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The map label for this gene is srrA [H]

Identifier: 114799615

GI number: 114799615

Start: 3321307

End: 3322008

Strand: Direct

Name: srrA [H]

Synonym: HNE_3142

Alternate gene names: 114799615

Gene position: 3321307-3322008 (Clockwise)

Preceding gene: 114800165

Following gene: 114799053

Centisome position: 89.64

GC content: 57.83

Gene sequence:

>702_bases
ATGCGCATTGTGCTGATCGACGATGACCGGATGGTTTTGGAAACCATCACCCTCGGCTGGCCCGATCCTGCCGATAAATT
CGATACATTCGAATCCTTCGAAGCGCTGAAACCGTTCCTTTATTCTGCGGACTTCCAATCGGTCAGTTGTGTGATCCTGG
ATCTCCAGCTGCCTGACGCATCCGGCTCGCAGGTTCTCGCGGAAATCCGCCGCCTCAGCGATGTGCCGATCATCATGCTG
TCGGGATGGGGAGATGCAGACTTTCGGGCCGACATCATCAACCGCGGAATTGATGATTATGTCCTCAAGCCCGCCAGCTC
AAAAGAACTGCACGCCCGCGCAAGCCGTCTGACAAGAAAGGCCAGCGCTCAGCCCCTCGCGGATTTGCCCGCGATTCTGA
CAATCGGCAATGTCGAGTATTTGCAGGAAGACCGCGCCCTGCGCCGCGCCGGTCAGGTCATCGAATTGACCCATGCGGAG
GCCAGCCTGCTTGACGCGCTCGCTGTCGCTGGCGGCAAGCCTGTCAGCCGGAACGACCTCTACTTTCAATCCTTCGGCCG
TCCCTACAAGGACGGAGAGAAAGTTCTAGAAACCTATATCAGCCGGTTGCGTCATAAGCTTGAGGAACTGGAAGCCGGAA
CAGGCCATGCTTTGCAGACAGCACGCGGAGTTGGATACCGGCTCGTCGCCCGAGCGGTCTAG

Upstream 100 bases:

>100_bases
TGTGTTATGGATGTGTAAATCCCGAAATGCCTAGCTCTGCCCGGAAGGAACACACCGGCAGCAGAACCGCTTTCAAAACC
TGTCGCAGCCGGAGCTGGCA

Downstream 100 bases:

>100_bases
GTGCTCGAAGGCAGCCGTTTGAAAATCCGGCCAAGCTTTCTGACAAGTTCATTCCGCTCATAGGGTTTACGCAACATCTC
GGCTCCCGGCTCCAGCGGGC

Product: DNA-binding response regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MRIVLIDDDRMVLETITLGWPDPADKFDTFESFEALKPFLYSADFQSVSCVILDLQLPDASGSQVLAEIRRLSDVPIIML
SGWGDADFRADIINRGIDDYVLKPASSKELHARASRLTRKASAQPLADLPAILTIGNVEYLQEDRALRRAGQVIELTHAE
ASLLDALAVAGGKPVSRNDLYFQSFGRPYKDGEKVLETYISRLRHKLEELEAGTGHALQTARGVGYRLVARAV

Sequences:

>Translated_233_residues
MRIVLIDDDRMVLETITLGWPDPADKFDTFESFEALKPFLYSADFQSVSCVILDLQLPDASGSQVLAEIRRLSDVPIIML
SGWGDADFRADIINRGIDDYVLKPASSKELHARASRLTRKASAQPLADLPAILTIGNVEYLQEDRALRRAGQVIELTHAE
ASLLDALAVAGGKPVSRNDLYFQSFGRPYKDGEKVLETYISRLRHKLEELEAGTGHALQTARGVGYRLVARAV
>Mature_233_residues
MRIVLIDDDRMVLETITLGWPDPADKFDTFESFEALKPFLYSADFQSVSCVILDLQLPDASGSQVLAEIRRLSDVPIIML
SGWGDADFRADIINRGIDDYVLKPASSKELHARASRLTRKASAQPLADLPAILTIGNVEYLQEDRALRRAGQVIELTHAE
ASLLDALAVAGGKPVSRNDLYFQSFGRPYKDGEKVLETYISRLRHKLEELEAGTGHALQTARGVGYRLVARAV

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790552, Length=232, Percent_Identity=30.1724137931034, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1786911, Length=206, Percent_Identity=31.0679611650485, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788394, Length=188, Percent_Identity=31.9148936170213, Blast_Score=80, Evalue=8e-17,
Organism=Escherichia coli, GI1789809, Length=189, Percent_Identity=32.2751322751323, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786599, Length=184, Percent_Identity=29.3478260869565, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082012, Length=230, Percent_Identity=28.2608695652174, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789402, Length=229, Percent_Identity=29.2576419213974, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1786784, Length=230, Percent_Identity=25.2173913043478, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787229, Length=190, Percent_Identity=32.1052631578947, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790860, Length=199, Percent_Identity=28.643216080402, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI2367329, Length=186, Percent_Identity=30.1075268817204, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787375, Length=238, Percent_Identity=28.1512605042017, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25798; Mature: 25798

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVLIDDDRMVLETITLGWPDPADKFDTFESFEALKPFLYSADFQSVSCVILDLQLPDA
CEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCC
SGSQVLAEIRRLSDVPIIMLSGWGDADFRADIINRGIDDYVLKPASSKELHARASRLTRK
CCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHH
ASAQPLADLPAILTIGNVEYLQEDRALRRAGQVIELTHAEASLLDALAVAGGKPVSRNDL
HCCCCCHHCCHHEEECCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCC
YFQSFGRPYKDGEKVLETYISRLRHKLEELEAGTGHALQTARGVGYRLVARAV
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHCC
>Mature Secondary Structure
MRIVLIDDDRMVLETITLGWPDPADKFDTFESFEALKPFLYSADFQSVSCVILDLQLPDA
CEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCC
SGSQVLAEIRRLSDVPIIMLSGWGDADFRADIINRGIDDYVLKPASSKELHARASRLTRK
CCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHH
ASAQPLADLPAILTIGNVEYLQEDRALRRAGQVIELTHAEASLLDALAVAGGKPVSRNDL
HCCCCCHHCCHHEEECCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCC
YFQSFGRPYKDGEKVLETYISRLRHKLEELEAGTGHALQTARGVGYRLVARAV
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA