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The map label for this gene is hemE

Identifier: 114800363

GI number: 114800363

Start: 3703903

End: 3704937

Strand: Reverse

Name: hemE

Synonym: HNE_3568

Alternate gene names: 114800363

Gene position: 3704937-3703903 (Counterclockwise)

Preceding gene: NA

Following gene: 114798830

Centisome position: 100.0

GC content: 60.48

Gene sequence:

>1035_bases
GTGGCAACGTCCGTTAAGAAATTGCTGGCTGGGCTGTCAGGCGAGGTTTTCAAGGTTCCTCCGGTATGGATGATGCGCCA
GGCAGGCCGGCATCTGCCAGAATATCTGGAGACCAGAGCCCGTTCAAAAGACTTCCTCGATTTCTGCTACACGCCGTCCC
TCGCAAGCGAAGCAACCCTTCAGCCCATCCGCCGCTATGGCATGGACGGGGCGATCCTGTTTGCCGACATTCTCCTCATC
CTGGATGCGATGGGTTTGAAAGTGGCTTTCGAGAAGGGCGAAGGCCCTCTGGTGGAGCAGATCAACGGACCCTCTGATCT
TGCACGGGTCAGTCCTCAAAAGGCTGCTGACCGTCTTTCGCCTGTCTATGAAACTGTCTCCCGTGTGAAGGCAGCCCTGC
CCGCGCAGACAACACTGATCGGATTTGCCGGGTCGCCCTGGACGGTCAGCCTTTATGCCATCGAAGGCCGGGGCAAGACC
GACAAGTCCACCGCCTGGCGCTGGGCACATGGCCGGCCGGATGATCTCGCAGCTGTCATGGATCTTGTGGCGGAAGCGAC
CGCTGAATACCTCGCCCGCCAGGTTGAGGCAGGCGCTGAAGCGCTGATGCTGTTCGACAGCTGGGCCGAAGGTCTTCCGG
ATAATATCTTCCGCGAGGTCGTGATCGCGCCGACCCGAAAGCTGGTTGCCCTTCTGAGGGAAAGAGGGATTACCGTTCCC
ATTATCGGCTTTCCGCGCGGGGCGGGTGTCATGCTGCCCGAATATGTCCGCGAGACAGGCGTGACGGCCGTAGGCCTTGA
TACGGCGGCTTCACCGGCGTTCATCAACGCGGAACTGGCAAAAGGCTTCCCTGTTCAGGGTCATCTGGACCCCCTCCTTC
TCATCGAAGGCGGCGCGCGACTTGACGCACGTGTCCGGGAATTGCTGGACGCTTACCGGGGACGGCCCCATATCTTCAAT
CTCGGTCATGGCGTTCGCCCCGAGACCCCCATCGCGCATGTCGAGCGCGTGCTGGAGCTGATCAGAAACGCGTAG

Upstream 100 bases:

>100_bases
ACGGGATAAAGCGTTAACAGACGGGTTATCCTCGAATCCCTCGGGGTTATAATCATAAGCGCCCTGACGGGCATTTGAGT
GAGATTGGGAAGGGGTCTGC

Downstream 100 bases:

>100_bases
GAAGAGAGAAGCCGATATGGGCCGCCGGATTGCTGTGGTGCTGTTCAATCTGGGGGGACCAGATACAGGGAACGATGTTC
AGCCTTTCCTGAAAAATTTA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MATSVKKLLAGLSGEVFKVPPVWMMRQAGRHLPEYLETRARSKDFLDFCYTPSLASEATLQPIRRYGMDGAILFADILLI
LDAMGLKVAFEKGEGPLVEQINGPSDLARVSPQKAADRLSPVYETVSRVKAALPAQTTLIGFAGSPWTVSLYAIEGRGKT
DKSTAWRWAHGRPDDLAAVMDLVAEATAEYLARQVEAGAEALMLFDSWAEGLPDNIFREVVIAPTRKLVALLRERGITVP
IIGFPRGAGVMLPEYVRETGVTAVGLDTAASPAFINAELAKGFPVQGHLDPLLLIEGGARLDARVRELLDAYRGRPHIFN
LGHGVRPETPIAHVERVLELIRNA

Sequences:

>Translated_344_residues
MATSVKKLLAGLSGEVFKVPPVWMMRQAGRHLPEYLETRARSKDFLDFCYTPSLASEATLQPIRRYGMDGAILFADILLI
LDAMGLKVAFEKGEGPLVEQINGPSDLARVSPQKAADRLSPVYETVSRVKAALPAQTTLIGFAGSPWTVSLYAIEGRGKT
DKSTAWRWAHGRPDDLAAVMDLVAEATAEYLARQVEAGAEALMLFDSWAEGLPDNIFREVVIAPTRKLVALLRERGITVP
IIGFPRGAGVMLPEYVRETGVTAVGLDTAASPAFINAELAKGFPVQGHLDPLLLIEGGARLDARVRELLDAYRGRPHIFN
LGHGVRPETPIAHVERVLELIRNA
>Mature_343_residues
ATSVKKLLAGLSGEVFKVPPVWMMRQAGRHLPEYLETRARSKDFLDFCYTPSLASEATLQPIRRYGMDGAILFADILLIL
DAMGLKVAFEKGEGPLVEQINGPSDLARVSPQKAADRLSPVYETVSRVKAALPAQTTLIGFAGSPWTVSLYAIEGRGKTD
KSTAWRWAHGRPDDLAAVMDLVAEATAEYLARQVEAGAEALMLFDSWAEGLPDNIFREVVIAPTRKLVALLRERGITVPI
IGFPRGAGVMLPEYVRETGVTAVGLDTAASPAFINAELAKGFPVQGHLDPLLLIEGGARLDARVRELLDAYRGRPHIFNL
GHGVRPETPIAHVERVLELIRNA

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=328, Percent_Identity=37.1951219512195, Blast_Score=204, Evalue=1e-52,
Organism=Escherichia coli, GI2367337, Length=328, Percent_Identity=38.719512195122, Blast_Score=225, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6320252, Length=333, Percent_Identity=32.7327327327327, Blast_Score=173, Evalue=3e-44,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=38.0813953488372, Blast_Score=222, Evalue=2e-58,
Organism=Drosophila melanogaster, GI19921920, Length=344, Percent_Identity=38.0813953488372, Blast_Score=222, Evalue=3e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_HYPNA (Q0BWA4)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_762239.1
- ProteinModelPortal:   Q0BWA4
- SMR:   Q0BWA4
- STRING:   Q0BWA4
- GeneID:   4288726
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_3568
- NMPDR:   fig|228405.5.peg.3417
- TIGR:   HNE_3568
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q0BWA4
- ProtClustDB:   PRK00115
- BioCyc:   HNEP81032:HNE_3568-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 37468; Mature: 37337

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 76-76 BINDING 152-152 BINDING 207-207 BINDING 323-323

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATSVKKLLAGLSGEVFKVPPVWMMRQAGRHLPEYLETRARSKDFLDFCYTPSLASEATL
CCCHHHHHHHCCCCCEEECCCHHHHHHHHCCCHHHHHHHHCCCHHHHHHCCCCCCHHHHH
QPIRRYGMDGAILFADILLILDAMGLKVAFEKGEGPLVEQINGPSDLARVSPQKAADRLS
HHHHHHCCCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHCCCHHHHHHCCHHHHHHHHH
PVYETVSRVKAALPAQTTLIGFAGSPWTVSLYAIEGRGKTDKSTAWRWAHGRPDDLAAVM
HHHHHHHHHHHHCCCHHEEEEECCCCEEEEEEEEECCCCCCCCCCEEECCCCCHHHHHHH
DLVAEATAEYLARQVEAGAEALMLFDSWAEGLPDNIFREVVIAPTRKLVALLRERGITVP
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHCCCEEE
IIGFPRGAGVMLPEYVRETGVTAVGLDTAASPAFINAELAKGFPVQGHLDPLLLIEGGAR
EEECCCCCCCCCHHHHHHCCCEEEECCCCCCCCEEEHHHHCCCCCCCCCCEEEEEECCCC
LDARVRELLDAYRGRPHIFNLGHGVRPETPIAHVERVLELIRNA
HHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
ATSVKKLLAGLSGEVFKVPPVWMMRQAGRHLPEYLETRARSKDFLDFCYTPSLASEATL
CCHHHHHHHCCCCCEEECCCHHHHHHHHCCCHHHHHHHHCCCHHHHHHCCCCCCHHHHH
QPIRRYGMDGAILFADILLILDAMGLKVAFEKGEGPLVEQINGPSDLARVSPQKAADRLS
HHHHHHCCCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHCCCHHHHHHCCHHHHHHHHH
PVYETVSRVKAALPAQTTLIGFAGSPWTVSLYAIEGRGKTDKSTAWRWAHGRPDDLAAVM
HHHHHHHHHHHHCCCHHEEEEECCCCEEEEEEEEECCCCCCCCCCEEECCCCCHHHHHHH
DLVAEATAEYLARQVEAGAEALMLFDSWAEGLPDNIFREVVIAPTRKLVALLRERGITVP
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHCCCEEE
IIGFPRGAGVMLPEYVRETGVTAVGLDTAASPAFINAELAKGFPVQGHLDPLLLIEGGAR
EEECCCCCCCCCHHHHHHCCCEEEECCCCCCCCEEEHHHHCCCCCCCCCCEEEEEECCCC
LDARVRELLDAYRGRPHIFNLGHGVRPETPIAHVERVLELIRNA
HHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA