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The map label for this gene is gor [H]

Identifier: 114799468

GI number: 114799468

Start: 718635

End: 720020

Strand: Direct

Name: gor [H]

Synonym: HNE_0707

Alternate gene names: 114799468

Gene position: 718635-720020 (Clockwise)

Preceding gene: 114798972

Following gene: 114797431

Centisome position: 19.4

GC content: 61.98

Gene sequence:

>1386_bases
ATGACCGACACCGCCTACGACTATGACCTGTTCGTGATTGGCGGTGGTTCGGGGGGCGTGCGCGCGGGCCGGATTGCGGC
GCAGGCAGGCGCAAAGGTCGCCCTTGCTGAAGAATACCGCATGGGCGGCACCTGCGTCGTGCGCGGCTGTGTGCCGAAGA
AGTTCATGGTGTATTCCAGCACCTATGGCAAACACATCAAGCTCTCTGCCGGGTACGGATGGTCCGTGGGCGACGTATCC
TATGACCATAGCGCGTTCATGGTGGCGCTGCACGCCGAGGTCGAGCGGCTGTCGGCGATCTATGACCGCAACCTCAAGAA
TGCCGGGGTTGATGTGTTCGATGACCGGGCCGAATTCGTGGACGCGCATACGCTGCGCCTGAAGAAATCCGGCAAGACGG
TCACGGCCGGGAAAATCCTGATCGCCACGGGTGGCCGCCCCTGGATGCCGTCGGCAGACGAGCTGCCCGGCATTGAGCAC
GCCATCGATTCCAACGGCGTGTTCGAAATGGACACGCTGCCAAAGCGGATGCTGATCGCGGGCGGGGGCTATATCGCAGT
CGAGTTTGCCCACATCTTTGCCGGGCTCGGCGCTGAGGTAACGCTGGTCTATCGCGGCGAGACCGTGCTGCGCGGCTTTG
ACGATGAGATCCGCCTCGCCGTGCATGAGGGCCTGAAGGAGGCCGGCGTGCGCGTCGTCACCAAGTGCACCTTCAAATCC
ATCGAGAAAACCGGGGGTGGCCTTATGGTCACCATGAGCAGCGGTAACGAGATCGACACCGATGTGGTGCTGATGGCGGT
TGGCCGCCGGGCGAATACGGATGATCTTGGCTGCGACAAGGCAGGCGTGAAGCTGGCCGAGCAGGGCGAGGTGATCGTCG
ACGAATGGTCGCGCACAAATGTGGAGAACATCTGGGCGGTGGGCGATGTCACGGGCCGCGTGGCGCTCACCCCTGTCGCC
ATCCGCGAAGGCCACGCCTTTGCCGATACAGAATTTGGTGACAAGCCCTGGAAGATGGATCACTCGAACATTCCGACCGC
CGTGTTCACCCAGCCGGAAGTCGGCACCGTCGGCATCTCCGAAGCCGAGGCACGCAAGACGTTCGGCGAGATCGATATCT
ACAAGACCAAATTCCGCCCGATGAAAAATATGCTGAACGGCGACCAGACACGCACGTTCATGAAGCTCGTCGTGCGTGCC
TCTGACCAGCGCGTCCTGGGCGTGCATGTGGTGGGCGAGGACGCTGCCGAGATGATCCAGACCGCCGCCATCGCTGTGAA
GATGGGCGCCACAAAGCAGGATTTCGACCAGACCTGCGCGCTGCACCCGTCATCTGCCGAAGAACTCGTCACGATGCGGA
CCAAATGGGTACCTGAGGGCGTTTGA

Upstream 100 bases:

>100_bases
GGTGATCATCGGCGAGGAAAATGGCGCCCATATCATTGAATACTGAGGCGGGCGCCTCACATCTGTTGCCGATAACCCGC
TGATACCCAAGGACCTTCCC

Downstream 100 bases:

>100_bases
CCTTGAAGCCCCTCTCCCCTGGGAGGGGGCTAAATCAATGCCGCGTCATCGCGTCATTCAGTCCACGGATTTCGAGTGCC
ACCTGTGTCAGGCTTTCGCG

Product: glutathione-disulfide reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTDTAYDYDLFVIGGGSGGVRAGRIAAQAGAKVALAEEYRMGGTCVVRGCVPKKFMVYSSTYGKHIKLSAGYGWSVGDVS
YDHSAFMVALHAEVERLSAIYDRNLKNAGVDVFDDRAEFVDAHTLRLKKSGKTVTAGKILIATGGRPWMPSADELPGIEH
AIDSNGVFEMDTLPKRMLIAGGGYIAVEFAHIFAGLGAEVTLVYRGETVLRGFDDEIRLAVHEGLKEAGVRVVTKCTFKS
IEKTGGGLMVTMSSGNEIDTDVVLMAVGRRANTDDLGCDKAGVKLAEQGEVIVDEWSRTNVENIWAVGDVTGRVALTPVA
IREGHAFADTEFGDKPWKMDHSNIPTAVFTQPEVGTVGISEAEARKTFGEIDIYKTKFRPMKNMLNGDQTRTFMKLVVRA
SDQRVLGVHVVGEDAAEMIQTAAIAVKMGATKQDFDQTCALHPSSAEELVTMRTKWVPEGV

Sequences:

>Translated_461_residues
MTDTAYDYDLFVIGGGSGGVRAGRIAAQAGAKVALAEEYRMGGTCVVRGCVPKKFMVYSSTYGKHIKLSAGYGWSVGDVS
YDHSAFMVALHAEVERLSAIYDRNLKNAGVDVFDDRAEFVDAHTLRLKKSGKTVTAGKILIATGGRPWMPSADELPGIEH
AIDSNGVFEMDTLPKRMLIAGGGYIAVEFAHIFAGLGAEVTLVYRGETVLRGFDDEIRLAVHEGLKEAGVRVVTKCTFKS
IEKTGGGLMVTMSSGNEIDTDVVLMAVGRRANTDDLGCDKAGVKLAEQGEVIVDEWSRTNVENIWAVGDVTGRVALTPVA
IREGHAFADTEFGDKPWKMDHSNIPTAVFTQPEVGTVGISEAEARKTFGEIDIYKTKFRPMKNMLNGDQTRTFMKLVVRA
SDQRVLGVHVVGEDAAEMIQTAAIAVKMGATKQDFDQTCALHPSSAEELVTMRTKWVPEGV
>Mature_460_residues
TDTAYDYDLFVIGGGSGGVRAGRIAAQAGAKVALAEEYRMGGTCVVRGCVPKKFMVYSSTYGKHIKLSAGYGWSVGDVSY
DHSAFMVALHAEVERLSAIYDRNLKNAGVDVFDDRAEFVDAHTLRLKKSGKTVTAGKILIATGGRPWMPSADELPGIEHA
IDSNGVFEMDTLPKRMLIAGGGYIAVEFAHIFAGLGAEVTLVYRGETVLRGFDDEIRLAVHEGLKEAGVRVVTKCTFKSI
EKTGGGLMVTMSSGNEIDTDVVLMAVGRRANTDDLGCDKAGVKLAEQGEVIVDEWSRTNVENIWAVGDVTGRVALTPVAI
REGHAFADTEFGDKPWKMDHSNIPTAVFTQPEVGTVGISEAEARKTFGEIDIYKTKFRPMKNMLNGDQTRTFMKLVVRAS
DQRVLGVHVVGEDAAEMIQTAAIAVKMGATKQDFDQTCALHPSSAEELVTMRTKWVPEGV

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=41.8300653594771, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI22035672, Length=472, Percent_Identity=36.0169491525424, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI148277065, Length=477, Percent_Identity=34.8008385744235, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI148277071, Length=477, Percent_Identity=34.8008385744235, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI33519430, Length=477, Percent_Identity=34.8008385744235, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI33519428, Length=477, Percent_Identity=34.8008385744235, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI33519426, Length=477, Percent_Identity=34.8008385744235, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI291045266, Length=482, Percent_Identity=34.4398340248963, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI291045268, Length=480, Percent_Identity=31.875, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI91199540, Length=463, Percent_Identity=29.5896328293737, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI1789915, Length=433, Percent_Identity=40.6466512702078, Blast_Score=321, Evalue=7e-89,
Organism=Escherichia coli, GI87081717, Length=454, Percent_Identity=28.8546255506608, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI87082354, Length=463, Percent_Identity=28.2937365010799, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI1786307, Length=458, Percent_Identity=28.1659388646288, Blast_Score=168, Evalue=8e-43,
Organism=Escherichia coli, GI1789065, Length=233, Percent_Identity=27.8969957081545, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71983419, Length=460, Percent_Identity=39.5652173913043, Blast_Score=278, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI71983429, Length=460, Percent_Identity=39.5652173913043, Blast_Score=278, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI17557007, Length=475, Percent_Identity=33.6842105263158, Blast_Score=249, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI71982272, Length=483, Percent_Identity=32.2981366459627, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI32565766, Length=458, Percent_Identity=29.9126637554585, Blast_Score=180, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6325166, Length=470, Percent_Identity=38.7234042553192, Blast_Score=313, Evalue=3e-86,
Organism=Saccharomyces cerevisiae, GI6321091, Length=463, Percent_Identity=27.8617710583153, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6325240, Length=480, Percent_Identity=28.5416666666667, Blast_Score=157, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24640551, Length=473, Percent_Identity=35.9408033826639, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24640553, Length=473, Percent_Identity=35.9408033826639, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24640549, Length=473, Percent_Identity=35.9408033826639, Blast_Score=269, Evalue=3e-72,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=32.8421052631579, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI21358499, Length=464, Percent_Identity=29.0948275862069, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49812; Mature: 49681

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTAYDYDLFVIGGGSGGVRAGRIAAQAGAKVALAEEYRMGGTCVVRGCVPKKFMVYSS
CCCCCEEEEEEEEECCCCCCCCCEEEHHCCCEEEEEHHHCCCCEEEEECCCCCEEEEEEC
TYGKHIKLSAGYGWSVGDVSYDHSAFMVALHAEVERLSAIYDRNLKNAGVDVFDDRAEFV
CCCCEEEEECCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCEECCHHHHH
DAHTLRLKKSGKTVTAGKILIATGGRPWMPSADELPGIEHAIDSNGVFEMDTLPKRMLIA
CCEEEEEECCCCEEEECEEEEEECCCCCCCCCCCCCCCHHHCCCCCEEEECCCCCEEEEE
GGGYIAVEFAHIFAGLGAEVTLVYRGETVLRGFDDEIRLAVHEGLKEAGVRVVTKCTFKS
CCCEEEEEHHHHHHCCCCEEEEEECCCCEECCCCHHHHHHHHHCHHHCCCEEEEHHHHHH
IEKTGGGLMVTMSSGNEIDTDVVLMAVGRRANTDDLGCDKAGVKLAEQGEVIVDEWSRTN
HHHCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCHHCCEECCCCCEEEECCCCCC
VENIWAVGDVTGRVALTPVAIREGHAFADTEFGDKPWKMDHSNIPTAVFTQPEVGTVGIS
CCCEEEEECCCCEEEEEEEEEECCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCEECCC
EAEARKTFGEIDIYKTKFRPMKNMLNGDQTRTFMKLVVRASDQRVLGVHVVGEDAAEMIQ
HHHHHHHHCCEEEEEHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHH
TAAIAVKMGATKQDFDQTCALHPSSAEELVTMRTKWVPEGV
HHHEEEEECCCHHCHHHHEECCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TDTAYDYDLFVIGGGSGGVRAGRIAAQAGAKVALAEEYRMGGTCVVRGCVPKKFMVYSS
CCCCEEEEEEEEECCCCCCCCCEEEHHCCCEEEEEHHHCCCCEEEEECCCCCEEEEEEC
TYGKHIKLSAGYGWSVGDVSYDHSAFMVALHAEVERLSAIYDRNLKNAGVDVFDDRAEFV
CCCCEEEEECCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCEECCHHHHH
DAHTLRLKKSGKTVTAGKILIATGGRPWMPSADELPGIEHAIDSNGVFEMDTLPKRMLIA
CCEEEEEECCCCEEEECEEEEEECCCCCCCCCCCCCCCHHHCCCCCEEEECCCCCEEEEE
GGGYIAVEFAHIFAGLGAEVTLVYRGETVLRGFDDEIRLAVHEGLKEAGVRVVTKCTFKS
CCCEEEEEHHHHHHCCCCEEEEEECCCCEECCCCHHHHHHHHHCHHHCCCEEEEHHHHHH
IEKTGGGLMVTMSSGNEIDTDVVLMAVGRRANTDDLGCDKAGVKLAEQGEVIVDEWSRTN
HHHCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCHHCCEECCCCCEEEECCCCCC
VENIWAVGDVTGRVALTPVAIREGHAFADTEFGDKPWKMDHSNIPTAVFTQPEVGTVGIS
CCCEEEEECCCCEEEEEEEEEECCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCEECCC
EAEARKTFGEIDIYKTKFRPMKNMLNGDQTRTFMKLVVRASDQRVLGVHVVGEDAAEMIQ
HHHHHHHHCCEEEEEHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHH
TAAIAVKMGATKQDFDQTCALHPSSAEELVTMRTKWVPEGV
HHHEEEEECCCHHCHHHHEECCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]