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The map label for this gene is bktB [H]

Identifier: 114799237

GI number: 114799237

Start: 973446

End: 974657

Strand: Direct

Name: bktB [H]

Synonym: HNE_0959

Alternate gene names: 114799237

Gene position: 973446-974657 (Clockwise)

Preceding gene: 114798582

Following gene: 114797581

Centisome position: 26.27

GC content: 65.1

Gene sequence:

>1212_bases
ATGCGCGACGTTGTGATTGTGGAGCCGGTGCGGACGGCGGTGGGTGGCTTTGGCGGCGCGTTCAAGGGCGTGCACGCGCA
TGAGCTGGGCGCGGCGGTGGTCGAAGGGCTGATGGCGCGCACGGGCCTGGCGAAAGACAAGGTCGATGATGTGATCTTCG
CCCAGTGCTACCCTTCGATGGACGCGCCCGCGCTGGGCCGGGTTGTGGCGCTCGATGCCGGGCTCCCGGTAGAAGTCACC
GGCATGCAGATCGACCGGCGCTGCGGCTCTGGCCTTCAGGCGATCATTAACGCCACGATGCAGGTGGCCACCGGCGCGAT
GGACTGCGTGATCGCCGGCGGCGCCGAGTCGATGAGCAATGCGCCGTTCTATTCCACCAACTGGCGCTGGGGTCTCGGTC
AGGGCAACATGACGGTGCATGATGGCCTCGTGAATGGCCGTCTGACAGCGGGTGGCAAGAACTTCCCCGTACCCGGCGGC
ATGCTGGAGACGGCCGAAAACCTTCGCCGCGATTACCAGATCACCCGCCAGGCGCAGGACGAATTCGCCGCCGCTTCTCA
TGCCAAGGCGGTTGCCGCGCAGAACTCCGGCGTGTTCGATGAGGAAATCATTCCGTTCACGGTCAAGGGCCGCAAGGGCG
ATACCGTAGTGACGAAGGACGAACACCCCCGTCCGGACTCAACCCTTGAAGTGCTCTCCAAACTGAAACCCATCCGCCAG
AAACAGGACGCTGAAGCCACCGTCACCGCCGGCAATGCCAGCGGCCAGAATGATGGCGGCTCGGCTTGTCTCGTGATGAC
GCGCGAAATGGCAGAGGCCAATGGCCTCAAGCCGCTCGCCCGGCTGGTCTCCTGGTCGGTGGCCGGGGTTGGCCCGGCGG
TGATGGGCATCGGCCCTGTTCCGTCCACGGAAAAGGCGCTGGCGCGCGCGGGCCTGACGCTGAAAGACATTGACCTGATC
GAACTCAACGAAGCGTTTGCCGCGCAGGTGCTTGCCTGCACCAAGGCGATGGGCTTCGCCAAGGAAGACTATGCGCGCCT
CAATGTGCACGGATCGGGCATTTCACTGGGCCATCCGGTCGGCGCGACCGGCGGGCGTATTCTGGCCACGCTGCTGCGTG
AAATGGACCGCCGCGAGGCGCGGTACGGCGTTGAAACCATGTGCATTGGCGGCGGGCAGGGCCTGGCTGCGGTGTTCGAG
CGCGTTAACTGA

Upstream 100 bases:

>100_bases
GACAGTTATGCTGAGCTTGCATGAAAGGCCCCGGGTTGCGCTGAGCCGCAGGCCGGGCTTAACAGGGGCGAAGTTTTGAA
GAGTTCCCGGGAGAAATTGA

Downstream 100 bases:

>100_bases
CATCTGCTCAGGCTCCGGCGATCCCGGAGCCTGACAGTAAATTAAACTTGCATTCGGCCTGTGGATAGCGCATATGGCTC
GCATCGACATTGGCCGGACG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MRDVVIVEPVRTAVGGFGGAFKGVHAHELGAAVVEGLMARTGLAKDKVDDVIFAQCYPSMDAPALGRVVALDAGLPVEVT
GMQIDRRCGSGLQAIINATMQVATGAMDCVIAGGAESMSNAPFYSTNWRWGLGQGNMTVHDGLVNGRLTAGGKNFPVPGG
MLETAENLRRDYQITRQAQDEFAAASHAKAVAAQNSGVFDEEIIPFTVKGRKGDTVVTKDEHPRPDSTLEVLSKLKPIRQ
KQDAEATVTAGNASGQNDGGSACLVMTREMAEANGLKPLARLVSWSVAGVGPAVMGIGPVPSTEKALARAGLTLKDIDLI
ELNEAFAAQVLACTKAMGFAKEDYARLNVHGSGISLGHPVGATGGRILATLLREMDRREARYGVETMCIGGGQGLAAVFE
RVN

Sequences:

>Translated_403_residues
MRDVVIVEPVRTAVGGFGGAFKGVHAHELGAAVVEGLMARTGLAKDKVDDVIFAQCYPSMDAPALGRVVALDAGLPVEVT
GMQIDRRCGSGLQAIINATMQVATGAMDCVIAGGAESMSNAPFYSTNWRWGLGQGNMTVHDGLVNGRLTAGGKNFPVPGG
MLETAENLRRDYQITRQAQDEFAAASHAKAVAAQNSGVFDEEIIPFTVKGRKGDTVVTKDEHPRPDSTLEVLSKLKPIRQ
KQDAEATVTAGNASGQNDGGSACLVMTREMAEANGLKPLARLVSWSVAGVGPAVMGIGPVPSTEKALARAGLTLKDIDLI
ELNEAFAAQVLACTKAMGFAKEDYARLNVHGSGISLGHPVGATGGRILATLLREMDRREARYGVETMCIGGGQGLAAVFE
RVN
>Mature_403_residues
MRDVVIVEPVRTAVGGFGGAFKGVHAHELGAAVVEGLMARTGLAKDKVDDVIFAQCYPSMDAPALGRVVALDAGLPVEVT
GMQIDRRCGSGLQAIINATMQVATGAMDCVIAGGAESMSNAPFYSTNWRWGLGQGNMTVHDGLVNGRLTAGGKNFPVPGG
MLETAENLRRDYQITRQAQDEFAAASHAKAVAAQNSGVFDEEIIPFTVKGRKGDTVVTKDEHPRPDSTLEVLSKLKPIRQ
KQDAEATVTAGNASGQNDGGSACLVMTREMAEANGLKPLARLVSWSVAGVGPAVMGIGPVPSTEKALARAGLTLKDIDLI
ELNEAFAAQVLACTKAMGFAKEDYARLNVHGSGISLGHPVGATGGRILATLLREMDRREARYGVETMCIGGGQGLAAVFE
RVN

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=402, Percent_Identity=39.3034825870647, Blast_Score=288, Evalue=7e-78,
Organism=Homo sapiens, GI148539872, Length=398, Percent_Identity=40.7035175879397, Blast_Score=284, Evalue=1e-76,
Organism=Homo sapiens, GI4501853, Length=407, Percent_Identity=38.3292383292383, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI4557237, Length=408, Percent_Identity=33.0882352941176, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4504327, Length=427, Percent_Identity=34.4262295081967, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI194353979, Length=92, Percent_Identity=50, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=44.3069306930693, Blast_Score=306, Evalue=1e-84,
Organism=Escherichia coli, GI87082165, Length=401, Percent_Identity=44.6384039900249, Blast_Score=301, Evalue=5e-83,
Organism=Escherichia coli, GI1787663, Length=410, Percent_Identity=41.7073170731707, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI48994986, Length=409, Percent_Identity=39.6088019559902, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1788683, Length=413, Percent_Identity=32.2033898305085, Blast_Score=179, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI133906874, Length=400, Percent_Identity=41.25, Blast_Score=298, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI17535921, Length=401, Percent_Identity=33.6658354114713, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI25147385, Length=401, Percent_Identity=33.1670822942643, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17551802, Length=430, Percent_Identity=33.7209302325581, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17535917, Length=413, Percent_Identity=24.6973365617433, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6325229, Length=406, Percent_Identity=35.9605911330049, Blast_Score=229, Evalue=6e-61,
Organism=Saccharomyces cerevisiae, GI6322031, Length=402, Percent_Identity=36.0696517412935, Blast_Score=219, Evalue=8e-58,
Organism=Drosophila melanogaster, GI17648125, Length=406, Percent_Identity=42.6108374384236, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24655093, Length=403, Percent_Identity=39.9503722084367, Blast_Score=289, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24640423, Length=401, Percent_Identity=35.1620947630923, Blast_Score=225, Evalue=5e-59,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=32.7868852459016, Blast_Score=188, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 42185; Mature: 42185

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDVVIVEPVRTAVGGFGGAFKGVHAHELGAAVVEGLMARTGLAKDKVDDVIFAQCYPSM
CCCEEEECCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
DAPALGRVVALDAGLPVEVTGMQIDRRCGSGLQAIINATMQVATGAMDCVIAGGAESMSN
CCCCCCEEEEECCCCCEEEECCCHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCHHHCCC
APFYSTNWRWGLGQGNMTVHDGLVNGRLTAGGKNFPVPGGMLETAENLRRDYQITRQAQD
CCEEECCCEEECCCCCEEEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EFAAASHAKAVAAQNSGVFDEEIIPFTVKGRKGDTVVTKDEHPRPDSTLEVLSKLKPIRQ
HHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHH
KQDAEATVTAGNASGQNDGGSACLVMTREMAEANGLKPLARLVSWSVAGVGPAVMGIGPV
HCCCCEEEEECCCCCCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHCCCCCHHEECCCC
PSTEKALARAGLTLKDIDLIELNEAFAAQVLACTKAMGFAKEDYARLNVHGSGISLGHPV
CCHHHHHHHCCCEEECCCEEECCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEECCCCC
GATGGRILATLLREMDRREARYGVETMCIGGGQGLAAVFERVN
CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCC
>Mature Secondary Structure
MRDVVIVEPVRTAVGGFGGAFKGVHAHELGAAVVEGLMARTGLAKDKVDDVIFAQCYPSM
CCCEEEECCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
DAPALGRVVALDAGLPVEVTGMQIDRRCGSGLQAIINATMQVATGAMDCVIAGGAESMSN
CCCCCCEEEEECCCCCEEEECCCHHHHHCCHHHHHHHHHHHHHCCCEEEEEECCHHHCCC
APFYSTNWRWGLGQGNMTVHDGLVNGRLTAGGKNFPVPGGMLETAENLRRDYQITRQAQD
CCEEECCCEEECCCCCEEEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EFAAASHAKAVAAQNSGVFDEEIIPFTVKGRKGDTVVTKDEHPRPDSTLEVLSKLKPIRQ
HHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHH
KQDAEATVTAGNASGQNDGGSACLVMTREMAEANGLKPLARLVSWSVAGVGPAVMGIGPV
HCCCCEEEEECCCCCCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHCCCCCHHEECCCC
PSTEKALARAGLTLKDIDLIELNEAFAAQVLACTKAMGFAKEDYARLNVHGSGISLGHPV
CCHHHHHHHCCCEEECCCEEECCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEECCCCC
GATGGRILATLLREMDRREARYGVETMCIGGGQGLAAVFERVN
CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA