Click here to switch to the map view.

The map label for this gene is ggt2 [H]

Identifier: 114799053

GI number: 114799053

Start: 3327785

End: 3329566

Strand: Direct

Name: ggt2 [H]

Synonym: HNE_3148

Alternate gene names: 114799053

Gene position: 3327785-3329566 (Clockwise)

Preceding gene: 114799615

Following gene: 114800430

Centisome position: 89.82

GC content: 65.71

Gene sequence:

>1782_bases
ATGCGCCACCTCCCCGCCCTCACAGCTGCCCTCATTCTGGCGGCTTGCGCCCCAGCGGCGAAGGCGCCGCCCGCCTCGAG
CATTACGCCCGTGTCAGACGAGACGCCCGAAGCGCTGGGCGACCTCTCCTGGACAAAAGGCGCGATGGTGGCCGCCGCAG
ATCCGCGCGCCGTTGAAGCGGGCCTGCGCGTATTGAGTGAAGGCGGTAATGCCGTTGATGCAGCCATTGCCGTGCATGCC
GTTCTCGGCCTGGTCGAGCCCCAAAGCTCGGGCATCGGCGGAGGCGCGTTCATGGTCTATTACGACCGCGCCAGCGACGA
GATCACCGTGTTTGATGGCCGCGAGACTGCGCCGGCCGCCGCAGGCCCGGACTGGTTCTCCAAGGACGGCAAGCCGATGG
ATTTCCTGACCGCCTGGCAGTCGGGCCGCTCGGTCGGCGTGCCGGGACAGATCGCGCTCTACAAGACCGCCCATGACGCG
GCCGGACAGGGGGATTGGGCGAGCCTTTTCCAACCGGCCATCGAGCTGGCTGAAGTCGGTTTTGAAGTCTCGCCGCGCCT
TGCCGAAGTGCTTGCCTCCGAGCGTCTGCGCGCCGTGATCCGTCTCGACGACAACCCGGTCACTGCCGCTTACTTCTATC
CCGATGGCCAGCCGCTGGCGGCCGGTTACCGGCGCACCAATGCGGCCTATGCGGCCACACTCGCGGCGGTCGCCAATGAA
GGCCCGGCTGCGTTCTATACCGGCGCGCTGGCGGCCGAGATCGTCAACGCGACCAATGAGGGCCCGGACGGCGGCAACAT
GACGCTCGACGACCTGGCCGGGTATGAGGTGAAGGTTCGCTCGGCACTCTGCGGCACGCTGCAGTCCGGCTACAAGATCT
GCTCGGCGCCGCCGCCAAGCTCGGGCGGCATCACGCAGAACATGATCATGGGTCTTTACGAGCATCTGAGGCCTGGCCCC
ACGGTCAATGCCGATGAGAGCCTGCTGCTCAAAGCCTTCGTGGATGCCCAGCGTCTCGCCTATGCCGACCGCGATCACTA
CGTGGCAGACGCCGATCATGTAACGGTGCCCTCCGCGGAACTGATCAACCCGGACTACCTTGAAGCGCGCGCCAAGGAAG
CGTTTGCCCCCGATGGCAAAGTCTTCCCCGGCGATCCCGGCGTCGTTCTGGGCGGTGAACCGATGCGGCCGATGTGGGGC
GAAGACCCCACCACCCCCGGCGCCGGCACAACCCATATCTCGATCATTGATCTTGAGGGCAATGCCGTCTCGATGACCGC
CACCGTGGAAGCCGCGTTCGGCTCCTCGCGCATGGCCGGCGGTTTCCTGCTCAATAACGAGCTGACCGACTTCTCCCTGA
TCCCCGAAATGGGCGGCAAGCCGGTGGCCAATGCGGTCGCCGCTGGCAAGCGCCCGCGCTCGTCGATGTCCCCTACCCTC
GTCTTCGATGAGGCCGGCGACCTCTTCATGGTCACCGGATCGCCCGGCGGAAATTCCATCGTCGCCTATGTTTCCAAGAC
GCTGATGGGCGTGCTCGAATGGGGCAAGACGGCTCAGGAAGCCGCCGCCCTGCCCAACATCATCGCCCGCGGAAACACTG
TCGGTGTTGAAGTGGACATCGACGGCGGCCCCGAAGCCGCCGAAGCGCTTCGCGGCATGGGCTATACTGTGGAAGAACGC
ACAGGCGAAAATTCCGGTCTCCATGTCATCGTCGTTCGTGACCAGGGCCTTGAGGGCGGCGCCGATCCGCGCCGTGAAGG
CGTCGCGCTGTCTCTTCGCTGA

Upstream 100 bases:

>100_bases
TTGCGCGTACCCGGTCTTGCCATGCTATGTGCCCTGCTACGTTTATGCTCCGCACTGACCCTTAGAGTGAGTGGAGCGCC
GCGCCAAGAAAGGGACGATC

Downstream 100 bases:

>100_bases
TCCAGACAGACGCAGGCCCGTCATGGCGAAACTCTATTTTTCCTACGCCGCCATGAATGCCGGCAAATCCACCATCCTCC
TGCAAGCGGCCTATAATTAC

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MRHLPALTAALILAACAPAAKAPPASSITPVSDETPEALGDLSWTKGAMVAAADPRAVEAGLRVLSEGGNAVDAAIAVHA
VLGLVEPQSSGIGGGAFMVYYDRASDEITVFDGRETAPAAAGPDWFSKDGKPMDFLTAWQSGRSVGVPGQIALYKTAHDA
AGQGDWASLFQPAIELAEVGFEVSPRLAEVLASERLRAVIRLDDNPVTAAYFYPDGQPLAAGYRRTNAAYAATLAAVANE
GPAAFYTGALAAEIVNATNEGPDGGNMTLDDLAGYEVKVRSALCGTLQSGYKICSAPPPSSGGITQNMIMGLYEHLRPGP
TVNADESLLLKAFVDAQRLAYADRDHYVADADHVTVPSAELINPDYLEARAKEAFAPDGKVFPGDPGVVLGGEPMRPMWG
EDPTTPGAGTTHISIIDLEGNAVSMTATVEAAFGSSRMAGGFLLNNELTDFSLIPEMGGKPVANAVAAGKRPRSSMSPTL
VFDEAGDLFMVTGSPGGNSIVAYVSKTLMGVLEWGKTAQEAAALPNIIARGNTVGVEVDIDGGPEAAEALRGMGYTVEER
TGENSGLHVIVVRDQGLEGGADPRREGVALSLR

Sequences:

>Translated_593_residues
MRHLPALTAALILAACAPAAKAPPASSITPVSDETPEALGDLSWTKGAMVAAADPRAVEAGLRVLSEGGNAVDAAIAVHA
VLGLVEPQSSGIGGGAFMVYYDRASDEITVFDGRETAPAAAGPDWFSKDGKPMDFLTAWQSGRSVGVPGQIALYKTAHDA
AGQGDWASLFQPAIELAEVGFEVSPRLAEVLASERLRAVIRLDDNPVTAAYFYPDGQPLAAGYRRTNAAYAATLAAVANE
GPAAFYTGALAAEIVNATNEGPDGGNMTLDDLAGYEVKVRSALCGTLQSGYKICSAPPPSSGGITQNMIMGLYEHLRPGP
TVNADESLLLKAFVDAQRLAYADRDHYVADADHVTVPSAELINPDYLEARAKEAFAPDGKVFPGDPGVVLGGEPMRPMWG
EDPTTPGAGTTHISIIDLEGNAVSMTATVEAAFGSSRMAGGFLLNNELTDFSLIPEMGGKPVANAVAAGKRPRSSMSPTL
VFDEAGDLFMVTGSPGGNSIVAYVSKTLMGVLEWGKTAQEAAALPNIIARGNTVGVEVDIDGGPEAAEALRGMGYTVEER
TGENSGLHVIVVRDQGLEGGADPRREGVALSLR
>Mature_593_residues
MRHLPALTAALILAACAPAAKAPPASSITPVSDETPEALGDLSWTKGAMVAAADPRAVEAGLRVLSEGGNAVDAAIAVHA
VLGLVEPQSSGIGGGAFMVYYDRASDEITVFDGRETAPAAAGPDWFSKDGKPMDFLTAWQSGRSVGVPGQIALYKTAHDA
AGQGDWASLFQPAIELAEVGFEVSPRLAEVLASERLRAVIRLDDNPVTAAYFYPDGQPLAAGYRRTNAAYAATLAAVANE
GPAAFYTGALAAEIVNATNEGPDGGNMTLDDLAGYEVKVRSALCGTLQSGYKICSAPPPSSGGITQNMIMGLYEHLRPGP
TVNADESLLLKAFVDAQRLAYADRDHYVADADHVTVPSAELINPDYLEARAKEAFAPDGKVFPGDPGVVLGGEPMRPMWG
EDPTTPGAGTTHISIIDLEGNAVSMTATVEAAFGSSRMAGGFLLNNELTDFSLIPEMGGKPVANAVAAGKRPRSSMSPTL
VFDEAGDLFMVTGSPGGNSIVAYVSKTLMGVLEWGKTAQEAAALPNIIARGNTVGVEVDIDGGPEAAEALRGMGYTVEER
TGENSGLHVIVVRDQGLEGGADPRREGVALSLR

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=520, Percent_Identity=31.9230769230769, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI73915090, Length=520, Percent_Identity=31.9230769230769, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI73915096, Length=520, Percent_Identity=31.9230769230769, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI73915094, Length=520, Percent_Identity=31.9230769230769, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI113429324, Length=520, Percent_Identity=32.1153846153846, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI113429326, Length=525, Percent_Identity=32, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI153266901, Length=534, Percent_Identity=30.1498127340824, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI153266885, Length=533, Percent_Identity=29.8311444652908, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI153266907, Length=533, Percent_Identity=28.5178236397749, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI109148539, Length=533, Percent_Identity=27.3921200750469, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI30581157, Length=187, Percent_Identity=32.0855614973262, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI30581155, Length=187, Percent_Identity=32.0855614973262, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789856, Length=554, Percent_Identity=33.7545126353791, Blast_Score=251, Evalue=9e-68,
Organism=Caenorhabditis elegans, GI17542894, Length=554, Percent_Identity=31.2274368231047, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI193208247, Length=569, Percent_Identity=31.9859402460457, Blast_Score=203, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI193208245, Length=569, Percent_Identity=31.9859402460457, Blast_Score=203, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI212646519, Length=496, Percent_Identity=33.2661290322581, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI72000294, Length=557, Percent_Identity=31.4183123877917, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17506189, Length=519, Percent_Identity=30.2504816955684, Blast_Score=185, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17564448, Length=426, Percent_Identity=25.3521126760563, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI72001497, Length=452, Percent_Identity=24.3362831858407, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI72001495, Length=309, Percent_Identity=25.5663430420712, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6323330, Length=161, Percent_Identity=32.9192546583851, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI161077496, Length=475, Percent_Identity=30.9473684210526, Blast_Score=172, Evalue=9e-43,
Organism=Drosophila melanogaster, GI18859893, Length=498, Percent_Identity=30.7228915662651, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45551474, Length=557, Percent_Identity=27.4685816876122, Blast_Score=162, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24642670, Length=557, Percent_Identity=27.4685816876122, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24642666, Length=557, Percent_Identity=27.4685816876122, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI161077878, Length=563, Percent_Identity=27.5310834813499, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI161077880, Length=563, Percent_Identity=27.5310834813499, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI18859741, Length=514, Percent_Identity=28.5992217898833, Blast_Score=149, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61436; Mature: 61436

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHLPALTAALILAACAPAAKAPPASSITPVSDETPEALGDLSWTKGAMVAAADPRAVEA
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEECCCHHHHH
GLRVLSEGGNAVDAAIAVHAVLGLVEPQSSGIGGGAFMVYYDRASDEITVFDGRETAPAA
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCC
AGPDWFSKDGKPMDFLTAWQSGRSVGVPGQIALYKTAHDAAGQGDWASLFQPAIELAEVG
CCCCHHCCCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCC
FEVSPRLAEVLASERLRAVIRLDDNPVTAAYFYPDGQPLAAGYRRTNAAYAATLAAVANE
CCCCHHHHHHHHHHHEEEEEEECCCCEEEEEECCCCCCHHCCHHHCCHHHHHHHHHHHCC
GPAAFYTGALAAEIVNATNEGPDGGNMTLDDLAGYEVKVRSALCGTLQSGYKICSAPPPS
CCCHHHHHHHHHHHHHCCCCCCCCCCEEHHHHCCCEEEEHHHHHHHHHCCCEEECCCCCC
SGGITQNMIMGLYEHLRPGPTVNADESLLLKAFVDAQRLAYADRDHYVADADHVTVPSAE
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCEECCCHH
LINPDYLEARAKEAFAPDGKVFPGDPGVVLGGEPMRPMWGEDPTTPGAGTTHISIIDLEG
HCCCHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECC
NAVSMTATVEAAFGSSRMAGGFLLNNELTDFSLIPEMGGKPVANAVAAGKRPRSSMSPTL
CEEEEEEEEEECCCCCCCCCCEEECCCCCCEEECCCCCCCCHHHHHHCCCCCCCCCCCEE
VFDEAGDLFMVTGSPGGNSIVAYVSKTLMGVLEWGKTAQEAAALPNIIARGNTVGVEVDI
EEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHCCCEEEEEEEE
DGGPEAAEALRGMGYTVEERTGENSGLHVIVVRDQGLEGGADPRREGVALSLR
CCCCHHHHHHHHCCCEEHHCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MRHLPALTAALILAACAPAAKAPPASSITPVSDETPEALGDLSWTKGAMVAAADPRAVEA
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEECCCHHHHH
GLRVLSEGGNAVDAAIAVHAVLGLVEPQSSGIGGGAFMVYYDRASDEITVFDGRETAPAA
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCC
AGPDWFSKDGKPMDFLTAWQSGRSVGVPGQIALYKTAHDAAGQGDWASLFQPAIELAEVG
CCCCHHCCCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCC
FEVSPRLAEVLASERLRAVIRLDDNPVTAAYFYPDGQPLAAGYRRTNAAYAATLAAVANE
CCCCHHHHHHHHHHHEEEEEEECCCCEEEEEECCCCCCHHCCHHHCCHHHHHHHHHHHCC
GPAAFYTGALAAEIVNATNEGPDGGNMTLDDLAGYEVKVRSALCGTLQSGYKICSAPPPS
CCCHHHHHHHHHHHHHCCCCCCCCCCEEHHHHCCCEEEEHHHHHHHHHCCCEEECCCCCC
SGGITQNMIMGLYEHLRPGPTVNADESLLLKAFVDAQRLAYADRDHYVADADHVTVPSAE
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCEECCCHH
LINPDYLEARAKEAFAPDGKVFPGDPGVVLGGEPMRPMWGEDPTTPGAGTTHISIIDLEG
HCCCHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECC
NAVSMTATVEAAFGSSRMAGGFLLNNELTDFSLIPEMGGKPVANAVAAGKRPRSSMSPTL
CEEEEEEEEEECCCCCCCCCCEEECCCCCCEEECCCCCCCCHHHHHHCCCCCCCCCCCEE
VFDEAGDLFMVTGSPGGNSIVAYVSKTLMGVLEWGKTAQEAAALPNIIARGNTVGVEVDI
EEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHCCCEEEEEEEE
DGGPEAAEALRGMGYTVEERTGENSGLHVIVVRDQGLEGGADPRREGVALSLR
CCCCHHHHHHHHCCCEEHHCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA