Click here to switch to the map view.

The map label for this gene is yxbG [H]

Identifier: 114799743

GI number: 114799743

Start: 3310556

End: 3311338

Strand: Direct

Name: yxbG [H]

Synonym: HNE_3131

Alternate gene names: 114799743

Gene position: 3310556-3311338 (Clockwise)

Preceding gene: 114799406

Following gene: 114798977

Centisome position: 89.35

GC content: 61.17

Gene sequence:

>783_bases
ATGGAACTTAATTCAAACATCTCCGCCGTCATTACAGGCGGCGCATCCGGTCTCGGCGCGGCAACCGCCCGCAAACTGGC
CAGCTACGGCGTGAAAGTCGCACTGTTCGACCTTAACGCAGAAAAGGGCGAAGCGCTTGCAAAAGAACTTGGCGGCGTCT
TCTGCAATGTCAACGTTACGGATGAAGCTTCGGTGGATGCCGGTTTTGAAAAAGCCCGCGCCGCCATCGGCCAGGAGCGT
ATCCTGATTAACTGCGCTGGCACGGGCAACGCTATCAAGACCGCCAGCCGCGACAAGAACACCGGTGAAATCAGCCACTT
TGCGCTCGATAAGTTCAATCTGATCATCCAGATCAACCTTGTCGGCACCTTCCGCTGCATCGCCAAATCTGCTGCCGGCA
TGATGAGCCTCGACCCGCTGCCTTGCGGCGACCGCGGCGCCATCGTCAATACCGCTTCTGTGGCGGCTGAAGATGGCCAG
ATCGGCCAGGCAGCCTACTCCGCCTCCAAAGGCGGCGTTGTCGGCATGACACTTCCGATCGCCCGCGACCTGTCGCGCGA
GAACATCCGCGTCAACACGATCCTGCCGGGCATCTTCAACACGCCGCTGCTCGCAGCGGCTCCCGAGCCCGTCAAGCAAG
CCCTCGGCGCGCAGGTTCCGTTCCCGCCGCGCCTTGGCAACCCGGAAGAGTATGCGTCGCTGGCCACCGAAATGGTTCGC
AACAACTACTTCAACGGCGAAGACGTCCGCCTCGACGGCGCTATCCGGATGGCTCCGCGCTGA

Upstream 100 bases:

>100_bases
TGACCGTCTCGATGATTTCCGCTGCGTCAGACATTGCGCTCTCCTAGGGGCATTATAATTGAAGTCCGCCGTTTTCGAAA
ACTAAGGAGGGCAGTGCCCC

Downstream 100 bases:

>100_bases
TCCGGCCGGCCACAGGCCAATTCACCTATCGAAAGGCCCGCTCAGACGAGTGGGCCTTTTTTGTTGGGCCGCGCCGCGCT
TTCCCTGTCGCAGCGTCAGG

Product: short chain dehydrogenase/reductase family protein

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MELNSNISAVITGGASGLGAATARKLASYGVKVALFDLNAEKGEALAKELGGVFCNVNVTDEASVDAGFEKARAAIGQER
ILINCAGTGNAIKTASRDKNTGEISHFALDKFNLIIQINLVGTFRCIAKSAAGMMSLDPLPCGDRGAIVNTASVAAEDGQ
IGQAAYSASKGGVVGMTLPIARDLSRENIRVNTILPGIFNTPLLAAAPEPVKQALGAQVPFPPRLGNPEEYASLATEMVR
NNYFNGEDVRLDGAIRMAPR

Sequences:

>Translated_260_residues
MELNSNISAVITGGASGLGAATARKLASYGVKVALFDLNAEKGEALAKELGGVFCNVNVTDEASVDAGFEKARAAIGQER
ILINCAGTGNAIKTASRDKNTGEISHFALDKFNLIIQINLVGTFRCIAKSAAGMMSLDPLPCGDRGAIVNTASVAAEDGQ
IGQAAYSASKGGVVGMTLPIARDLSRENIRVNTILPGIFNTPLLAAAPEPVKQALGAQVPFPPRLGNPEEYASLATEMVR
NNYFNGEDVRLDGAIRMAPR
>Mature_260_residues
MELNSNISAVITGGASGLGAATARKLASYGVKVALFDLNAEKGEALAKELGGVFCNVNVTDEASVDAGFEKARAAIGQER
ILINCAGTGNAIKTASRDKNTGEISHFALDKFNLIIQINLVGTFRCIAKSAAGMMSLDPLPCGDRGAIVNTASVAAEDGQ
IGQAAYSASKGGVVGMTLPIARDLSRENIRVNTILPGIFNTPLLAAAPEPVKQALGAQVPFPPRLGNPEEYASLATEMVR
NNYFNGEDVRLDGAIRMAPR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=50.9803921568627, Blast_Score=232, Evalue=2e-61,
Organism=Homo sapiens, GI83715985, Length=255, Percent_Identity=48.6274509803922, Blast_Score=214, Evalue=5e-56,
Organism=Homo sapiens, GI15277342, Length=264, Percent_Identity=28.7878787878788, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI40254992, Length=252, Percent_Identity=27.7777777777778, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI31542939, Length=266, Percent_Identity=29.3233082706767, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI59889578, Length=239, Percent_Identity=27.6150627615063, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI5031737, Length=263, Percent_Identity=25.4752851711027, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1787335, Length=253, Percent_Identity=31.2252964426877, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1790717, Length=258, Percent_Identity=27.5193798449612, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082100, Length=262, Percent_Identity=29.0076335877863, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789057, Length=240, Percent_Identity=30, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI2367175, Length=259, Percent_Identity=29.7297297297297, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788459, Length=258, Percent_Identity=27.1317829457364, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=28.7937743190661, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789208, Length=257, Percent_Identity=28.0155642023346, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787905, Length=233, Percent_Identity=28.3261802575107, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=251, Percent_Identity=47.808764940239, Blast_Score=232, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17555706, Length=256, Percent_Identity=31.25, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25147288, Length=259, Percent_Identity=28.5714285714286, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI72000259, Length=270, Percent_Identity=28.1481481481481, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=271, Percent_Identity=29.520295202952, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=270, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=270, Percent_Identity=28.8888888888889, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=203, Percent_Identity=30.5418719211823, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737361, Length=256, Percent_Identity=53.90625, Blast_Score=250, Evalue=8e-67,
Organism=Drosophila melanogaster, GI24639444, Length=257, Percent_Identity=31.9066147859922, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI21355319, Length=250, Percent_Identity=27.6, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI116007236, Length=219, Percent_Identity=26.027397260274, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24644339, Length=202, Percent_Identity=29.7029702970297, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 27076; Mature: 27076

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELNSNISAVITGGASGLGAATARKLASYGVKVALFDLNAEKGEALAKELGGVFCNVNVT
CCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCEEEEEEEC
DEASVDAGFEKARAAIGQERILINCAGTGNAIKTASRDKNTGEISHFALDKFNLIIQINL
CCCCCCCCHHHHHHHCCCCEEEEEECCCCCCEECCCCCCCCCCHHEEEEEEEEEEEEEEE
VGTFRCIAKSAAGMMSLDPLPCGDRGAIVNTASVAAEDGQIGQAAYSASKGGVVGMTLPI
EHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHCCCCCCCCHHHHCCCCCCEEEEEEHH
ARDLSRENIRVNTILPGIFNTPLLAAAPEPVKQALGAQVPFPPRLGNPEEYASLATEMVR
HHCCCCCCEEEEEECCCHHCCCEECCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
NNYFNGEDVRLDGAIRMAPR
CCCCCCCEEEECCEEEECCC
>Mature Secondary Structure
MELNSNISAVITGGASGLGAATARKLASYGVKVALFDLNAEKGEALAKELGGVFCNVNVT
CCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCEEEEEEEC
DEASVDAGFEKARAAIGQERILINCAGTGNAIKTASRDKNTGEISHFALDKFNLIIQINL
CCCCCCCCHHHHHHHCCCCEEEEEECCCCCCEECCCCCCCCCCHHEEEEEEEEEEEEEEE
VGTFRCIAKSAAGMMSLDPLPCGDRGAIVNTASVAAEDGQIGQAAYSASKGGVVGMTLPI
EHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHCCCCCCCCHHHHCCCCCCEEEEEEHH
ARDLSRENIRVNTILPGIFNTPLLAAAPEPVKQALGAQVPFPPRLGNPEEYASLATEMVR
HHCCCCCCEEEEEECCCHHCCCEECCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
NNYFNGEDVRLDGAIRMAPR
CCCCCCCEEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377 [H]