGCCGGAAA
GGCAGACGTCACCGTCGCCCATCTGATGAGCCACTCAGCCGGCCTCTCGGGCTGGAAGGAGCCGATTGTCCGCGAAGACC
TCTACGATTGGGAAAAGGCCACCAGCCTGCTCGCGGCCCAGGAACCCTACTGGAAACCCGGCAGCGCGCCGGGCTACCAC
GCCATGACGCAGGGCTATCTCGTCGGTGAAGTCATCCGCCGCGTTGCGGGCGAAACAGTCGGCACCGTCTTCCGCAAGGA
AATCGCCGGACCGCTGGGTGCAGACTTCCACATTGGCCTTCCGGCTACGGAAGATCACCGCGTCGCCGATCTCACGCCCC
CGCCGCCCGGCGCGGGCATGGGCGAGGGCGCGGTTGATCCCCTCATCATGAACCTCATGAACCCGCCCATCAATCCGCTG
GATACGCGCACCCGCGCCTGGCGCGCCGCTGAAATCCCGGCCGCAGGCGGCACAGGCAATGCCCGCTCCGTCGCGCTCGT
CCACACGATCCTTGCCAATGGCGGCTATGCAAACGGCAAGCAGATCATGTCCGAGGCCGGCTGCCGCAAGGCTTTGGAAT
TCCAGATCGAGGGCGAAGACAAGATCCTCCGCGTCCCCGTCCGCTATGGCCTCGGCTTCGGCCTGCCCGGCGGCATCGCA
AACTTTCCCAACCCCAACACCATCTTCTGGGGCGGCTATGGCGGCTCCCTCGCCGTCATCGACATGGACCAGCGCGCCAC
CTACGCCTACGTCATGAACAAGATGGCCCCCACCACCACGGGCGACCTGCGCGCCTTCGGCATGCTCATGGCCGCCTGGC
AGGTGTTCATGGCGGGGTGA

Upstream 100 bases:

>100_bases
GCCCCCGCGTCAGCCTTGCCAGCTTTCCGCAGCTGGCTTACCCAAATCGCTGAAACAGACCTGCCCATGAAGGCAGGCCA
TATCCTTTTGGGGGAAACCA

Downstream 100 bases:

>100_bases
TCCGCGCAGCTTGGCTTCCATGGGGCGCTCCCGTATAGGAGCGCCCCATGGCTACGTTCCCGTTTGAAATTTCCGCCCGT
GAGGGTAAGGCGCGCACCGG

Product: putative esterase

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: Esterase; Carboxylesterase; Beta-Lactamase Class C; Esterase/Lipase LipP; Esterase A; Beta-Lactamase Family Protein; Esterase/Lipase/Beta-Lactamase; Lactone Hydrolase; Lipase LipE; Beta-Lactamase Protein; Esterase LipL; Secreted Protein; Lipase LipD; Lipase/Esterase/Beta-Lactamase; Beta-N-Acetylglucosaminidase; Fusion Of Enoyl-CoA Hydratase; Beta-Lactamase-Like Protein; Hydrolase; Esterase/Lipase; Carboxylesterase EstC; Serine Hydrolase; Beta-Lactamase Family

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MSQTEIHGSVEARFAPVRDAFAQNFTNGGENGAAFCMTLEGKPIVDIWGGYADEEQTRPWQKGTLVNVYSTTKTMTALTA
LFLADKGALKFEDPVAKYWPEFAAAGKADVTVAHLMSHSAGLSGWKEPIVREDLYDWEKATSLLAAQEPYWKPGSAPGYH
AMTQGYLVGEVIRRVAGETVGTVFRKEIAGPLGADFHIGLPATEDHRVADLTPPPPGAGMGEGAVDPLIMNLMNPPINPL
DTRTRAWRAAEIPAAGGTGNARSVALVHTILANGGYANGKQIMSEAGCRKALEFQIEGEDKILRVPVRYGLGFGLPGGIA
NFPNPNTIFWGGYGGSLAVIDMDQRATYAYVMNKMAPTTTGDLRAFGMLMAAWQVFMAG

Sequences:

>Translated_379_residues
MSQTEIHGSVEARFAPVRDAFAQNFTNGGENGAAFCMTLEGKPIVDIWGGYADEEQTRPWQKGTLVNVYSTTKTMTALTA
LFLADKGALKFEDPVAKYWPEFAAAGKADVTVAHLMSHSAGLSGWKEPIVREDLYDWEKATSLLAAQEPYWKPGSAPGYH
AMTQGYLVGEVIRRVAGETVGTVFRKEIAGPLGADFHIGLPATEDHRVADLTPPPPGAGMGEGAVDPLIMNLMNPPINPL
DTRTRAWRAAEIPAAGGTGNARSVALVHTILANGGYANGKQIMSEAGCRKALEFQIEGEDKILRVPVRYGLGFGLPGGIA
NFPNPNTIFWGGYGGSLAVIDMDQRATYAYVMNKMAPTTTGDLRAFGMLMAAWQVFMAG
>Mature_378_residues
SQTEIHGSVEARFAPVRDAFAQNFTNGGENGAAFCMTLEGKPIVDIWGGYADEEQTRPWQKGTLVNVYSTTKTMTALTAL
FLADKGALKFEDPVAKYWPEFAAAGKADVTVAHLMSHSAGLSGWKEPIVREDLYDWEKATSLLAAQEPYWKPGSAPGYHA
MTQGYLVGEVIRRVAGETVGTVFRKEIAGPLGADFHIGLPATEDHRVADLTPPPPGAGMGEGAVDPLIMNLMNPPINPLD
TRTRAWRAAEIPAAGGTGNARSVALVHTILANGGYANGKQIMSEAGCRKALEFQIEGEDKILRVPVRYGLGFGLPGGIAN
FPNPNTIFWGGYGGSLAVIDMDQRATYAYVMNKMAPTTTGDLRAFGMLMAAWQVFMAG

Specific function: This Protein Is A Serine Beta-Lactamase With A Substrate Specificity For Cephalosporins. [C]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790593, Length=182, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17535191, Length=378, Percent_Identity=34.1269841269841, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI71983659, Length=376, Percent_Identity=35.1063829787234, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71983666, Length=292, Percent_Identity=38.3561643835616, Blast_Score=199, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17538001, Length=385, Percent_Identity=32.4675324675325, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17535177, Length=398, Percent_Identity=33.1658291457286, Blast_Score=190, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI17538474, Length=388, Percent_Identity=29.1237113402062, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71990590, Length=387, Percent_Identity=27.1317829457364, Blast_Score=118, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 40643; Mature: 40511

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTEIHGSVEARFAPVRDAFAQNFTNGGENGAAFCMTLEGKPIVDIWGGYADEEQTRPW
CCCCCCCCCHHEEEHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEEECCCCCCCHHCCCC
QKGTLVNVYSTTKTMTALTALFLADKGALKFEDPVAKYWPEFAAAGKADVTVAHLMSHSA
CCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCHHHHCCCCCCHHHHHHHHHHC
GLSGWKEPIVREDLYDWEKATSLLAAQEPYWKPGSAPGYHAMTQGYLVGEVIRRVAGETV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GTVFRKEIAGPLGADFHIGLPATEDHRVADLTPPPPGAGMGEGAVDPLIMNLMNPPINPL
HHHHHHHHCCCCCCCEEECCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCC
DTRTRAWRAAEIPAAGGTGNARSVALVHTILANGGYANGKQIMSEAGCRKALEFQIEGED
CCHHHHHECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEEECCCC
KILRVPVRYGLGFGLPGGIANFPNPNTIFWGGYGGSLAVIDMDQRATYAYVMNKMAPTTT
CEEEEEHHHCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCHHHHHHHHHCCCCCC
GDLRAFGMLMAAWQVFMAG
CHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQTEIHGSVEARFAPVRDAFAQNFTNGGENGAAFCMTLEGKPIVDIWGGYADEEQTRPW
CCCCCCCCHHEEEHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEEECCCCCCCHHCCCC
QKGTLVNVYSTTKTMTALTALFLADKGALKFEDPVAKYWPEFAAAGKADVTVAHLMSHSA
CCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCHHHHCCCCCCHHHHHHHHHHC
GLSGWKEPIVREDLYDWEKATSLLAAQEPYWKPGSAPGYHAMTQGYLVGEVIRRVAGETV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GTVFRKEIAGPLGADFHIGLPATEDHRVADLTPPPPGAGMGEGAVDPLIMNLMNPPINPL
HHHHHHHHCCCCCCCEEECCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCC
DTRTRAWRAAEIPAAGGTGNARSVALVHTILANGGYANGKQIMSEAGCRKALEFQIEGED
CCHHHHHECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEEECCCC
KILRVPVRYGLGFGLPGGIANFPNPNTIFWGGYGGSLAVIDMDQRATYAYVMNKMAPTTT
CEEEEEHHHCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCHHHHHHHHHCCCCCC
GDLRAFGMLMAAWQVFMAG
CHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA