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The map label for this gene is clpP [H]

Identifier: 114800297

GI number: 114800297

Start: 2160460

End: 2161083

Strand: Reverse

Name: clpP [H]

Synonym: HNE_2087

Alternate gene names: 114800297

Gene position: 2161083-2160460 (Counterclockwise)

Preceding gene: 114799820

Following gene: 114799276

Centisome position: 58.33

GC content: 56.25

Gene sequence:

>624_bases
ATGTCGACATCACTTCAGACCGCTCTCAACCTTGTTCCGATGGTCGTCGAGCAGACGAGCCGTGGAGAGCGCGCGTTTGA
TATTTTCTCCCGCCTCCTCAAGGAGCGGATCATTTTCGTGACCGGCGGGATCGATGATGGCATCGCGTCCCTCATCACAG
CGCAGCTTCTGTTCCTTGAATCAGAGAACCCGAAGCGCGAAATCGCCATGTATATCAACAGCCCCGGCGGGTACGTCTCC
TCCGGCCTCGCGATCTACGACACCATGCAGTATGTCCGCTGCCCGATCTCTACAGTCTGTATTGGCCAGGCTGCCTCGAT
GGGGTCGCTCCTGCTTGCCGCTGGGGAAAAAGGCCTGCGCATCGCCCTGCCAAATGCCCGCGTGATGCTGCACCAGCCTT
CTGGCGGATATTCGGGCGTCGCGACAGATATTGAGCGCCACGCTGAGGAAATCATCGAACTCAAGCGCCGGTTGAACGAT
ATTTACGTTCGCCACACGGGCCAAGAATACGATGTAGTTGAAAGAAAGCTCGATCGCGACACCTTCCTTACGGCCGAAGA
AGCCATGGAGTTCGGGATTGTTGACAAGGTTTATGAGCGTCGCACCGCTGAAGACGAAAAATAA

Upstream 100 bases:

>100_bases
CAGCAGGCGCGGCCTTGCAGTGGGCGGCGAATGGACAAATATAAAGGCATCTGCCAATCCTGCAGGCGGCGATTCAGCCC
TGATCCACAAGGTCATTTTT

Downstream 100 bases:

>100_bases
TCGCCTGTGTTTCAAGGTGCGGCCCAGCCCTTGCAGGGCAGGCGAACAGGTTTATTGTCTAGAAAAAGACCATGCTTGGC
AGGGGCTTAAAGCCCACGTT

Product: ATP-dependent Clp protease, proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MSTSLQTALNLVPMVVEQTSRGERAFDIFSRLLKERIIFVTGGIDDGIASLITAQLLFLESENPKREIAMYINSPGGYVS
SGLAIYDTMQYVRCPISTVCIGQAASMGSLLLAAGEKGLRIALPNARVMLHQPSGGYSGVATDIERHAEEIIELKRRLND
IYVRHTGQEYDVVERKLDRDTFLTAEEAMEFGIVDKVYERRTAEDEK

Sequences:

>Translated_207_residues
MSTSLQTALNLVPMVVEQTSRGERAFDIFSRLLKERIIFVTGGIDDGIASLITAQLLFLESENPKREIAMYINSPGGYVS
SGLAIYDTMQYVRCPISTVCIGQAASMGSLLLAAGEKGLRIALPNARVMLHQPSGGYSGVATDIERHAEEIIELKRRLND
IYVRHTGQEYDVVERKLDRDTFLTAEEAMEFGIVDKVYERRTAEDEK
>Mature_206_residues
STSLQTALNLVPMVVEQTSRGERAFDIFSRLLKERIIFVTGGIDDGIASLITAQLLFLESENPKREIAMYINSPGGYVSS
GLAIYDTMQYVRCPISTVCIGQAASMGSLLLAAGEKGLRIALPNARVMLHQPSGGYSGVATDIERHAEEIIELKRRLNDI
YVRHTGQEYDVVERKLDRDTFLTAEEAMEFGIVDKVYERRTAEDEK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=201, Percent_Identity=61.6915422885572, Blast_Score=260, Evalue=5e-70,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=59.2783505154639, Blast_Score=261, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17538017, Length=197, Percent_Identity=58.3756345177665, Blast_Score=246, Evalue=5e-66,
Organism=Drosophila melanogaster, GI20129427, Length=192, Percent_Identity=63.5416666666667, Blast_Score=261, Evalue=3e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23037; Mature: 22905

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSLQTALNLVPMVVEQTSRGERAFDIFSRLLKERIIFVTGGIDDGIASLITAQLLFLE
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHEE
SENPKREIAMYINSPGGYVSSGLAIYDTMQYVRCPISTVCIGQAASMGSLLLAAGEKGLR
CCCCCEEEEEEECCCCCHHHCCHHHHHHHHHHHCCHHHHHHCCHHCHHHHHEECCCCCCE
IALPNARVMLHQPSGGYSGVATDIERHAEEIIELKRRLNDIYVRHTGQEYDVVERKLDRD
EECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHCCH
TFLTAEEAMEFGIVDKVYERRTAEDEK
HHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
STSLQTALNLVPMVVEQTSRGERAFDIFSRLLKERIIFVTGGIDDGIASLITAQLLFLE
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHEE
SENPKREIAMYINSPGGYVSSGLAIYDTMQYVRCPISTVCIGQAASMGSLLLAAGEKGLR
CCCCCEEEEEEECCCCCHHHCCHHHHHHHHHHHCCHHHHHHCCHHCHHHHHEECCCCCCE
IALPNARVMLHQPSGGYSGVATDIERHAEEIIELKRRLNDIYVRHTGQEYDVVERKLDRD
EECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHCCH
TFLTAEEAMEFGIVDKVYERRTAEDEK
HHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA