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The map label for this gene is iorA [H]

Identifier: 114799494

GI number: 114799494

Start: 2612062

End: 2612517

Strand: Reverse

Name: iorA [H]

Synonym: HNE_2483

Alternate gene names: 114799494

Gene position: 2612517-2612062 (Counterclockwise)

Preceding gene: 114800492

Following gene: 114798763

Centisome position: 70.51

GC content: 59.43

Gene sequence:

>456_bases
ATGGCCAATCTGAAAGTCAATGGGAAACCGGTGTCCGTCGAGGCGGATGAGAGTACGCCGCTTTTGTGGGTTCTGAGGGA
ACAGCTTGGCCTGACGGGGACGAAATACGGATGCGGGATTGCAGCCTGCGGCGCCTGTACCATCCATATTGATGGGGCCG
CCGTGCGCGCCTGCGTTTATCCGCTGGGCGCCCTTTCCGGGGAAGAAGAGATCACGACCATCGAGGGCCTTTCGGCGGAT
GGCAGCCATCCCGTTCAACAGGCCTGGGTGGAACTGGACGTGCCCCAGTGCGGTTATTGCCAGCCCGGCATGATCATGGC
CGTGGCCGGCATGCTCAACAGCAACCCCAATCCTACCGACGAAGACATTGATCTTGAGATCACCAATATCTGCCGGTGCG
GAACATTCACGCGTGTGCGCAAGGGCGTGCATCTTGCCAAGACCAAGAAAGCCTGA

Upstream 100 bases:

>100_bases
CTGGTCGGGAATCCTGTTCTCCGAATGGTAGATGAGAGCCCAGCACACGTGATACGCACCTGCAGACGCACCCTGCAGCG
AATGGAAATGGAGACGCGAC

Downstream 100 bases:

>100_bases
GGACGGGAGACGGATATGACTGGAATTACGGATCTTTCCCGCCGCGCCTTTATCATTGCCACCGGAGCGACCGGCTTGGC
GATTGGTGTTCTTGCCGCCT

Product: putative isoquinoline 1-oxidoreductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 151; Mature: 150

Protein sequence:

>151_residues
MANLKVNGKPVSVEADESTPLLWVLREQLGLTGTKYGCGIAACGACTIHIDGAAVRACVYPLGALSGEEEITTIEGLSAD
GSHPVQQAWVELDVPQCGYCQPGMIMAVAGMLNSNPNPTDEDIDLEITNICRCGTFTRVRKGVHLAKTKKA

Sequences:

>Translated_151_residues
MANLKVNGKPVSVEADESTPLLWVLREQLGLTGTKYGCGIAACGACTIHIDGAAVRACVYPLGALSGEEEITTIEGLSAD
GSHPVQQAWVELDVPQCGYCQPGMIMAVAGMLNSNPNPTDEDIDLEITNICRCGTFTRVRKGVHLAKTKKA
>Mature_150_residues
ANLKVNGKPVSVEADESTPLLWVLREQLGLTGTKYGCGIAACGACTIHIDGAAVRACVYPLGALSGEEEITTIEGLSADG
SHPVQQAWVELDVPQCGYCQPGMIMAVAGMLNSNPNPTDEDIDLEITNICRCGTFTRVRKGVHLAKTKKA

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=153, Percent_Identity=37.2549019607843, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI71773480, Length=144, Percent_Identity=37.5, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1786480, Length=153, Percent_Identity=41.1764705882353, Blast_Score=102, Evalue=1e-23,
Organism=Escherichia coli, GI1789232, Length=139, Percent_Identity=41.0071942446043, Blast_Score=92, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17540638, Length=143, Percent_Identity=39.8601398601399, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17539860, Length=154, Percent_Identity=35.0649350649351, Blast_Score=93, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI32566215, Length=154, Percent_Identity=34.4155844155844, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17737937, Length=151, Percent_Identity=35.7615894039735, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24647197, Length=147, Percent_Identity=34.0136054421769, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24647195, Length=147, Percent_Identity=34.0136054421769, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24647201, Length=141, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24647193, Length=124, Percent_Identity=37.0967741935484, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24647199, Length=141, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 15958; Mature: 15827

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
5.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLKVNGKPVSVEADESTPLLWVLREQLGLTGTKYGCGIAACGACTIHIDGAAVRACVY
CCCEECCCEEEEEECCCCCCCCEEEHHHHCCCCCCCCCCEEECCEEEEEECCHHHHHHHH
PLGALSGEEEITTIEGLSADGSHPVQQAWVELDVPQCGYCQPGMIMAVAGMLNSNPNPTD
HHHCCCCCCCEEEEECCCCCCCCCHHHHEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCC
EDIDLEITNICRCGTFTRVRKGVHLAKTKKA
CCCCEEEEEEECCCCHHHHHCCEECCCCCCC
>Mature Secondary Structure 
ANLKVNGKPVSVEADESTPLLWVLREQLGLTGTKYGCGIAACGACTIHIDGAAVRACVY
CCEECCCEEEEEECCCCCCCCEEEHHHHCCCCCCCCCCEEECCEEEEEECCHHHHHHHH
PLGALSGEEEITTIEGLSADGSHPVQQAWVELDVPQCGYCQPGMIMAVAGMLNSNPNPTD
HHHCCCCCCCEEEEECCCCCCCCCHHHHEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCC
EDIDLEITNICRCGTFTRVRKGVHLAKTKKA
CCCCEEEEEEECCCCHHHHHCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]