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The map label for this gene is mscS [H]

Identifier: 114799133

GI number: 114799133

Start: 593606

End: 594772

Strand: Reverse

Name: mscS [H]

Synonym: HNE_0598

Alternate gene names: 114799133

Gene position: 594772-593606 (Counterclockwise)

Preceding gene: 114800088

Following gene: 114797606

Centisome position: 16.05

GC content: 61.7

Gene sequence:

>1167_bases
ATGAGCATACCGAGCGAGACTTCGCGCCTGTTGGCGCTGCTGAATATTGATACCTCCACCTGGCCGGCCTGGGCGGCGAC
TGCCTGGCCGCATGTGGTACAGTGGAGCCTGGTGCTAGCCTCGGTATTGCTGATCTGGCTGCTGGCGACGGGCGTGAAGC
ATATCATCCGCTTCATCGGCAAACTGGCAACGCCCAAGGACAAGGATTTCGATGGCTCGGCCTGGGATCTGACAGCCTCC
GTGGCGCGGGTGTTTGCGCTGATCCTGTTCTCGCCGCTGCCCCTTGGCCTGGCAGGATATGACTGGGAAACGCTGGTGGA
TTCACGCGGGCCCGGCGCACTGGCGGCGGTTGCGATCCTCTTCTTTGCGCTGATGGGCGCCAACATGATTGCCCGCTCGC
TGAGGAAGTTTGGCGAGAAAGCCCATGCCCACGCCGGCGCCGATGATACGCTGATCGCGTTCTCCGCCTCGCTGATCAAA
TATGTGATCTTTGCCATCGCCATCGTGACGGCGCTGATCCAGCTGGGCTTTCCGGCCGCTTCGCTGGCGGCGGTGCTGGG
CGCAGCCGGCCTCGCCATCGGCCTGGCGCTGCAGGATACGCTGAAAGCGGTGGCGGCGGGCGTGATGCTGGCGATTTTCC
GGCCGTTCCGGATCGGGGATTATGTGACGCTGGCCGATCTTGAAGGCGAGGTGACCAACATCACCCCCTTCACCACGACG
ATGAAGCAGATCGATAACAAGATTGTCTCGCTGACCAATGACAAGGTGTGGGGCTCTCCCCTCATCAACCATACGATCCA
GCCCTACCGGCGGCTGGATATGCTGTATGGCATTTCCTATGGCGACGATATCGACAAGGCACTGGAAGTTCTCAACCATG
CGGCCGAATCCCACCCCAAGATCATCAGCTATATGCCGATCTGGGCGGGGGTTCAGTCGCTGGACGACTGGGCGGTGACG
CTGCGCCTGCGCGCCTGGGTGCCCACCCTGGACATGATCCAGGTGCGCGCCGATCTGATAAAGAGCATCAAGCAGAACTT
CGACAGTTCGGGGATCACGATCCCTTTCCCGACGACGACCGAATACCGGATGGAAAAGCCGGAAAAGGCCGGCGCCGAAG
CGCCCAAAGACCTTCCCCCACCCCCGAGCCGCGATACCAGCGGCTGA

Upstream 100 bases:

>100_bases
AGACGGGCATGCACCTGATCGGGCATTTTACCGCTGGCTGTCTTATTCTTCTGCTGACCCTGAGGCTGACGCGGGGCGCA
AAGGCAGGTAAACGGGCGGC

Downstream 100 bases:

>100_bases
ATACATTCAATGCTGCAACAACAAGGAAAGGATCGCAGCCACACATAAATGCCGTATGCTGACCAACGACAGCAGGCTCA
CCTCAAAAGGAGACTGACAT

Product: small conductance mechanosensitive ion channel (MscS) family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MSIPSETSRLLALLNIDTSTWPAWAATAWPHVVQWSLVLASVLLIWLLATGVKHIIRFIGKLATPKDKDFDGSAWDLTAS
VARVFALILFSPLPLGLAGYDWETLVDSRGPGALAAVAILFFALMGANMIARSLRKFGEKAHAHAGADDTLIAFSASLIK
YVIFAIAIVTALIQLGFPAASLAAVLGAAGLAIGLALQDTLKAVAAGVMLAIFRPFRIGDYVTLADLEGEVTNITPFTTT
MKQIDNKIVSLTNDKVWGSPLINHTIQPYRRLDMLYGISYGDDIDKALEVLNHAAESHPKIISYMPIWAGVQSLDDWAVT
LRLRAWVPTLDMIQVRADLIKSIKQNFDSSGITIPFPTTTEYRMEKPEKAGAEAPKDLPPPPSRDTSG

Sequences:

>Translated_388_residues
MSIPSETSRLLALLNIDTSTWPAWAATAWPHVVQWSLVLASVLLIWLLATGVKHIIRFIGKLATPKDKDFDGSAWDLTAS
VARVFALILFSPLPLGLAGYDWETLVDSRGPGALAAVAILFFALMGANMIARSLRKFGEKAHAHAGADDTLIAFSASLIK
YVIFAIAIVTALIQLGFPAASLAAVLGAAGLAIGLALQDTLKAVAAGVMLAIFRPFRIGDYVTLADLEGEVTNITPFTTT
MKQIDNKIVSLTNDKVWGSPLINHTIQPYRRLDMLYGISYGDDIDKALEVLNHAAESHPKIISYMPIWAGVQSLDDWAVT
LRLRAWVPTLDMIQVRADLIKSIKQNFDSSGITIPFPTTTEYRMEKPEKAGAEAPKDLPPPPSRDTSG
>Mature_387_residues
SIPSETSRLLALLNIDTSTWPAWAATAWPHVVQWSLVLASVLLIWLLATGVKHIIRFIGKLATPKDKDFDGSAWDLTASV
ARVFALILFSPLPLGLAGYDWETLVDSRGPGALAAVAILFFALMGANMIARSLRKFGEKAHAHAGADDTLIAFSASLIKY
VIFAIAIVTALIQLGFPAASLAAVLGAAGLAIGLALQDTLKAVAAGVMLAIFRPFRIGDYVTLADLEGEVTNITPFTTTM
KQIDNKIVSLTNDKVWGSPLINHTIQPYRRLDMLYGISYGDDIDKALEVLNHAAESHPKIISYMPIWAGVQSLDDWAVTL
RLRAWVPTLDMIQVRADLIKSIKQNFDSSGITIPFPTTTEYRMEKPEKAGAEAPKDLPPPPSRDTSG

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=269, Percent_Identity=34.2007434944238, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI1786670, Length=237, Percent_Identity=27.4261603375527, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787591, Length=241, Percent_Identity=24.0663900414938, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 42043; Mature: 41912

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPSETSRLLALLNIDTSTWPAWAATAWPHVVQWSLVLASVLLIWLLATGVKHIIRFIG
CCCCCHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLATPKDKDFDGSAWDLTASVARVFALILFSPLPLGLAGYDWETLVDSRGPGALAAVAIL
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHHHHH
FFALMGANMIARSLRKFGEKAHAHAGADDTLIAFSASLIKYVIFAIAIVTALIQLGFPAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
SLAAVLGAAGLAIGLALQDTLKAVAAGVMLAIFRPFRIGDYVTLADLEGEVTNITPFTTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHH
MKQIDNKIVSLTNDKVWGSPLINHTIQPYRRLDMLYGISYGDDIDKALEVLNHAAESHPK
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
IISYMPIWAGVQSLDDWAVTLRLRAWVPTLDMIQVRADLIKSIKQNFDSSGITIPFPTTT
EEECCHHHHHHHHHHHHHHEEEHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCC
EYRMEKPEKAGAEAPKDLPPPPSRDTSG
HHHCCCCHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SIPSETSRLLALLNIDTSTWPAWAATAWPHVVQWSLVLASVLLIWLLATGVKHIIRFIG
CCCCHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLATPKDKDFDGSAWDLTASVARVFALILFSPLPLGLAGYDWETLVDSRGPGALAAVAIL
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHHHHH
FFALMGANMIARSLRKFGEKAHAHAGADDTLIAFSASLIKYVIFAIAIVTALIQLGFPAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
SLAAVLGAAGLAIGLALQDTLKAVAAGVMLAIFRPFRIGDYVTLADLEGEVTNITPFTTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHH
MKQIDNKIVSLTNDKVWGSPLINHTIQPYRRLDMLYGISYGDDIDKALEVLNHAAESHPK
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
IISYMPIWAGVQSLDDWAVTLRLRAWVPTLDMIQVRADLIKSIKQNFDSSGITIPFPTTT
EEECCHHHHHHHHHHHHHHEEEHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCC
EYRMEKPEKAGAEAPKDLPPPPSRDTSG
HHHCCCCHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]