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The map label for this gene is proA

Identifier: 114799184

GI number: 114799184

Start: 3569216

End: 3570502

Strand: Direct

Name: proA

Synonym: HNE_3429

Alternate gene names: 114799184

Gene position: 3569216-3570502 (Clockwise)

Preceding gene: 114800268

Following gene: 114798022

Centisome position: 96.33

GC content: 67.6

Gene sequence:

>1287_bases
ATGACCGTCCAGACCTCTCCGCCTAGCGCTGCGCTTGCAGAAACGATGCTCGACATGGGGCGCCGCGCCCGCGCCGCGTC
GCGCGAACTTGGCCTCTTGACCGCGCAGGACCGCACGCGTGGCCTCAAAGCCATCGCCGCCGCCATCCGCGCCGCCGCCC
CGGACGTCCTGCGCGCCAATGCCGAAGATATGGCAGCAGCCCGCGCCAAGGGTCTCGCTCCGGCCATGCTGGACCGGCTC
GCGCTCGACGAAAAACGCCTCGAAGGCGTGGCGGCCGGCGTTGAAACGGTTGCCGCCCTGCCCGATCCGCTGGGCCGGGA
ACTGGCGCGCTGGACCCCGCCCAACGGGCTCGACATTGCGCGCATCGCGGTGCCGCTGGGTGTCATCGGCATCATCTATG
AAAGCCGCCCGAATGTGACCGTGGACGCGGGCGTGCTCTGCCTGCGCTCGGGCAACGCGGCCATCCTGCGTGGCGGCTCG
GAAAGCGCGAAGTCGTCCGCTGCGCTCGCGAACGCCATGCGCGGCGCGCTGAAATCTGAAGAACTGCCCGTTGATGCGAT
CCAGCTGGTTGCCACGACAAACCGTGAAGCGGTTGGCCATATGCTGGGCGGCCTTGAAGGCGCGCTCGATGTCATCGTGC
CGCGCGGCGGGCGCAGCCTCGTTGAGCGCGTGCAGGCCGAAGCCCGCGTGCCAGTGATCGGCCATCTTGAAGGCCTCTGC
CATACCTATGTCCACGCCGCCGCCGACCCGAAGAAGGCCGTCGACATCGTGCTGAACGCCAAGATGCGCCGCACGGGCGT
GTGCGGATCGACCGAGACGCTGCTTATTGATGTGGCCGTTGCCGCAACCCTGTTGCCGCAGATCGCCAAAGCGCTGACCG
ATGCAGGCTGCGAGCTGCGCGGGGATGGCCGCACGCGCGCCATTCTGGGCGACATCACGCCGGCAACCGAGGCAGACTGG
GCGACCGAATATCTCGACGCCATTCTCTCCATCGCCGTCGTCGATGGCCTGCCCGGCGCGCTGGCTCATCTGGCGCGCTG
GTCGTCGGGCCATACCGACGCAATCATCACCGAAGATACGGCCGCAGCCGAAACCTTCATCGCGAATGTCGACAGCGCCA
TCGTGCTGCACAATGCCTCCACCCAGTTTGCCGATGGCGGGGAGTTTGGCTTTGGCGCCGAGATCGGTATCGCGACGGGA
CGCATCCATGCGCGGGGGCCCGTGGGCGCCGAGCAGCTGACCACCTATAAATATGCCGTGCGCGGAACAGGCCAGGTCCG
CCCTTGA

Upstream 100 bases:

>100_bases
GACCTATGAACCGGTGGCGCGCGGCGCCTTCGCTCTTCTCAATTCCCTTCCCTGAGCCAAACCTTGCAGCAAAAGCCCTT
TTGCGGCACTTGATGGCGCC

Downstream 100 bases:

>100_bases
AGCGCCCTCGCCTGCCCGGCCCCGCCAAGGGTCTTGCCATCGGGCTCTTTGGCGGCAGTTTCAATCCCGCCCATGCCGGC
CATCTGCTGGTCGCGCAGAC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MTVQTSPPSAALAETMLDMGRRARAASRELGLLTAQDRTRGLKAIAAAIRAAAPDVLRANAEDMAAARAKGLAPAMLDRL
ALDEKRLEGVAAGVETVAALPDPLGRELARWTPPNGLDIARIAVPLGVIGIIYESRPNVTVDAGVLCLRSGNAAILRGGS
ESAKSSAALANAMRGALKSEELPVDAIQLVATTNREAVGHMLGGLEGALDVIVPRGGRSLVERVQAEARVPVIGHLEGLC
HTYVHAAADPKKAVDIVLNAKMRRTGVCGSTETLLIDVAVAATLLPQIAKALTDAGCELRGDGRTRAILGDITPATEADW
ATEYLDAILSIAVVDGLPGALAHLARWSSGHTDAIITEDTAAAETFIANVDSAIVLHNASTQFADGGEFGFGAEIGIATG
RIHARGPVGAEQLTTYKYAVRGTGQVRP

Sequences:

>Translated_428_residues
MTVQTSPPSAALAETMLDMGRRARAASRELGLLTAQDRTRGLKAIAAAIRAAAPDVLRANAEDMAAARAKGLAPAMLDRL
ALDEKRLEGVAAGVETVAALPDPLGRELARWTPPNGLDIARIAVPLGVIGIIYESRPNVTVDAGVLCLRSGNAAILRGGS
ESAKSSAALANAMRGALKSEELPVDAIQLVATTNREAVGHMLGGLEGALDVIVPRGGRSLVERVQAEARVPVIGHLEGLC
HTYVHAAADPKKAVDIVLNAKMRRTGVCGSTETLLIDVAVAATLLPQIAKALTDAGCELRGDGRTRAILGDITPATEADW
ATEYLDAILSIAVVDGLPGALAHLARWSSGHTDAIITEDTAAAETFIANVDSAIVLHNASTQFADGGEFGFGAEIGIATG
RIHARGPVGAEQLTTYKYAVRGTGQVRP
>Mature_427_residues
TVQTSPPSAALAETMLDMGRRARAASRELGLLTAQDRTRGLKAIAAAIRAAAPDVLRANAEDMAAARAKGLAPAMLDRLA
LDEKRLEGVAAGVETVAALPDPLGRELARWTPPNGLDIARIAVPLGVIGIIYESRPNVTVDAGVLCLRSGNAAILRGGSE
SAKSSAALANAMRGALKSEELPVDAIQLVATTNREAVGHMLGGLEGALDVIVPRGGRSLVERVQAEARVPVIGHLEGLCH
TYVHAAADPKKAVDIVLNAKMRRTGVCGSTETLLIDVAVAATLLPQIAKALTDAGCELRGDGRTRAILGDITPATEADWA
TEYLDAILSIAVVDGLPGALAHLARWSSGHTDAIITEDTAAAETFIANVDSAIVLHNASTQFADGGEFGFGAEIGIATGR
IHARGPVGAEQLTTYKYAVRGTGQVRP

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=415, Percent_Identity=37.8313253012048, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI21361368, Length=415, Percent_Identity=37.8313253012048, Blast_Score=249, Evalue=5e-66,
Organism=Escherichia coli, GI1786438, Length=413, Percent_Identity=40.6779661016949, Blast_Score=308, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI17569969, Length=424, Percent_Identity=37.2641509433962, Blast_Score=268, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI17569967, Length=424, Percent_Identity=37.2641509433962, Blast_Score=267, Evalue=6e-72,
Organism=Saccharomyces cerevisiae, GI6324899, Length=431, Percent_Identity=37.5870069605568, Blast_Score=255, Evalue=8e-69,
Organism=Drosophila melanogaster, GI21357643, Length=407, Percent_Identity=37.1007371007371, Blast_Score=248, Evalue=6e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_HYPNA (Q0BWP1)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_762102.1
- ProteinModelPortal:   Q0BWP1
- SMR:   Q0BWP1
- STRING:   Q0BWP1
- GeneID:   4288401
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_3429
- NMPDR:   fig|228405.5.peg.3283
- TIGR:   HNE_3429
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- ProtClustDB:   PRK00197
- BioCyc:   HNEP81032:HNE_3429-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 44310; Mature: 44179

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVQTSPPSAALAETMLDMGRRARAASRELGLLTAQDRTRGLKAIAAAIRAAAPDVLRAN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHCCCHHHHCC
AEDMAAARAKGLAPAMLDRLALDEKRLEGVAAGVETVAALPDPLGRELARWTPPNGLDIA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHH
RIAVPLGVIGIIYESRPNVTVDAGVLCLRSGNAAILRGGSESAKSSAALANAMRGALKSE
HHHHHHHHEEEEEECCCCEEEECCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCC
ELPVDAIQLVATTNREAVGHMLGGLEGALDVIVPRGGRSLVERVQAEARVPVIGHLEGLC
CCCHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHH
HTYVHAAADPKKAVDIVLNAKMRRTGVCGSTETLLIDVAVAATLLPQIAKALTDAGCELR
HHHHHHCCCCHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEE
GDGRTRAILGDITPATEADWATEYLDAILSIAVVDGLPGALAHLARWSSGHTDAIITEDT
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEECCH
AAAETFIANVDSAIVLHNASTQFADGGEFGFGAEIGIATGRIHARGPVGAEQLTTYKYAV
HHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECEEEECCCCCHHHHHHEEEEE
RGTGQVRP
ECCCCCCC
>Mature Secondary Structure 
TVQTSPPSAALAETMLDMGRRARAASRELGLLTAQDRTRGLKAIAAAIRAAAPDVLRAN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHCCCHHHHCC
AEDMAAARAKGLAPAMLDRLALDEKRLEGVAAGVETVAALPDPLGRELARWTPPNGLDIA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHH
RIAVPLGVIGIIYESRPNVTVDAGVLCLRSGNAAILRGGSESAKSSAALANAMRGALKSE
HHHHHHHHEEEEEECCCCEEEECCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCC
ELPVDAIQLVATTNREAVGHMLGGLEGALDVIVPRGGRSLVERVQAEARVPVIGHLEGLC
CCCHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHH
HTYVHAAADPKKAVDIVLNAKMRRTGVCGSTETLLIDVAVAATLLPQIAKALTDAGCELR
HHHHHHCCCCHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEE
GDGRTRAILGDITPATEADWATEYLDAILSIAVVDGLPGALAHLARWSSGHTDAIITEDT
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEECCH
AAAETFIANVDSAIVLHNASTQFADGGEFGFGAEIGIATGRIHARGPVGAEQLTTYKYAV
HHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECEEEECCCCCHHHHHHEEEEE
RGTGQVRP
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA