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The map label for this gene is icd [H]

Identifier: 114799491

GI number: 114799491

Start: 1185186

End: 1186403

Strand: Reverse

Name: icd [H]

Synonym: HNE_1177

Alternate gene names: 114799491

Gene position: 1186403-1185186 (Counterclockwise)

Preceding gene: 114797528

Following gene: 114798743

Centisome position: 32.02

GC content: 58.95

Gene sequence:

>1218_bases
ATGGCGAAGATCAAGGTCAAAAACCCGATTGTCGAGATGGACGGGGACGAGATGACCCGGATCATCTGGCAACTCATCAA
AGACAAGCTGATCCACCCCTACCTCGATATCGACCTGAAATATTACGACCTCTCGATCGAGAAACGCGACGAGACCGACG
ACCAGATCACCATCGACTCGGCCGAAGCCACCAAGAAATACGGCGTCGCCGTCAAGTGCGCGACCATCACGCCGGACGAA
GCCCGCGTTGAGGAATTCGGTCTGAAGAAGATGTGGAAGTCGCCCAACGGCACCATCCGCAACATCCTTGGCGGCGTTGT
CTTCCGCGAGCCGATCGTCATCTCCAACATCCCGCGCCTCGTGCCCGGCTGGACCAAGCCAGTCATCATCGGCCGCCATG
CTTTCGGCGACCAGTACCGCGCCACTGACTTCCTCGTCCCCGGCAAGGGCAAGCTGACGATGAAATTCGAAGGCGAAGAC
GGCAAGGTCATCGAAAAGGAAATCTTCGATTTCCCGAGCGCCGGCATCGCCATGGGTATGTACAACCTTGACGACTCGAT
CCGCGACTTCGCCCGCGCCTCGTTCAACTATGGCCTCCAGCGCAAACTGCCGGTCTACCTCTCCACCAAGAACACGATCC
TGAAAGCCTATGACGGCCGCTTCAAGGACATCTTCCAGGAAGAGTGGGACAAAGAGTTCAAAGCCAAGTTCGCCGAATTC
AAAGGCACCTACGAGCACCGCCTCATCGACGACATGGTCGCGGCTGCCATGAAATGGTCGGGCGGCTATGTCTGGGCCTG
TAAGAACTATGACGGCGACGTTCAGTCCGACACGGTTGCTCAAGGTTATGGCTCGCTCGGTCTGATGACGTCGGTCCTGC
TCAGCCCCGATGGCAAGACCGTCGAAGCCGAAGCCGCCCACGGCACCGTCACCCGCCACTACCGCGCCCACCAGAAGGGC
GAAGCCACTTCGACCAACTCGATCGCGTCGATCTACGCCTGGACGCAGGGCCTCGACCATCGCGGCCGCATGGACGAGAC
CCCCGAAGTGCGCAAGTTCGCCCAGACGCTTGAGAAAACCATCATCAAGACCGTCGAAGCCGGCTTCATGACCAAAGACC
TCGCCCTCCTCGTCGGCCCCGACCAGGGCTATCTGACGACCGAAGGCTTCATCGAAAAAGTCGCCCAGAACCTCGAAATC
GAGATGGGCAAAGCGTAA

Upstream 100 bases:

>100_bases
CAGGAGCGCGTTGCATGACTGCCTCGTTTCCGGGTTTTGACGCGGCCTGTGGGTCTGCTATAGCCCCGCCCAACCGTATG
CAGCGCAAGGATTCCAAAAA

Downstream 100 bases:

>100_bases
CGCACATACAGGTCAGGCCCCTCCCCAAAGGAGGGGCCTCTCCACCAGGCACCCAGGGAAGGCGCATTAGATGACCGCAT
CAGCCGCCCCCCGCCGCCCC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MAKIKVKNPIVEMDGDEMTRIIWQLIKDKLIHPYLDIDLKYYDLSIEKRDETDDQITIDSAEATKKYGVAVKCATITPDE
ARVEEFGLKKMWKSPNGTIRNILGGVVFREPIVISNIPRLVPGWTKPVIIGRHAFGDQYRATDFLVPGKGKLTMKFEGED
GKVIEKEIFDFPSAGIAMGMYNLDDSIRDFARASFNYGLQRKLPVYLSTKNTILKAYDGRFKDIFQEEWDKEFKAKFAEF
KGTYEHRLIDDMVAAAMKWSGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLLSPDGKTVEAEAAHGTVTRHYRAHQKG
EATSTNSIASIYAWTQGLDHRGRMDETPEVRKFAQTLEKTIIKTVEAGFMTKDLALLVGPDQGYLTTEGFIEKVAQNLEI
EMGKA

Sequences:

>Translated_405_residues
MAKIKVKNPIVEMDGDEMTRIIWQLIKDKLIHPYLDIDLKYYDLSIEKRDETDDQITIDSAEATKKYGVAVKCATITPDE
ARVEEFGLKKMWKSPNGTIRNILGGVVFREPIVISNIPRLVPGWTKPVIIGRHAFGDQYRATDFLVPGKGKLTMKFEGED
GKVIEKEIFDFPSAGIAMGMYNLDDSIRDFARASFNYGLQRKLPVYLSTKNTILKAYDGRFKDIFQEEWDKEFKAKFAEF
KGTYEHRLIDDMVAAAMKWSGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLLSPDGKTVEAEAAHGTVTRHYRAHQKG
EATSTNSIASIYAWTQGLDHRGRMDETPEVRKFAQTLEKTIIKTVEAGFMTKDLALLVGPDQGYLTTEGFIEKVAQNLEI
EMGKA
>Mature_404_residues
AKIKVKNPIVEMDGDEMTRIIWQLIKDKLIHPYLDIDLKYYDLSIEKRDETDDQITIDSAEATKKYGVAVKCATITPDEA
RVEEFGLKKMWKSPNGTIRNILGGVVFREPIVISNIPRLVPGWTKPVIIGRHAFGDQYRATDFLVPGKGKLTMKFEGEDG
KVIEKEIFDFPSAGIAMGMYNLDDSIRDFARASFNYGLQRKLPVYLSTKNTILKAYDGRFKDIFQEEWDKEFKAKFAEFK
GTYEHRLIDDMVAAAMKWSGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLLSPDGKTVEAEAAHGTVTRHYRAHQKGE
ATSTNSIASIYAWTQGLDHRGRMDETPEVRKFAQTLEKTIIKTVEAGFMTKDLALLVGPDQGYLTTEGFIEKVAQNLEIE
MGKA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=409, Percent_Identity=66.0146699266504, Blast_Score=566, Evalue=1e-162,
Organism=Homo sapiens, GI28178825, Length=412, Percent_Identity=64.0776699029126, Blast_Score=543, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17540874, Length=407, Percent_Identity=66.8304668304668, Blast_Score=560, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI17550822, Length=399, Percent_Identity=63.4085213032581, Blast_Score=538, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6323203, Length=410, Percent_Identity=65.1219512195122, Blast_Score=553, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6324319, Length=407, Percent_Identity=65.6019656019656, Blast_Score=553, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6320137, Length=408, Percent_Identity=63.4803921568627, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI21356561, Length=410, Percent_Identity=63.9024390243902, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI221330987, Length=410, Percent_Identity=63.9024390243902, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI221330985, Length=410, Percent_Identity=63.9024390243902, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI28574947, Length=410, Percent_Identity=63.9024390243902, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24660849, Length=410, Percent_Identity=63.9024390243902, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24660856, Length=410, Percent_Identity=63.9024390243902, Blast_Score=546, Evalue=1e-156,
Organism=Drosophila melanogaster, GI221330983, Length=410, Percent_Identity=63.9024390243902, Blast_Score=546, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24660868, Length=410, Percent_Identity=63.9024390243902, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24660860, Length=410, Percent_Identity=63.9024390243902, Blast_Score=545, Evalue=1e-155,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45592; Mature: 45460

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKVKNPIVEMDGDEMTRIIWQLIKDKLIHPYLDIDLKYYDLSIEKRDETDDQITIDS
CCEEEECCCEEECCCHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEEECCCCCCCEEEEEC
AEATKKYGVAVKCATITPDEARVEEFGLKKMWKSPNGTIRNILGGVVFREPIVISNIPRL
HHHHHHCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCC
VPGWTKPVIIGRHAFGDQYRATDFLVPGKGKLTMKFEGEDGKVIEKEIFDFPSAGIAMGM
CCCCCCCEEEEECCCCCCCCCCEEEECCCCEEEEEEECCCCCCHHHHHHCCCCCCCEEEE
YNLDDSIRDFARASFNYGLQRKLPVYLSTKNTILKAYDGRFKDIFQEEWDKEFKAKFAEF
ECCCHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEHHCCHHHHHHHHHHCHHHHHHHHHH
KGTYEHRLIDDMVAAAMKWSGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLLSPDGKT
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHCCCCHHHHHHHHCCCCCCE
VEAEAAHGTVTRHYRAHQKGEATSTNSIASIYAWTQGLDHRGRMDETPEVRKFAQTLEKT
EEECCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
IIKTVEAGFMTKDLALLVGPDQGYLTTEGFIEKVAQNLEIEMGKA
HHHHHHHCCCEECEEEEECCCCCCEEHHHHHHHHHHCCCEEECCC
>Mature Secondary Structure 
AKIKVKNPIVEMDGDEMTRIIWQLIKDKLIHPYLDIDLKYYDLSIEKRDETDDQITIDS
CEEEECCCEEECCCHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEEECCCCCCCEEEEEC
AEATKKYGVAVKCATITPDEARVEEFGLKKMWKSPNGTIRNILGGVVFREPIVISNIPRL
HHHHHHCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCC
VPGWTKPVIIGRHAFGDQYRATDFLVPGKGKLTMKFEGEDGKVIEKEIFDFPSAGIAMGM
CCCCCCCEEEEECCCCCCCCCCEEEECCCCEEEEEEECCCCCCHHHHHHCCCCCCCEEEE
YNLDDSIRDFARASFNYGLQRKLPVYLSTKNTILKAYDGRFKDIFQEEWDKEFKAKFAEF
ECCCHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEHHCCHHHHHHHHHHCHHHHHHHHHH
KGTYEHRLIDDMVAAAMKWSGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLLSPDGKT
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHCCCCHHHHHHHHCCCCCCE
VEAEAAHGTVTRHYRAHQKGEATSTNSIASIYAWTQGLDHRGRMDETPEVRKFAQTLEKT
EEECCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
IIKTVEAGFMTKDLALLVGPDQGYLTTEGFIEKVAQNLEIEMGKA
HHHHHHHCCCEECEEEEECCCCCCEEHHHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]