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The map label for this gene is hemH

Identifier: 114798830

GI number: 114798830

Start: 3702813

End: 3703886

Strand: Reverse

Name: hemH

Synonym: HNE_3567

Alternate gene names: 114798830

Gene position: 3703886-3702813 (Counterclockwise)

Preceding gene: 114800363

Following gene: 114798055

Centisome position: 99.97

GC content: 58.85

Gene sequence:

>1074_bases
ATGGGCCGCCGGATTGCTGTGGTGCTGTTCAATCTGGGGGGACCAGATACAGGGAACGATGTTCAGCCTTTCCTGAAAAA
TTTATTCCGTGATCCCGCCATCATCCGGGCACCCTTACCGGTCCGCTGGCTGGTTGCCCGGTTAATTTCTACCTTGCGCG
CGCCAGTCGTGAAGCAAAACTATGCCATGATGGATGCTGGCGGCGGATCTCCCCTGCTCCGGGAAACGAAGAAGCAAGCC
GACGCCCTTCAGGCAGAGCTCGCCAAAAAGCTGCCCGGCGATGAAGTCCGCTGTTTTATCGCCATGCGCTACTGGCACCC
ATTCACGGAAGAAGCCGCCGCTGAGGTCCAGAAATGGGGCGCGGACGAAGTCGTGCTGCTGCCGCTCTATCCGCAGTTTT
CGACCACCACGACGGGGTCTTCCCTCTCCGCCTGGCATAAAGCCTATAAGGGCAAAAGCCGCACGATCTGCTGCTATCCG
TTTGAAGAAAACTTCGTCTCCGCACATGTCGATCAGATCATGGCTGCGTGGGAACGTGCCGGCCGTCCGGGAAACGTAAA
CCTGCTCCTGTCGGCGCATGGTCTGCCCGAGAGCGTCGTTAAATCAGGTGACCCGTATCAGTGGCAGTGTGAAGCGCTGG
CCGAAATGATTGCGGGCCGCGTACCGGCCGATTGGGAGGTGAGCGTCTGCTACCAGTCCCGTGTTGGCCCCATGAAATGG
ATCGGGCCACCGACCGAAGAAGAGATTGCCCGCATTTCAGACCAGGGCCGTAATATATTGATTGCGCCGATCGCTTTTGT
TTCGGAGCACATCGAGACACTGGTTGAACTGGGCGAAGAATACCGGCTGGTCGCAGAAAAACATGGCGCCGCCAGTTATA
CGCGAGTTGAAGCGCTTGGTGTGCATCCGGGATTTATCAGCACGCTGACGGGCGAAGTCCTGGCGGCGCTCGGGATGAAA
GAAACCATCCGCTCCTGCGCGGGCGGGCGTCTCTGCCCGTCTGGTTGGAGTGGGTGCCCGCAGGCCGAATTGAAACAGAA
AGCCGGCGTGCGCATTACTGAAACCGCCGGCTGA

Upstream 100 bases:

>100_bases
ATCTTCAATCTCGGTCATGGCGTTCGCCCCGAGACCCCCATCGCGCATGTCGAGCGCGTGCTGGAGCTGATCAGAAACGC
GTAGGAAGAGAGAAGCCGAT

Downstream 100 bases:

>100_bases
GGGGAGATGCCAAGTGGATCTGTATAACTGGCTGAAGGCTGGCCATGTCATTTTTGTCGTCGCTTTGATGGCAGCCCTGC
TTGTTTATCCCCGCTACAAA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MGRRIAVVLFNLGGPDTGNDVQPFLKNLFRDPAIIRAPLPVRWLVARLISTLRAPVVKQNYAMMDAGGGSPLLRETKKQA
DALQAELAKKLPGDEVRCFIAMRYWHPFTEEAAAEVQKWGADEVVLLPLYPQFSTTTTGSSLSAWHKAYKGKSRTICCYP
FEENFVSAHVDQIMAAWERAGRPGNVNLLLSAHGLPESVVKSGDPYQWQCEALAEMIAGRVPADWEVSVCYQSRVGPMKW
IGPPTEEEIARISDQGRNILIAPIAFVSEHIETLVELGEEYRLVAEKHGAASYTRVEALGVHPGFISTLTGEVLAALGMK
ETIRSCAGGRLCPSGWSGCPQAELKQKAGVRITETAG

Sequences:

>Translated_357_residues
MGRRIAVVLFNLGGPDTGNDVQPFLKNLFRDPAIIRAPLPVRWLVARLISTLRAPVVKQNYAMMDAGGGSPLLRETKKQA
DALQAELAKKLPGDEVRCFIAMRYWHPFTEEAAAEVQKWGADEVVLLPLYPQFSTTTTGSSLSAWHKAYKGKSRTICCYP
FEENFVSAHVDQIMAAWERAGRPGNVNLLLSAHGLPESVVKSGDPYQWQCEALAEMIAGRVPADWEVSVCYQSRVGPMKW
IGPPTEEEIARISDQGRNILIAPIAFVSEHIETLVELGEEYRLVAEKHGAASYTRVEALGVHPGFISTLTGEVLAALGMK
ETIRSCAGGRLCPSGWSGCPQAELKQKAGVRITETAG
>Mature_356_residues
GRRIAVVLFNLGGPDTGNDVQPFLKNLFRDPAIIRAPLPVRWLVARLISTLRAPVVKQNYAMMDAGGGSPLLRETKKQAD
ALQAELAKKLPGDEVRCFIAMRYWHPFTEEAAAEVQKWGADEVVLLPLYPQFSTTTTGSSLSAWHKAYKGKSRTICCYPF
EENFVSAHVDQIMAAWERAGRPGNVNLLLSAHGLPESVVKSGDPYQWQCEALAEMIAGRVPADWEVSVCYQSRVGPMKWI
GPPTEEEIARISDQGRNILIAPIAFVSEHIETLVELGEEYRLVAEKHGAASYTRVEALGVHPGFISTLTGEVLAALGMKE
TIRSCAGGRLCPSGWSGCPQAELKQKAGVRITETAG

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=330, Percent_Identity=34.8484848484849, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI60499025, Length=330, Percent_Identity=34.8484848484849, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1786681, Length=323, Percent_Identity=30.030959752322, Blast_Score=113, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324750, Length=321, Percent_Identity=29.9065420560748, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI17864156, Length=333, Percent_Identity=30.6306306306306, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24651774, Length=257, Percent_Identity=28.4046692607004, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45552018, Length=143, Percent_Identity=35.6643356643357, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_HYPNA (Q0BWA5)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_762238.1
- ProteinModelPortal:   Q0BWA5
- SMR:   Q0BWA5
- STRING:   Q0BWA5
- GeneID:   4287560
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_3567
- NMPDR:   fig|228405.5.peg.3416
- TIGR:   HNE_3567
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   HSLPMEI
- PhylomeDB:   Q0BWA5
- BioCyc:   HNEP81032:HNE_3567-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 39056; Mature: 38925

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRRIAVVLFNLGGPDTGNDVQPFLKNLFRDPAIIRAPLPVRWLVARLISTLRAPVVKQN
CCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCHHHCC
YAMMDAGGGSPLLRETKKQADALQAELAKKLPGDEVRCFIAMRYWHPFTEEAAAEVQKWG
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCC
ADEVVLLPLYPQFSTTTTGSSLSAWHKAYKGKSRTICCYPFEENFVSAHVDQIMAAWERA
CCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHC
GRPGNVNLLLSAHGLPESVVKSGDPYQWQCEALAEMIAGRVPADWEVSVCYQSRVGPMKW
CCCCCEEEEEEECCCCHHHHCCCCCCEEHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCC
IGPPTEEEIARISDQGRNILIAPIAFVSEHIETLVELGEEYRLVAEKHGAASYTRVEALG
CCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEC
VHPGFISTLTGEVLAALGMKETIRSCAGGRLCPSGWSGCPQAELKQKAGVRITETAG
CCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCEEEECCC
>Mature Secondary Structure 
GRRIAVVLFNLGGPDTGNDVQPFLKNLFRDPAIIRAPLPVRWLVARLISTLRAPVVKQN
CCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCHHHCC
YAMMDAGGGSPLLRETKKQADALQAELAKKLPGDEVRCFIAMRYWHPFTEEAAAEVQKWG
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCC
ADEVVLLPLYPQFSTTTTGSSLSAWHKAYKGKSRTICCYPFEENFVSAHVDQIMAAWERA
CCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHC
GRPGNVNLLLSAHGLPESVVKSGDPYQWQCEALAEMIAGRVPADWEVSVCYQSRVGPMKW
CCCCCEEEEEEECCCCHHHHCCCCCCEEHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCC
IGPPTEEEIARISDQGRNILIAPIAFVSEHIETLVELGEEYRLVAEKHGAASYTRVEALG
CCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEC
VHPGFISTLTGEVLAALGMKETIRSCAGGRLCPSGWSGCPQAELKQKAGVRITETAG
CCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA